トップ研究者を探す統合失調症の中間表現型のゲノムワイド関連解析

統合失調症の中間表現型のゲノムワイド関連解析

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-22390225
研究種目 基盤研究(B)
研究分野 生物系
医歯薬学
内科系臨床医学
精神神経科学
研究機関 大阪大学
代表研究者 橋本 亮太
研究分担者 安田 由華
研究分担者 山森 英長
研究分担者 岩瀬 真生
研究分担者 数井 裕光
研究分担者 武田 雅俊
研究期間 開始年月日 2010/4/1
研究期間 終了年度 2012
研究ステータス 完了 (2012/4/1)
配分額(合計) 18,850,000 (直接経費 :14,500,000、間接経費 :4,350,000)
配分額(履歴) 2012年度:5,200,000 (直接経費 :4,000,000、間接経費 :1,200,000)
2011年度:5,200,000 (直接経費 :4,000,000、間接経費 :1,200,000)
2010年度:8,450,000 (直接経費 :6,500,000、間接経費 :1,950,000)
キーワード 統合失調症
中間表現型
ゲノム
認知機能
脳画像
神経生理機能

研究成果

[学会発表] Genome-wide association study of cognitive decline in schizophrenia

Hashimoto R, Ikeda M, Kazutaka O, Yasuda Y, Yamamori H, Fukumoto M, Umeda-Yano S, Dickinson D, Aleksic B, Iwase M, Kazui H, Ozaki N, Weinberger DR, Iwata N, Takeda M 2013

[雑誌論文] The AKT1 gene is associated with attention and brain morphology in schizophrenia

Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Nemoto K, Ohnishi T, Yamamori H, Takahashi H, Iike N, Kamino K, Yoshida T, Azechi M, Ikezawa K, Tanimukai H, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Iwase M, Kazui H, Takeda M 2013

[雑誌論文] The KCNH2 gene is associated with neurocognition and the risk of schizophrenia

Hashimoto R, Ohi K, Yasuda Y, Fukumnoto M, Yamamori H, Kamino K, Morihara T, Iwase M, Kazui H, Takeda M. 2013

[雑誌論文] Meta-analysis of association studies between DISC1 missense variants and schizophrenia in Japanese population.

Kinoshita M, et al 2012

[学会発表] 統合失調症の分子メカニズム研究の新しい潮流:中間表現型を用いた統合失調症の病態解明

橋本亮太、大井一高、安田由華、山森英長、梅田知美、岩瀬真生、数井裕光、武田雅俊 2012

[雑誌論文] Relationship of Prepulse Inhibition to Temperament and Character in Healthy Japanese subjects.

Takahashi H, Iwase M, Yasuda Y, Ohi Y, Fukumoto M, Iike N, Yamamori H, Nakahachi T, Ikezawa K, Azechi M, Canuet L, Ishii R, Kazui H, Hashimoto R, Takeda M 2012

[雑誌論文] Functional genetic variation at the NRGN gene and schizophrenia: evidence from a gene-based case-control study and gene expression analysis.

Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Yamamori H, Umeda-Yano S, Okada T, Kamino K, Morihara T, Iwase M, Kazui H, Numata S, Ikeda M, Ohmura T, Iwata N, Ueno S, Ozaki N, Ohmori T, Arai H, Takeda M 2012

[雑誌論文] The p250GAP Gene is Associated with Risk for Schizophrenia and Schizotypal Personality Traits

Ohi K, Hashimoto R, Nakazawa T, Okada T, Yasuda Y, Yamamori H, Fukumoto M, Umeda-Yano S, Iwase M, Kazui H, Yamamoto T, Kano M, Takeda M 2012

[雑誌論文] A promoter variant in the Chitinase 3-Like 1 gene is associated with serum YKL-40 level and personality trait

Yamamori H, Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Kasahara E, Sekiyama A, Umeda-Yano S, Okada T, Iwase M, Kazui H, Ito A, Takeda M 2012

[雑誌論文] Impact of the Genome Wide Supported NRGN Gene on Anterior Cingulate Morphology in Schizophrenia

Ohi K, Hashimoto R, Yasuda Y, Nemoto K, Ohnishi T, Fukumoto M, Yamamori H, Umeda-Yano S. Okada T, Iwase M, Kazui H, Takeda M 2012

[学会発表] Variants of the RELA gene are associated with schizophrenia and their startleresponses

Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Yamamori H, Takahashi H, Iwase M, Okochi T, Kazui H, Saitoh O, Tatsumi M, Iwata N, OzakiN, Kamijima K, Kunugi H, Takeda M 2012

[学会発表] The p250GAP Gene is Associated with Risk for Schizophrenia and Schizotypal Personality Trait

Hashimoto R, Ohi K, Nakazawa T, Yasuda Y, Yamamori H, Fukumoto M, Iwase M, Kazui H, Yamamoto T, Kano M, Takeda M 2012

[雑誌論文] Personality traits and schizophrenia: evidence from a case-control study and meta-analysis.

Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Yamamori H, Iwase M, Kazui H, Takeda M 2012

[学会発表] The KCNH2 gene is associated with neurocognition and the risk of schizophrenia

Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Yamamori H, Kamino K, Morihara T, Iwase M, Kazui H, Takeda M 2011

[雑誌論文] No association between the PCM1 gene and schizophrenia: a multi-center case-control study and a meta-analysis.

Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Yamamori H, Kamino K, Morihara T, Iwase M, Kazui H, Numata S, Ikeda M, Ueno S, Ohmori T, Iwata N, Ozaki N, Takeda M 2011

[学会発表] Variants of the RELA gene are associated with schizophrenia and their startle responses

Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Yamamori H, Takahashi H, Iwase M, Okochi T, Kazui H, Saitoh O, Tatsumi M, Iwata N, OzakiN, Kamijima K, Kunugi H, Takeda M 2011

[学会発表] ヒト脳表現型と分子を結ぶ新しいアプローチ:ヒト脳表現型コンソーシアム

橋本亮太、大井一高、安田由華、福本素由己、山森英長、梅田知美、岡田武也、岩瀬真生、数井裕光、武田雅俊 2011

[学会発表] KCNH2 Gene is associated with Neurocognition and Risk for Schizophrenia

Hashimoto R, Ohi K, Yasuda Y, Fukumoto M,Yamamori H,Kamino K, Morihara T, Iwase M, Kazui K, Takeda M 2011

[学会発表] 統合失調症の中間表現型研究の最前線-The front line of intermediate phenotype study in schizophrenia-

橋本亮太、大井一高、安田由華、福本素由己、山森英長、梅田知美、岩瀬真生、数井裕光、武田雅俊 2011

[雑誌論文] Impact on schizotypal personality trait of a genome-wide supported psychosis variant of the ZNF804A gene

Yasuda Y, Hashimoto R, Ohi K , Fukumoto M, Umeda-Yano S, Yamamori H, Okochi T, Iwase M, Kazui H, Iwata N, Takeda M 2011

[雑誌論文] Different Characteristics of Cognitive Impairment in Elderly Schizophrenia and Alzheimer's Disease in the Mild Cognitive Impairment Stage

Kazui H, Yoshida T, Takaya M, Sugiyama H, Yamamoto D, Kito Y, Wada T, Nomura K, Yasuda Y, Yamamori H, Ohi K, Fukumoto M, Iike N, Iwase M, Morihara T, Tagami S, Shimosegawa E, Hatazawa J, Ikeda Y, Uchida E, Tanaka T, Kudo T, Hashimoto R, Takeda M 2011

[雑誌論文] Variants of the RELA gene are associated with schizophrenia and their startle responses

Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Yamamori H, Takahashi H, Iwase M, Okochi T, Kazui H, Saitoh O, Tatsumi M, Iwata N, Ozaki N, Kamijima K, Kunugi H, Takeda M 2011

[雑誌論文] The SIGMAR1 gene is associated with a risk of schizophrenia and activation of the prefrontal cortex

Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Yamamori H, Umeda-Yano S, Kamino K, Ikezawa K, Azechi M, Iwase M, Kazui H, Kasai K, Takeda M 2011

[学会発表] ヒトにおける脳表現型の分子機構の解明:ヒト脳表現型コンソーシアムについて

橋本亮太、安田由華、大井一高、福本素由己、山森英長、岩瀬真生、数井裕光、高雄啓三、宮川剛、武田雅俊 2010

[学会発表] 統合失調症の中間表現型解析-その現状と展望

橋本亮太、安田由華、大井一高、福本素由己、山森英長、岩瀬真生、数井裕光、武田雅俊 2010

[学会発表] The Impact of a Genome-Wide Supported Psychosis Variant in the ZNF804A Gene on Memory Function in Schizophrenia

Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Iwase M,Iike N, Azechi M, Ikezawa K, Takaya M, Takahashi H, Yamamori H,Okochi T, Tanimukai H, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Kazui H, Iwata N, Takeda M 2010

[雑誌論文] Association study of KIBRA gene with memory performance in a Japanese population

Yasuda Y, Hashimoto R, Ohi K, Fukumoto M, Takamura H, Iike N, Kiribayashi M, Yoshida T, Hayashi N, Takahashi H, Yamamori H, Morihara T, Tagami S, Okochi M, Tanaka T, Kudo T, Kamino K, Ishii R, Iwase M, Kazui H, Takeda M 2010

[雑誌論文] Relationship between prepulse inhibition of acoustic startle response and schizotypy in healthy Japanese subjects.

Takahashi H, Iwase M, Canuet L, Yasuda Y, Ohi K, Fukumoto M, Iike N, Nakahachi T, Ikezawa K, Azechi M, Kurimoto R, Ishii R, Yoshida T, Kazui H, Hashimoto R, Takeda M 2010

[雑誌論文] The Impact of a Genome-Wide Supported Psychosis Variant in the ZNF804A Gene on Memory Function in Schizophrenia.

Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Iwase M, Iike N, Azechi M, Ikezawa K, Takaya M, Takahashi H, Yamamori H, Okochi T, Tanimukai H, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Kazui H, Iwata N, Takeda M 2010

[学会発表] 統合失調症のゲノムワイド関連解析にて見出されたZNF804A遺伝子のリスク多型は統合失調症の記憶機能と関連する

橋本亮太、大井一高、安田由華、福本素由己、岩瀬真生、井池直美、疇地道代、池澤浩二、高屋雅彦、高橋秀俊、石井良平、数井裕光、岩田仲生、武田雅俊 2010