トップ研究者を探すアレルギー性結膜疾患発症におけるマクロファージの関与

アレルギー性結膜疾患発症におけるマクロファージの関与

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-21592259
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
外科系臨床医学
眼科学
研究機関 高知大学
代表研究者 福島 敦樹
研究期間 開始年月日 2009/4/1
研究期間 終了年度 2011
研究ステータス 完了 (2011/4/1)
配分額(合計) 3,770,000 (直接経費 :2,900,000、間接経費 :870,000)
配分額(履歴) 2011年度:650,000 (直接経費 :500,000、間接経費 :150,000)
2010年度:1,560,000 (直接経費 :1,200,000、間接経費 :360,000)
2009年度:1,560,000 (直接経費 :1,200,000、間接経費 :360,000)
キーワード アレルギー
結膜
抗原提示細胞
FcεRIα
好塩基球
T細胞
マクロファージ
好酸球
免疫染色
電子顕微鏡

研究成果

[雑誌論文] Adjuvants determine the contribution of basophils to antigen sensitization in vivo

Ishida W, Fukuda K, Sumi T, Ebihara N, Kajisako M, Matsuda H, Yagita H, Fukushima A 2011

[雑誌論文] Evaluation of histamine-induced conjunctival edema in guinea-pigs using image analysis.

Takahashi A, Sumi T, Tada K, Mibu, Shii D, Kayasuga A, Fukushima A. 2010

[雑誌論文] Participation of CD11b and F4/80 molecules in the conjunctival eosinophilia of experimental allergic conjunctivitis.

Fukushima A, Ishida W, Ojima A, Kajisako M, Sumi T, Yamada J, Tsuru E, Miyazaki J-i, Tominaga A, Yagita H. 2010

[雑誌論文] Participation of CD11b and F4/ 80 molecules in the conjunctival eosinophilia of experimental allergic conjunctivitis

Fukushima A, Ishida W, Ojima A, Kajisako M, Sumi T, Yamada J, Tsuru E, Miyazaki J-i, Tominaga A, Yagita H 2010

[雑誌論文] Aggravation of conjunctival early-phase reaction by staphylococcus aureus enterotoxin B via augmentation of IgE production.

Miyazaki D, Ishida W, Tominaga T, Sumi T, Fukushima A 2010

[雑誌論文] T cell-related co-stimulatory molecules in the conjunctiva of patients with severe allergic conjunctivitis.

Sumi T, Ishida W.Ebihara N, Fukushima A. 2010

[雑誌論文] Conjunctival macrophages act as antigen-presenting cells in the conjunctiva during the development of experimental allergic conjunctivitis

Ishida W, Kajisako M, Takahashi A, Sumi T, van Rooijen N, Fukuda K, Fukushima A 2010

[学会発表] Severe allergic keratoconjunctivitis

Atsuki Fukushima 2010

[雑誌論文] A randomised, placebo-controlled clinical trial of tacrolimus ophthalmic suspension 0.1% in severe allergic conjunctivitis.

Ohashi Y, Ebihara N, Fujishima H, Fukushima A, Kumagai N, Nakagawa Y, Nanba K, Okamoto S, Shoji J, Takamura E, Hayashi K 2010

[図書] 眼のサイエンス 眼疾患の謎.涙液にあるラクトフェリンやリゾチームはどんな働きをしているのか?

福島敦樹 2010

[雑誌論文] Conjunctival macrophages act as antigen-presenting cells in the conjunctiva during the development of experimental allergic conjunctivitis.

Ishida W, Kajisako M, Takahashi A, Sumi T, van Rooijen N, Fukuda K, Fukushima A 2010

[雑誌論文] Ablation of type I hypersensitivity in experimental allergic conjunctivitis by eotaxin-1/CCR3 blockade

Miyazaki D, Nakamura T, Ohbayashi M, Kuo CH, Komatsu N, Yakura K, Tominaga T, Inoue Y, Higashi H, Murata M, Takeda S, Fukushima A, Liu FT, Rothenberg ME, Ono SJ. 2009

[雑誌論文] MHC-matched corneal allograft rejection in an IFN-gamma/IL-17-independent manner in C57BL/6 mice

Yamada J, Hamuro J, Fukushima A, Ohteki T, Term K, Iwakura Y, Yagita H, Kinoshita S. 2009

[雑誌論文] The NF90-NF45 complex functions as a negative regulator in the microRNA processing pathway

Sakamoto S, Aoki K, Higuchi T, Todaka H, Morisawa K, Tamaki N, Hatano E, Fukushima A, Taniguchi T, Agata Y. 2009

[雑誌論文] Activation of tumor necrosis factor-related apoptosis-inducing ligand receptor enhances the severity of murine allergic conjunctivitis

Fujishima H, Fukagawa K, Takano Y, Tanaka M, Okamoto S, Miyazaki D, Yamada J, Fukushima A, Uchio E. 2009

[学会発表] アレルギー性結膜炎モデルを用いた病態の解析

福島敦樹 2009

[雑誌論文] Image analyses of conjunctival hyperemia in guinea pig allergic conjunctivitis

Fukushima A, Tomita T. 2009

[雑誌論文] Treatment with FTY720 during the induction or effector phase suppresses the development of experimental allergic conjunctivitis in mice

Sumi T, Fukushima A, Nishino K, Fukuda K, Kumagai N, Nishida T, Ueno H. 2009

[雑誌論文] A large prospective observational study of novel cyclosporine 0.1% aqueous ophthalmic solution in thetreatment of severe allergic conjunctivitis

Ebihara N, Ohashi Y, Uchio E, Okamoto S, Kumagai N, Shoji J, Takamura E, Nakagawa Y, Nanba K, Fukushima A, Fujishima H. 2009

[雑誌論文] Image analyses of the kinetic changes of conjunctival hyperemia in histamine-induced conjunctivitis in guinea pigs

Fukushima A, Tomita T. 2009

[雑誌論文] Activation of tumor necrosis factor-related apoptosis-inducing ligand receptor enhances the severity of murine allergic conjunctivitis

Sumi T, Ishida W, Okumura K, Yagita H, Fukushima A. 2009

[雑誌論文] Systemic overexpression of IFN-γ and IL-5 exacerbates early phase reaction and conjunctival eosinophilia, respectively, in experimental all ergic conjunctivitis

Ishida W, Tsuru E, Tominaga A, Miyazaki J-i, Higuchi T, Sakamoto S, Fukushima A. 2009