トップ›研究者を探す›疾患モデルマウスを用いた遺伝性自己免疫疾患の病態解析

疾患モデルマウスを用いた遺伝性自己免疫疾患の病態解析

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-21390298
研究種目 基盤研究(B)
研究分野 生物系
医歯薬学
内科系臨床医学
膠原病・アレルギー内科学
研究機関 徳島大学
代表研究者 松本 満
研究分担者 西川 裕美子
研究分担者 毛利 安宏
研究期間 開始年月日 2009/4/1
研究期間 終了年度 2011
研究ステータス 完了 (2011/4/1)
配分額（合計） 17,810,000 (直接経費 :13,700,000、間接経費 :4,110,000)
配分額（履歴） 2011年度：5,980,000 (直接経費 :4,600,000、間接経費 :1,380,000)
2010年度：5,200,000 (直接経費 :4,000,000、間接経費 :1,200,000)
2009年度：6,630,000 (直接経費 :5,100,000、間接経費 :1,530,000)
キーワード 自己免疫疾患
胸腺
AIRE
自己寛容
胸線

研究成果

[学会発表] Aire-dependent organization of thymic microenvironment for the establishment of self tolerance

Matsumoto, M., et al 2011

[雑誌論文] Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stroma

Mouri, Y., Yano, M., Shinzawa, M., Shimo, Y., Hirota, F., Nishikawa, Y., Nii, T., Kiyonari, H., Abe, T., Uehara, H., Izumi, K., Tamada, K., Chen, L., Penninger, J. M., Inoue, J., Akiyama, T., and Matsumoto, M 2011

[学会発表] Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stroma

Mouri, Y., Yano, M., Shinzawa, M., Shimo, Y., Nishikawa, Y., Tamada, K., Chen, L., Penninger, J. M., Inoue, J., Akiyama, T., and Matsumoto, M 2011

[雑誌論文] Contrasting models for the roles of Aire in the differentiation program of epithelial cells in the thymic medulla

Matsumoto, M 2011

[学会発表] IRE遺伝子を導入したHeLa細胞における細胞周期依存的なAIREタンパク質のリン酸化

西嶋仁、毛利安宏、西川裕美子、松本満 2011

[学会発表] Role of self-antigen expressed by Aire-expressing cells in the negative selection process

Matsumoto, M., et al 2011

[学会発表] Aire-dependent organization of thymic microenvironment for the establishment of self-tolerance

Nishikawa, Y., Mouri, Y., Nishijima, H., and Matsumoto, M 2011

[学会発表] Role of self-antigen expressed by Aire-expressing cells in the negative selection process

Matsumoto, M., Mouri, Y., Nishikawa, Y., and Nishijima, H 2011

[学会発表] Role of Aire in the organization of thymic microenvironment

Matsumoto, M., et al. 2011

[学会発表] Aire-dependent organization of thymic microenvironment for the establishment of self tolerance

Matsumoto, M., et al 2011

[雑誌論文] Unc93B1 restricts systemic lethal inflammation by orchestrating Toll-like receptor 7 and 9 trafficking

Fukui, R., Saitoh, S.-I., Kanno, A., Onji, M., Shibata, T., Ito, A., Onji, M., Matsumoto, M., Akira, S., Yoshida, N., and Miyake, K 2011

[学会発表] Expression of Aite, a gene responsible for autoimmune disease, in ES cells

Matsumoto, M., et al 2011

[雑誌論文] Contrasting models for the roles of Aire in the differentiation program of epithelial cells in the thymic medulla

Matsumoto, M. 2011

[学会発表] Negative selectionにおけるAire発現細胞由来自己抗原の役割

毛利安宏、西川裕美子、西嶋仁、松本満 2011

[雑誌論文] Aire-dependent thymic expression of desmoglein 3, the autoantigen in pemphigus vulgaris, and its role in T cell tolerance

Wada, N., Nishifuji, K., Yamada, T., Kudoh, J., Shimizu, N., Matsumoto, M., Peltonen, L., Nagafuchi, S., and Amagai, M 2011

[学会発表] Aire-dependent organization of thymic microenvironment for the establishment of self tolerance

Matsumoto, M., Nishikawa, Y., Mouri, Y., and Nishijima, H 2011

[雑誌論文] Biphasic Aire expression in early embryos and in medullary thymic epithelial cells before end-stage terminal differentiation

Nishikawa, Y., Hirota, F., Yano, M., Kitajima, H., Miyazaki, J-i., Kawamoto, H., Mouri, Y., and Matsumoto, M 2010

[学会発表] Aire in thymic epithelial cells in the medulla controls developmental process of thymocytes

Mouri, Y., Nishikawa, Y., and Matsumoto, M 2010

[学会発表] Biphasic Aire expression in early embryos and in medullary thymic epithelial cells prior to end-stage terminal differentiation

Matsumoto, M., Nishikawa, Y., Hirota, F., Yano, M., Kawamoto, H. and Mouri, Y 2010

[学会発表] Biphasic Aire expression in early embryos and in medullary thymic epithelial cells priorto_end-stage terminal differentiation

Matsumoto, M., et al. 2010

[学会発表] AIRE and autoimmune disease

Matsumoto, M., Nishikawa, Y., Hirota, F. and Mouri, Y 2010

[学会発表] Biphasic Aire expression in early embryos and in medullary thymic epithelial cells prior to end-stage terminal differentiation

Nishikawa, Y., Mouri, Y., and Matsumoto, M 2010

[学会発表] Roles of thymic epithelial cells for the establishment of self-tolerance

Matsumoto, M 2010

[学会発表] Aife-depeadent organization of thymic microenvironment

Matsumoto, M. 2009

[雑誌論文] The role of autoimmune regulator(Aire) in the development of the immune system

Matsumoto, M 2009

[雑誌論文] The role of autoimmune regulator (Aire) in the development of the immune system

Matsumoto, M. 2009

[学会発表] Aire-dependent organization of thymic microenvironment

Matsumoto, M 2009

[学会発表] Aire-dependent organization of thymic microenvironment

Matsumoto, M., et al. 2009

[学会発表] Roles of NIK in thymic epithelial cells for the establishment of central tolerance

Mouri, Y., Yano, M., and Matsumoto, M 2009

[学会発表] ire in thymic epithelial cells in the medulla controls developmental process of thymocytes

Mouri, Y., and Matsumoto, M 2009

[図書] 炎症・再生医学事典 炎症 炎症メディエーターと細胞AIRE

松本満 2009

[学会発表] Aire in thymic epithelial cells in the medulla controls developmental process of thymocytes

Mouri, Y., et at. 2009