トップ研究者を探す長期縦断大規模ゲノム疫学研究による生活習慣病発症の遺伝因子に関するエビデンス構築

長期縦断大規模ゲノム疫学研究による生活習慣病発症の遺伝因子に関するエビデンス構築

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-21390099
研究種目 基盤研究(B)
研究分野 生物系
医歯薬学
基礎医学
人類遺伝学
研究機関 愛媛大学
代表研究者 三木 哲郎
研究分担者 上島 弘嗣
研究分担者 梅村 敏
研究分担者 小原 克彦
研究分担者 田原 康玄
研究期間 開始年月日 2009/4/1
研究期間 終了年度 2011
研究ステータス 完了 (2011/4/1)
配分額(合計) 18,590,000 (直接経費 :14,300,000、間接経費 :4,290,000)
配分額(履歴) 2011年度:6,110,000 (直接経費 :4,700,000、間接経費 :1,410,000)
2010年度:6,240,000 (直接経費 :4,800,000、間接経費 :1,440,000)
2009年度:6,240,000 (直接経費 :4,800,000、間接経費 :1,440,000)
キーワード 遺伝疫学
遺伝子多型
ゲノム疫学
生活習慣病
肥満
高血圧
糖尿病

研究成果

[雑誌論文] Mice Lacking Hypertension Candidate Gene ATP2B1 in Vascular Smooth Muscle Cells Show Significant Blood Pressure Elevation

Kobayashi Y, Hirawa N, Tabara Y, Muraoka H, Fujita M, Miyazaki N, Fujiwara A, Ichikawa Y, Yamamoto Y, Ichihara N, Saka S, Wakui H, Yoshida S, Yatsu K, Toya Y, Yasuda G, Kohara K, Kita Y, Takei K, Goshima Y, Ishikawa Y, Ueshima H, Miki T, Umemura S 2012

[雑誌論文] Hemoglobin is associated with serum high molecular weight adiponectin in Japanese community-dwelling persons

Kawamoto R, Tabara Y, Kohara K, Miki T, Kusunoki T, Takayama S, Abe M 2011

[雑誌論文] Leptin in sarcopenic visceral obesity : possible link between adipocytes and myocytes

Kohara K, et al 2011

[雑誌論文] Genotype risk score of common susceptible variants for prediction of type 2 diabetes mellitus in Japanese : the Shimanami Health Promoting Program(J-SHIPP study). Development of type 2 diabetes mellitus and genotype risk score

Tabara Y, OsawaH, Kawamoto R, Onuma H, Shimizu I, Makino H, Kohara K, Miki T 2011

[雑誌論文] Lept in insarcopenic visceral obesity : possible link between adipocytes and myocytes

Kohara K, Ochi M, Tabara Y, NagaiT, Igase M, Miki T 2011

[雑誌論文] Relatively lower central aortic pressure in patients with impaired insulin sensitivity andresistance : the Toon Health Study

Tabara Y, Saito I, NishidaW, Kohara K, Sakurai S, Kawamura R, Onuma H, TakataY, OsawaH, Miki T, Tanigawa T 2011

[雑誌論文] Arterial stiffness is associated with low thigh muscle mass in middle-aged to elderly men

Ochi M, Kohara K, Tabara Y, Kido T, Uetani E, Ochi N, Igase M, Miki T 2010

[雑誌論文] Postural instability is associated with brain atrophy and cognitive impairment in the elderly : the J-SHIPP study

Kido T, Tabara Y, Igase M, Ochi N, Uetani E, Nagai T, Yamamoto M, Taguchi K, Miki T, Kohara K 2010

[雑誌論文] The GCKR rs780094 polymorphism is associated with susceptibility of type 2 diabetes, reduced fasting plasma glucose levels, increased triglycerides levels and lower HOMA-IR in Japanese population

Onuma H, Tabara Y, Kawamoto R, Shimizu I, Kawamura R, Takata Y, Nishida W, Ohashi J, Miki T, Kohara K, Makino H, Osawa H 2010

[雑誌論文] Low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio is the best surrogate marker for insulin resistance in non-obese Japanese adults

Kawamoto R, Tabara Y, Kohara K, Miki T, Kusunoki T, Takayama S, Abe M, Katoh T, Ohtsuka N 2010

[雑誌論文] Abdominal fat, adipose-derived hormones and mild cognitive impairment : the J-SHIPP study

Kamogawa K, Kohara K, Tabara Y, Uetani E, Nagai T, Yamamoto M, Igase M, Miki T 2010

[雑誌論文] A at single nucleotide polymorphism-358 is required for G at-420 to confer the highest plasma resistin in the general Japanese population

Onuma H, Tabara Y, Kawamura R, Tanaka T, Ohashi J, Nishida W, Takata Y, Ochi M, Yamada K, Kawamoto R, Kohara K, Miki T, Makino H, Osawa H 2010

[雑誌論文] Accumulation of common polymorphisms is associated with development of hypertension : a 12-year follow-up from the Ohasama study

Watanabe Y, Metoki H, Ohkubo T, Katsuya T, Tabara Y, Kikuya M, Hirose T, Sugimoto K, Asayama K, Inoue R, Hara A, Obara T, Nakura J, Kohara K, Totsune K, Ogihara T, Rakugi H, Miki T, Imai Y 2010

[雑誌論文] Serum high molecular weight adiponectin is associated with mild renal dysfunction in Japanese adults

Kawamoto R, Tabara Y, Kohara K, Miki T, Abe M, Kusunoki T, Katoh T, Ohtsuka N 2010

[雑誌論文] Common variants in the ATP2B1 gene are associated with susceptibility to hypertension : the Japanese Millennium Genome Project

Tabara Y, Kohara K, Kita Y, Hirawa N, Katsuya T, Ohkubo T, Hiura Y, Tajima A, Morisaki T, Miyata T, Nakayama T, Takashima N, Nakura J, Kawamoto R, Takahashi N, Hata A, Soma M, Imai Y, Kokubo Y, Okamura T, Tomoike H, Iwai N, Ogihara T, Inoue I, Tokunaga K, Johnson T, Caulfield M, Munroe P ; Global Blood Pressure Genetics Consortium, Umemura S, Ueshima H, Miki T 2010

[雑誌論文] Association of four genetic loci with uric acid levels and reduced renal function : the J-SHIPP Suita study

Tabara Y, Kohara K, Kawamoto R, Hiura Y, Nishimura K, Morisaki T, Kokubo Y, Okamura T, Tomoike H, Iwai N, Miki T 2010

[雑誌論文] Alcohol drinking status is associated with serum high molecular weight adiponectin in community-dwelling Japanese men

Kawamoto R, Tabara Y, Kohara K, Miki T, Ohtsuka N, Kusunoki T, Abe M 2010

[雑誌論文] High-sensitivity C-reactive protein and gamma-glutamyl transferase levels are synergistically associated with metabolic syndrome in community-dwelling persons

Kawamoto R, Tabara Y, Kohara K, Miki T, Kusunoki T, Takayama S, Abe M, KatohT, Ohtsuka N 2010

[雑誌論文] PPARgamma Pro12Ala Pro/Pro and resistin SNP-420 G/G genotypes are synergistically associated with plasma resistin in the Japanese general population

Osawa H, Tabara Y, Kawamoto R, Ohashi J, Ochi M, Onuma H, Nishida W, Yamada K, Nakura J, Miki T, Makino H, Kohara K 2009

[雑誌論文] Prognostic significance of FTO genotype in the development of obesity in Japanese : the J-SHIPP study

Tabara Y, Osawa H, Guo H, Kawamoto R, Onuma H, Shimizu I, Takara Y, Nishida W, Yamamoto M, Makino H, Kohara K, Miki T 2009