トップ›研究者を探す›自己免疫疾患制御分子PD-1およびAIDAによる炎症関連発がん制御機構の解析

自己免疫疾患制御分子PD-1およびAIDAによる炎症関連発がん制御機構の解析

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-21790473
研究種目 若手研究(B)
研究分野 生物系
医歯薬学
基礎医学
免疫学
研究機関 徳島大学
代表研究者 岡崎 一美
研究期間 開始年月日 2009/4/1
研究期間 終了年度 2010
研究ステータス 完了 (2010/4/1)
配分額（合計） 4,290,000 (直接経費 :3,300,000、間接経費 :990,000)
配分額（履歴） 2010年度：2,080,000 (直接経費 :1,600,000、間接経費 :480,000)
2009年度：2,210,000 (直接経費 :1,700,000、間接経費 :510,000)
キーワード 遺伝子
細胞
実験動物
炎症
発がん
免疫学
がん
自己免疫疾患
突然変異

研究成果

[雑誌論文] PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice.

Okazaki T, et al. 2011

[雑誌論文] PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice.

Okazaki T, Okazaki IM, Wang J, Sugiura D, Nakaki F, Yoshida T, Kato Y, Fagarasan S, Muramatsu M, Eto T, Hioki K, Honjo T. 2011

[雑誌論文] Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation.

Okazaki IM, Okawa K, Kobayashi M, Yoshikawa K, Kawamoto S, Nagaoka H, Shinkura R, Kitawaki Y, Taniguchi H, Natsume T, Iemura S, Honjo T. 2011

[学会発表] Requirement of isotype-switched and somatically mutated autoantibodies for the development of autoimmune diseases in BALB/c-PD-1KO mice.

Okazaki T, Sugiura D, Okazaki IM, Honjo T. 2010

[雑誌論文] PD-1 deficiency results in the development of fatal myocarditis in MRL mice.

Wang J, Okazaki IM, Yoshida T, Chikuma S, Kato Y, Nakaki F, Hiai H, Honjo T, Okazaki T. 2010

[学会発表] Identification of QTLs that modify peripheral neuropathy in NOD.H2b-PD-1KO mice.

Okazaki IM, et al. 2010

[学会発表] a newly established animal model of autoimmunity.

Okazaki T, Okazaki IM, Sugiura D.Aida 2010

[学会発表] PD-1 deficiency results in the development of fatal myocarditis in MRL mice.

岡崎拓, 他 2010

[学会発表] PD-1 deficiency results in the development of fatal myocarditis in MRL mice.

岡崎拓、岡崎一美 2010

[学会発表] Identification of the causal gene of aida mouse, a newly established animal model of autoimmunity.

Okazaki T, et al. 2010

[学会発表] Aida, a newly established animal model of autoimmunity.

Okazaki T, et al. 2010

[学会発表] Identification of the causal gene of aida mouse, a newly established animal model of autoimmunity.

Okazaki T, Sugiura D, Okazaki IM, Honjo T. 2010

[学会発表] Identification of QTLs that modify peripheral neuropathy in NOD.H2b-PD-1KO mice.

Okazaki IM, Jiang F, Honjo T, Okazaki T. 2010

[学会発表] Requirement of isotype-switched and somatically mutated autoantibodies for the development of autoimmune diseases in BALB/c-PD-1KO mice.

Okazaki T, et al. 2010

[雑誌論文] Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes.

Sabouri Z, Okazaki IM, Shinkura R, Begum N, Nagaoka H, Tsuchimoto D, Nakabeppu Y, Honjo T. 2009

[学会発表] Involvement of Topoisomerase I in class switch recombination of Immunoglobulin genes.

Kobayashi M, Aida M, Doi T, Nagaoka H, Kitawaki Y, Nakata M, Kato L, Stanlie A, Begum NA, Okazaki IM, Shinkura R, Muramatsu M, Kinoshita K, Honjo T. 2009

[雑誌論文] AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination.

Kobayashi M, Aida M, Nagaoka H, Begum NA, Kitawaki Y, Nakata M, Stanlie A, Doi T, Kato L, Okazaki IM, Shinkura R, Muramatsu M, Kinoshita K, Honjo T. 2009

[学会発表] 自己免疫性胃炎モデルマウスにお ける自己抗原同定の試み

梶原武雄, 杉浦大祐, 岡崎一美, 岡崎拓 2009

[学会発表] Involvement of Topoisomerase I in class switch recombination.

Kobayashi M, Aida M, Nagaoka H, Begum NA, Kitawaki Y, Nakata M, Stanlie A, Doi T, Kato L, Okazaki IM, Shinkura R, Muramatsu M, Kinoshita K, Honjo T. 2009