研究成果

[学会発表] BGL と XTPA の技術紹介

根本尚夫 2012

[学会発表] 簡便大量合成技術を活かした独創型MRI造影剤の開発

根本尚夫 2012

[雑誌論文] Cytotoxicity Evaluation of Symmetrically Branched Glycerol Trimer in Human Hepatocellular Carcinoma HepG2 cells

Miyamoto, Licht; Watanabe, Masashi; Kono, Mai; Matsushita, Tsuyoshi; Hattori, Hatsuhiko; Ishizawa, Keisuke; Nemoto, Hisao; Tsuchiya, Koichiro 2012

[雑誌論文] Synthesis of Highly Water-soluble Fibrate Derivatives via BGLation

Nemoto, Hisao et al (Nemoto, Hisao) 2012

[雑誌論文] Acute Oral Toxicity Evaluation of Symmetrically Branched Glycerol Trimer in ddY Mice

Miyamoto, Licht; Watanabe, Masashi; Tomida, Yosuke; Kono, Mai; Fujii, Shoko; Matsushita, Tsuyoshi; Hattori, Hatsuhiko; Ishizawa, Keisuke; Nemoto, Hisao; Tsuchiya, Koichiro 2012

[雑誌論文] A Novel Liposome Surface Modification Agent that Prolongs Blood Circulation and Retains Surface Ligand Reactivity

Ishihara, Atsushi; Yamauchi, Masahiro; Tsuchiya, Tomoko; Mimura, Yukiteru; Tomoda, Yutaka; Katagiri, Ayato; Kamiya, Masaki; Nemoto, Hisao; Suzawa, Toshiyuki; Yamasaki, Motoo 2012

[雑誌論文] An Efficient Method for C8-Prenylation of Flavonols and Flavanones

Kawamura, Tomoyuki; Hayashi, Moemi; Mukai, Rie; Terao, Junji; Nemoto, Hisao 2012

[雑誌論文] Synthesis of Paclitaxe-BGL Conjugates

Nemoto, Hisao et al (Nemoto, Hisao) 2012

[雑誌論文] Evaluation of the inhibitory effects of quercetin-related flavonoids and tea catechins on the monoamine oxidase-A reaction in mouse brain mitochondria

Bandaruk, Yauhen; Mukai, Rie; Kawamura, Tomoyuki; Nemoto, Hisao; Terao, Junji 2012

[学会発表] 「有機合成技術による新しいMRI用検査薬(造影剤)の開発」 ～放射線無用かつ切らずに挿さずに体内を視る～

根本尚夫 2012

[学会発表] 「有機合成技術による新しい MRI 用検査薬(造影剤)の開発」 放射線無用かつ切らずに挿さずに体内を視る

根本尚夫 2012

[雑誌論文] Synthesis of Highly Water-soluble Fibrate Derivatives via BGLation

Nemoto, Hisao; Kamiya, Masaki; Nakamoto, Aki; Matsushita, Tsuyoshi; Matsumura, Kosuke; Hattori, Hatsuhiko; Kawamura, Tomoyuki; Taoka, Chiaki; Abe, Shinji; Ishizawa, Keisuke; Miyamoto, Licht; Tsuchiya, Koichiro 2012

[学会発表] 簡便大量合成技術を活かした独創型 MRI 造影剤の開発 A versatile and practical synthetic intermediate for MRI imaging agents

根本尚夫 2012

[雑誌論文] Frequency of C-allylations on oligoglycinates via N-ylides

Nemoto, Hisao; Tamagawa, Shin-ya; Yatsuzuka, Kenji; Kawamura, Tomoyuki 2012

[雑誌論文] Synthesis and Evaluation of Water-soluble Resveratrol and Piceatannol via BGLation

Nemoto, Hisao et al (Nemoto, Hisao) 2012

[雑誌論文] Prevention of Disuse Muscle Atrophy by Dietary Ingestion of 8-Prenylnaringenin in Denervation Mice

Mukai, Rie; Horikawa, Hitomi; Fujikura, Yutaka; Kawamura, Tomoyuki; Nemoto, Hisao; Nikawa, Takeshi; Terao, Junji 2012

[雑誌論文] Frequency of C-allylations on oligoglycinates via N-ylides

Nemoto, Hisao et al (Nemoto, Hisao) 2012

[雑誌論文] Synthesis and Evaluation of Water-soluble Resveratrol and Piceatannol via BGLation

Nemoto, Hisao; Katagiri, Ayato; Kamiya, Masaki; Matsushita, Tsuyoshi; Hattori, Hatsuhiko; Matsumura, Kosuke; Itou, Tomohiro; Kawamura, Tomoyuki; Kita, Toshiyuki; Nishida, Hana; Arakaki, Naokatu 2012

[雑誌論文] An Efficient Method for the Refinement of 1,3-Methyleneglycerol via Bridged Acetal Exchange and Synthesis of the Symmetrically Branched Glycerol Trimer

Hattori, Hatsuhiko; Matsushita, Tsuyoshi; Yoshitomi, Kohsuke; Katagiri, Ayato; Nemoto, Hisao 2012

[学会発表] BGLとXTPAの技術紹介

根本尚夫 2012

[雑誌論文] Synthesis of Paclitaxel-BGL Conjugates

Nemoto, Hisao; Katagiri, Ayato; Kamiya, Masaki; Kawamura, Tomoyuki; Matsushita, Tsuyoshi; Matsumura, Kosuke; Itou, Tomohiro; Hattori, Hatsuhiko; Tamaki, Miho; Ishizawa, Keisuke; Miyamoto, Licht; Abe, Shinji; Tsuchiya, Koichiro 2012

[学会発表] 新規MRI造影剤の開発研究(The new development of MRI contrast medium)

玉川晋也・八塚研治・阿部真司・久保均・原田雅史・根本尚夫 2011

[雑誌論文] A highly selective mono-C-allylation of DTPA pentaethyl ester

Nemoto, Hisao; Yatsuzuka, Kenji; Tamagawa, Shin-ya; Hirao, Naoko; Kamiya, Masaki; Kawamura, Tomoyuki 2011

[学会発表] Synthesis of DTPA-Cholestanol Derivatives toward Potential MRI Contrast Medium

Shin-ya Tamagawa, Kenji Yatsuzuka, Shinji Abe, Hitoshi Kubo, Koichiro Tsuchiya, Masafumi Harada, Hisao Nemoto 2011

[学会発表] 機能性MRI造影剤を指向したDTPA-Cholestanol誘導体の合成

玉川晋也・八塚研治・山崎豊・河村知志・根本尚夫 2011

[学会発表] 機能性 MRI 造影剤を指向したDTPA-cholestanol 誘導体の合成 (Design and synthesis of DTPA-cholestanol conjugations toward potential MRI contrast medium

玉川晋也・八塚研治・山崎豊・河村知志・根本尚夫 2011

[学会発表] 構造ではなく性能を創る有機化学

根本尚夫 2011

[学会発表] 新規 MRI造影剤の開発研究(The new development of MRI contrast medium)

玉川晋也・八塚研治・阿部真司・久保均・土屋浩一郎・原田雅史・根本尚夫 2011

[雑誌論文] Improved performance by replacing iminodiacetic residues with glyceryl residues in symmetrically branched oligoglycerols

Nemoto, Hisao; Ishihara, Atsushi; Araki, Takaaki; Katagiri, Ayato; Kamiya, Masaki; Matsushita, Tsuyoshi; Hattori, Hatsuhiko; Mimura, Yukiteru; Tomoda, Yutaka; Yamasaki, Motoo 2011

[雑誌論文] A Highly Selective Mono-C-allylation of DTPA Pentaethyl Ester

Hisao Nemoto 2011

[学会発表] Synthesis of DTPA-Cholestanol Derivatives toward Potential MRI Contrast Medium

Shin-ya Tamagawa, Kenji Yatsuznka, Shinji Abe, Hitoshi Kubo, Koichiro Tsuchiya, Masafumi Harada, Hisao Nemoto 2011

[学会発表] 薬を「溶かす」「視る」-水溶性化およびMR I造影剤創製に関する最近の成果-

根本尚夫 2011

[学会発表] 薬を「溶かす」「視る」 水溶性化およびMRI造影剤創製に関する最近の成果ー

根本尚夫 2011

[学会発表] Synthesis of C-Branched DTPA Derivatives toward MRI Contrast Medium

Kenji Yatsuzuka, Shin-ya Tmagawa, Tomoyuki Kawamura, Hisao Nemoto 2010

[学会発表] Kenji Yatsuzuka, Shin-ya Tmagawa, Tomoyuki Kawamura, Hisao Nemoto

Kenji Yatsuzuka, Shin-ya Tmagawa, Tomoyuki Kawamura, Hisao Nemoto 2010

[学会発表] 機能性 MRI 造影剤創製に向けた連結用官能基を有する DTPA 誘導体の合成

八塚研治、玉川晋也、河村知志、根本尚夫 2010

[学会発表] 二段階型Stevens転位を用いた高選択的モノアリル化反応

玉川晋也・八塚研治・河村知志・根本尚夫 2010

[学会発表] 機能性MRI造影剤創製に向けた連結用官能基を有するDTPA誘導体の合成

八塚研治、玉川晋也、河村知志、根本尚夫 2010

[雑誌論文] An Efficient and Practical Method for the Preparation of a Branched Oligoglycerol with Acetonide Protection Groups

Hisao Nemoto 2010

[学会発表] Highly selective mono-allylation of the compounds possessing multi-glycinate moieties

Shin-ya Tmagawa, Kenji Yatsuzuka, Tomoyuki Kawamura, Hisao Nemoto 2010

ジエチレントリアミン五酢酸誘導体の製造方法およびジエチレントリアミン五酢酸誘導体