メニエール病発作発現時と治療時における前庭機能に関する研究

トップ›研究者を探す›メニエール病発作発現時と治療時における前庭機能に関する研究

代表研究者	柿木章伸
研究課題番号	KAKENHI-PROJECT-21592159
研究種目	基盤研究(C)
研究分野	生物系医歯薬学外科系臨床医学耳鼻咽喉科学
研究機関	東京大学
研究期間開始年月日	2009/4/1
研究期間終了年度	2012
研究ステータス	完了 (2012/4/1)
配分額（合計）	4,550,000 (直接経費 :3,500,000、間接経費 :1,050,000)
配分額（履歴）	2012年度：780,000 (直接経費 :600,000、間接経費 :180,000) 2011年度：780,000 (直接経費 :600,000、間接経費 :180,000) 2010年度：780,000 (直接経費 :600,000、間接経費 :180,000) 2009年度：2,210,000 (直接経費 :1,700,000、間接経費 :510,000)
キーワード	メニエール病内リンパ水腫抗利尿ホルモンめまい発作自発眼振前庭機能

研究成果

[学会発表] Water Transport in the Rat Inner Ear; Translational Research of Meniere's Disease.

Nishimura M, Kakigi A, Takeda T, Takeda S, Okada T, Murata J, Ikeda K. 2013

[学会発表] Morphological and Functional Changes in a New Animal Model for Meniere's Disease.

Egami N, Kakigi A, Takeda T, Yamasoba T. 2013

[学会発表] 「内リンパ水腫と水代謝」　―基礎から臨床まで―

柿木章伸 2012

[学会発表] メニエール病モデル動物におけるV2R拮抗的阻害薬の効果に関する検討

江上直也、柿木章伸、竹田泰三、兵頭政光、山岨達也 2012

[学会発表] Cochlear Function in A New Animal Model for Meniere’s Disease

Kakigi A, Egami N, Sakamoto T, Yamasoba T 2012

[学会発表] Immunolocalization of Aquaporin1 and 2 inThe Rat Vestibule and Semicircular Canal.

Kakigi A, Egami N, Sakamoto T, Nishioka R, Takumida M, Hyodo M, Yamasoba T. 2012

[雑誌論文] Type 1 allergy-induced endolymphatic hydrops and the suppressive effect of leukotriene receptor antagonist.

Takeda T, Takeda S, Egami N, Kakigi A, Nishioka R, Yamasoba T. 2012

[学会発表] メニエール病モデル動物におけるV2R拮抗的阻害薬の効果に関する検討

江上直也、柿木章伸、竹田　泰三、兵頭　政光、山岨　達也 2012

[学会発表] Cochlear Function in A New Animal Model for Meniere's Disease.

Kakigi A, Egami N, Sakamoto T, Yamasoba T. 2012

[学会発表] Expression of aquaporins (AQPs)-10/11/12 in the lateral wall of the rat cochlea.

R. Nishioka, T. Takeda, A. Kakigi, M. Komori, T. Kobayashi, M. Hyodo. 2012

[雑誌論文] Type 1 allergy-induced endolymphatic hydrops and the suppressive effect of leukotriene receptor antagonist.

Takeda T, Takeda S, Egami N, Kakigi A, Nishioka R, Yamasoba T. 2012

[学会発表] Immunolocalization of Aquaporins and Vasopressin V2 Receptor in The Rat Vestibule and Semicircular Canal.

Kakigi A, Egami N, Sakamoto T, Nishioka R, Takumida M, Hyodo M, Yamasoba T. 2012

[雑誌論文] Localization of aquaporins 1, 2, and 3 and vasopressin type 2 receptor in the mouse inner ear.

Takumida M, Kakigi A, Egami N, Nishioka R, Anniko M. 2012

[学会発表] ラット内リンパ嚢におけるAQP11の発現

田口大藏、柿木章伸、竹田泰三、北野博也 2012

[学会発表] Vasopressin投与によるラット血管条細胞間隙の経時的変化とVasopressin type 2 antagonist投与における効果.

西村将彦、柿木章伸、竹田泰三、土井勝美、兵頭政光 2011

[雑誌論文] Endocytosis of cationized ferritin in marginal cells of the stria vascularis is regulated by protein kinase, protein phosphatase, and MEK/EEK and PI3-K signaling pathways

Kakigi A, Okada T, Takeda T, Takeda S, Nishioka R, Taguchi D, Nishimura M, Yamasoba T 2011

[学会発表] 内リンパ嚢におけるロイコトリエン受容体の発現について

江上直也、柿木章伸、竹田泰三、西岡利恵、山岨達也 2011

[雑誌論文] Endocytosis of microperoxidase in marginal cells is mainly regulated by RhoA signaling cascade, but not by Rho-associated protein kinase, myosin light-chain kinase and myosin phosphatase.

Kakigi A , Okada T, Takeda T, Takeda S, Nishioka R, Taguchi D, Nishimura M, Yamasoba T. 2011

[学会発表] A new animalmodel for Meniere's disease.

Kakigi A , Egami N, Sakamoto T, Nishioka R,Hyodo M, Takeda T, Yamosoba T. 2011

[学会発表] A new animal model for Meniere's disease

Kakigi A, Egami N, Sakamoto T, Nishioka R, Hyodo M, Takeda T, Yamosoba T 2011

[雑誌論文] Endocytosis of microperoxidase in marginal cells is mainly regulated by RhoA signaling cascade, but not by Rho-associated protein kinase, myosin light-chain kinase and myosin phosphatase

Kakigi A, Okada T, Takeda T, Takeda S, Nishioka R, Taguchi D, Nishimura M, Yamasoba T 2011

[学会発表] 実験的内リンパ水腫動物にめまいは起きるか?

柿木章伸、江上直也、坂本幸士、西岡利恵、兵頭政光、山岨達也 2011

[学会発表] Type-1 Allergy-Induced Endolymphatic Hydrops and the Suppressive Effect of Leukotrien and Histamin Antagonists.

Egami N, Kakigi A, Takeda T, Takeda S, Nishioka R, Yamasoba T. 2011

[雑誌論文] Endocytosis of cationized ferritin in marginal cells of the stria vascularis is regulated by protein kinase, protein phosphatase, and MEK/ERK and PI3-K signaling pathways.

Kakigi A , Okada T, Takeda T, Takeda S, Nishioka R, Taguchi D, Nishimura M, Yamasoba T. 2011

[学会発表] Type-1 allergy-induced endolymphatic hydrops and the suppressive effect of anti-allergy drugs.

Takeda T, Takeda S, Egami N, Kakigi A, Nishioka R. 2010

[雑誌論文] The clinical value of extratympanic electrocochleography in the diagnosis of Meniere's disease.

Takeda T, Kakigi A. 2010

[雑誌論文] Endocytosis of MPO in marginal cells is regulated by PKC, protein phosphatase, ERK and PI3-K signaling cascades, but not by PKA and MEK signaling cascades.

Kakigi A , Okada T, Takeda T, Takeda S, Taguchi D, Nishimura M, Yamasoba T. 2010

[学会発表] Vestibular Function in A New Animal Model for

Kakigi A, Egami N, Sakamoto T, Nishioka R, Hyodo M, Takeda T, Yamasoba T. 2010

[雑誌論文] Time course of vestibular function changes of experimental endolymphatic hydrops in guinea pigs.

Kakigi A , Taguchi D, Takeda T, Takeda S, Nakatani H. 2010

[雑誌論文] Expression of aquaporins and vasopressin type 2 receptor in the stria vascularis of the cochlea.

Nishioka R, Takeda T, Kakigi A , Okada T, Takebayashi S, Taguchi D, Nishimura M, Hyodo M. 2010

[学会発表] 内リンパ水腫動物の前庭機能(第2報)

柿木章伸,江上直也,山岨達也,西岡利恵,竹田泰三 2010

[学会発表] Mechanisms underlying the Formation of Endolymphatic Hydrops and its Clinical Pictures

柿木章伸 2010

[学会発表] Mechanisms underlying theFormation of Endolymphatic Hydrops and itsClinical Pictures.

Kakigi A. 2010

[学会発表] Vasopressin 投与によるラット血管条の形態変化について(第 3 報)

西村将彦、柿木章伸、竹田泰三、土井勝美 2009

[学会発表] 内リンパ水腫動物の前庭機能

柿木章伸、山岨達也、竹田泰三 2009

[学会発表] Type-1 allergy-induced endolymphatic hydrops and the suppressive effect of leukotriene antagonist.

Takeda T, Takeda S, Kakigi A. 2009

[学会発表] ラット蝸牛血管条における水チャネルの局在.

西岡利恵、柿木章伸、兵頭政光 2009

[雑誌論文] Expression of aquaporins, vasopressin type 2 receptor, and Na+_K+_Cl^_ cotransporters in the rat endolymphatic sac.

Nishimura M, Kakigi A , Takeda T, Takeda S, Doi K. 2009

[学会発表] Aquaporins as Potentials Drug Targets for Meniere's disease and its Related Disease.

Takeda T, Kakigi A. 2009

[学会発表] ラット内耳前庭におけるAQPの発現

西岡利恵、柿木章伸、兵頭政光 2009

[学会発表] ラット内耳血管条におけるアクアポリン10～12の発現.

西岡利恵、柿木章伸、兵頭政光. 2009

[雑誌論文] Time course changes of vasopressin-induced enlargement of the rat intrastrial space and the effects of a vasopressin type 2 antagonist.

Nishimura M, Kakigi A , Takeda T, Okada T, Doi K. 2009

[学会発表] Bumetanide投与によるラット血管条の形態変化とOPC-31260投与における効果.

西村将彦、柿木章伸、竹田泰三、土井勝美 2009

[学会発表] Vestibular function in a new animal model for Meniere's disease.

Kakigi A, Yamasoba T, Takeda T. 2009