トップ›研究者を探す›通常食で自然肝発癌する非アルコール性脂肪肝炎モデルマウスにおける発癌の分子機構

通常食で自然肝発癌する非アルコール性脂肪肝炎モデルマウスにおける発癌の分子機構

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-21590849
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
内科系臨床医学
消化器内科学
研究機関 高知大学
代表研究者 西原 利治
連携研究者 戸田 勝巳
連携研究者 越智 経浩
連携研究者 宗景 玄祐
研究期間 開始年月日 2009/4/1
研究期間 終了年度 2011
研究ステータス 完了 (2011/4/1)
配分額（合計） 4,550,000 (直接経費 :3,500,000、間接経費 :1,050,000)
配分額（履歴） 2011年度：1,170,000 (直接経費 :900,000、間接経費 :270,000)
2010年度：1,430,000 (直接経費 :1,100,000、間接経費 :330,000)
2009年度：1,950,000 (直接経費 :1,500,000、間接経費 :450,000)
キーワード 肝臓学
NASH
NAFLD
肝細胞癌
マイクロアレイ

研究成果

[雑誌論文] BART inhibits pancreatic cancer cell invasion by Rac1 inactivation through direct binding to active Rac1

Taniuchi K, Saibara T 2012

[雑誌論文] Usefulness of Technetium-99 m-2-methoxy-isobutyl-isonitrile liver scintigraphy for evaluating disease activity of non-alcoholic fatty liver disease

Masuda K, Ono M, Saibara T 2012

[雑誌論文] The Japan NASH Study Group : Clinical and pathological progression of non-alcoholicsteatohepatitis to hepato-cellular carcinoma

Koike K, Shima T, Kanbara Y, Saibara T 2012

[雑誌論文] Impact of ovarian sex steroids on ovulation and ovulatory gene induction in aromatase-null mice

Toda K, Hayashi Y, Ono M, Saibara T 2012

[雑誌論文] BART inhibits pancreatic cancer cell invasion by PKC alpha inactivation through binding to ANX7

Taniuchi K, Saibara T 2012

[図書] 8非アルコール性脂肪性肝疾患,林紀夫・日比紀文・上西紀夫・下瀬川徹編, Annual Review消化器

西原利治, 他 2012

[雑誌論文] Angiotensinogen gene haplotype is associated with the prevalence of Japanese non-alcoholic steatohepatitis

Ono M, Ochi T, Munekage K, Ogasawara M, Saibara T 2011

[雑誌論文] A simple clinical scoring system using ferritin, fasting insulin, and type IV collagen 7S for predicting steatohepatitis in nonalcoholic fatty liver disease.

Sumida Y, Yoneda M, Saibara T, Kawada N, Fujimoto K, Kohgo Y, Okanoue T 2011

[図書] 非アルコール性脂肪肝炎(NASH),病気と薬パーフェクトBOOK

西原利治, 他 2011

[雑誌論文] Japan NASH Study Group, Ministry of Health, Labour, and Welfare of Japan : Characteristics of patients with nonalcoholic steatohepatitis who develop hepatocellular carcinoma

Yasui K, Hashimoto E, Komorizono Y, Saibara T 2011

[図書] 病気と薬パーフェクトBOOK2011

西原利治 2011

[雑誌論文] Serum Dehydroepiandrosterone Sulphate Levels in Patients with Non-Alcoholic Fatty Liver Disease

Koga M, Saito H, Mukai M, Saibara T, Kasayama S 2011

[雑誌論文] A novel and comprehensive mouse model of human non-alcoholic steatoh epatitis with the full range of dysm etabolic and histological abnormalit ies induced by gold thioglucose and a high-fat diet

Ogasawara M, Ogasawara M, Hirose A, Ono M, Aritake K, Nozaki Y, Takahashi M, Okamoto N, Sakamoto S, Iwasaki S, Asanuma T, Taniguchi T, Urade Y, Onishi S, Saibara T, Oben JA 2011

[雑誌論文] Japan Study Group of Nonalcoholic Fatty Liver Disease(JSG-NAFLD): A simple clinical scoring system using ferritin

Sumida Y, Yoneda M, Saibara T, Okanoue T 2011

[雑誌論文] BART inhibits pancreatic cancer cell invasion by inhibiting ARL2-mediated RhoA inactivation

Taniuchi K, Iwasaki S, Saibara T 2011

[学会発表] Clinical feature and therapeutic strategy for tamoxifen-induced nonalcoholic steatohepatitis

Saibara T 2010

[学会発表] Therapeutic strategy of primary and secondary NASH

Saibara T 2010

[図書] NAFLD, NASH,幕内雅敏・菅野健太郎・工藤正俊編,今日の消化器疾患治療方針第3版

西原利治 2010

[雑誌論文] The latest idea in NAFLD/NASH pathogenesis.

Ono M, Okamoto N, Saibara T 2010

[図書] NASH・NAFLDの診療ガイド

西原利治 2010

[雑誌論文] Effects of Eriobotrya Japonica seed extract on oxidative stress in rats with non-alcoholic steatohepatitis

Yoshioka S, Hamada A, Jobu K, Saibara T 2010

[学会発表] Therapeutic strategy of primary and secondary NASH.

Saibara T 2010

[雑誌論文] Super paramagnetic iron oxide MRI shows defective Kupffer cell uptake function in non-alcoholic fatty liver disease

Asanuma T, Ono M, Kubota K, Hirose A, Hayashi Y, Saibara T 2010

[雑誌論文] Efficacy of bezafibrate for chronic GVHD of the liver after allogeneic hematopoietic stem cell transplantation.

Hidaka M, Iwasaki S, Saibara T, Onishi S, Kawano F. 2010

[雑誌論文] Super paramagnetic iron oxide MRI shows defective Kupffer cell uptake function in non-alcoholic fatty liver disease.

Asanuma T, Ono M, Kubota K, Saibara T 2010

[雑誌論文] Efficacy ofbezafibrate for chronic GVHD of the liver after allogeneic hematopoietic stem cell transplantation

Hidaka M, Iwasaki S, Matsui T, Saibara T 2010

[学会発表] Clinical feature and therapeutic strategy for tamoxifen-induced nonalcoholic steatohepatitis (NASH).

Saibara T 2010

[学会発表] Genetic Predisposition to NAFLD/ NASH

Saibara T 2010

[雑誌論文] Effects of Eriobotrya Japonica seed extract on oxidative stress in rats with non-alcoholic steatohepatitis.

Yoshioka S, Hamada A, Saibara T 2010

[雑誌論文] Deletion of tumor necrosis factor-alpha receptor type 1 exacerbates insulin resistance and hepatic steatosis in aromatase knockout mice

Toda K, Hayashi Y, Saibara T 2010

[雑誌論文] Deletion of tumor necrosis factor-α receptor type 1 exacerbates insulin resistance and hepatic steatosis in aromatase knot kout mice

Toda K 2010

[雑誌論文] Deletion of tumor necrosis factor-α receptor type 1 exacerbates insulin resistance and hepatic steatosis in aromatase knockout mice.

Toda K, Hayashi Y, Saibara T 2010

[雑誌論文]

西原利治, 大西三朗 2009

[雑誌論文] Recurrent familial hypobeta lipo-proteinemia-induced non-alcoholic fatty liver disease after living donor liver transplantation

Harada N, Soejima Y, Taketomi A, Yoshizumi T, Uchiyama H, Ikegami T, Saibara T, Nishizaki T, Maehara Y 2009

[雑誌論文] メタボリックシンドロームの肝臓での表現型としてのNAFLD/NASH

西原利治 2009

[雑誌論文] 肝・胆・膵NAFLD/NASH

西原利治 2009

[雑誌論文]

西原利治, 小野正文 2009

[雑誌論文]

西原利治 2009

[雑誌論文]

西原利治 2009

[雑誌論文]

西原利治 2009

[雑誌論文]

西原利治 2009

[雑誌論文]

西原利治 2009

[学会発表] メタボリックシンドロームにおけるNASH線維化進展への影響

越智経浩 2009