トップ研究者を探す抗酸化ストレス及びアポトーシス抑制効果を有する希少糖を用いた新規腹膜透析液の開発

抗酸化ストレス及びアポトーシス抑制効果を有する希少糖を用いた新規腹膜透析液の開発

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-21591055
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
内科系臨床医学
腎臓内科学
研究機関 東北大学
香川大学
代表研究者 清元 秀泰
研究期間 開始年月日 2009/4/1
研究期間 終了年度 2011
研究ステータス 完了 (2011/4/1)
配分額(合計) 4,810,000 (直接経費 :3,700,000、間接経費 :1,110,000)
配分額(履歴) 2011年度:390,000 (直接経費 :300,000、間接経費 :90,000)
2010年度:1,170,000 (直接経費 :900,000、間接経費 :270,000)
2009年度:3,250,000 (直接経費 :2,500,000、間接経費 :750,000)
キーワード 腹膜中皮細胞
希少糖
D-プシコース
酸化ストレス
慢性腎不全
腹膜透析
NADPHオキシターゼ
アポトーシス
稀少糖
NADPHオキシダーゼ

研究成果

[雑誌論文] Early treatment with olmesartan prevents juxtamedullary glomerular podocyte injury and the onset of microalbuminuria in type 2 diabetic rats

Sofue T, Kiyomoto H, Kobori H, Urushihara M, Nishijima Y, Kaifu K, Hara T, Matsumoto S, Ichimura A, Ohsaki H, Hitomi H, Kawachi H, Hayden MR, Whaley-Connell A, Sowers JR, Ito S, Kohno M, Nishiyama A. 2012

[図書] Oxidative Stress in Basic Research and Clinical Practice Studies on Renal Disorders

Kiyomoto H, et.al. 2011

[雑誌論文] Chronic blockade of the (pro)renin receptor ameliorates the kidney damages in non-clipped kidney of Goldblatt hypertension.

Kiyomoto H, Moriwaki K 2011

[雑誌論文] New era for drug discovery and development in renal disease

Miyata T, Kikuchi K, Kiyomoto H, van Ypersele de Strihou C 2011

[図書] Chapter 4. Oxidative Stress in Basic Research and Clinical Practice : Renal Disorders(Miyata T, Eckardt KU, Nangaku M ed., Series Ed. : Armstrong D)(Springer, Humana Press, New York)

Kiyomoto H, Kobori H, Nishiyama A 2011

[雑誌論文] Angiotensin II shifts insulin signaling into vascular remodeling from glucose metabolism in vascular smooth muscle cells

Hitomi H, Kaifu K, Fujita Y, Sofue T, Nakano D, Moriwaki K, Hara T, Kiyomoto H, Kohno M, Kobori H, Nishiyama A. 2011

[雑誌論文] Chronic block-ade of the (pro)renin receptor amelio-rates the kidney damages in non-clipped kidney of Goldblatt hypertension

Kiyomoto H, Moriwaki K 2011

[雑誌論文] Chronic blockade of the (pro)renin receptor ameliorates the kidney damages in non-clipped kidney of Goldblatt hypertension

Kiyomoto H, Moriwaki K 2011

[雑誌論文] Involvement of mineralocorticoid receptor in high glucose-induced big mitogen-activated protein kinase 1 activation and mesangial cell proliferation

Liu G, Miyata K, Hitomi H, Yao L, Sun GP, Suzaki Y, Hosomi N, Kiyomoto H, Nakano D, Tamaki T, Yoshizumi M, Nishiyama A. 2010

[雑誌論文] Insulin attenuates apoptosis induced by high glucose via the PI3-kinase/Akt pathway in rat peritoneal mesothelial cells

Kaifu K, Kiyomoto H, Hitomi H, Matsubara K, Hara T, Moriwaki K, Ihara G, Fujita Y, Sugasawa S, Nagata D, Nishiyama A, Kohno M. 2010

[雑誌論文] 急性腎障害(AKI)の診療. 保存的治療(薬物療法などを含む)

清元秀泰、森脇久美子 2010

[雑誌論文] Regression ofsuperficial glomerular podocyte injury in type 2 diabetic rats with overt albuminuria : effect of angiotensin II blockade

Ihara G, Kiyomoto H, Kobori H, Nagai Y, Ohashi N, Hitomi H, Nakano D, Pelisch N, Hara T, Mori T, Ito S, Kohno M, Nishiyama A. 2010

[図書] Renin angiotensin system in the kidney and oxidative stress-Local Renin Angiotensin Aldosterone System (RAAS)and NAD(P)H oxidase-dependent oxidative stress in the kidney-. Oxidative Stress in Basic Research and Clinical Practice : Renal Disorders

Kiyomoto H, Kobori H, Nishiyama A. 2010

[学会発表] The remedial effect of strict diet treatment and exercise therapy using information technology (IT)on metabolic syndrome

Kiyomoto H, et. al 2010

[学会発表] The remedial effect of strict diet treatment and exercise therapy using information technology (IT) on metabolic syndrome.

Kiyomoto H, et.al. 2010

[雑誌論文] Regression of superficial glomerular podocyte injury in type 2 diabetic rats with overt albuminuria : effect of angiotensin II blockade.

Ihara C, Kiyomoto H, et.al. 2010

[雑誌論文] 急性腎障害(AKI)の診療.保存的治療(薬物療法などを含む)

清元秀泰、森脇久美子 2010

[学会発表] Psicose containing solution suppresses glucose-induced reactive oxygen species (ROS) dependent epithelial to mesenchymal transition (EMT) in cultured rat peritoneal mesothelial cells

Kiyomoto H, 他 2009

[学会発表] Psicose containing solution suppresses glucose-induced reactive oxygen species (ROS)dependent epithelial to mesenchymal transition (EMT)in cultured rat peritoneal mesothelial cells

Kiyomoto H, 他 2009

[学会発表] The inhibitory effect of rare sugars on epithelial-mesenchymal transition (EMT) induced by high concentration of D-glucose in cultured rat peritoneal mesothelial cells

Kiyomoto H, 他 2009

[学会発表] The inhibitory effect of rare sugars on epithelial-mesenchymal transition (EMT)induced by high concentration of D-glucose in cultured rat peritoneal mesothelial cells

Kiyomoto H, 他 2009

[雑誌論文] Insulin attenuates apoptosis induced by high glucose via the PI_3-kinase/Akt pathway in rat peritoneal mesothelial cells

Kiyomoto H, 他9名 2009