トップ研究者を探す骨髄単球細胞の分化過程における破骨細胞分化因子受容体(RANK)の発現制御

骨髄単球細胞の分化過程における破骨細胞分化因子受容体(RANK)の発現制御

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-21590419
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
基礎医学
実験病理学
研究機関 神戸大学
代表研究者 北澤 理子
研究期間 開始年月日 2009/4/1
研究期間 終了年度 2011
研究ステータス 完了 (2011/4/1)
配分額(合計) 4,420,000 (直接経費 :3,400,000、間接経費 :1,020,000)
配分額(履歴) 2011年度:1,040,000 (直接経費 :800,000、間接経費 :240,000)
2010年度:1,040,000 (直接経費 :800,000、間接経費 :240,000)
2009年度:2,340,000 (直接経費 :1,800,000、間接経費 :540,000)
キーワード 破骨細胞
RANK
遺伝子プロモータ
転写因子
RANKL
造血細胞

研究成果

[雑誌論文] CIZ/NMP4 is expressed in B16 melanoma and forms a positive feedback loop with RANKL to promote migration of the melanoma cells

Sakuma T, Nakamoto T, Hemmi H, Kitazawa S, Kitazawa R, Notomi T, Hayata, T, Ezura Y, Amagasa T, Noda M 2012

[雑誌論文] A. p D116G mutation in CREB1 leads to novel multiple malformation syndrome resembling CrebA knockout mouse

Kitazawa S, Kondo T, Mori K, Yokoyama N, Matsuo M, Kitazawa R. 2012

[雑誌論文] Pyruvate dehydrogenase kinase 4 induces bone loss at unloading by promoting Osteoclastogenesis

Wang Y, Liul W, Masuyama R, Fukuyama R, Ito M, Zhang Q, Komori H, Murakami T, Moriishi T, Miyazaki T, Kitazawa R, Yoshida CA, Kawai Y, Izumi S, Komori T 2012

[雑誌論文] Epigenetic Alteration by DNA Promoter Hypermethylation of Genes Related to Transforming Growth Factor-β(TGF-β) Signaling in Cancer(review). Sann Sanda Khin

Kitazawa R, Kondo T, Idei Y, Fujimoto M, Haraguchi R, Mori K, Kitazawa S 2011

[雑誌論文] Identification and analysis of function of a novel splicing variant of mouse receptor activator of NF-kappaB

Mukai S, Kitazawa R, Ishii J, Kondo T, Hakozaki A, Hosiuchi K, Kiyoshi M, Kitazawa S. 2011

[図書] In situ detection of specific gene expression during and immediately after transcription at electron microscopic level. In Microscopy : Science, Technology, Applications and Education

S.Kitazawa, et al 2011

[雑誌論文] Parathyroid hormone-responsive Smad3-related factor, Tmem119, promotes osteoblast differentiation and interacts with the bone morphogenetic protein-Runx2 pathway

Hisa I, Inoue Y, Hendy GN, Canaff L, Kitazawa R, Kitazawa S, Komori T, Sugimoto T, Seino S, Kaji H 2011

[学会発表] AP-1応答配列を介するマウスRANK遺伝子発現制御機構の解析

金籐聡美, 北澤理子, 他 2011

[学会発表] 破骨細胞分化因子RANKLによる受容体RANKの発現制御機構

北澤理子, 向井智美, 他 2011

[学会発表] Analysis of Regulatory Mechanism of Mouse RANK Gene Expression through AP-1 Response Element

Kitazawa R, Kinto S, et al 2011

[雑誌論文] Carvedilol ameliorates low-turnover bone disease in nonobese type 2 diabetes

Goto S, Fujii H, Kono K, NakaiK, Hamada H, Yamato H, Shinohara M, Kitazawa R, Kitazawa S, Nishi S, Fukagawa M 2011

[図書] 病理と臨床29巻臨時増刊号「病理診断に役立つ分子生物学」第1部-4 DNAシークエンス

北澤荘平、森清、近藤武史、北澤理子 2011

[雑誌論文] Oxidative and nitrosative stress and progression of diabetic nephropathy in type 2 diabetes

Fujii H, Kono K, Nakai K, Goto S, Komaba H, Hamada Y, Shinohara M, Kitazawa R, Kitazawa S, Fukagawa M 2010

[学会発表] RANKL upregulates mouse RANK gene transcriptionthrough the NFAT binding site of RANK gene promoter

Kitazawa R, Ishii J, Mukai S, Kondo T, Mori M, Mori K, Kitazawa S 2010

[学会発表] Analysis of Regulatory Mechanism of Mouse RANK Gene Expression through AP-1 Response Element

Kitazawa R, Kinto S, Ishii J, Kondo T, Mori K, Kitazawa S 2010

[雑誌論文] Enhancement of ultraviolet B-induced skintumor development in phospholipase Cknockout mice is associated with decreased apoptosis

Oka M, Edamatsu H, Kunisada M, Dien S, Kitazawa R, Kataoka T, Nishigori C 2010

[学会発表] 破骨細胞分化因子RANKLはNFATを介して受容体RANK発現を促進する

北澤理子, 他 2010

[雑誌論文] The effect of the receptor for advanced glycation end products(RAGE) on bone metabolism under physiological and diabetic conditions

Hamada Y, Kitazawa S, Kitazawa R, Kone K, Goto S, Komaba H, Fujii H, Yamamoto Y, Yamamoto H, Usami M, Fukagawa M 2010

[図書] 組織細胞化学2010-組織細胞化学イメージングの基礎と最前線:生体内分子局在と機能を探る-

北澤荘平, 森清, 近藤武史, 北澤理子 2010

[雑誌論文] Depressed expression of Klotho and FGFR1 in hyperplastic parathyroid glands from uremic patients

Komaba H, Goto S, Fujii H, Hamada Y, Kobayashi A, Shibuya K, Tominaga Y, Otsuki N, Nibu K, Kitazawa R, Fukagawa M 2010

[学会発表] Identification and functional analysis of a novel splicing variant of mouse RANK

Mukai S, Kitazawa R, Ishii J, Kondo T, Hakozaki A, Horiuchi K, Mori K, Kitazawa S 2010

[学会発表] Derepression of mouse SFRP-4 gene expression by oxidative stress : A plausible mechanism leading to low-turnover osteoporosis in diabetes and senescence

Mori K, Kitazawa R, Kondo T, Mukai S, Mori M, Kitazawa S 2010

[学会発表] RANKL upregulates mouse RANK gene transcription through the NFAT binding site of its gene promoter

Kitazawa R, Ishii J, Mukai S, Kondo T, Mori K, Kitazawa S 2009

[雑誌論文] Osteosarcoma in a pregnant patient with McCune-Albright syndrome

Kanazawa I, Yamauchi M, Yano S. Imanishi Y, Kitazawa R, Nariai Y, Araki A, Kobayashi K, Inaba M, Maruyama R, Yamaguchi T, Sugimoto T 2009

[雑誌論文] Oral charcoal adsorbent(AST-120) prevents progression of cardiac damage in chronic kidney disease through suppression of oxidative stress

Fujii H, Nishijima F, Goto S, Sugano M, Yamato H, Kitazawa R, Kitazawa S, Fukagawa M 2009

[雑誌論文] Thioredoxin-1 overexpression in transgenic mice attenuates streptozotocin-induced diabetic osteopenia

Hamada Y, Fujii H, Kitazawa R, Yodoi J, Kitazawa S, Fukagawa M 2009

[雑誌論文] BAMBI gene is epigenetically silenced in a subset of high-grade bladder cancer

Sann Sanda Khin, Kitazawa R, Win N, Than TA, Mori K, Kondo T, Kitazawa S 2009

[学会発表] Oxidative DNA damage to methylated CpG located at five bases upstream of TATA-box restores suppressed sFRP-4 gene expression : proposal of a unique mechanism towards diabetic osteoporosis

Mori K, Kitazawa R, Fukagawa M, Hamada Y, Kondo T, Kitazawa S 2009

[学会発表] マウスRANK遺伝子転写におけるNFATの機能解析

北澤理子, 他 2009

[図書] DNA Methylation Research Trends, Epigenetic roles of CpG methylation at non-CpG-islands revealed by morphology-oriented epigenetic research

Kitazawa S, Mori K, Kondo T, Fujimoto M, Kitazawa R