トップ研究者を探す細胞間接着に依存しない始原的な上皮極性形成の機構

細胞間接着に依存しない始原的な上皮極性形成の機構

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-22570195
研究種目 基盤研究(C)
研究分野 生物系
生物学
生物科学
細胞生物学
研究機関 独立行政法人理化学研究所
代表研究者 米村 重信
研究期間 開始年月日 2010/4/1
研究期間 終了年度 2012
研究ステータス 完了 (2012/4/1)
配分額(合計) 4,680,000 (直接経費 :3,600,000、間接経費 :1,080,000)
配分額(履歴) 2012年度:1,040,000 (直接経費 :800,000、間接経費 :240,000)
2011年度:1,820,000 (直接経費 :1,400,000、間接経費 :420,000)
2010年度:1,820,000 (直接経費 :1,400,000、間接経費 :420,000)
キーワード 上皮細胞
極性
ミオシン
細胞外基質
上皮極性
微小管
細胞周期
細胞極性
細胞間接着装置
細胞接着装置

研究成果

[雑誌論文] Homeostatic epithelial renewal in the gut is required for dampening a fatal systemic wound response in Drosophila

Takeishi A, Kuranaga E, Tonoki A, Misaki K, Yonemura S, Kanuka H, Miura M 2013

[学会発表] Mechanosensing function of alpha-catenin in epithelial morphogenesis Session 1

Yonemura, S 2013

[雑誌論文] Epithelial cell-intrinsic Notch signaling plays an essential role in the maintenance of gut immune homeostasis

Obata Y, Takahashi D, Ebisawa M, Kakiguchi K, Yonemura S, Jinnohara T, Kanaya T, Fujimura Y, Ohmae M, Hase K, Ohno H 2012

[雑誌論文] Trichoplein and Aurora A block aberrant primary cilia assembly in proliferating cells

Inoko A, Matsuyama M, Goto H, Ohmuro-Matsuyama Y, Hayashi Y, Enomoto M, Ibi M, Urano T, Yonemura S, Kiyono T, Izawa I, Inagaki M 2012

[雑誌論文] Talin couples the actomyosin cortex to the plasma membrane during rear retraction and cytokinesis

Tsujioka M, Yumura S, Inouye K, Patel H, Ueda M, Yonemura S 2012

[雑誌論文] Loss of N-cadherin from the endothelium causes stromal edema and epithelial dysgenesis in the mouse cornea

Vassilev VS, Mandai M, Yonemura S, Takeichi M 2012

[雑誌論文] Self-formation of optic cups and storable stratified neural retina from human ESCs

Nakano T, Ando S, Takata N, Kawada M, Muguruma K, Sekiguchi K, Saito K, Yonemura S, Eiraku M, Sasai Y 2012

[雑誌論文] Furuse M. Snakeskin, a membrane protein associated with smooth septate junctions, is required for intestinal barrier function in Drosophila

Yanagihashi Y, Usui T, Izumi Y, Yonemura S, Sumida M, Tsukita S, Uemura T 2012

[学会発表] 隣り合う細胞を引っ張る力が多細胞形態形成を制御する

米村重信 2012

[学会発表] 細胞間接着装置形成における張力伝達の調節の意義

米村重信 2012

[雑誌論文] Joint morphology in the insect leg: evolutionary history inferred from Notch loss-of-function phenotypes in Drosophila

Tajiri R, Misaki K, Yonemura S, Hayashi S 2011

[雑誌論文] Modulating F-actin organization induces organ growth by affecting the Hippo pathway

Sansores-Garcia L, Bossuyt W, Wada K, Yonemura S, Tao C, Sasaki H, Halder G 2011

[学会発表] 隣接する細胞からの張力刺激に対する細胞の応答

米村重信 2011

[雑誌論文] Cadherin-actin interactions at adherens junctions

Yonemura S 2011

[雑誌論文] IKKε regulates cell elongation through recycling endosome shuttling

Otani T, Oshima K, Onishi S, Takeda M, Shinmyozu K, Yonemura S, Hayashi S 2011

[雑誌論文] A mechanism of mechanotransduction at the cell-cell interface : Emergence of α-catenin as the center of a force-balancing mechanism for morphogenesis in multicellular organisms

Yonemura, S 2011

[雑誌論文] Hippo pathway regulation by cell morphology and stress fibers

Wada K, Itoga K, Okano T, Yonemura S, Sasaki H 2011

[雑誌論文] Involvement of afadin in barrier function and homeostasis of mouse intestinal epithelia

Tanaka-Okamoto M, Hori K, Ishizaki H, Itoh Y, Onishi S, Yonemura S, Takai Y, Miyoshi J 2011

[学会発表] Perception of the death of an adjacent cell in an epithelial sheet and the mechanism of cell junction development according to forces applied during wound closure movement

米村重信 2011

[雑誌論文] Cadherin-actin interactions at adherens junctions

Yonemura, S. 2011

[雑誌論文] Self-formation of functional adenohypophysis in three-dimensional culture

Suga H, Kadoshima T, Minaguchi M, Ohgushi M, Soen M, Nakano T, Takata N, Wataya T, Muguruma K, Miyoshi H, Yonemura S, Oiso Y, Sasai Y 2011

[雑誌論文] A mechanism of mechanotransduction at the cell-cell interface: emergence of α-catenin as the center of a force-balancing mechanism for morphogenesis in multicellular organisms

Yonemura S 2011

[学会発表] アドへレンスジャンクション(AJ)におけるメカノセンシング

米村重信 2011

[雑誌論文] The TRPV4 channel contributes to intercellular junction formation in keratinocytes

Sokabe T, Fukumi-Tominaga T, Yonemura S, Mizuno A, Tominaga M 2010

[学会発表] 上皮損傷修復の特性とバリア機能の維持

米村重信 2010

[雑誌論文] alpha-Catenin as a tension transducer that induces adherens junction development

Yonemura S, Wada Y, Watanabe T, Nagafuchi A, Shibata M 2010

[学会発表] 上皮損傷修復の特性とバリア機能の維持

米村重信, 柴田真依 2010

[雑誌論文] α-catenin as a tension transducer that induces adherens junction development.

Yonemura, S. 2010

[雑誌論文] Mib-Jag1-Notch signalling regulates patterning and structural roles of the notochord by controlling cell-fate decisions

Yamamoto M, Morita R, Mizoguchi T, Matsuo H, Isoda M, Ishitani T, Chitnis AB, Matsumoto K, Crump JG, Hozumi K, Yonemura S, Kawakami K, Itoh M 2010

[雑誌論文] Dynamic shape changes of ECM-producing cells drive morphogenesis of ball-and-socket joints in the fly leg

Tajiri R, Misaki K, Yonemura S, Hayashi S 2010

[雑誌論文] Metalloprotease-dependent onset of blood circulation in zebrafish

Iida A, Sakaguchi K, Sato K, Sakurai H, Nishimura D, Iwaki A, Takeuchi M, Kobayashi M, Misaki K, Yonemura S, Kawahara A, Sehara-Fujisawa A 2010

[学会発表] Mechanosensing function of alpha-catenin in epithelial morphogenesis

Yonemura S