慢性腎臓病から腎不全に至る不可逆的形質変化の分子機構解明

トップ›研究者を探す›慢性腎臓病から腎不全に至る不可逆的形質変化の分子機構解明

代表研究者	安部秀斉
研究課題番号	KAKENHI-PROJECT-21591033
研究種目	基盤研究(C)
研究分野	生物系医歯薬学内科系臨床医学腎臓内科学
研究機関	徳島大学
研究分担者	秋山治彦
連携研究者	岸誠司
研究期間開始年月日	2009/4/1
研究期間終了年度	2011
研究ステータス	完了 (2011/4/1)
配分額（合計）	4,550,000 (直接経費 :3,500,000、間接経費 :1,050,000)
配分額（履歴）	2011年度：1,040,000 (直接経費 :800,000、間接経費 :240,000) 2010年度：1,170,000 (直接経費 :900,000、間接経費 :270,000) 2009年度：2,340,000 (直接経費 :1,800,000、間接経費 :540,000)
キーワード	糖尿病性腎症 Sox9 Smad1 BMP4 軟骨細胞様形質変化不可逆的腎機能低下 ALK3/6 Scleraxis HIF1 ALK3 6

研究成果

[雑誌論文] Scleraxis modulates bone morphogenetic protein 4 (BMP4)-Smad1-smooth muscle α actin(SMA) signal transduction in diabetic nephropathy

Abe H, Tominaga T, Matsubara T, Abe N, Kishi S, Nagai K, Murakami T, Araoka T, Doi T. 2012

[雑誌論文] Activation of Src Mediates PDGF-Induced Smad1 Phosphorylation and Contributes to the Progression of Glomerulosclerosis in Glomerulonephritis

Mima A, Abe H, Nagai K, Arai H, Matsubara T, Araki M, Torikoshi K, Tominaga T, Iehara N, Fukatsu A, Kita T, Doi T 2011

[学会発表] Trophoblast glycoprotein regulates the podocyte injuries in experimental glomerulonephritis.

Murakami T, Abe H, Nagai K, Tominaga T, Matsuura M, Kishi S, Kishi F, Yoshikawa K, Kondo N, Jeffrey Kopp, Doi T 2011

[図書] 腎疾患の病態形成におけるBMP4・Smad1の役割

安部秀斉 2011

[雑誌論文] BMP4・Smad1シグナルと糖尿病性腎症

安部秀斉, ら 2011

[学会発表] Overexpression of Smad1 Causes Remarkable Glomerulosclerosis in Diabetic Mice

Matsubara T, Abe H, Ueda O, Jishage K, Mima A, Goto C, Tominaga T, Nagai K, Iehara N, Fukushima N, Fukatsu A, Arai H, Doi T 2011

[雑誌論文] Recent progress in understanding the molecular pathogenesis of diabetic nephropathy

Abe H 2011

[雑誌論文] Role of Smad1 in diabetic nephropathy : Molecular mechanisms and implications as a diagnostic marker

Abe H, Matsubara T, Arai H, Doi T 2011

[学会発表] 糖尿病性腎症の分子病態-BMP4-Smad1シグナル

安部秀斉 2011

[雑誌論文] Transcription factor 7-like 2(TCF7L2) regulates activin receptor-like kinase 1(ALK1)/ Smad1 pathway for development of diabetic nephropathy

Araoka T, Abe H, Tominaga T, Mima A, Matsubara T, Murakami T, Kishi S, Nagai K, Doi T 2010

[学会発表] BMP4/ Smad1 Signaling Is a Critical Therapeutic Target for Diabetic Nephropathy

Matsubara T, Abe H, Ueda O, Tominaga T, Mima A, Nagai K, Torikoshi K, Araki M, Goto C, Kinosaki M, Jishage K, Fukushima N, Iehara N, Fukatsu A, Arai H, Doi T 2010

[学会発表] Conditional Knockout of Smad1 Ameliorates Glomerulosclerosis in Progressive Glomerulonephritis

Araki M, Abe H, Torikoshi K, Mima A, Matsubara T, Iehara N, Fukatsu A, Salant DJ, Arai H, Doi T 2010

[学会発表] Chondrogenic phenotypic change contributes to the irreversible progression of the diabetic nephropathy

Kishi S, Abe H, Murakami T, Tominaga T, Nagai K, Mima A, Doi T 2010

[学会発表] PIASy Regulates SMα-Actin Expression by Interacting with E12 in Mesangial Proliferative Glomerulonephritis

Torikoshi K, Araki M, Matsubara T, Mima A, Hirano T, Abe H, Fukatsu A, Arai H, Doi T 2010

[学会発表] Chondrogenic Potential of Mesangial Cells in Diabetic Nephropathy

Kishi S, Abe H, Akiyama H, Doi T 2009

[学会発表] The Novel Function of Trophoblast Glycoprotein(Tpbg) on Actin Remodeling in Podocyte Injured in Experimental Glomerulonephritis

Murakami T, Abe H, Matsuura M, Araoka T, Kishi S, Tominaga T, Shigeta R, Yoshikawa K, Kishi F, Takamatsu N, Takahashi T, Mima A, Nagai K, Takai Y, Doi T 2009

[学会発表] TCF7L2(Transcription factor 7-like 2) Regulates Activin Receptor-Like Kinase1(ALK1)/ Smad1 Pathway for Development of Diabetic Nephropathy.(Araoka T : Young Investigator Travel Grant Award)

Araoka T, Abe H, Matsuura M, Murakami T, Kishi S, Tominaga T, Shigeta R, Yoshikawa K, Kishi F, Mima A, Takahashi T, Hirano T, Doi T 2009