トップ›研究者を探す›流行地変異株原虫に対するRipr5マラリア赤血球期ワクチン効果の検証

流行地変異株原虫に対するRipr5マラリア赤血球期ワクチン効果の検証

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-21KK0138
研究種目 国際共同研究加速基金(国際共同研究強化(B))
研究分野
研究機関 愛媛大学
代表研究者 高島 英造
研究分担者 長岡 ひかる
研究分担者 森田 将之
研究期間 開始年月日 2021/4/1
研究期間 終了年度 2024
研究ステータス 完了 (2024/4/1)
配分額（合計） 19,110,000 (直接経費 :14,700,000、間接経費 :4,410,000)
配分額（履歴） 2024年度：5,200,000 (直接経費 :4,000,000、間接経費 :1,200,000)
2023年度：4,810,000 (直接経費 :3,700,000、間接経費 :1,110,000)
2022年度：4,810,000 (直接経費 :3,700,000、間接経費 :1,110,000)
2021年度：4,290,000 (直接経費 :3,300,000、間接経費 :990,000)
キーワード マラリア
ワクチン
コムギ無細胞系
抗体

研究成果

[雑誌論文] Ultrastructural expansion microscopy (U-ExM) visualization of malaria parasite dense granules using RESA as a representative marker protein

Fukumoto Junpei、Tsuboi Takafumi、Takashima Eizo 2025

[雑誌論文] Antibody responses in Burkinabe children against P. falciparum proteins associated with reduced risk of clinical malaria

Yuguchi Takaaki、Dankyi Benedicta O.、Rojrung Rattanaporn、Nagaoka Hikaru、Kanoi Bernard N.、Tiono Alfred B.、Nebie Issa、Ouedraogo Alphonse、Miura Kazutoyo、Sattabongkot Jetsumon、Sirima Sodiomon B.、Tsuboi Takafumi、Takashima Eizo 2025

[雑誌論文] Targeting Plasmodium falciparum chondroitin sulfate a ligand: A highly conserved malaria antigen with potential for pregnancy-associated malaria vaccine development

Rotich Alex K.、Mbogo Kevin、Adamba Paulus、Takashima Eizo、Gitaka Jesse、Kanoi Bernard N. 2025

[雑誌論文] The Need for Novel Asexual Blood-Stage Malaria Vaccine Candidates for Plasmodium falciparum

Takashima Eizo、Otsuki Hitoshi、Morita Masayuki、Ito Daisuke、Nagaoka Hikaru、Yuguchi Takaaki、Hassan Ifra、Tsuboi Takafumi 2024

[学会発表] Wheat Germ Cell-Free System: A New Frontier in Candidate Antigen Discovery for Malaria Vaccine and Seroepidemiology (Keynote)

Takashima E 2024

[雑誌論文] A systems serology approach to identifying key antibody correlates of protection from cerebral malaria in Malawian children

Walker Isobel S.、Dini Saber、Aitken Elizabeth H.、Damelang Timon、Hasang Wina、Alemu Agersew、Jensen Anja T. R.、Rambhatla Janavi S.、Opi D. Herbert、Duffy Michael F.、Takashima Eizo、Harawa Visopo、Tsuboi Takafumi、Simpson Julie A.、Mandala Wilson、Taylor Terrie E.、Seydel Karl B.、Chung Amy W.、Rogerson Stephen J. 2024

[学会発表] Evaluation of a novel malaria vaccine candidate flCSP/SA-1 in comparison to RTS,S/AS01 in two pre-clinical models

Takashima E, Tachibana M, Culleton R, Morita M, Nagaoka H, Fukushima A, Aoki M, Hayashi H, Nemoto D, Tomita Y, Torii M, Miura K, Locke E, King RC, Wu Y, Tsuboi T. 2024

[学会発表] Comparison of a flCSP/SA-1 malaria vaccine candidate with RTS,S/AS01 in two pre-clinical models

Takashima E, Tachibana M, Culleton R, Morita M, Nagaoka H, Fukushima A, Aoki M, Hayashi H, Nemoto D, Tomita Y, Torii M, Miura K, Locke E, King RC, Wu Y, Tsuboi T. 2024

[雑誌論文] RH5: rationally-designed malaria vaccine antigen improving efficacy

Takashima Eizo、Tsuboi Takafumi 2024

[学会発表] Combat malaria using an innovative protein expression system (Keynote)

Takashima E 2024

[学会発表] Immunoprofiling of naturally acquired transmission-blocking immunity against plasmodium vivax

Rojrung R, Thongpoon S, Takaaki Y, Roobsoong W, Nagaoka H, Nguitragool W, Kanoi BN, Chotirat S, Tachibana M, Cui L, Ishino T, Miura K, Tsuboi T, Sattabongkot J, Takashima E 2024

[雑誌論文] Autoantibodies inhibit Plasmodium falciparum growth and are associated with protection from clinical malaria

Hagadorn Kelly A.、Peterson Mary E.、Kole Hemanta、Scott Bethany、Skinner Jeff、Diouf Ababacar、Takashima Eizo、Ongoiba Aissata、Doumbo Safiatou、Doumtabe Didier、Li Shanping、Sekar Padmapriya、Yan Mei、Zhu Chengsong、Nagaoka Hikaru、Kanoi Bernard N.、Li Quan-Zhen、Long Carole、Long Eric O. 2024

[学会発表] Immunoscreening of P. falciparum Antigens to Identify Gametocyte Carriers

Hikaru Nagaoka, Shuya Ninose, Gyamah Bredu, Linda Eva Amoah, Eizo Takashima. 2024

[雑誌論文] Naturally acquired antibodies to gametocyte antigens are associated with reduced transmission of Plasmodium vivax gametocytes to Anopheles arabiensis mosquitoes

Tebeje Surafel K.、Chali Wakweya、Hailemeskel Elifaged、Ramjith Jordache、Gashaw Abrham、Ashine Temesgen、Nebret Desalegn、Esayas Endashaw、Emiru Tadele、Tsegaye Tizita、Teelen Karina、Lanke Kjerstin、Takashima Eizo、et al 2023

[雑誌論文] Naturally Acquired Transmission-Blocking Immunity Against Different Strains of <i>Plasmodium vivax</i> in a Malaria-Endemic Area in Thailand

Thongpoon Sataporn、Roobsoong Wanlapa、Nguitragool Wang、Chotirat Sadudee、Tsuboi Takafumi、Takashima Eizo、Cui Liwang、Ishino Tomoko、Tachibana Mayumi、Miura Kazutoyo、Sattabongkot Jetsumon 2023

[雑誌論文] A Pvs25 mRNA vaccine induces complete and durable transmission-blocking immunity to Plasmodium vivax

Kunkeaw Nawapol、Nguitragool Wang、Takashima Eizo、Kangwanrangsan Niwat、Muramatsu Hiromi、Tachibana Mayumi、Ishino Tomoko、Lin Paulo J. C.、Tam Ying K.、Pichyangkul Sathit、Tsuboi Takafumi、Pardi Norbert、Sattabongkot Jetsumon 2023

[学会発表] Harnessing the Power of Wheat Germ Cell-Free System for Malaria Vaccine Candidate Discovery: Immunoscreening and Reverse Vaccinology Approaches

Eizo Takashima 2023

[学会発表] タンパク質工学と医学の狭間・コムギ無細胞系とマラリアワクチン

高島英造 2023

[雑誌論文] High-Throughput Antibody Profiling Identifies Targets of Protective Immunity against P. falciparum Malaria in Thailand

Hassan Ifra、Kanoi Bernard N.、Nagaoka Hikaru、Sattabongkot Jetsumon、Udomsangpetch Rachanee、Tsuboi Takafumi、Takashima Eizo 2023

[雑誌論文] GATS tag system is compatible with biotin labelling methods for protein analysis

Yamada Kohdai、Soga Fumiya、Tokunaga Soh、Nagaoka Hikaru、Ozawa Tatsuhiko、Kishi Hiroyuki、Takashima Eizo、Sawasaki Tatsuya 2023

[雑誌論文] Roles of the RON3 C-terminal fragment in erythrocyte invasion and blood-stage parasite proliferation in Plasmodium falciparum

Ito Daisuke、Kondo Yoko、Takashima Eizo、Iriko Hideyuki、Thongkukiatkul Amporn、Torii Motomi、Otsuki Hitoshi 2023

[雑誌論文] Pfs230 Domain 7 is targeted by a potent malaria transmission-blocking monoclonal antibody

Inklaar Maartje R.、de Jong Roos M.、Bekkering Ezra T.、Nagaoka Hikaru、Fennemann Felix L.、Teelen Karina、van de Vegte-Bolmer Marga、van Gemert Geert-Jan、Stoter Rianne、King C. Richter、Proellochs Nicholas I.、Bousema Teun、Takashima Eizo、Tsuboi Takafumi、Jore Matthijs M. 2023

[学会発表] Wheat-germ cell-free system; a genome-wide eukaryotic protein expression system

Eizo Takashima 2023

[学会発表] コムギ無細胞系を基盤としたコアコンピタンス戦略によるマラリア研究

高島英造 2022

[学会発表] Wheat-germ cell-free system; Antigen expression system for the post-genomic era

Eizo Takashima 2022

[雑誌論文] Anti-Gametocyte Antigen Humoral Immunity and Gametocytemia During Treatment of Uncomplicated Falciparum Malaria: A Multi-National Study

O’Flaherty Katherine、Chan Jo-Anne、Takashima Eizo、Tsuboi Takafumi、et al 2022

[雑誌論文] Comparison of Antibody Responses and Parasite Clearance in Artemisinin Therapeutic Efficacy Studies in the Democratic Republic of Congo and Asia

Cutts Julia C、O’Flaherty Katherine、Takashima Eizo、Tsuboi Takafumi、et al 2022

[雑誌論文] Plasmodium vivax malaria serological exposure markers: Assessing the degree and implications of cross-reactivity with P.?knowlesi

Longley Rhea J.、Grigg Matthew J.、Schoffer Kael、Obadia Thomas、Hyslop Stephanie、Piera Kim A.、Nekkab Narimane、Mazhari Ramin、Takashima Eizo、et al 2022

[雑誌論文] A novel asexual blood-stage malaria vaccine candidate: PfRipr5 formulated with human-use adjuvants induces potent growth inhibitory antibodies

Takashima Eizo、Nagaoka Hikaru、Correia Ricardo、Alves Paula M.、Rold?o Ant?nio、Christensen Dennis、Guderian Jeffrey A.、Fukushima Akihisa、Viebig Nicola K.、Depraetere Hilde、Tsuboi Takafumi 2022

[雑誌論文] マラリアワクチン開発の最新情報

高島英造 2022

[学会発表] A NOVEL BLOOD-STAGE MALARIA VACCINE CANDIDATE, PFRIPR5 FORMULATED WITH ADJUVANTS FOR HUMAN USE, INDUCED POTENT GROWTH INHIBITORY ANTIBODIES

Eizo Takashima, Hikaru Nagaoka, Ricardo Correia, Antonio Roldao, Akihisa Fukushima, Nicola Viebig, Takafumi Tsuboi 2022

[学会発表] PfRipr5, a novel blood-stage malaria vaccine candidate, formulated with adjuvants for human use, induced potent growth inhibitory antibodies

Eizo Takashima, Hikaru Nagaoka, Ricardo Correia, Antonio Roldao, Akihisa Fukushima, Nicola Viebig, Takafumi Tsuboi 2022

[雑誌論文] Assessment of IgG3 as a serological exposure marker for Plasmodium vivax in areas with moderate?high malaria transmission intensity

Tayipto Yanie、Rosado Jason、Gamboa Dionicia、White Michael T.、Kiniboro Benson、Healer Julie、Opi D. Herbert、Beeson James G.、Takashima Eizo、Tsuboi Takafumi、Harbers Matthias、Robinson Leanne、Mueller Ivo、Longley Rhea J. 2022

[雑誌論文] Towards identification and development of alternative vaccines against pregnancy-associated malaria based on naturally acquired immunity

Rotich Alex K.、Takashima Eizo、Yanow Stephanie K.、Gitaka Jesse、Kanoi Bernard N. 2022

[学会発表] Asexual blood-stage falciparum malaria vaccine candidate discovery with wheat-germ cell-free system

Eizo Takashima 2022