研究成果

[雑誌論文] Deferoxamine promotes angiogenesis via the activation of vascular endothelial cell function

Ikeda Y, Tajima S, Yoshida S, Yamano N, Kihira Y, Ishizawa K, Aihara K, Tomita S, Tsuchiya K and Tamaki T 2011

[雑誌論文] Pathophysiological Response to Hypoxia - From the Molecular Mechanisms of Malady to Drug Discovery:Inflammatory Responses of Hypoxia-Inducible Factor 1.ALPHA. (HIF-1.ALPHA.) in T Cells Observed in Development of Vascular Remodeling

Tomita S, et al 2011

[雑誌論文] Pharmacology in Health Food:<BR>Metabolism of Quercetin In Vivo and Its Protective Effect Against Arteriosclerosis

Ishizawa K, et al 2011

[雑誌論文] Basic fibroblast growth factor regulates glucose metabolism through glucose transporter 1 induced by hypoxia-inducible factor-1αin adipocytes

Kihira Y, Yamano N, Izawa-Ishizawa Y, Ishizawa K, Ikeda Y, Tsuchiya K, Tamaki T, Tomita S 2011

[学会発表] Inhibition of Adipocyte Hypertrophy by Deferoxiamine Diabetic KKAy mice

Tajima S, Ikeda Y, Yamano N, Tsuchiya K, Ishizawa Y, Kihira Y, Ishizawa K, Kawazoe K, Tomita S, Minakuchi K, Tamaki T. 2011

[雑誌論文] Protective effect of photodegradation product of nifedipine against tumor necrosis factor alpha-induced oxidative stress in human glomerular endothelial cells

Fukuhara Y, Tsuchiya K, Horinouchi Y, Tajima S, Kihira Y, Hamano S, Kawazoe K, Ikeda Y, Ishizawa K, Tomita S and Tamaki T 2011

[学会発表] Preconditionining of mice with prolyl hydroxylase inhibitor, dimethyloxalylglycine, prevents skin flap necrosis

Takaku M, Tomita S, Kihira Y, Hashimoto I, Nakanishi H, Tamaki T. 2011

[学会発表] Hypoxia-inducible Factor-1αDeficiency in Smooth Muscle Cells Suppresses AngiotensinII-induced Vascular Remodeling in Mice

Imanishi M, Ishizawa K, Kihira Y, Ikeda Y, Yamano N, Ishizawa Y, Tsuciya K, Tamaki T, Tomita S. 2011

[学会発表] Estrogen action on iron metabolism

Ikeda Y, Tajima S, Yamano N, Kihira Y, Ishizawa K, Tomita S, Tsuchiya K, Tamaki T. 2011

[学会発表] Nitorosonifedipine is a new class drug to improves angiotensin II-induced vascular remodeling

Ishizawa K, Sakurada T, Imanishi M, Fujii S, Ishizawa Y, Kihira Y, Ikeda Y, Tomita S, Tsuchiya K, Tamaki T 2011

[雑誌論文] Antioxidant Effects of Photodegradation Product of Nifedipine

Horinouchi Y, Tsuchiya K, Taoka C, Tajima S, Kihira Y, Matsuda Y, Shishido K, Yoshida M, Hamano S, Kawazoe K, Ikeda Y, Ishizawa K, Tomita S, Tamaki T 2011

[学会発表] Preconditioning of mice with a PHD inhibitor, dimethyloaxylglycine, prevent skin flap necrosis

Takaku M, Tomita S, Kurobe H, Hashimoto I, Nakanishi H, Tamaki T 2011

[学会発表] Heparin Cofactor II Promotes Angiogenesis via an AMPK-eNOS Signaling Pathway

Ikeda Y, Aihara KI, Yoshida S, Kihira Y, Ishizawa K, Izawa-Ishizawa Y, Tomita S, Sata M, Akaike M, Kato S, Matsumoto T, Tamaki T. 2011

[学会発表] Increment intracellular labile iron enhances angiotensin-induced intracellular adhesion molecule-1(ICAM-1) expression in human glomerular endothelial cells

Imanishi M, Tajima S, Kihira Y, Ishizawa K, Ikeda Y, Kondo S, Kagami S, Tomita S, Ikeda Y, Tsuchiya K, Tamaki S. 2011

[学会発表] Smooth Muscle Cell-Specific Hypoxia-Inducible Factor-1αDeficiency Attenuates Angiotensin II-Induced Vascular Remodeling in Mice

Imanishi M, Ishizawa K, Kihira Y, Ikeda Y, Yamano Y, Ishizawa Y, Tsuchiya K, Tamaki T, Tomita S 2011

[学会発表] Glucose Metabolism of Adipocytes is Regulated by Basic Fibroblast Growth Factor via Hypoxia-inducible Factor-1α

Yamaguchi K, Kihira Y, Yamano N, Izawa-Ishizawa Y, Ishizawa K, Ikeda Y, Tsuchiya K, Tomita S, Tamaki T 2011

[雑誌論文] Iron reduction by deferoxamine leads to amelioration of adiposity via the regulation of oxidative stress and inflammation in obese and type 2 diabetes KKAy mice

Tajima S, Ikeda Y, Sawada K, Yamano N, Horinouchi Y, Kihira Y, Ishizawa K, Izawa-Ishizawa Y, Kawazoe K, Tomita S, Minakuchi K, Tsuchiya K, and Tamaki T 2011

[雑誌論文] Angiotensin II receptor blocker attenuates PDGF-induced mesangial cell migration in a receptor-independent manne

Ishizawa K, Izawa-Ishizawa Y, Dorjsuren N, Miki E, Kihira Y, Ikeda Y, Hamano S, Kawazoe K, Minakuchi K, Tomita S, Tsuchiya K and Tamaki T 2010

[雑誌論文] Effect of angiotensin II on iron-transporting protein expression and subsequent intracellular labile iron concentration in human glomerular endothelial cells

Tajima S, Tsuchiya K, Horinouchi Y, Ishizawa K, Ikeda Y, Kihira Y, Shono M, Kawazoe K, Tomita S, Tamaki T 2010

[図書] アンジオテンシンII刺激による細胞内遊離鉄を介した酸化ストレス増強機構

田島壮一郎, 土屋浩一郎, 濱本磨以, 久住祥子, 堀ノ内裕也, 八木祐子, 櫻田巧, 石澤啓介, 池田康将, 木平孝高, 冨田修平, 玉置俊晃 2010

[学会発表] Global gene expression analyses in renal ischemia-reperfusion injury (IRI) from mice lucking Hif-la gene.

Tamaki T, et al. 2010

[学会発表] Deferoxamine, an iron chelator, promotes angiogenesis after ischemic hind limb through Akt-eNOS-dependent pathway

Tajima S, Ikeda Y, Kihira Y, Ishizawa K, Kawazoe K, Tomita S, Minakuchi K, Tamaki T, Tsuchiya K 2010

[学会発表] Amelioration of acute tubular necrosis in ischemic acute renal failure was impaired in mice lacking hypoxia inducible factor-1 gene

Tamaki T, Yamaguchi K, Kihira Y, Ikeda Y, Ishizawa K, Tsuchiya K, Tomita S. 2010

[雑誌論文] Role of Hif-1a in T cells as a negative regulator in development of vascular remodeling

Kurobe H, Urata M, Ueno M, Ueki M, Ono S, Izawa-Ishizawa Y, Fukuhara Y, Lei Y, Ripen AM, Kanbara T, Aihara K, Ishizawa K, Akaike M, Gonzalez FJ, Tamaki T, Takahama Y, Yoshizumi M, Kitagawa T, Tomita S 2010

[学会発表] Iron elimination ameliorated glucose tolerance through suppression of oxidative stress and inflammation on fat in diabetic mice

Ikeda Y, Tajima S, Yamano N, Kihira Y, Ishizawa K, Tomita S, Tsuchiya K, Tamaki T. 2010

[学会発表] Endothelial-targeted hypoxia-inducible factor-1b(HIF-1b) loss-of function alleviates the monocrotaline-induced pulmonary hypertension in mice

Tomita S, Urata M, Fukuhara Y, Kihira Y, Ikeda Y, Ishizawa K, Tsuchiya K, Kitagawa T, Tamaki T 2010

[学会発表] Nitroso-Nifedipine is A New Class Drug to Protect Endotherial Function for Overcoming Organ Damage

Ishizawa K, Imanishi M, Horinouchi Y, Fukuhara Y, Izawa-Ishizawa Y, Ikeda Y, Kihira Y, Tomita S, Tsuchiya K, Tamaki T 2010

[学会発表] Global gene expression analyses in renal ischemia-reperfusion injury(IRI) from mice lucking Hif-1a gene

Tamaki T, Yamaguchi K, Kihira Y, Ikeda Y, Ishizawa K, TsuchiyaK, Kondo S, Kagami S and Tomita S 2010

[学会発表] Deferoxamine, an iron chelator, promotes angiogenesis after ischemic hind limb through Akt-eNOS-dependent pathway

Ikeda Y, Kihira Y, Ishizawa K, Tomita S, Tsuchiya K, Tamaki T 2010

[学会発表] Role of HIF-1b in endothelial cells in monocrotalineinduced pulmonary hypertension in mice

Fukuhara Y, Tomita S, Imamura Y, Horinouchi Y, Imanishi M, Sakurada T, Kitagawa T, Tamaki T 2010

[学会発表] Basic fibroblast growth factor upregulates hypoxia inducible factor 1 and glucose transporter 1 in adipose cells

Kihira Y, Tomita S, Ikeda Y, Ishizawa K, Tsuchiya K and Tamaki T 2010

[学会発表] IRON DERIVATION AMELIORATES GLUCOSE TOLERANCE THROUGH REDUCTION OF OXIDATIVE STRESS AND INFLAMMATION IN DIABETIC KKAY MICE

Tajima S, Ikeda Y, Yamano N, Tsuchiya K, Kihira Y, Ishizawa K, Kawazoe K, Tomita S, Minakuchi K, Tamaki T 2010

[学会発表] Deferoxamine, an iron chelator, enhances angiogenesis through Akt-eNOS pathway in endothelial cells

Ikeda Y, Tajima S, Yamano N, Kihira Y, Ishizawa K, Tomita S, Tsuchiya K, Tamaki T. 2010