トップ研究者を探す標的化プロテオミクスによるタンパク質巨大複合体の翻訳後修飾の網羅的解析

標的化プロテオミクスによるタンパク質巨大複合体の翻訳後修飾の網羅的解析

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-22370042
研究種目 基盤研究(B)
研究分野 生物系
生物学
生物科学
構造生物化学
研究機関 徳島大学
代表研究者 谷口 寿章
研究分担者 真板 宣夫
研究分担者 池田 和子
研究分担者 小迫 英尊
研究期間 開始年月日 2010/4/1
研究期間 終了年度 2013
研究ステータス 完了 (2013/4/1)
配分額(合計) 18,980,000 (直接経費 :14,600,000、間接経費 :4,380,000)
配分額(履歴) 2012年度:4,940,000 (直接経費 :3,800,000、間接経費 :1,140,000)
2011年度:5,460,000 (直接経費 :4,200,000、間接経費 :1,260,000)
2010年度:8,580,000 (直接経費 :6,600,000、間接経費 :1,980,000)
キーワード プロテオミクス
巨大分子複合体
翻訳後修飾
オルガネラ
質量分析

研究成果

[雑誌論文] GRK6 deficiency in mice causes autoimmune disease due to impaired apoptotic cell clearance

Nakaya M, Kosako H, Taniguchi H, Sato Kurose H 2013

[雑誌論文] Using Whole-Exome Sequencing to Identify Inherited Causes of Autism

Yu TW, Okamura-Ikeda K, Taniguchi H, Walsh CA 2013

[雑誌論文] Human α-L-iduronidase uses its own N-glycan as a substrate-binding and catalytic module

Maita N, Tsukimura T, Taniguchi T, Saito S, Ohno K, Taniguchi H, Sakuraba H 2013

[雑誌論文] Human α-L-iduronidase uses its own N-glycan as a substrate-binding and catalytic module.

Maita N 2013

[雑誌論文] Observation of the controlled assembly of preclick components in the in situ click chemistry generation of a chitinase inhibitor

Hirose T, Maita N, Taniguchi H, Sharpless KB, Omura S, Sunazuka T 2013

[雑誌論文] The Action of D-Dopachrome Tautomerase as an Adipokine in Adipocyte Lipid Metabolism

Iwata T, et al. 2012

[雑誌論文] Crystallization, X-ray diffraction analysis and SIRAS phasing of human α-L-iduronidase

Maita N, Taniguchi H, and Sakuraba H 2012

[雑誌論文] d-Dopachrome tautomerase promotes IL-6 expression and inhibits adipogenesis in preadipocytes

Ishimoto K, Iwata T, Taniguchi H, Mizusawa N, Tanaka E, Yoshimoto K 2012

[雑誌論文] CrystallizationkX-ray diffraction analysis and SIRAS phasing of Human α-L-iduronidase.

Maita N 2012

[学会発表] ヒトα-L-イズロニダーゼの結晶構造解析

真板 宣夫 2012

[雑誌論文] Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation

Okazaki IM, Okawa K, Kobayashi M, Yoshikawa K, Kawamoto S, Nagaoka H, Shinkura R, Kitawaki Y, Taniguchi H, Natsume T, Iemura S, and Honjo T 2011

[雑誌論文] Identification and Characterization of the 480 kDa Template-Specific RNA-Dependent RNA Polymerase Complex of Red Clover Necrotic Mosaic Virus

Mine, A., Takeda, A., Taniguchi, T., Taniguchi, H., Kaido, M., Mise, K., and Okuno, T 2010

[雑誌論文] Crystal structure of aminomethyltransferase in complex with dihydrolipoyl-H-protein of the glycine cleavage system : Implications for recognition of lipoyl protein substrate, disease-related mutations, and reaction mechanism

Okamura-Ikeda, K. Hosaka, H. Maita, N. Fujiwara, K. Yoshizawa, A.C. Nakagawa, A. and Taniguchi, H 2010

[雑誌論文] New functional proteins identified by proteomic analysis in the epidermal growth factor receptor-mediated signaling pathway and application for practical use

Tashiro K, Konishi H, Nabeshi H, Yamauchi E, and Taniguchi H 2010

[雑誌論文] Dead time loss correction of mass errors occurring in high-throughput proteoinics based on electrospray ionization time-of-flight tandem mass spectrometry

Taniguchi T, et al. 2010

[雑誌論文] Mechanical stress activates Smad pathway through PKCδ to enhance in terleukin-11 gene transcription in osteoblasts

Taniguchi T, et al. 2010

[雑誌論文] Global conformational change associated with the two step reaction catalyzed by Escherichia coli lipoate-protein ligase A

Fujiwara, K. Maita, N. Hosaka, H. Okamura-Ikeda, K. Nakagawa, A. and Taniguchi, H 2010

[雑誌論文] Dead time loss correction of mass errors occurring in high-throughput proteomics based on electrospray ionization time-of-flight tandem mass spectrometry

Ishino Y, and Taniguchi H 2010

[雑誌論文] Induction of Endosomal/lysosomal Pathways in Differentiating Osteoblasts as Revealed by Combined Proteomic and Transcriptomic Analyses

Taniguchi T, et al. 2010