非アルコール性脂肪性肝炎と原発性胆汁性肝硬変の発症過程における類似性

トップ›研究者を探す›非アルコール性脂肪性肝炎と原発性胆汁性肝硬変の発症過程における類似性

非アルコール性脂肪性肝炎と原発性胆汁性肝硬変の発症過程における類似性

代表研究者	常山幸一
研究課題番号	KAKENHI-PROJECT-21590433
研究種目	基盤研究(C)
研究分野	生物系医歯薬学基礎医学実験病理学
研究機関	富山大学
研究期間開始年月日	2009/4/1
研究期間終了年度	2011
研究ステータス	完了 (2011/4/1)
配分額（合計）	4,680,000 (直接経費 :3,600,000、間接経費 :1,080,000)
配分額（履歴）	2011年度：910,000 (直接経費 :700,000、間接経費 :210,000) 2010年度：1,300,000 (直接経費 :1,000,000、間接経費 :300,000) 2009年度：2,470,000 (直接経費 :1,900,000、間接経費 :570,000)
キーワード	疾患モデル動物 NASH, PBC,酸化ストレス NASH PBC 酸化ストレス

研究成果

[雑誌論文] Pathological features of new animal models for primary biliary cirrhosis

Tsuneyama K, et al. 2012

[雑誌論文] Pathological features of new animal models for primary biliary cirrhosis

Tsuneyama K. 2012

[雑誌論文] Comparative analysis of portal cell infiltrates in AMAy-positive versus AMA-negative PBC

Jin Q, Moritoki Y, Lleo A, Tsuneyama K, et al. 2012

[雑誌論文] Serum soluble MD-1 levels increase with disease progression in autoimmune prone MRL(lpr/lpr) mice

Sasaki S. 2012

[雑誌論文] Mechanism of exacerbative effect of progesterone on drug-induced liver injury

Toyoda Y, Endo S, Tsuneyama K, et al. 2012

[雑誌論文] Plasma cells and the chronic nonsuppurative destructive cholangitis of primary biliary cirrhosis

Takahashi T. 2012

[雑誌論文] The role of natural killer(NK) and NK T cells in the loss of tolerance in murine PBC

Shimoda S, Tsuneyama K, et al. 2012

[雑誌論文] Spirulina improves non-alcoholic steatohepatitis, visceral fat macrophage aggregation, and serum leptin in a mouse model of metabolic syndrome

Fujimoto M, Tsuneyama K, et al. 2012

[雑誌論文] Cattle bile but not bear bile or pig bile induces lipid profile changes and fatty liver injury in mice: mediation by cholic acid

Watanabe S. 2012

[学会発表] Pathological characteristics of the Iidney and bone of patients with itai-itai disease (chronic cadmium toxicity)

Tsuneyama K. 2012

[雑誌論文] B cells promote hepatic inflammation, biliary cyst formation, and salivary gland inflammation in the NOD.c3c4 model of autoimmune cholangitis.

Moritoki Y, Tsuda M, Tsuneyama K, et al. 2011

[雑誌論文] Innate immunity and primary biliary cirrhosis : Activated invariant natural killer T cells exacerbate murine autoimmune cholangitiS and fibrosis

Wu SJ, Yang YH, Tsuneyama K, et al. 2011

[学会発表] 自然発症肥満・糖尿病・NASHモデル(TSOD)マウス脾臓における異常鉄沈着の病理組織学的検討

常山幸一, 他 2011

[雑誌論文] B cell depletion therapy exacerbates murine PBC

Dhirapong A, Lleo A, Yang GX, Tsuneyama K, et al. 2011

[雑誌論文] B cells promote hepatic inflammation, biliary cyst formation, and salivary gland inflammation in the NOD. c3c4 model of autoimmune cholangitis

Moritoki Y, Tsuda M, Tsuneyama K, et al. 2011

[雑誌論文] Estradiol and progesterone modulate halothane-induced liver injury in mice

Toyoda Y, Miyashita T, Endo S, Tsuneyama K, et al. 2011

[学会発表] 深層水の医療分野への応用について

常山幸一 2011

[雑誌論文] Innate immunity and primary biliary cirrhosis : activated invariantnatural killer T cells exacerbate murine autoimmune cholangitis and fibrosis

Wu SJ, Yang YH, Tsuneyama K, et al. 2011

[学会発表] 肝疾患モデル動物

常山幸一 2011

[雑誌論文] Advantages and disadvantages of hyperbaric oxygen treatment in mice with obesity hyperlipidemia and steatohepatitis

Tsuneyama K, et al. 2011

[雑誌論文] IL-4 mediates dicloxacillin-induced liver injury in mice.

Higuchi S, Kobayashi M, Yoshikawa Y, Tsuneyama K, et al. 2011

[雑誌論文] Septic shock is associated with receptor for advanced glycation end products ligation of LPS.

Yamamoto Y, Harashima A, Saito H, Tsuneyama K, et al. 2011

[雑誌論文] Advantages and disadvantages of hyperbaric oxygen treatment in mice with obesity hyperlipidemia and steatohepatitis

Tsuneyama K. 2011

[学会発表] Autoimmune biliary damages and NASH

Tsuneyama K 2010

[学会発表] TSODマウスにおける異常鉄沈着の病理組織学的検討

常山幸一、西田健志、藤本誠 2010

[雑誌論文] Kangen-karyu improves memory deficit caused by aging through normalization of neuro-plasticity-related signaling system and VEGF system in the brain.

Zhao Q, Yokozawa T, Yamabe N, Tsuneyama K, et al. 2010

[雑誌論文] The traditional Japanese formula keishibukuryogan reduces liver injury and inflammation in patients with nonalcoholic fatty liver disease.

Fujimoto M, Tsuneyama K, et al. 2010

[雑誌論文] Olive leaf extract prevents spontaneous occurrence of non-alcoholic steat ohepatitis in SHR/NDmcr-cp rats.

Omagari K, Kato S, Tsuneyama K, et al. 2010

[学会発表] Autoimmune biliary damages and NASH.

Koichi Tsuneyama 2010

[雑誌論文] Usefulness of Positron Emission Tomography for management of ocular sebaceous carcinoma.

Yasumura S, Shojaku H, Wada R, Watanabe Y, Shojaku H, Seto H, Kawano M, Tsuneyama K. 2010

[雑誌論文] Interleukin-17 is involved in alpha-naphthylisothiocyanate-induced liver injury in mice.

Kobayashi M, Higuchi S, Mizuno K, Tsuneyama K, et al. 2010

[雑誌論文] Nutrition, geoepidemiology, and autoimmunity

Selmi C, Tsuneyama K. 2010

[雑誌論文] Identification of candidate genes involved in endogenous protection mechanisms against acute pancreatitis in mice.

Nakada S, Tsuneyama K, et al. 2010

[学会発表] 自然発症肥満・糖尿病モデル(TSOD)マウスに発症するNASH様肝病変の発症機序の解明

常山幸一, 他 2010

[学会発表] 自然発症肥満・糖尿病モデル(TSOD)マウスに発症ずるNASH肝腫瘍の経時的変化:病理学的解析

常山幸一、藤本誠 2010

[学会発表] メタボリック症候群関連肝疾患モデル動物を用いた和漢薬・機能性食品の効果解析と臨床への展開

常山幸一 2010

[学会発表] Pathological characterization of new animal models of Primary Biliary Cirrhosis

Tsuneyama K. 2010

[雑誌論文] Endometrioid adenocarcinoma of the vagina with a microglandular pattern arising from endometriosis after hysterectomy.

Nomoto K, Hori T, Kiya C, Fukuoka J, Nakashima A, Hidaka T, Saito S, Mikami Y, Tsuneyama K, Takano Y. 2010

[学会発表] Pathological characterization of new animal models of Primary Biliary Cirrhosis

Koichi Tsuneyama 2010

[学会発表] TSOD mouse : a new spontaneous model of nonalcoholic steatohepatitis and hepatocellular carcinoma associated with obesity, type 2 diabetes, and hyperlipidemia

Tsuneyama K, et al. 2010

[雑誌論文] Development of an ultrasound-emitting device for performing rapid immunostaining procedures.

Hatta H, Tsuneyama K, Kondo T, Takano Y. 2010

[雑誌論文] Treatment of hepatocellular carcinoma with adeno-associated virus encoding interleukin-15 superagonist.

Chang CM, Lo CH, Shih YM, Chen Y, Wu PY, Tsuneyama K, et al 2010

[学会発表] Evidence-based efficacy of Chinese herbal medicine and functional foods in animal models of metabolic syndrome associated liver diseases

Tsuneyama K 2010

[雑誌論文] Application of a new histological staging and grading system for primary biliary cirrhosis to liver biopsy specimens : Interobserver agreement.

Nakanuma Y, Zen Y, Harada K, Sasaki M, Nonomura A, Uehara T, Sano K, Kondo F, Fukusato T, Tsuneyama K, et al 2010

[雑誌論文] Deletion of interleukin-6 in mice with the dominant negative form of transforming growth factor beta receptor II improves colitis but exacerbates autoimmune cholangitis

Zhang W, Tsuda M, Yang GX, Tsuneyama K, et al. 2010

[雑誌論文] B cell depletion therapy exacerbates murine primary biliary cirrhosis.

Dhirapong A, Lleo A, Yang GX, Tsuneyama K, et al. 2010

[雑誌論文] The traditional Japanese formula keishibukuryogan reduces liver injury and inflammation in patients with nonalcoholic fatty liver disease

Fujimoto M, Tsuneyama K, et al. 2010

[雑誌論文] Nutrition, geoepidemiology, and autoimmunity.

Selmi C, Tsuneyama K. 2010

[雑誌論文] Autoimmune Liver injury and Non-alcoholic fatty liver disease.

Li J, Wang J, Tsuneyama K, Liu Y. 2010

[学会発表] Evidence-based efficacy of Chinese herbal medicine and functional foods in animal models of metabolic syndrome associated liver diseases.

Koichi Tsuneyama 2010

[学会発表] Spirulina and its constituent phycocyanin improve visceral fat macrophage aggregation, serum adiponectin level, and stea tohepatitis in a mouse model of NAFLD associated with metabolic syndrome

Koichi Tsuneyama 2010

[雑誌論文] Drug-induced hepatotoxicity test using gamma-glutamylcysteine synthetase knockdown rat.

Morita M, Akai S, Hosomi H, Tsuneyama K, et al. 2009

[雑誌論文] Role of CX3CL1/fractalkine in osteoclast differentiation and bone resorption.

Koizumi K, Saitoh Y, Minami T, Takeno N, Tsuneyama K, et al. 2009

[雑誌論文] Peribiliary cyst of common bile duct : possible cause of refractory jaundice.

Takahashi H, Miwa S, Nomoto K, Hayashi S, Tsuneyama K, Takano Y. 2009

[学会発表] 自然発症NASH(非アルコール性脂肪性肝炎)-HCC(肝細胞癌)モデルマウスとしてのTSODマウスの有用性

常山幸一 2009

[雑誌論文] Treatment of hepatocellular carcinoma with adeno-associated virus encoding interleukin-15 superagonist.

Chang CM, Lo CH, Shih YM, Chen Y, Wu PY, Tsuneyama K, et al. 2009

[雑誌論文] A role for IL-17 in induction of an inflammation at the fetomaternal interface in preterm labour.

Ito M, Nakashima A, Hidaka T, Okabe M, Bac ND, Ina S, Yoneda S, Shiozaki A, Sumi S, Tsuneyama K, et al. 2009

[学会発表] 自然発症肥満・糖尿病モデル(TSOD)マウスの肝病変NAFLD/NASHモデルとしての有用性

常山幸一 2009

[雑誌論文] CX3CL1 (fractalkine) : a signpost for biliary in flammation in primary biliary cirrhosis.

Shimoda S, Harada K, Niiro H, Taketomi A, Maehara Y, Tsuneyama K, et al. 2009

[雑誌論文] B-cell depletion with anti-CD20 ameliorates autimmune cholangitis but exacerbates colitis in transforming growth factor-beta receptor II dominant negative mice.

Moritoki Y, Lian' ZX, Lindor K, Tuscano J, Tsuneyama K, et al. 2009

[学会発表] 富山湾海洋深層水か調整した等張液による創傷治癒促進効果 in vitro study

常山幸一 2009

[学会発表] New Animal model of Non-alcoholic Fatty Liver Disease (NAFLD) based on Metabolic Syndrome : MSG mice & TSOD mice.

Koichi Tsuneyama 2009

[雑誌論文] Beta-glucosylceramide ameliorates liver inflammation in murine autoim munecholangitis.

Zhang W, Moritoki Y, Tsuneyama K, et al. 2009

[雑誌論文] Dose dependent development of diabetes mellitus and non-alcoholic stea tohepatitis in monosodium glutamate-induced obese mice.

Sasaki Y, Suzuki W, Shimada T, Iizuka S, Nakamura S, Nagata M, Fujimoto M, Tsuneyama K, et al. 2009

[学会発表] メタボリック症候群関連脂肪性肝炎モデルマウス(MSGマウス)におけるスピルリナの疾患予防効果

常山幸一 2009

[雑誌論文] Beta-glucosylceramide ameliorates liver inflammation in murine autoimmune cholangitis

Zhang W, Moritoki Y, Tsuneyama K, et al. 2009

[雑誌論文] Regulatory mechanisms for adipose tissue M1 and M2 macrophges in diet-induced obese mice.

Fujisaka S, Usui I, Bukhari A, Ikutani M, Oya T, Kanatani Y, Tsuneyama K, et al. 2009

[学会発表] 自然発症肥満・糖尿病モデル(TSOD)マウスの肝病NAFLD/NASHモデルとしての有用性

常山幸一, 他 2009

[学会発表] メタボリック症候群関連脂肪性肝炎モデルマウス(MSGマウス)を用いたカロリー制限の効果

常山幸一 2009

[雑誌論文] Knockdown of superoxide dismutase 2 enhances acetaminophen-induced hepatotoxicity in rat.

Yoshikawa Y, Morita M, Hosomi H, Tsuneyama K, et al. 2009

[雑誌論文] Deletion of interleukin-12p40 suppresses autoimmune cholangitis in dominant negative transforming growth factor beta receptor type II mice

Yoshida K, Yang GX, Zhang W, Tsuda M, Tsuneyama K, et al. 2009

[学会発表] New Animal model of Non-alcoholic Fatty Liver Disease(NAFLD) based on Metabolic Syndrome : MSG mice & TSOD mice

Tsuneyama K 2009

[学会発表] New animal models for Non-alcoholic steatohepatitis (NASH) based on metabolic syndrome

Koichi Tsuneyama 2009

[雑誌論文] Role of liver-infiltrating CD3+CD56+ natural killer T cells in the patho genesis of nonalcoholic fatty liver disease.

Tajiri K, Shimizu Y, Tsuneyama K, et al. 2009

[雑誌論文] B-cell depletion with anti-CD20 ameliorates autoimmune cholangitis but exacerbates colitis in transforming growth factor-beta receptor II dominant negative mice

Moritoki Y, Lian ZX, Lindor K, Tuscano J, Tsuneyama K, et al. 2009

[学会発表] New animal models for Non-alcoholic steatohepatitis(NASH) based on metabolic syndrome

Tsuneyama K 2009