トップ研究者を探す腎疾患におけるオートファジー・リソゾーム系の病態への関与

腎疾患におけるオートファジー・リソゾーム系の病態への関与

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-21659214
研究種目 挑戦的萌芽研究
研究分野 生物系
医歯薬学
内科系臨床医学
腎臓内科学
研究機関 高知大学
代表研究者 寺田 典生
研究期間 開始年月日 2009/4/1
研究期間 終了年度 2011
研究ステータス 完了 (2011/4/1)
配分額(合計) 3,180,000 (直接経費 :3,000,000、間接経費 :180,000)
配分額(履歴) 2011年度:780,000 (直接経費 :600,000、間接経費 :180,000)
2010年度:900,000 (直接経費 :900,000、間接経費 :0)
2009年度:1,500,000 (直接経費 :1,500,000)
キーワード 腎障害
オートファジー
リソゾーム
マイトファジー
腎臓
アポトーシス
急性腎障害
再生医学
尿細管
虚血
慢性腎臓病
急性腎不全
慢性腎障害
透析療法

研究成果

[雑誌論文] Possible involvement of intracellular angiotensin II receptor in high-glucose-induced damage in renal proximal tubular cells

Takao T, Terada T, et al 2011

[雑誌論文] 炭酸脱水酵素阻害薬,浸透圧利尿薬,バソプレッシン拮抗薬(臨床医が知っておくべきこと,将来性を含めて)

緒方巧二、島村芳子、井上紘輔、香川亨、寺田典生 2011

[雑誌論文] 多発性骨髄腫と腎障害

緒方巧二、上田訓子、島村芳子、井上紘輔、香川亨、寺田典生 2011

[学会発表] Two Independent, Pathways, BNIP3 and Sestrin2, Mediate Autophagy of Renal Tubular Cells in Acute Kidney Injury In Vitro and In Vivo

Ishihara M、Bun M、Hisa M、Hamada K、Shimamura Y、Ogata K、Inoue K、Kagawa T、Takao T、Terada Y、 2011

[学会発表] Serum Levels of Soluble SecretedαKlotho Are Modulated by Renal Function, Age, FGF23, and May Play a Key Role in CKD-MBD in Chronic Kidney Disease Patients

Shimamura Y、Ogata、Inoue K、Kagawa T、Ishihara M、Takao T、Yuasa K、Terada Y、 2011

[雑誌論文] Possible involvement of intra-cellular angiotensinIIreceptor in high-glucose-induced damage in renal proximal tubular cells

Takao T、Horino T、Kagawa T、Matsumoto R、Shimamura Y、Ogata K、Inoue K、Taniguchi Y、Taguchi T、Morita T、Terada Y、 2011

[雑誌論文] Weber-Christian disease associated with granulomatous mastitis : a variant type of Weber-Christian disease

Taniguchi Y、Kagawa T、Ishibashi A、Horino T、Kumon Y、Terada Y、 2011

[雑誌論文] 高齢者と腎障害

島村芳子、寺田典生 2011

[雑誌論文] 新しい糖尿病薬のCKDでの可能性

上田訓子、井上眞理、島村芳子、緒方巧二、寺田典生 2011

[図書] ファンコニ症候群.症候群ハンドブック

島村芳子, 寺田典生 2011

[雑誌論文] F18 FDG PET/CT Provides the Earliest Findings of Enthesitis in Reactive Arthritis

Taniguchi Y, Terada Y, et al 2011

[雑誌論文] 巣状糸球体硬化症-病因から治療まで-

緒方巧二、濱田佳寿、上田訓子、島村芳子、井上紘輔、谷口義典、香川亨、寺田典生 2011

[雑誌論文] Atypical generalized morphea-like scleroderma presenting deep sclerosis on the fingers

Taniguchi Y、Okazaki M、Kagawa T、Nakajima K、Nakajima H、Terada Y、 2011

[雑誌論文] 急性腎障害における尿中バイオマーカーの現状、腎と透析

井上紘輔、緒方巧二、島村芳子、香川亨、寺田典生 2011

[学会発表] Urinary IL-18 and L-FABP as early predictive biomarkers in contrast-induced AKI (acute kidney injury) on chronic kidney disease (CKD) atage 3 patients

Terada Y, et al 2011

[雑誌論文] Rapidly progressive destructive arthritis in psoriatic arthritis sine psoriasis : do bone resorption marker levels predict outcome of bone destruction in psoriatic arthritis

Taniguchi Y、Kumon Y、Shimamura Y、Kobayashi S、Terada Y、 2011

[雑誌論文] 緒方巧二、尿細管の障害と再生

寺田典生、上田訓子、石原正行、島村芳子 2011

[雑誌論文] Secondary Retroperitoneal Fibrosis Due to Polyarteritis Nodosa Evaluated by F-18 FDG PET/CT

Taniguchi Y, Terada Y, et al 2011

[図書] ファンコニ症候群.症候群ハンドブック

島村芳子, 寺田典 2011

[学会発表] Six2-GDNF Pathway Is Activated during Experimental Acute Kidney Injury and Plays a Crucial Role in Renal Tubular Regeneration

Hirano S、Okada N、Urushido M、Bun M、Hisa M、Ogata K、Shimamura Y、Inoue K、Ishihara M、Kagawa T、Takao T、Terada Y、 2011

[雑誌論文] F-18 FDG PET/ CT provides the earliest findings of enthesitis in reactive arthritis

Taniguchi Y、Kumon Y、Nakayama S、Arii K、Ohnishi T、Ogawa Y、Kobayashi S、Terada Y、 2011

[学会発表] Urinary IL-18 Is the Most Useful Early Predictive Biomarker of ontrast-Induced Nephropathy(CIN) on Chronic Kidney Disease(CKD) Stage 3 Patients in Comparison with NGAL and L-FABP

Inoue K、Shimamura Y、Ogata K、Ishihara M、Kagawa T、Terada Y、 2011

[雑誌論文] Clinical implication of 18F-fluorodeoxyglucose PET/ CT in monitoring disease activity in spondyloarthritis

Taniguchi Y、Kumon Y、Arii K、Tsugita M、Fukumoto M、Ohnishi T、Kobayashi S、Terada Y、 2010

[雑誌論文] Cisplatin-induced macroautophagy occurs prior to apoptosis in proximal tubules in vivo

Inoue K、Kuwana H、Shimamura Y、Ogata K、Taniguchi Y、Kagawa T、Horino T、Takao T、Morita T、Sasaki S、Mizushima N、Terada Y、 2010

[雑誌論文] Hypoglycemic encephalopathy as a result of an attempted suicide

Taguchi T、Mizobuchi M、Terada Y、 2010

[学会発表] Urinary IL-18 and L-FABP as early predictive biomarkers in contrast-induced AKI(acute kidney injury) on Chronic kidney disease(CKD) stage 3 patients

Inoue K、Shimamura Y、Ogata K、Taniguchi Y、Kagawa T、Ishihara M、Horino T、Kitaoka H、Doi Y、Terada Y、 2010

[雑誌論文] PPARbeta/ delta regulates the human SIRT1 gene transcription via Sp1

Okazaki M、Iwasaki Y、Nishiyama M、Taguchi T、Tsugita M、Nakayama S、Kambayashi M、Hashimoto K、Terada Y、 2010

[学会発表] Up-regulated Sirt1 in renal ischemia/ reperfusion injury protects against oxidative stress-induced renal tubular cell apoptosis、

Shimamura Y、Ogata K、Inoue K、Taniguchi Y、Kagawa T、Horino T、Takao T、Iwasaki Y、Morita T、Terada Y、 2010

[雑誌論文] Hormonal regulation of acetyl-CoA carboxylase isoenzyme gene transcription

Zhao LF、Iwasaki Y、Zhe W、Nishiyama M、Taguchi T、Tsugita M、Kambayashi M、Hashimoto K、Terada Y、 2010

[雑誌論文] Role of protein kinase C in pitavastatin-induced human paraoxonase I expression in Huh7 cells、

Arii K、Suehiro T、Ikeda Y、Kumon Y、Inoue M、Inada S、Takata H、Ishibashi A、Hashimoto K、Terada Y、 2010

[学会発表] PGC-1αis Transcriptionally Up-regulated in Renal Tubules of Ischemia/ Reperfusion AKI via Hypoxia and AMPK

Terada Y、Ueda S、Shimamura Y、Ogata K、Inoue K、Taniguchi Y、Ishihara M、Kagawa T、Takao T、Horino T、 2010

[雑誌論文] Serum fetuin-A is an independent marker of insulin resistance in Japanese men

Ishibashi A、Ikeda Y、Ohguro T、Kumon Y、Yamanaka S、Takata H、Inoue M、Suehiro T、Terada Y、 2010

[学会発表] Up-regulated Sirt1 in Renal Ischemia/ Reperfusion Injury Causes Autophagy and Inhibits Apoptosis and Protects Against Oxidative Stress in Renal Tubules

Shimamura Y、Ueda S、Ogata K、Inoue K、Taniguchi Y、Ishihara M、Kagawa T、Horino T、Takao T、Terada Y、 2010

[図書] 一般の急性腎不全・原因と鑑別診断の進め方、急性腎不全・AKIハンドブック

香川亨、寺田典生 2010

[雑誌論文] Coincidental double erythema caused by Vibrio vulnificus

Taguchi T、Mizobuchi M、Terada Y、 2010

[雑誌論文] Glucocorticoid receptor-βand receptor-γexert dominant negative effect on gene repression but not on gene induction

Taniguchi Y、Iwasaki Y、Tsugita M、Nishiyama M、Taguchi T、Okazaki M、Nakayama S、Kambayashi M、Hashimoto K、Terada Y、 2010

[学会発表] Steroid Resistance of Nephrotic Syndrome : Glucocorticoid receptor-βand receptor-γexert dominant negative effect on gene repression but not on gene induction

Taniguchi Y、Shimamura Y、Ogata K、Inoue K、Kagawa T、Horino T、Iwasaki Y、Terada Y、 2010

[雑誌論文] IgA nephropathy in a patient with systemic lupus erythematosus

Horino T、Takao T、Terada Y、 2010

[雑誌論文] Positron emission tomography/ computed tomography : a clinical tool for evaluation of enthesitis in patients with spondyloarthritides

Taniguchi Y、Arii K、Kumon Y、Fukumoto M、Ohnishi T、Horino T、Kagawa T、Kobayashi S、Ogawa Y、Terada Y、 2010

[雑誌論文] Cisplatin-induced macroautophagy occurs prior to apoptosis in proximal tubules in vivo

Inoue K, Terada Y, et al 2010

[雑誌論文] Acute pulmonary arterial hypertension associated with anti-synthetase syndrome

Taniguchi Y、Horino T、Kato T、Terada Y、 2010

[学会発表] Effects of Telmisartan and Imidapril on High Glucose/ Antimycin A-Induced Cell Damage In Human Renal Proximal Tubular Epithelial Cells

Takao T、Horino T、Shimamura Y、Ogata K、Inoue K、Taniguchi Y、Taguchi T、Kagawa T、Morita T、Terada Y、 2010

[学会発表] Up-regulated Sirt1 in Renal Ischemia/ Reperfusion Injury Protects Against Oxidative Stress-Induced Renal Tubular Cell Apoptosis and Causes Autophagy

Terada Y、Shimamura Y、Ogata K、Inoue K、Taniguchi Y、Kagawa T、Horino T、Takao T、Morita T、 2010

[雑誌論文] The activity of carotidynia syndrome is correlated with the soluble intracellular adhesion molecule-1(sICAM-1) level

Taniguchi Y、Horino T、Terada Y, Jinnouchi Y、 2010

[学会発表] Localization of(Pro) renin Receptor in Glomeruli of IgA Nephropathy, Diabetic Nephropathy, and Minimal Change Nephropathy Using Renal Biopsy Specimen

Ueda S、Shimamura Y、Inoue K、Taniguchi Y、Kagawa T、Horino T、Takao T、Furihata M、Ichihara A、Nishiyama A、Terada Y、 2010

[雑誌論文] Rapid recurrence of cranio pharyngioma following recombinant human growth hormone replacement

Taguchi T、Takao T、Iwasaki Y、Pooh K、Okazaki M、Hashimoto K、Terada Y、 2010

[学会発表] HNF-1β, SOCS3, and STAT3 are regulated during experimental acute kidney injury in vivo and affect renal tubular proliferation in vitro

Ogata K、Shimamura Y、Inoue K、Taniguchi Y、Kagawa T、Horino T、Takao T、Morita T、Terada Y、 2010

[図書] 急性腎不全・AKIハンドブック

香川亨, 寺田典生(菱田明:編集) 2010

[学会発表] 尿細管再生における脱分化

寺田典生 2010

[雑誌論文] HLA-B51-related seronegative spondylo arthropathy associated with membranous nephropathy

Horino T、Nakayama S、Takao T、Terada Y、 2010

[雑誌論文] Diagnostic value of 18F-dihydroxyphenylalanine positronemission tomography for growth hormone-producing pituitary adenoma

Taguchi T、Takao T、Iwasaki Y、Oyama K、Yamada S、Inoue M、Terada Y、 2010

[雑誌論文] A case of post-streptococcal reactive arthritis in which lesions were detected with[ 18F]-fluorodeoxyglucose positron emission tomography-CT imaging and magnetic resonance imaging

Horino T、Takao T、Terada Y、 2010

[雑誌論文] Regulation of glucocorti-coid receptor transcription and nuclear translocation during single and repeated immobiliza tion stress

Noguchi T、Makino S、Matsumoto R、Nakayama S、Nishiyama M、Terada Y、Hashimoto K、 2010

[雑誌論文] Cisplatin-induced macroautophagy occurs prior to apoptosis in proximal tubules in vivo

Inoue K, Terada Y., et al 2010

[学会発表] Sestrin2 is up-regulated and causes autophagy of renal tubular cells in the acute kidney injury in vitro and in vivo

Ishihara M、Shimamura Y、Ueda S、Ogata K、Inoue K、Taniguchi Y、Kagawa T、Horino T、Takao T、Terada Y、 2010

[学会発表] Up-Regulated HNF-1βduring Experimental Acute Kidney Injury Plays a Crucial Role in Renal Tubular Regeneration

Ogata K、Ueda S、Shimamura Y、Inoue K、Taniguchi Y、Ishihara M、Kagawa T、Horino T、Takao T、Terada Y、 2010

[雑誌論文] A case of post-streptococcal reactive arthritis in which lesions were detected with [18F]-fluorodeoxyglucose positron emission tomography-CT imaging and magnance imaging

Horino T, Takao T, Terada Y 2010

[雑誌論文] Plasma adiponectin level is increased despite insulin resistance in corticotropin-releasing hormone transgenic mice, an animal model of Cushing syndrome

Shinahara M、Nishiyama M、Iwasaki Y、Nakayama S、Noguchi T、Kambayashi M、Okada Y、Tuda M、Stenzel-Poore MP、Hashimoto K、Terada Y、 2009

[雑誌論文] Glucocorticoid receptor plays an indispensable role in mineralocorticoid receptor-dependent transcription in GR-deficient BE(2)C and T84 cells in vitro

Tsugita M, Terada Y, et al. 2009

[雑誌論文] Visceral obesity is associated with the metabolic syndrome and elevated plasma retinol binding protein-4 level in obstructive sleep apnea syndrome

Makino S、Fujiwara M、Suzukawa K、Handa H、Fujie T、Ohtaka Y、Komatsu Y、Aoki Y、Maruyama H、Terada Y、Hashimoto K、Sugimoto T、 2009

[雑誌論文] 急性腎障害とは(特集腎疾患-最近の進展)

堀野太郎、寺田典生 2009

[学会発表] Cisplatin-Induced Macroautophagy Occurs Prior to Apoptosis in Proximal Tubules In Vivo

Inoue K、Kuwana H、Shimamura Y、Ogata K、Taniguchi Y、Kagawa T、Horino T、Takao T、Morita T、Ikeda Y、Sasaki S、Terada Y、 2009

[雑誌論文] Hormonal regulation of glycolytic enzyme gene and pyruvate dehydrogenase dinase/ phosphatase gene transcription

Wang Z、Iwasaki Y、Zhao LF、Nishiyama M、Taguchi T、Tsugita M、Kambayashi M、Hashimoto K、Terada Y、 2009

[雑誌論文]

堀野太郎, 寺田典生 2009

[図書] 高ナトリウム血症、輸液療法パーフェクト

堀野太郎、寺田典 2009

[雑誌論文] 酸塩基平衡(産生量,肺・腎での調節,腎のトランスポーターなど)

森田達仁、寺田典生 2009

[図書] 電解質異常、高・低Na血症、高・低Cl血症.専門医のための腎臓病学第2版

堀野太郎、寺田典生 2009

[雑誌論文] A case with spontaneous bladder rupture mimicking acute kidney injury

Horino T、Okazaki M、Nishikawa H、Takao T、Taniguchi Y、Morita T、Terada Y、 2009

[雑誌論文] Symmetric giant xanthogranulo mas in Erdheim-Chester disease

Taguchi T、Sano S、Iwasaki Y、Terada Y 2009

[雑誌論文] Glucocorticoid receptor plays an indispensable role in mineralo corticoid receptor-dependent transcription in GR-deficient BE(2) C and T84 cells in vitro

Tsugita M、Iwasaki Y、Nishiyama M、Taguchi T、Shinahara M、Taniguchi Y、Kambayashi M、Nishiyama A、Gomez-Sanchez CE、Terada Y、Hashimoto K、 2009

[雑誌論文] Effect of Sevelamer Hydrochloride on Bone in Experimental Uremic Rats

Kuwahara M、Inoshita S、Terada Y、Sasaki S、 2009

[雑誌論文] Pitavastation induces PON1 expression through P44/ 42 mitogen-activated protein kinase signaling cascade in Huh7 cells

Arii K、Suehiro T、Ikeda Y、Kumon Y、Osaki F、Inoue M、Inada S、Ogami N、Takada H、Hashimoto K、Terada Y、 2009

[図書] 症候群.内分泌代謝専門医ガイドブック

香川亨、寺田典生 2009

[学会発表] Aldosterone Stimulates NF-κB Activity and Transcription of ICAM-1 via SGK-1 in Rat Mesangial Cells in vivo and in vitro

Terada Y 2009

[雑誌論文] Insulin exhibits short-term anti-inflammatory but long-term proinflammatory effects in vitro

Iwasaki Y、Nishiyama M、Taguchi T、Asai M、Yoshida M、Kambayashi M、Terada Y、Hashimoto K、 2009

[雑誌論文] Effects of angiotensin II type 1 receptor blocker on albumin-induced cell damage in human renal proximal tubular epithelial cells

Takao T、Horino T、Kagawa T、Matsumoto R、Inoue K、Taguchi T、Morita T、Iwasaki Y、Hashimoto K、Terada Y、 2009

[雑誌論文] Cutaneous amyloidosis associated with amyopathic dermatomyositis

Taniguchi Y、Horino T、Terada Y、 2009

[雑誌論文] ネフローゼ症候群:診断と治療の進歩. II.一次性ネフローゼ症候群の病態・診断・治療. 5.メサンギウム増殖性糸球体腎炎,管内増殖性糸球体腎炎,半月体形成性糸球体腎炎

堀野太郎、寺田典生 2009

[雑誌論文] Effects of angiotensin II type 1 receptor blocker on albumin-induced cell damage in human renal proximal tubular epithelial cells

Takao T, Terada Y, et al. 2009