免疫難病モデルマウスを用いた生物学的製剤の分子作用機序の解明

トップ›研究者を探す›免疫難病モデルマウスを用いた生物学的製剤の分子作用機序の解明

免疫難病モデルマウスを用いた生物学的製剤の分子作用機序の解明

代表研究者	藤本穣
研究課題番号	KAKENHI-PROJECT-21591276
研究種目	基盤研究(C)
研究分野	生物系医歯薬学内科系臨床医学膠原病・アレルギー内科学
研究機関	独立行政法人医薬基盤研究所
研究期間開始年月日	2009/4/1
研究期間終了年度	2011
研究ステータス	完了 (2011/4/1)
配分額（合計）	4,550,000 (直接経費 :3,500,000、間接経費 :1,050,000)
配分額（履歴）	2011年度：910,000 (直接経費 :700,000、間接経費 :210,000) 2010年度：1,300,000 (直接経費 :1,000,000、間接経費 :300,000) 2009年度：2,340,000 (直接経費 :1,800,000、間接経費 :540,000)
キーワード	膠原病学自己免疫疾患サイトカイン生物学的製剤モデルマウス難病モデル動物生物単的製剤

研究成果

[雑誌論文] Serum leucine-rich alpha-2 glycoprotein is a disease activity biomarker in ulcerative colitis

Serada S, Fujimoto M, Terabe F, Iijima H, Shinzaki S, Matsuzaki S, Ohkawara T, Nezu R, Nakajima S, Kobayashi T, Plevy SE, Takehara T, Naka T 2012

[雑誌論文] Periostin, a matricellular protein, accelerates cutaneous wound repair by activating dermal fibroblasts

Ontsuka K, Kotobuki Y, Shiraishi H, Serada S, Ohta S, Tanemura A, Yang L, Fujimoto M, Arima K, Suzuki S, Murota H, Toda S, Kudo A, Conway S, Izuhara K, Katayama I, Naka T 2012

[雑誌論文] Blockade of interleukin-6 receptor alleviates disease in mouse model of scleroderma

Kitaba S, Murota H, Terao M, Azukizawa H, Terabe F, Shima Y, Fujimoto M, Tanaka T, Naka T, Kishimoto T, Katayama I 2012

[雑誌論文] IL-6によるレギュラトリーT細胞の抑制:nTregとiTregの相違

藤本穣、寺部文隆、仲哲治 2012

[雑誌論文] Dysregulation of melanocyte function by Th17-related cytokines : significance of Th17 cell infiltration in autoimmune vitiligo vulgaris

Kotobuki Y, Tanemura A, Yang L, Itoi S, Wataya-Kaneda M, Murota H, Fujimoto M, Serada S, Naka T, Katayama I 2012

[雑誌論文] The influence of excessive IL-6 production in vivo on the development and function of Foxp3+regulatory T cells

Fujimoto M, Nakano M, Terabe F, Kawahata H, Ohkawara T, Han Y, Ripley B, Serada S, Nishikawa T, Kimura A, Nomura S, Kishimoto T, Naka T 2011

[雑誌論文] Overexpression of SOCS3 exhibits preclinical antitumor activity against malignant pleural mesothelioma

Iwahori K, Serada S, Fujimoto M, Nomura S, Osaki T, Lee CM, Mizuguchi H, Takahashi T, Ripley B, Okumura M, Kawase I, Kishimoto T, Naka T 2011

[雑誌論文] Comparative analysis of the effects of anti-IL-6 receptor mAb and anti-TNF mAb treatment on CD4+T-cell responses in murine colitis

Terabe F, Fujimoto M, Serada S, Shinzaki S, Iijima H, Tsujii M, Hayashi N, Nomura S, Kawahata H, Jang MH, Miyasaka M, Mihara M, Ohsugi Y, Kishimoto T, Naka T 2011

[雑誌論文] Blockade of interleukin-6 signaling suppresses not only th17 but also interphotoreceptor retinoid binding protein-specific Th1 by promoting regulatory T cells in experimental autoimmune uveoretinitis

Haruta H, Ohguro N, Fujimoto M, Hohki S, Terabe F, Serada S, Nomura S, Nishida K, Kishimoto T, Naka T 2011

[雑誌論文] IL-6-mediated Th17 differentiation through ROR{gamma} t is essential for the initiation of experimental autoimmune myocarditis

Yamashita T, Iwakura T, Matsui K, Kawaguchi H, Obana M, Hayama A, Maeda M, Izumi Y, Komuro I, Ohsugi Y, Fujimoto M, Naka T, Kishimoto T, Nakayama H, Fujio Y 2011

[学会発表] Tregの分化、機能におけるIL-6の作用

藤本穣、仲哲治 2011

[雑誌論文] Comparative analysis of the effects of anti-IL-6 receptor mAb and anti-TNF mAb treatment on CD4+ T-cell responses in murine colitis

Terabe F, Fujimoto M, Serada S, Shinzaki S, Iijima H, Tsujii M, Hayashi N, Nomura S, Kawahata H, Myoung Ho Jang, Miyasaka M, Mihara M, Ohsugi Y, Kishimoto T, Naka T 2011

[学会発表] Nuclear receptor PPAR-gamma interacts with IRF7 to negatively regulate TLR7/9-mediated type I interferon production and the development of murine lupus

Ripley B, Fujimoto M, Han A, Millrine D, Lee S, Kawai T, Akira S, Naka T, Kishimoto T 2011

[雑誌論文] The Influence of Excessive IL-6 Production In Vivo on the Development and Function of Foxp3+ Regulatory T Cells.

Fujimoto M, Nakano M, Terabe F, Kawahata H, Ohkawara T, Han Y, Ripley B, Serada S, Nishikawa T, Kimura A, Nomura S, Kishimoto T, Naka T. 2011

[学会発表] TGFbeta1 promotes bleomycin induced murine dermal sclerosis via its downstream molecule of periostin

Yan L, Fujimoto M, Serada S, Murota H, Kotobuki Y, Kitaba S, Katayama I, Naka T 2011

[学会発表] Quantitative proteomic analysis of cell-surface membrane proteins : Biomarker discovery in endometrial cancer

Takuhei Yokoyama, Takayuki Enomoto, Satoshi Serada, Shinya Matsuzaki, Toshihiro Kimura, Yutaka Ueda, Masami Fujita, Kiyoshi Yoshino, Ayako Kim, Minoru Fujimoto, Tadashi Kimura, Tetsuji Naka 2011

[学会発表] 定量的プロテオーム解析による子宮内膜癌抗原蛋白質の探索

Satoshi Serada, Takuhei Yokoyama, Takayuki Enomoto, Shinya Matsuzaki, Akiko Morimoto, Ayako Kim, Minoru Fujimoto, Tadashi Kimura, Tetsuji Naka 2011

[学会発表] PERIOSTIN GENE KNOCKOUT IS PROTECTIVE AGAINST THE DEVELOPMENT OF BLEOMYCIN-INDUCED MURINE SKIN SCLERODERMA

L. Yang, M. Fujimoto, S. Serada, H. Murota, B. Ripley, S. Kitaba, Y. Kotobuki, T. Naka, I. Katayama 2011

[学会発表] Tregの分化、機能におけるIL-6の作用

藤本穣、仲哲治 2011

[学会発表] MYD88 GENE KNOCKOUT INHIBITS THE DEVELOPMENT OF LUPUS-LIKE DISEASE IN NZB/W F1 MICE

T. Ohkawara, B. Ripley, M. Fujimoto, T. Naka 2011

[学会発表] NUCLEAR RECEPTOR PPAR-GAMMA NEGATIVELY REGULATES TYPE I INTERFERON PRODUCTION VIA INTERACTION WITH IRF7

B. Ripley, M. Fujimoto, S. Serada, L.-L. Yang, F. Terabe, Y.-M. Han, T. Ohkawara, T. Nishikawa, T. Naka 2011

[雑誌論文] IL-6-mediated Th17 differentiation through RORγt is essential for the initiation of experimental autoimmune myocarditis

Yamashita T, Iwakura T, Matsui K, Kawaguchi H, Obana M, Hayama A, Maeda M, Izumi Y, Komuro I, Ohsugi Y, Fujimoto M, Naka T, Kishimoto T, Nakayama H, Fujio 2011

[学会発表] Leucine rich alpha 2 glycoprotein(LRG) is a novel biomarker for monitoring disease activity in patients with Ulcerative Colitis

Satoshi Serada, Minoru Fujimoto, Fumitaka Terabe, Tetsuji Naka 2011

[学会発表] SOCS-1,-3 gene delivery in gastric cancer cells induces a potent anti-proliferative effect via the suppression of JAK/STAT and P38 MAPK signaling pathways

Maiko Urase, Satoshi Serada, Yoshihito Souma, Kouta Iwahori, Kazuki Shimada, Toshirou Nishida, Minoru Fujimoto, Tetsuji Naka 2011

[雑誌論文] Antiproliferative effect of SOCS-1 through the suppression of STAT3 and p38 MAPK activation in gastric cancer cells

Souma Y, Nishida T, Serada S, Iwahori K, Takahashi T, Fujimoto M, Ripley B, Nakajima K, Miyazaki Y, Mori M, Doki Y, Sawa Y, Naka T 2011

[学会発表] SOCS-1, -3 gene delivery in gastric cancer cells induces a potent anti-proliferative effect via the suppression of JAK/STAT and P38 MAPK signaling pathways

Maiko Urase, Satoshi Serada, Yoshihito Souma, Kouta Iwahori, Kazuki Shimada, Toshirou Nishida, Minoru Fujimoto, Tetsuji Naka 2011

[学会発表] TGFbeta1 promotes bleomycin-induced murine dermal sclerosis via its downstream molecule of periostin

Yan L, Fujimoto M, Serada S, Murota H, Kotobuki Y, Kitaba S, Katayama I, Naka T 2011

[学会発表] Leucine rich alpha 2 glycoprotein (LRG) is a novel biomarker for monitoring disease activity in patients with Ulcerative Colitis

Satoshi Serada, Minoru Fujimoto, Fumitaka Terabe, Tetsuji Naka 2011

[雑誌論文] Blockade of interleukin-6 signaling suppresses experimental autoimmune uveoretinitis by the inhibition of inflammatory Th17 responses

Hohki S, Ohguro N, Haruta H, Nakai K, Terabe F, Serada S, Fujimoto M, Nomura S, Kawahata H, Kishimoto T, Naka T 2010

[雑誌論文] SOCS1, a Negative Regulator of Cytokine Signals and TLR Responses, in Human Liver Diseases

Fujimoto M, Naka T 2010

[雑誌論文] Green tea polyphenol epigallocatechin gallate inhibits cell signaling by inducing SOCS1 gene expression

Ripley BJ, Fujimoto M, Serada S, Ohkawara T, Nishikawa T, Terabe F, Matsukawa Y, Stephanou A, Knight RA, Isenberg DA, Latchman DS, Kishimoto T, Naka T 2010

[学会発表] The effect of IL-6 overproduction in vivo on wound healing, Cytokines in Infectious Diseases

Fujimoto M, Kotobuki Y, Kitaba S, Ukita T, Terabe F, Haruta H, Kishimoto T, Naka T 2010

[雑誌論文] Thl7細胞とレギュラトリーT細胞のバランスを決定する要因

藤本穣 2010

[雑誌論文] Th17細胞とレギュラトリーT細胞のバランスを決定する要因

藤本穣 2010

[雑誌論文] iTRAQ-based proteomic identification of leucine-rich alpha-2 glycoprotein as a novel inflammatory biomarker in autoimmune diseases

Serada S, Fujimoto M, et. al. 2010

[雑誌論文] Blockade of Interleukin-6 Signaling Suppresses Experimental Autoimmune Uveoretinitis by the Inhibition of Inflammatory Thl7 Responses.

Hohki S, Ohguro N, Haruta H, Nakai K, Terabe F, Serada S, Fujimoto M, Nomura S, Kawahata H, Kishimoto T, Naka T. 2010

[雑誌論文] SOCS1, a Negative Regulator of Cytokine Signals and TLR Respouses, in Human Liver Diseases.

Fujimoto M, Naka T. 2010

[学会発表] The effect of IL-6 overproduction on T helper cell differentiation in vivo

Fujimoto M, Terabe F, Ukita T, Mei Y, Serada S, Nishikawa T, Ripley B, Kishimoto T, Naka T 2010

[雑誌論文] IL-6阻害による自己免疫性関節炎治療効果はTh17抑制を介している

大河原知治、藤本穣、仲哲治 2010

[雑誌論文] iTRAQ-based proteomic identification of leucine-rich alpha-2 glycoprotein as a novel inflammatory biomarker in autoimmune diseases

Serada S, Fujimoto M, Ogata A, Terabe F, Hirano T, Iijima H, Shinzaki S, Nishikawa T, Ohkawara T, Iwahori K, Ohguro N, Kishimoto T, Naka T 2010

[雑誌論文] IL-6阻害による自己免疫性関節炎治療効果はTh17抑制を介している

大河原知治、藤本穣、仲哲治 2010

[学会発表] The effect of IL-6 overproduction on T helper cell differentiation in vivo

Fujimoto M, Terabe F, Ukita T, Mei Y, Serada S, Nishikawa T, Ripley B, Kishimoto T, Naka T 2010

[学会発表] Myd88 gene knockout inhibits the development of lupus-like disease in NZB/W F1 mice

Ohkawara T, Fujimoto M and Naka T 2009

[学会発表] Myd88 gene knockout inhibits the development of lupus-like disease in NZB/W F1 mice

Ohkawara T, Fujimoto M, Naka T 2009

[雑誌論文] Comparative Analysis of the Effects of Anti-IL-6 Receptor mAb and Anti-TNF mAb Treatment on CD4+ T Cell Responses in Murine Colitis.

Terabe F, Fujimoto M, et. al.