癌遺伝子AKT1を分子標的とした新規口腔癌治療

トップ›研究者を探す›癌遺伝子AKT1を分子標的とした新規口腔癌治療

代表研究者	中城公一
研究課題番号	KAKENHI-PROJECT-21592557
研究種目	基盤研究(C)
研究分野	生物系医歯薬学歯学外科系歯学
研究機関	愛媛大学
研究期間開始年月日	2009/4/1
研究期間終了年度	2011
研究ステータス	完了 (2011/4/1)
配分額（合計）	4,550,000 (直接経費 :3,500,000、間接経費 :1,050,000)
配分額（履歴）	2011年度：910,000 (直接経費 :700,000、間接経費 :210,000) 2010年度：1,690,000 (直接経費 :1,300,000、間接経費 :390,000) 2009年度：1,950,000 (直接経費 :1,500,000、間接経費 :450,000)
キーワード	口腔癌 AKT1 RNA干渉 siRNA 分子標的治療

研究成果

[雑誌論文] Premetastic vasculogenesis in oral squamous cell carcinoma xenograft-draining lymph nodes

Mayorca-Guilliani AE, Yano H, Nakashiro K, Hamakawa H, Tanaka J 2012

[雑誌論文] Growth inhibition and apoptosis by an active component of OK-432, a streptococcal agent, via Toll-like receptor 4 in human head and neck cancer cell lines

Tano T, Okamoto M, Kan S, Nakashiro K, Shimodaira S, Yamashita N, Kawakami Y, Hamakawa H 2012

[雑誌論文] Gene therapy for oral squamous cell carcinoma with IAI. 3B promoter-driven oncolytic adenovirus-infected carrier cells

Zhang T, Hamada K, Hyodo M, Itoh H, Goda H, Nakashiro K, Hamakawa H. 2011

[雑誌論文] Human FAT1 cadherin controls cell migration and invasion of oral squamous cell carcinoma through the localization ofβ-catenin

Nishikawa Y, Miyazaki T, Nakashiro K, Yamagata H, Isokane M, Goda H, Tanaka H, Oka R, Hamakawa H. 2011

[雑誌論文] Spindle cell carcinoma after irradiated oral squamous cell carcinoma treated with S-1

Nakashiro K, Nishikawa H, Hamakawa H. 2010

[雑誌論文] Conditional deletion of Stat3 promotes neurogenesis and inhibits astrogliogenesis in neural stem cells

Cao F, Hata R, Zhu P, Nakashiro K, Sakanaka M. 2010

[学会発表] ヒト口腔扁平上皮癌細胞の癌遺伝子依存

中城公一 2010

[雑誌論文] Carrier cell-mediated cell lysis of squamous cell carcinoma cells by squamous cell carcinoma antigen 1 promoter-driven oncolytic adenovirus

Hamada K, Zhang T, Desaki J., Nakashiro K, Itoh H, Tani K, Koyama Y, Hamakawa H. 2010

[雑誌論文] Genome-wide cDNA microarray screening to reveal gene-expression profiles correlated to chemosensitivity of oral squamous cell carcinoma cell lines

Shintani S, Nakashiro K, Hamakawa H, Shirota T, Hatori M., Kawamoto K, Sasaki A. 2010

[雑誌論文] Mandibular osteoblastic metastasis of poorly differentiated carcinoma of the thyroid gland

Nishikawa T, Nakashiro K, Sumida T, Sugita A, Hamakawa H. 2010

[雑誌論文] Friend leukaemia insertion(Fli)-1 is a prediction marker candidate for radiotherapy resistant oral squamous cell carcinoma

Shintani S, Hamakawa H, Nakashiro K, Shirota T, Hatori M, Tanaka M, Kuroshita Y, Kurokawa Y. 2010

[雑誌論文] Mandibular osteoblastic metastasis of poorly differentiated carcinoma of the thyroid gland

Nishikawa H, Nakashiro K, et al. 2010

[雑誌論文] Anti-tumor effect of small interfering RNA targeting the androgen receptor in human androgen-independent prostate cancer cells

Azuma K, Nakashiro K, Sasaki T, Goda H, Onodera J, Tanji N, Yokoyama M, Hamakawa H. 2010

[雑誌論文] Knockdown of Akt isoforms by RNA silencing suppresses the growth of human prostate cancer cells in vitro and in vivo

Sasaki T, Nakashiro K, Tanaka H, Azuma K, Goda H, Hara S, Onodera J, Fujimoto I, Tanji N, Yokoyama M, Hamakawa H. 2010

[雑誌論文] Anti-tumor effect of small interfering RNA targeting the androgen receptor in human androgen-independent prostate cancer cells

Azuma K, Nakashiro K, et al. 2010

[学会発表] ヒト口腔扁平上皮癌細胞の癌遺伝子依存

中城公一 2010

[雑誌論文] Hypoxia enhances CXCR4 expression by activating HIF-1 in oral squamous cell carcinoma

Ishikawa T, Nakashiro K, Klosek SK, Goda H, Hara S, Uchida D, Hamakawa H. 2009

[雑誌論文] 18F-Fluorodeoxyglucose positron emission tomography-computed tomography for diagnosis of cervical lymph node metastasis of oral squamous cell carcinoma

Nishikawa H, Nakashiro K, et al. 2009

[雑誌論文] CD151 regulates HGF-stimulated morphogenesis of human breast cancer cells

Klosek SK, Nakashiro K, Hara S, Goda H, Hasegawa H, Hamakawa H. 2009

[学会発表] 口腔扁平上皮癌における癌関連遺伝子発現の経時的変化

中城公一, 合田啓之, 住田知樹, 浜川裕之 2009

[学会発表] 口腔扁平上皮癌の原発およびリンパ節転移腫瘍における癌関連遺伝子発現プロファイル

中城公一, 合田啓之, 住田知樹, 浜川裕之 2009

[雑誌論文] 18F-fluorodeoxyglucose positron emission tomography computed tomography for the diagnosis of cervical lymph-node metastases of oral squamous cell carcinoma

Nishikawa T, Nakashiro K, Sumida T, Miyagawa M, Hamakawa H. 2009