バリア破綻による皮膚炎発症の機序:表皮セラミド欠損マウスを用いた解析

トップ›研究者を探す›バリア破綻による皮膚炎発症の機序:表皮セラミド欠損マウスを用いた解析

バリア破綻による皮膚炎発症の機序:表皮セラミド欠損マウスを用いた解析

代表研究者	佐野栄紀
研究課題番号	KAKENHI-PROJECT-21591436
研究種目	基盤研究(C)
研究分野	生物系医歯薬学内科系臨床医学皮膚科学
研究機関	高知大学
研究分担者	中島喜美子
研究分担者	山本真有子
研究期間開始年月日	2009/4/1
研究期間終了年度	2011
研究ステータス	完了 (2011/4/1)
配分額（合計）	4,420,000 (直接経費 :3,400,000、間接経費 :1,020,000)
配分額（履歴）	2011年度：1,170,000 (直接経費 :900,000、間接経費 :270,000) 2010年度：1,300,000 (直接経費 :1,000,000、間接経費 :300,000) 2009年度：1,950,000 (直接経費 :1,500,000、間接経費 :450,000)
キーワード	皮膚病理学乾癬表皮セラミド IL-17 IL-23 表皮バリア Th17 γδT細胞アトピー性皮膚炎 TSLP 表皮バリア破綻 Th2

研究成果

[雑誌論文] Distinct roles of IL-23 and IL-17 in the development of psoriasis-like lesions in a mouse model

Nakajima K, Kanda T, Takaishi M, Shiga T, Miyoshi K, Nakajima H, Kamijima R, Tarutani M, Benson JM, Elloso MM, Gutshall LL, Naso MF, Iwakura Y, DiGiovanni J, Sano S 2011

[学会発表] Development of psoriasis-like lesions in a mouse model by IL-23-dependent but IL-22-independent signaling

Takaishi M, Nakajima K, Ouyang W, Sano S 2011

[学会発表] 表皮特異的セラミドノックアウトマウスの皮膚バリア異常のイメージング

中島喜美子、佐野栄紀 2011

[雑誌論文] Safety and effectiveness of a new enzyme-targeting radiosensitization treatment (KORTUC II) for intratumoral injection for low-LET radioresistant tumors

Ogawa Y, Kubota K, Ue H, Tadokoro M, Matsui R, Yamanishi T, Hamada N, Kariya S, Nishioka A, Nakajima H, Tarutani M, Sano S 2011

[雑誌論文] XI.乾癬モデル動物を用いた研究と新たな治療法

佐野栄紀 2011

[学会発表] Topical tacrolimus treatment does not facilitate UV-induced carcinogenesis in a mouse model

Shiga T, Yokogawa M, Tarutani M, Sano S 2011

[学会発表] Pityriasis rubra pilaris treated with maxacalcitol and narrow-band uvbirradiation

Okino T, Kitagawa C, Nakajima H, Tarutani M, Sano S 2011

[雑誌論文] Th17細胞と乾癬

佐野栄紀 2011

[学会発表] 乾癬研究・治療の新たな展開

佐野栄紀 2011

[学会発表] Epicutaneous treatment with TLR7 agonist leads to lupus glomerulonephritis in wild-type mice

Sano S, Yokogawa M, Takaishi M, Nakajima K, Kataoka S 2011

[雑誌論文] Ramsay-Hunt syndrome

Taguchi T, Ueda S, Kudo T, Nakajima H, Nishioka R, Sano S, Terada Y 2011

[雑誌論文] 乾癬の発症機序

佐野栄紀 2011

[学会発表] Inhibitory Effect of a Cathepsin K Inhibitor on the Development of Psoriasis-Like Lesions in a Mouse Model

Hirai T, Kanda T, Nakajima K, Yamamoto M, Sano S 2011

[学会発表] Anti-tumor effect of imiquimod on UVB-induced SCC is mediated through Th1/Th17 cells

Yokogawa M, Shiga T, Nakajima K, Takaishi M, Tarutani M, DiGiovanni J, Sano S 2011

[雑誌論文] Presence of Merkel cell polyomavirus in Japanese cutaneous squamous cell carcinoma

Murakami M, Imajoh M, Ikawa T, Nakajima H, Kamioka M, Nemoto Y, Ujihara T, Uchiyama J, Matsuzaki S, Sano S, Daibata M 2011

[雑誌論文] Stat3 as a therapeutic target for the treatment of psoriasis. A clinical feasibility study with STA-21, a Stat3 Inhibitor

Miyoshi K, Takaishi M, Nakajima K, Ikeda M, Kanda T, Tarutani M, Iiyama T, Asao N, Digiovanni J, Sano S 2011

[学会発表] Inhibitory effect of a cathepsin K inhibitor on the development of psoriasis-like lesions

Hirai T, Kanda T, Nakajima K, Yamamoto M, Sano S 2011

[学会発表] A case of nevoid basal cell carcinomasyndrome

Kudo T, Shiga T, Nakajima H, Tarutani M, Sano S 2011

[雑誌論文] Kinetics of circulating Th17 cytokines and adipokines in psoriasis patients

Nakajima H, Nakajima K, Tarutani M, Morishige R, Sano S 2011

[学会発表] A novel link between Th 17 cutokines and adipokines in psoriasis

Nakajima H, Nakajima K, Tarutani M, Morishige R, Sano S. 2011

[学会発表] Psoriasis-like skin lesion induced by Raf-MAPK signaling requires Stat3 activation

Tarutani M, Miyoshi K, Takaishi M, Sano S 2011

[学会発表] Genome-wide expression profiling of five mouse models identifies similarities and differences with human psoriasis

Swindell WR, Johnston A, Carbajal S, Han G, Wohn C, Lu J, Xing X, Nair R P, Voorhees J J, Elder JT, Wang X-J, Sano S, Prens EP, DiGiovanni J, Pittelkow MR, Ward NL, Gudjonsson JE 2011

[雑誌論文] Altered lipid profiles in the stratum corneum of Sjogren-Larsson Syndrome.

Kimiko Nakajima, Yoshikazu Uchida; Masashi Akiyama; Yukari Morita; Hiroshi Shimizu; Shigetoshi Sano. 2011

[雑誌論文] Stat3 as a therapeutic target for the treatment of psoriasis : a clinical feasibility study with STA-21, a Stat3 inhibitor.

Miyoshi K, Takaishi M, Nakajima K, Ikeda M, Kanda T, Tarutani M, Iiyama T, Asao N, DiGiovanni J, Sano S. 2011

[学会発表] 乾癬発症のためのサイトカインヒエラルキー

佐野栄紀 2011

[学会発表] Primary ceramide deficiency in keratinocytes leads to gene alterations linked to dermatitis

Nakajima K, Terao M, Azukizawa H, Katayama I, Takeda J, Sano S 2011

[雑誌論文] Presence of Merkel cell polyomavirus in Japanese cutaneous squamous cell carcinoma.

Murakami M, Imajoh M, Ikawa T, Nakajima H, Kamioka M, Nemoto Y, Ujihara T, Uchiyama J, Matsuzaki S, Sano S, Daibata M. 2011

[学会発表] Increased expression of endothelin-1 in cultured keratinocyte by combined treatments with narrow-band ultraviolet B irradation and tacalcitol

Takata T, Tarutani M, Sano S 2011

[雑誌論文] 18FDG PET/CT is a powerful tool for detecting subclinical arthritis in patients with psoriatic arthritis and/or psoriasis vulgaris

Takata T, Taniguchi Y, Ohnishi T, Kohsaki S, Nogami M, Nakajima H, Kumon Y, Terada Y, Ogawa Y,Tarutani M, Sano S 2011

[学会発表] Induction of mesenchymal-epithelial transition in fibroblast-like spindle cancer cells by reprogramming factors

Takaishi M, Takeda J, Sano S 2011

[学会発表] Genome-wide expression profiling of five mouse models identifies similarities and differences with human psoriasis

Swindell WR, Johnston A, Carbajal S, Han G, Wohn C, Lu J, Xing X, Nair R P, Voorhees J J, Elder JT, Wang X-J, Sano S, Prens EP, DiGiovanni J, Pittelkow MR, Ward NL, Gudjonsson JE. 2011

[学会発表] Novel imaging mass spectrometry to visualize essential epidermal barrier ceramides required for mammalian survival

Uchida Y, Goto-Inoue N, Hayasaka T, Zaima N, Nakajima K, Sano S, Holleran WM, Setou M 2011

[学会発表] Mouse Model for Psoriatic Arthritis

Sano S 2011

[雑誌論文] Kinetics of circulating Th17 cytokines and adipokines in psoriasis patients

Nakajima H, Nakajima K, Tarutani M, Morishige R, Sano S 2011

[学会発表] Anti-tumor effect of imiquimod on UVB-induced SCC is mediated through Th1/ Th17 cells

Yokogawa M, Shiga T, Nakajima K, Takaishi M, Tarutani M, DiGiovanni J, Sano S 2011

[雑誌論文] Genome-wide expression profiling of five mouse models identifies similarities and differences with human psoriasis

Swindell WR, Johnston A, Carbajal S, Han G, Wohn C, Lu J, Xing X, Nair RP, Voorhees JJ, Elder JT, Wang XJ, Sano S, Prens EP, Digiovanni J, Pittelkow MR, Ward NL, Gudjonsson JE 2011

[雑誌論文] 炎症性角化症尋常性乾癬病態と治療の進歩

佐野栄紀 2011

[学会発表] IL-23 is essential, but IL-22 is dispensable for the development of psoriasis-like lesions in K5.Stat3C mice

Takaishi M, Nakajima K, Wenjun Ouyang, Sano S 2011

[学会発表] Mouse Model for Psoriatic Arthritis

Sano S 2011

[雑誌論文] Th17と乾癬

中島喜美子、佐野栄紀 2011

[雑誌論文] 序～乾癬:新たなパラダイム～

佐野栄紀 2011

[学会発表] Epicutaneous treatment with TLR7 agonist leads to lupus glomerulonephritis in wild-type mice

Sano S, Yokogawa M, Takaishi M, Nakajima K, Kataoka S 2011

[学会発表] A novel link between Th17 cutokines and adipokines in psoriasis

Nakajima H, Nakajima K, Tarutani M, Morishige R, Sano S 2011

[学会発表] Development of psoriasis-like lesions in a mouse model by IL-23-dependent but IL-22-independent signaling

Takaishi M, Nakajima K, Ouyang W, Sano S 2011

[学会発表] Sebaceous glands as the primary target of EGFR-inhibitor in the development of papulopustular eruption

Takata T, Tarutani M, Sano S 2011

[学会発表] Cytokine aberrations in a mouse model of psoriatic arthritis

Yamamoto M, Sano S 2011

[雑誌論文] Stat3 as a therapeutic target for the treatment of psoriasis. A clinical feasibility study with STA-21, a Stat3 Inhibitor

Miyoshi K, Takaishi M, Nakajima K, Ikeda M, Kanda T, Tarutani M, Iiyama T, Asao N, Digiovanni J, Sano S 2011

[雑誌論文] Th17細胞と乾癬

佐野栄紀 2011

[学会発表] Reprogramming genes for induced pluripotent stem cells (iPSCs) reversed changes. associated with epithelial-to-mesenchymal transition of skin cancer cells

Takaishi M, Yamamoto M, Yokogawa M, Takeda J, Sano S 2011

[雑誌論文] Diminished regulatory T cells in cutaneous lesions of thymoma-associated multi-organ autoimmunity : A newly described paraneoplastic autoimmune disorder with fatal clinical course

Hanafusa T, Azukizawa H, Kitaba S, Murota H, Umegaki N, Terao M, Sano S, Nakagiri T, Okumura M, Katayama I 2011

[雑誌論文] 序乾癬:新たなパラダイム

佐野栄紀 2011

[学会発表] Psoriasis-like skin lesion induced by Raf-MAPK signaling requires Stat3 activation

Tarutani M, Miyoshi K, Takaishi M, Sano S 2011

[学会発表] Topical tacrolimus treatment does not facilitate UV-induced carcinogenesis in a mouse model

Shiga T, Kawamura K, Kamijima R, Yokogawa M, Tarutani M, Sano S 2011

[雑誌論文] Altered lipid profiles in the stratum comeum of Sjogren-Larsson Syndrome

Nakajima K, Sano S, Uchida Y, Akiyama M, Morita Y, Shimizu H 2011

[学会発表] 乾癬研究・治療の新たな展開

佐野栄紀 2011

[雑誌論文] Distinct Roles of IL-23 and IL-17 in the Development of Psoriasis-Like Lesions in a Mouse Model.

Nakajima K, Kanda T, Takaishi M, Shiga T, Miyoshi K, Nakajima H, Kamijima R, Tarutani M, Benson JM, Elloso MM, Gutshall LL, Naso MF, Iwakura Y, Digiovanni J, Sano S. 2011

[学会発表] T cell subcet of tumor-infiltrating lymphocytes predict prognosis of patients with cutaneous angiosarcoma

Fujii H, Arakawa A, Kitoh A, Matsumura T, Konishi K, Sano S, Miyachi Y, Tanioka M 2011

[雑誌論文] Distinct roles of IL-23 and IL-17 in the development of psoriasis-like lesions in a mouse model

Nakajima K, Kanda T, Takaishi M, Shiga T, Miyoshi K, Nakajima H, Kamijima R, Tarutani M, Benson JM, Elloso MM, Gutshall LL, Naso MF, Iwakura Y, DiGiovanni J, Sano S 2011

[学会発表] 乾癬・関節症性乾癬の病態・治療の最新話題

佐野栄紀 2011

[学会発表] Inhibitory effect of a cathepsin K inhibitor on the development of psoriasis-like lesions

Hirai T, Kanda T, Nakajima K, Yamamoto M, Sano S 2011

[学会発表] Cytokine aberrations in a mouse model of psoriatic arthritis

Yamamoto M, Sano S 2011

[学会発表] Primary ceramide deficiency in keratinocytes leads to gene alterations linked to dermatitis

Nakajima K, Terao M, Azukizawa H, Katayama I, Takeda J, Sano S 2011

[学会発表] Psoriasis-like skin lesion induced by Raf-MAPK signaling requires Stat3 activation

Tarutani M, Miyoshi K, Takaishi M, Sano S 2011

[雑誌論文] 表皮角化細胞のStat3シグナル(前編)

佐野栄紀 2010

[雑誌論文] High prevalence of coinfection with mucosal high-risk type HPV(HR-HPV)and cutaneous HR-HPV in Bowen's disease in the fingers.

Nakajima H, Teraishi M, Tarutani M, Sano S. 2010

[雑誌論文] Favorable response of reticular erythematous mucinosis to UVB irradiationusing a 308-nm excimer lamp

Miyoshi, K.Miyajima, O.Yokogawa, M.Sano, S. 2010

[学会発表] マウスモデルで明らかになった乾癬におけるIL23/ Th17径路の役割

佐野栄紀 2010

[学会発表] 皮膚疾患モデル動物の未来

佐野栄紀 2010

[雑誌論文] 関節症性乾癬とその成因(解説)

佐野栄紀 2010

[学会発表] 乾癬の発症に関わるリンフォカインネットワーク

佐野栄紀 2010

[雑誌論文] Circulating level of chemerin is upregulated in psoriasis.

Nakajima H, Nakajima K, Nagano Y, Yamamoto M, Tarutani M, Takahashi M, Takahashi Y, Sano S. 2010

[学会発表] Recent progress in psoriasis research on mechanistic interaction between cytokines and keratinocytes : a distinct role of the IL-23/Th17 axis

S.Sano 2010

[雑誌論文] 表皮角化細胞の Stat3 シグナル(中編)

佐野栄紀 2010

[雑誌論文] 表皮とStat3-もろ刃の剣としてのマスターシグナル-

佐野栄紀 2010

[図書] 今日の治療指針2010年版

佐野栄紀 2010

[学会発表] K5.Stat3C transgenic mouse as a model of psoriasis.

S.Sano 2010

[学会発表] 乾癬の発症に関わるリンフォカインネットワーク

佐野栄紀 2010

[学会発表] Recent progress in psoriasis research on mechanistic interaction between cytokines and keratinocytes : A distinct role of the IL-23/ Th17 axis

Sano S 2010

[図書] 今日の治療指針2010年版(魚鱗癬.飯塚一編)

佐野栄紀 2010

[学会発表] Merkel細胞癌とポリオーマウイルス

佐野栄紀 2010

[学会発表] 皮膚疾患モデル動物の未来

佐野栄紀,堀江恭二,竹田潤二 2010

[雑誌論文] 表皮角化細胞のStat3シグナル(後編)

佐野栄紀 2010

[雑誌論文] 表皮角化細胞のStat3シグナル(後編)

佐野栄紀 2010

[学会発表] 乾癬モデルマウス(K5. Stat3C transgenic mice)におけるIL23/ Th17 axisについて

中島喜美子,佐野栄紀 2010

[雑誌論文] 表皮角化細胞の Stat3 シグナル(前編)

佐野栄紀 2010

[雑誌論文] 表皮とStat3もろ刃の剣としてのマスターシグナル

佐野栄紀 2010

[学会発表] 表皮バリアと炎症

佐野栄紀 2010

[雑誌論文] 表皮角化細胞のStat3シグナル(中編)

佐野栄紀 2010

[学会発表] マウスモデルで明らかになった乾癬におけるIL23/Th17径路の役割

佐野栄紀 2010

[雑誌論文] 新しい治療法Stat3阻害剤の臨床応用

佐野栄紀, 横川真紀, 三好研 2009

[学会発表] 乾癬とTh17

佐野栄紀 2009

[学会発表] Recent progress in psoriasis research on mechanistic interaction between cytokines and keratinocytes

佐野栄紀 2009

[学会発表] 活性型ビタミンD3が持つ乾癬以外の多様な疾患に対する効果

佐野栄紀 2009

[雑誌論文] 乾癬発症のメカニズム

佐野栄紀 2009

[雑誌論文] Constitutive activation and targeted disruption of signal transducer and activator of transcription 3(Stat3)in mouse epidermis reveal its critical role in UVB-induced skin carcinogenesis

Kim, D.J.Angel, J.M.Sano, S.DiGiovanni, J. 2009

[学会発表] 近未来の乾癬治療

佐野栄紀 2009

[学会発表] 活性型ビタミンD3が持つ乾癬以外の多様な疾患に対する効果

佐野栄紀 2009

[学会発表] Skin barrier disruption results in alteration of cutaneous immuneresponses

Nakajima, K.Takaishi, M.Terao, M.Azukizawa, H.Katayama, I.Takeda, J.Sano, S. 2009

[学会発表] Recent progress in psoriasis research on mechanistic interaction between cytokinesand keratinocytes

Sano S 2009

[雑誌論文] 乾癬発症のメカニズム

佐野栄紀 2009

[学会発表] 日光角化症の発症におけるStat3の役割および特異的Stat3阻害軟膏による治療の試み:モデルマウスを用いた解析

佐野栄紀 2009

[学会発表] 乾癬の発症機序

佐野栄紀 2009

[雑誌論文] Constitutive activation and targeted disruption of signal transducer and activator of transcription 3(Stat3) in mouse epidermis reveal its critical role in UVB-induced skin carcinogenesis

Kim DJ, Angel JM, Sano S, DiGiovanni J 2009

[雑誌論文] Screening of the specific polyoma virus as diagnostic and prognostic tools for Merkel cell carcinoma

Nakajima, H.Takaishi, M.Yamamoto, M.Kamijima, R.Kodama, H.Tarutani, M.Sano, S. 2009

[学会発表] Impact of Stat3 on Skin Biology

Sano S 2009

[学会発表] Impact of Stat3 on Skin Biology

佐野栄紀 2009

[学会発表] Ceramide deficiency in epidermis results in development of drmatitis through Langerhans cell maturation and expasion of IL-17-producing gd T cells

佐野栄紀 2009

[学会発表] Stat3阻害剤の臨床応用

佐野栄紀 2009

[学会発表] Ceramide deficiency in epidermis results in development of drmatitis through Langerhans cell maturation and expasion of IL-17-producing gd T cells

Sano S, Nakajima K, Terao M, Takaishi M, Azukizawa H, Katayama I, Takeda J 2009

[雑誌論文] 新しい治療法 Stat3 阻害剤の臨床応用

佐野栄紀 2009

[学会発表] 乾癬とTh17

佐野栄紀 2009

[学会発表] 近未来の乾癬治療

佐野栄紀 2009

[学会発表] Stat3阻害剤の臨床応用

佐野栄紀 2009