トップ研究者を探すジストニアの分子病態と治療に関する総合的研究

ジストニアの分子病態と治療に関する総合的研究

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-21390269
研究種目 基盤研究(B)
研究分野 生物系
医歯薬学
内科系臨床医学
神経内科学
研究機関 徳島大学
代表研究者 梶 龍兒
研究分担者 後藤 恵
研究分担者 浅沼 光太郎
研究期間 開始年月日 2009/4/1
研究期間 終了年度 2011
研究ステータス 完了 (2011/4/1)
配分額(合計) 17,420,000 (直接経費 :13,400,000、間接経費 :4,020,000)
配分額(履歴) 2011年度:5,590,000 (直接経費 :4,300,000、間接経費 :1,290,000)
2010年度:5,590,000 (直接経費 :4,300,000、間接経費 :1,290,000)
2009年度:6,240,000 (直接経費 :4,800,000、間接経費 :1,440,000)
キーワード 臨床神経生理学
神経科学
脳神経疾患
遺伝子
ゲノム
国際協力
ジストニア
DYT3
PET

研究成果

[図書] ジストニア診療とケアマニュアル

堀内正浩・梶龍兒 2012

[雑誌論文] Parkin interacts with Klokin1 for mitochondrial import and maintenance of membrane potential

Kuroda Y, Sako W, Goto S, Kaji R et al. 2012

[雑誌論文] Efficacy of zolpidem for dystonia : a study among different subtypes

Miyazaki Y, Sako W, Asanuma K, Izumi Y, Miki T, Kaji R. 2012

[雑誌論文] Cell type-specific localization of optineurin in the striatal neurons of mice : implications for neuronal vulnerability in Huntington' s disease

Okita S, Morigaki R, Koizumi H, Kaji R, Nagahiro S, Goto S. 2012

[図書] ボツリヌス療法アトラス

梶龍兒 2012

[雑誌論文] Reduced serum ceruloplasmin levels in cervical dystonia

Mezaki T, Kaji R. 2012

[図書] ジストニア診療とケアマニュアル

堀内正浩、梶龍兒 2011

[雑誌論文] Temporal evolution of sporadic Creutzfeldt-Jakob disease monitored by 3-Tesla MR spectroscopy.

Fujita K, Harada M, Yuasa T, Sasaki M, Izumi Y, Kaji R. 2011

[雑誌論文] Bilateral pallidal deep brain stimulation in primary Meige syndrome

Sako W, Morigaki R, Mizobuchi Y, Kaji R et al. 2011

[雑誌論文] The UCHL1 S18Y polymorphism and Parkinson's disease in a Japanese population.

Snapinn KW, Larson EB, Kawakami H, Ujike H, Borenstein AR, Izumi Y, Kaji R, Maruyama H, Mata IF, Morino H, Oda M, Tsuang DW, Yearout D, Edwards KL, Zabetian CP. 2011

[雑誌論文] Identification and localization of a neuron-specific isoform of TAF1 in rat brain : implications for neuropathology of DYT3 dystonia

Sako W, Morigaki R, Kaji R, et al. 2011

[雑誌論文] Type A1 but not type A2 botulinum toxin decreases the grip strength of the contralateral foreleg through axonal transport from the toxin-treated foreleg of rats

Torii Y, Akaike N, Harakawa T, Kaji R et al. 2011

[雑誌論文] New and emerging indications of botulinum toxin therapy

Kaji R. 2011

[雑誌論文] Practical management of botulinum toxin therapy

Lim EC, Bhidayasiri R, Rosales RL, Kaji R. 2011

[学会発表] Neuropathology update Lessons from DYT3 and other dystonias

Kaji R 2011

[学会発表] Neuropathology update : Lessons from DYT3 and other dystonias

Kaji R 2011

[雑誌論文] Olfactory type G-protein alpha subunit in striosome-matrix dopamine systems in adult mice.

Sako W, Morigaki R, Nagahiro S, Kaji R, Goto S. 2010

[学会発表] Japanese study experience sharing Upper limb study(BTX108509)/Lower limb study(BTX108512)

梶龍兒 2010

[雑誌論文] Effects of A2 type botulinum toxin on spontaneous miniature and evoked transmitter release from the rat spinal excitatory and inhibitory synapses.

Akaike N, Ito Y, Shin MC, Nonaka K, Torii Y, Harakawa T, Ginnaga A, Kozaki S, Kaji R. 2010

[雑誌論文] Mutations of optineurin in amyotrophic lateral sclerosis.

Maruyama H, Morino H, Ito H, Izumi Y, Kato H, Watanabe Y, Kinoshita Y, Kamada M, Nodera H, Suzuki H, Komure O, Matsuura S, Kobatake K, Morimoto N, Abe K, Suzuki N, Aoki M, Kawata A, Hirai T, Kato T, Ogasawara K, Hirano A, Takumi T, Kusaka H, Hagiwara K, Kaji R, Kawakami H. 2010

[雑誌論文] Entrapment neuropathy and beyond.

Kaji R. 2010

[雑誌論文] GSK1358820 Spasticity Study Group. Botulinum toxin type A in post-stroke upper limb spasticity.

Kaji R, Osako Y, Suyama K, Maeda T, Uechi Y, Iwasaki M 2010

[雑誌論文] Long-term suppression of Meige syndrome after pallidal stimulation : a 10-year follow-up study

Inoue N, Nagahiro S, Kaji R, Goto S. 2010

[雑誌論文] Comparison of effects of botulinum toxin subtype A1 and A2 using twitch tension assay and rat grip strength test.

Torii Y, Kiyota N, Sugimoto N, Mori Y, Goto Y, Harakawa T, Nakahira S, Kaji R, Kozaki S, Ginnaga A. 2010

[学会発表] Japanese study experience sharing Upper limb study(BTX108509)

Kaji R 2010

[雑誌論文] Mutations of optineurin in amyotrophic lateral sclerosis

Maruyama H, Morino H, Ito H, . Kaji R, Kawakami H. 2010

[雑誌論文] Olfactory type G-protein alpha subunit in striosome-matrix dopamine systems in adult mice

Sako W, Morigaki R, Nagahiro S, Kaji R, Goto S. 2010

[雑誌論文] Botulinum toxin type A in post-stroke lower limb spasticity : a multicenter, double-blind, placebo-controlled trial.

Kaji R, Osako Y, Suyama K, Maeda T, Uechi Y, Iwasaki M 2010

[雑誌論文] Bilateral pallidal deep brain stimulation in primary Meige syndrome.

Sako W, Morigaki R, Mizobuchi Y, Tsuzuki T, Ima H, Ushio Y, Nagahiro S, Kaji R, Goto S. 2010

[雑誌論文] Screening for TARDBP mutations in Japanese familial amyotrophic lateral sclerosis

Kamada M, Maruyama H, Tanaka E, Morino H, Wate R, Ito H, Kusaka H, Kawano Y, Miki T, Nodera H, Izumi Y, Kaji R, Kawakami H. 2009

[学会発表] Multifocal Motor neuropathy : Prof Bostock's contribution to clarify its pathophysiology

梶龍兒 2009

[学会発表] Dopa-responsive dystonias : An update MDS

Kaji R 2009

[学会発表] Pathophysiology of dystonia

梶龍兒 2009

[学会発表] Molecular dissection of dystonia

梶龍兒 2009

[学会発表] Multifocal Motor Neuropathy

梶龍兒 2009

[雑誌論文] uantitative determination of the biological activity of botulinum toxin type A by measuring the compound muscle action potential (CMAP) in rats.

Sakamoto T, Torii Y, Takahashi M, Ishida S, Goto Y, Nakano H, Harakawa T, Ginnaga A, Kozaki S, Kaji R. 2009

[雑誌論文] Subthalamic nucleus deep brain stimulation for camptocormia associated with Parkinson's disease.

Sako W, Nishio M, Maruo T, Shimazu H, Matsuzaki K, Tamura T, Mure H, Ushio Y, Nagahiro S, Kaji R, Goto S. 2009

[学会発表] Molecular dissection of dystonia

Kaji R 2009

[雑誌論文] LRRK2 mutations and risk variants in Japanese patients with Parkinson's disease.

Zabetian CP, Yamamoto M, Lopez AN, Ujike H, Mata IF, Izumi Y, Kaji R, Maruyama H, Morino H, Oda M, Hutter CM, Edwards KL, Schellenberg GD, Tsuang DW, Yearout D, Larson EB, Kawakami H. 2009

[雑誌論文] Long-term suppression of tremor by deep brain stimulation of the ventral intermediate nucleus of the thalamus combined with pallidotomy in hemiparkinsonian patients.

Nishio M, Korematsu K, Yoshioka S, Nagai Y, Maruo, T, Ushio Y, Kaji R, Goto S. 2009

[学会発表] Pathophysiology of dystonia 2009 Spring KMDS Sympo

Kaji R 2009

[学会発表] Dopa-responsive dystonias : An update

梶龍兒 2009

[学会発表] Therapeutic approach to spasticity : an update

梶龍兒 2009