トップ›研究者を探す›口腔癌の浸潤・転移機構の解明とその悪性度診断ならびに遺伝子治療への応用

口腔癌の浸潤・転移機構の解明とその悪性度診断ならびに遺伝子治療への応用

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-21249088
研究種目 基盤研究(A)
研究分野 生物系
医歯薬学
歯学
形態系基礎歯科学
研究機関 広島大学
代表研究者 高田 隆
研究分担者 工藤 保誠
研究分担者 進藤 正信
研究分担者 樋田 京子
研究期間 開始年月日 2009/4/1
研究期間 終了年度 2012
研究ステータス 完了 (2012/4/1)
配分額（合計） 45,630,000 (直接経費 :35,100,000、間接経費 :10,530,000)
配分額（履歴） 2012年度：7,280,000 (直接経費 :5,600,000、間接経費 :1,680,000)
2011年度：7,280,000 (直接経費 :5,600,000、間接経費 :1,680,000)
2010年度：7,280,000 (直接経費 :5,600,000、間接経費 :1,680,000)
2009年度：23,790,000 (直接経費 :18,300,000、間接経費 :5,490,000)
キーワード 口腔癌
浸潤・転移
microRNA
浸潤
転移
血管新生
微小環境
MMP10
MMP13

研究成果

[学会発表] FGFR-1 inhibitor PD173074 induces mesenchymal-epithelial tramsition through suppression of AP-1 in Head and Neck Squamous Cel Carcinoma

Nguyen PT, Inubushi T, Tsunematsu T, Kudo Y, Kamata N, Ogawa I, Takata T 2012

[学会発表] The role as tumor suppressor gene and the expression of Ameloblastin in osteosarcoma

安藤俊範，常松貴明，工藤保誠，小川郁子,宮内睦美，高田　隆 2012

[学会発表] The novel function of Ameloblastin as a tumor suppressor gene in osteosarcoma

安藤俊範，常松貴明，工藤保誠， 小川郁子,宮内睦美，高田　隆 2012

[学会発表] FGFR-1 inhibitor PD173074 induces mesenchymal-epithelial tramsition through suppression of AP-1 in Head and Neck Squamous Cell Carcinoma

Nguyen PT, Inubushi T, Tsunematsu T, Kudo Y, Kamata N, Ogawa I, Takata T 2012

[学会発表] 細胞分裂期キナーゼAurora-AによるDNA複製調節機構

常松貴明, 工藤保誠, 高田　隆 2012

[雑誌論文] Periostin Directly and Indirectly Promotes Tumor Lymphangiogenesis of Head and Neck Cancer

Kudo Y, Takata T et al. 2012

[雑誌論文] Overexpression of receptor for hyaluronan-mediated motility (RHAMM) in MC3T3-E1 cells induces proliferation and differentiation through phosphorylation of ERK1/2

Hatano H, Shigeishi H, Kudo Y, Takata T 2012et al. 2012

[学会発表] Identification of microRNA-203 as an invasion in oral cancer

大林真理子, 吉田真希, 工藤保誠, 高田 隆 2012

[雑誌論文] Establishment of Mesenchymal Cell Line Derived from Human Developing Odontoma

Hatano H, Kudo Y, Takata T et al. 2012

[学会発表] Identification of microRNA-203 as an invasion in oral cancer

大林真理子, 吉田真希, 工藤保誠, 高田 隆 2012

[学会発表] Ameloblastinの癌抑制遺伝子としての役割の解明

安藤俊範，常松貴明，工藤保誠，小川郁子，宮内睦美, 高田　隆 2012

[学会発表] 細胞分裂期におけるDNA複製因子Gemininのユビキチン分解機構とその新たな役割

常松貴明, 工藤保誠, 高田　隆 2012

[学会発表] 分裂期キナーゼAurora-AによるDNAライセンス化抑制因子Gemininの安定化機構

常松貴明, 工藤保誠, 高田 隆 2012

[雑誌論文] Periostin Directly and Indirectly Promotes Tumor Lymphangiogenesis of Head and Neck Cancer.

Kudo Y, Iizuka S, Yoshida M, Nguyen PT, Siriwardena BSMS, Tsunematsu T, Ohbayashi M, Ando T, Hatakeyama D, Shibata T, Koizumi K, Maeda M, Ishimaru N, Ogawa I, Takata T 2012

[雑誌論文] Matrix metalloproteinase-13 (MMP-13) directly and indirectly promotes tumor angiogenesis

Kudo Y, Takata T et al. 2012

[雑誌論文] The 3D tissue microenvironment modulates DNA methylation and E-cadherin expression in squamous cell carcinoma

Desrochers TM, Shamis Y, Alt-Holland A, Kudo Y, Takata T, Wang G, Jackson-Grusby L, Garlick JA. 2012

[学会発表] The Novel Tumor Suppressor Function Of Ameloblastin In Osteosarcoma

Ando T, Tsunematsu T, Kudo Y, Ogawa I, Miyauchi M, Takata T 2012

[雑誌論文] Matrix metalloproteinase-13(MMP-13) directly and indirectly promotes tumor angiogenesis.

Kudo.Y, Iizuka.S, Yoshida.M, Tsunematsu.T, Kondo T, Subarnbhesaj A, Deraz EM, Siriwardena SB, Tahara H, Ishimaru N, Ogawa I,Takata T 2012

[雑誌論文] Overexpression of Receptor for Hyaluronan-Mediated Motility (RHAMM) in MC3T3-E1 induces the proliferation and differentiation through phosphorypation of ERK1/2

Hatano, H., Shigeishi, H., Kudo, Y., et al 2012

[学会発表] Geminin escapes from ubiquitin-mediated degradation by Aurora-A induced phosphorylation during mitosis

常松 貴明, 工藤 保誠, 高田　隆 2012

[学会発表] FGFR-1 inhibitor PD173074 induces mesenchymal-epithelial tramsition through suppression of AP-1 in Head and Neck Squamous Cell Carcinoma

Nguyen PT, Inubushi T, Tsunematsu T, Kudo Y, Kamata N, Ogawa I, Takata T 2012

[学会発表] FGFR-1 inhibitor PD173074 induces mesenchymal-epithelial tramsition through suppression of AP-1 in Head and Neck Squamous Cell Carcinoma

Nguyen PT, Inubushi T, Tsunematsu T, Kudo Y, Kamata N, Ogawa I, Takata T 2012

[雑誌論文] miR-22 represses cancer progression by inducing celular senescence

Xu D, Takeshita F, Hino Y, Fukunaga S, Kudo Y, Tamaki A, Matsunaga J, Takahashi R, Takata T, Shimamoto A, Ochiya T, Tahara H 2011

[雑誌論文] N-cadherin expression is correlated with metastasis of spindle cell carcinoma of head and neck region.

Nguyen PT, Kudo Y, Yoshida M, Iizuka S, Ogawa I, Takata T. 2011

[雑誌論文] N-cadherin expression is correlated with metastasis of spindle cell carcinoma of head and neck region

Nguyen PT, Kudo Y, Yoshida M, Iizuka S, Ogawa I, Takata T 2011

[雑誌論文] MMP-10/stromelysin-2 promotes invasion of head and neck cancer

Deraz, E.M., Kudo, Y., et al 2011

[雑誌論文] MMP-10/stromelysin-2promotes invasion of head and neck cancer

Deraz EM, Kudo Y, Yoshida M, Tani H, Tsunematsu, T, Siriwardena B.S.M.S, Kiekhaee MR, Qi G, Iizuka S, Ogawa, I, Campisi G, Lo Muzio L, Abiko Y, Kikuchi A, Takata T 2011

[学会発表] 口腔癌における浸潤抑制因子としてのmiR-203の同定

大林真理子,工藤保誠,吉田真希,日野由美子,福永早央里,田原栄俊,高田 隆 2011

[学会発表] Identification of microRNA-203 as an inhibitor of invasion in oral cancer

Obayashi M, Kudo Y, Yoshida M, Hino Y, Fukunaga S, Tahara H,Takata T 2011

[雑誌論文] N-cadherin expression is involved in malignant behavior of head and neck cancer in relation to epithelial-mesenchymal transition.

Nguyen PT, Kudo Y, Yoshida M, Kamata N, Ogawa I, Takata T. 2011

[雑誌論文] Oncogenic role of RUNX3 in head and neck cancer

Kudo Y, Tsunematsu T, Takata T 2011

[雑誌論文] miR-22 represses cancer progression by inducing cellular senescence

Xu, D., Takeshita, F., Hino, Y., Fukunaga, S., Kudo, Y., et al 2011

[雑誌論文] miR-22 provides a direct link between cellular senescence and tumorigenesis.

Xu, D., Takeshita, F., Hino, Y., Fukunaga, S., Kudo, Y., Tamaki, A., Matsunaga, J., Takahashi, R., Takata, T., Shimamoto, A., Ochiya, T., Tahara, H. 2011

[雑誌論文] Oncogenic role of RUNX3 in head and neck cancer.

Kudo Y, Tsunematsu T, Takata T 2011

[雑誌論文] N-cadherin expression is involved in malignant behavior of head and neck cancer in relation to epithelial-mesenchymal transition

Nguyen PT, Kudo Y, Yoshida M, Kamata N, Ogawa I, Takata T 2011

[学会発表] Identification of novel invasion related molecules in oral cancer

工藤保誠 2011

[学会発表] 頭頸部癌の浸潤に関わるmicroRNAの探索

吉田真希, 工藤保誠, 高田隆 2010

[学会発表] 口腔扁平上皮癌における転写因子RUNX3の発現制御機構とその役割

常松貴明, 工藤保誠, 高田隆 2010

[学会発表] HSulf-1 は頭頸部癌の浸潤を促進する

吉田真希,工藤保誠,小川郁子,高田 隆 2010

[学会発表] 口腔癌の浸潤における MMP-10 の役割

工藤保誠,高田 隆 2010

[学会発表] Identification and characterization of new invasion relating molecules of head and neck squamous cell carcinoma

Kudo Y 2010

[学会発表] N-cadherin expression is involved in malignant behavior of head and neck cancer in relation to epithelial-mesenchymal transition

Ohbayashi M,Nguyen PT,Kudo Y, Yoshida M,Miyauchi M,Ogawa I,Takata T 2010

[雑誌論文] Nuclear Survivin expression is correlated with malignant behaviors of head and neck cancer together with Aurora-B

Qi G, Kudo Y, Ando T, Tsunematsu T, Shimizu N, Siriwardena S, Yoshida M, Keikhaee M, Ogawa I, Takata T. 2010

[学会発表] Runx3 has an Oncogenic role in head and neck cancer

工藤保誠、常松貴明、高田隆 2010

[学会発表] HSulf-1は頭頸部癌の浸潤を促進する

吉田真希, 工藤保誠, 小川郁子, 高田隆 2010

[学会発表] 口腔扁平上皮癌における転写因子RUNX3の発現制御機構とその役割

常松貴明, 工藤保誠, 高田隆 2010

[学会発表] 口腔癌の浸潤に関与する microRNA の網羅的解析

吉田真希、工藤保誠、高田 隆 2010

[学会発表] 口腔癌の浸潤に関与するmicroRNAの網羅的解析

吉田真希、工藤保誠、高田隆 2010

[雑誌論文] Nuclear Survivin expression is correlated with malignant behaviors of head and neckcancer together with Aurora-B

Qi G, Kudo Y, Ando T, Tsunematsu T, Shimizu N, Siriwardena S, Yoshida M, Keikhaee M, Ogawa I, Takata T 2010

[学会発表] N-cadherin expression is involved in malignant behavior of head and neck cancer in relation to epithelial-mesenchymal transition

Ohbayashi M, Nguyen PT, Kudo Y, Yoshida M, Miyauchi M, Ogawa I, Takata T. 2010

[学会発表] 口腔扁平上皮癌におけるSurvivinとAurora-Bの過剰発現

工藤保誠, 斉広塋, 小川郁子, 高田隆 2010

[学会発表] 頭頸部扁平上皮癌におけるRUNX3の過剰発現機構

常松貴明, 工藤保誠, 高田隆 2010

[学会発表] Identification and characterization of new invasion relating molecules of head and neck squamous cell carcinoma

工藤保誠 2010

[学会発表] 頭頸部癌の浸潤に関わる microRNA の探索

吉田真希,工藤保誠,高田 隆 2010

[学会発表] HSulf-1 promotes the invasion of head and neck cancer

吉田真希,工藤保誠,小川郁子,高田 隆 2009

[学会発表] HSulf-1 は頭頚部癌の浸潤を促進する

吉田真希,工藤保誠, ヌーウィン・ティ・フーン・タオ,小川郁子, 高田 隆 2009

[学会発表] Co-expression of nuclear Survivin and Aurora-B shows malignant behavior of head and neck cancer

斉広塋, 工藤保誠, 安藤敏範, 吉田真希, 高田隆 2009

[雑誌論文] Oncogenic role of nuclear accumulated Aurora-A.

Tatsuka M, Sato S, Kanda A, Miki T, Kamata N, Kitajima S, Kudo Y, Takata T 2009

[雑誌論文] Oncogenic role of nuclear accumulated Aurora-A

Tatsuka M, Sato S, Kanda A, Miki T, Kamata N, Kitajima S, Kudo Y, Takata T. 2009

[雑誌論文] RUNX3 has an oncogenic role in head and neck cancer

Tsunematsu T, Kudo Y, Iizuka S, Ogawa I, Fujita T, Kurihara H, Abiko Y, Takata T. 2009

[雑誌論文] RUNX3 has an oncogenic role in head and neck cancer.

Tsunematsu T, Kudo Y, Iizuka S, Ogawa I, Fujita T, Kurihara H, Abiko Y, Takata T 2009

[雑誌論文] Aberrant β-catenin expression and adenomatous polyposis coli gene mutation in ameloblastoma and odontogenic carcinoma

Siriwardena BS, Kudo Y, Ogawa I, Tilakaratne WM, Takata T 2009