トップ›研究者を探す›がん特異的T細胞レセプターとケモカインレセプター同時発現によるがん免疫療法の開発

がん特異的T細胞レセプターとケモカインレセプター同時発現によるがん免疫療法の開発

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-21390294
研究種目 基盤研究(B)
研究分野 生物系
医歯薬学
内科系臨床医学
血液内科学
研究機関 愛媛大学
代表研究者 安川 正貴
連携研究者 長谷 川均
連携研究者 藤原 弘
研究期間 開始年月日 2009/4/1
研究期間 終了年度 2011
研究ステータス 完了 (2011/4/1)
配分額（合計） 17,940,000 (直接経費 :13,800,000、間接経費 :4,140,000)
配分額（履歴） 2011年度：5,720,000 (直接経費 :4,400,000、間接経費 :1,320,000)
2010年度：5,720,000 (直接経費 :4,400,000、間接経費 :1,320,000)
2009年度：6,500,000 (直接経費 :5,000,000、間接経費 :1,500,000)
キーワード がん免疫療法
T細胞レセプター遺伝子
ケモカイン・ケモカインレセプター
WT1
Aurora-A kinase
白血病
肺がん
WTI
遺伝子治療
細胞傷害性T細胞
T細胞レセプター
ケモカイン
ヒト化マウス
がん免疫
レトロウイルスベクター

研究成果

[雑誌論文] The role of activation-induced cytidine deaminase (AID/AICDA) in the progression of follicular lymphoma

Shikata H, Yasukawa M, et al 2012

[図書] 「造血器腫瘍に対する細胞免疫療法」Annual Review血液2012

安川正貴 2012

[図書] 「免疫療法」造血器腫瘍学

安川正貴 2012

[雑誌論文] Aurora kinase A-specific T-cell receptor gene transfer redirects T-lymphocytes to display effective anti-leukemia reactivity

Nagai, K., Fujiwara, H., Yasukawa, M., 他9名 2012

[雑誌論文] The role of activation-induced cytidine deaminase(AID/AICDA) in the progression of follicular lymphoma

Shikata, H. Yasukawa, M., 他8名 2012

[雑誌論文] Lysophosphatidylcholine enhances the suppressive function of human naturally occurring regulatory T cells through TGF-βproduction

Hasegawa, H. Yasukawa, M., 他4名 2011

[雑誌論文] Lysophosphatidylcholine enhances the suppressive function of human naturally occurring regulatory T cells through TGF-ss production

Hasegawa H, Yasukawa M, et al 2011

[雑誌論文] Feasibility of gene-immunotherapy using WT1-specific T-cell receptor gene transfer for infant acute lymphoblastic leukemia with MLL gene rearrangement

Nagai, K., Yasukawa, M., et al. 2011

[学会発表] Human Telomerase Reverse Transcriptase-Specific T-Cell Receptor Gene Transfer Redirects T-Lymphocytes to Exert Effective Antitumor Reactivity Against Adult T-Cell Leukemia

Miyazaki Y, Yasukawa M, et al 2011

[雑誌論文] Activation of T-cell receptor signaling in peripheral T-cell lymphoma cells plays an important role in the development of lymphoma-associated hemophagocytosis

An J, Yasukawa M, et al 2011

[雑誌論文] Activation of T-cell receptor signaling in peripheral T-cell lymphoma cells plays an important role in the development of lymphoma-associated hemophagocytosis

An, J., Fujiwara, H., Yasukawa, M., 他10名 2011

[学会発表] Redirected CD4^+ T Cells Using WT1-Specific T-Cell Receptor Gene Transfer Can Supply Multifactorial Help to Enhance the Anti-Leukemia Reactivity Mediated by Similarly Redirected CD8^+ T Cells Using the Identical Gene Transfer

Ochi T, Yasukawa M, et al 2011

[学会発表] Redirected CD4+ T Cells Using WT1-Specific T-Cell Receptor Gene Transfer Can Supply Multifactorial Help to Enhance the Anti-Leukemia Reactivity Mediated by Similarly Redirected CD8+ T Cells Using the Identical Gene Transfer

Ochi T, Yasukawa M, et al 2011

[学会発表] Forced Expression of CC Chemokine Receptor 2 Enhances Anti-Cancer Reactivity Mediated by T Lymphocytes Beforehand Redirected Toward WT1 Inside the Tumor Microenvironment

Asai A, Yasukawa M, et al 2011

[図書] みんなに役立つ悪性リンパ腫の基礎と臨床 改訂版

安川正貴 2011

[雑誌論文] Feasibility of gene-immunotherapy using WT1-specific T-cell receptor gene transfer for infant acute lymphoblastic leukemia with MLL gene rearrangement

Nagai K, Yasukawa M, et al 2011

[雑誌論文] Gemcitabine enhances Wilms' tumor gene WT1 expression and sensitizes human pancreatic cancer cells with WT1-specific T-cell-mediated antitumor immune response

Takahara, A., Fujiwara, H., Yasukawa, M., 他13名 2011

[雑誌論文] FDG-PET can evaluate the treatment for fungal liver abscess much earlier than other imagings

Miyazaki, Yasukawa, M., 他7名 2011

[雑誌論文] Gemcitabine enhances Wilms' tumor gene WT1 expression and sensitizes human pancreatic cancer cells with WT1-specific T-cell-mediated antitumor immune response

Takahara A, Yasukawa M, et al 2011

[雑誌論文] Requisite considerations for successful adoptive immunotherapy with engineered T lymphocytes using tumor antigen-specific T-cell receptor genetransfer

Ochi, T., Fujiwara, H., Yasukawa M. 2011

[学会発表] Human Telomerase Reverse Transcriptase-Specific T-Cell Receptor Gene Transfer Redirects T-Lymphocytes to Exert Effective Antitumor Reactivity Against Adult T-Cell Leukemia.

Miyazaki Y, Yasukawa M, et al 2011

[雑誌論文] Novel adoptive T-cell immunotherapy using a WT1-specific TCR vector encoding silencers for endogenous TCRs shows marked anti-leukemia reactivity and safety

Ochi, T., Fujiwara, H., Yasukawa, M., 他7名 2011

[雑誌論文] Vasodilator-stimulated phosphoprotein (VASP) phosphorylation assay for platelet response to cilostazol

Yamanouchi, J., Yasukawa, M., et al. 2011

[雑誌論文] Adoptive T-cell immunotherapy using T-cell receptor gene transfer : aiming at a cure for cancer

Yasukawa, M. Fujiwara, H., 他1名 2011

[雑誌論文] Requisite considerations for successful adoptive immunotherapy with engineered T lymphocytes using tumor antigen-specific T-cell receptor gene transfer

Ochi, T., Fujiwara, H. and Yasukawa, M. 2011

[雑誌論文] Feasibility of gene-immunotherapy using WT1-specific T-cell receptor gene transfer for infant acute lymphoblastic leukemia with MLL gene rearrangement

Nagai, K., Fujiwara, H., Yasukawa, M., 他7名 2011

[学会発表] Forced Expression of CC Chemokine Receptor 2 Enhances Anti-Cancer Reactivity Mediated by T Lymphocytes Beforehand Redirected Toward WT1 Inside the Tumor Microenvironment

Asai A, Yasukawa M, et al 2011

[雑誌論文] Peroxisome proliferator^-activated receptorαandγagonists together with TGF-βconvert human CD4^+ CD25^-T cells into functional Foxp3^+ regulatory T cells

Lei, J., Hasegawa, H., Yasukawa, M., 他2名 2010

[雑誌論文] Application of adoptive T-cell therapy using tumor antigen-specific T-cell receptor gene transfer for the treatment of human leukemia

Ochi T, Yasukawa M, et al. 2010

[学会発表] Augmented Expression of WT1-Specific TCR and Inhibition of Mispaired-TCR Formation In TCR-Gene Modified T-Cells Can Concomitantly Be Achieved Using a Novel Retroviral Vector with Silencers for Endogenous TCRs

Ochi, T., Yasukawa, M., et al. 2010

[学会発表] Dual Engineering of Human CD8^+ T-Cells with WT1-Specific TCR Gene and Chemokine Receptor Gene Transfer Confers Functionally Strengthened Anti-Cancer Reactivity

Miyazaki, Y., Yasukawa, M., et al. 2010

[学会発表] Engineering of Human T-Cells with a Novel Aurora-A Kinase-Specific T-Cell Receptor Gene Transfer Confers Anti-Leukemia Reactivity

Nagai, K., Yasukawa, M., et al. 2010

[雑誌論文] Generation of functional human T cells with HLA-restricted immune responses in HLA-class I expressing NOD/SCID/IL2rγ^<null> humanized mice

Shultz, L., Fujiwara, H., Yasukawa, M., 他9名 2010

[雑誌論文] Allo-HLA reactivity of leukemia-specific cytotoxic T lymphocytes. e-Letter

Yasukawa, M. Fujiwara, H., 他5名 2010

[雑誌論文] Subtypes of familial hemophagocytic lymphohistiocytosis in Japan based on genetic and functional analyses of cytotoxic T lymphocytes

Nagai, K., Yasukawa, M., et al. 2010

[雑誌論文] Generation of functional human T cells with HLA-restricted immune responses in HLA-class I expressing NOD/SCID/IL2rγ^<null> humanized mice

Shultz, L., Yasukawa, M., et al. 2010

[雑誌論文] Relapse of renal cell carcinoma with disappearance of HLA class I following hTERT peptide vaccination

Yasukawa, M., Ochi, T., Fujiwara, H. 2010

[雑誌論文] HLA class I binding of HBZ determines outcome in HTLV-1 infection

MacNamara, A., Yasukawa, M., et al. 2010

[雑誌論文] HLA class I binding of HBZ determines outcome in HTLV-1 infection

MacNamara, A., Fujiwara, H., Yasukawa, M., 他7名 2010

[雑誌論文] Improved expression and reactivity of transduced tumor-specific TCRs in human lymphocytes by specific silencing of endogenous TCR

Okamoto, S, Fujiwara, H., Yasukawa, M., 他4名 2010

[雑誌論文] Derivative(1 ; 18)(q10 ; q10) in essential thrombocythemia

Azuma, T., Fujiwara, H., Yasukawa M., 他6名 2010

[雑誌論文] Relapse of renal cell carcinoma with disappearance of HLA class I following hTERT peptide vaccination

Yasukawa, M. Fujiwara, H., 他2名 2010

[雑誌論文] Peroxisome proliferator-activated receptor α and γ agonists together with TGF-β convert human CD4+CD25- T cells into functional Foxp3^+ regulatory T cells

Lei, J., Yasukawa, M., et al. 2010

[雑誌論文] Subtypes of familial hemophagocytic lymphohistiocytosis in Japan based on genetic and functional analyses of cytotoxic T lymphocytes

Nagai, K., Fujiwara, H., Yasukawa, M., 他9名 2010

[雑誌論文] HBZ is an immunogenic protein but not a target antigen for HTLV-1-specific cytotoxic T lymphocytes

Suemori K, Yasukawa M, et al 2009

[雑誌論文] HBZ is an immunogenic protein but not a target antigen for HTLV-1-specific cytotoxic T lymphocytes

Suemori, K., Fujiwara, H., Yasukawa, M., 他5名 2009

[学会発表] ウイルス感染とアレルギー

安川正貴 2009

[雑誌論文] Aurora-A kinase : A novel target of cellular immunotherapy for leukemia

Ochi T, Yasukawa M, et al. 2009

[雑誌論文] Improved expression and reactivity of transduced tumor-specific TCRs in human lymphocytes by specific silencing of endogenous TCR

Okamoto S, Yasukawa M, et al 2009

[雑誌論文] Aurora-A kinase : A novel target of cellular immunotherapy for leukemia

Ochi, T., Fujiwara, H., Yasukawa, M., 他5名 2009

[雑誌論文] The role of zinc finger protein 521/early hematopoietic zinc finger protein in erythroid cell differentiation

Matsubara E, Yasukawa M, et al. 2009

[雑誌論文] Aurora-A kinase : a novel target both for cellular immunotherapy and molecular target therapy against human leukemia

Ochi T, Yasukawa M, et al. 2009

[雑誌論文] Identification of a novel epitope derived from CML66 which is recognized by anti-leukaemia cytotoxic T lymphocytes

Suemori, K., Fujiwara, H., Yasukawa, M., 他6名 2009

[雑誌論文] Identification of a novel epitope derived from CML66 which is recognized by anti-leukaemia cytotoxic T lymphocytes

Suemori K, Yasukawa M, et al 2009

[学会発表] HHV-6感染症-薬剤性過敏症症候群を中心として-

安川正貴 2009

[雑誌論文] The role of zinc finger protein 521/early hematopoietic zinc finger protein in erythroid cell differentiation

Matsubara, E., Yasukawa, M., 他6名 2009

[雑誌論文] Clinical efficacy of WT1 peptide vaccination in patients with acute myelogenous leukemia and myelodysplastic syndrome

Yasukawa, M. Fujiwara, H., 他5名 2009

[雑誌論文] Clinical efficacy of WT1 peptide vaccination in patients with acute myelogenous leukemia and myelodysplastic syndrome

Yasukawa M, et al. 2009

T細胞レセプター及び当該レセプターをコードする核酸