トップ研究者を探す加齢黄斑変性に対するテーラーメード医療の実現

加齢黄斑変性に対するテーラーメード医療の実現

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-21249084
研究種目 基盤研究(A)
研究分野 生物系
医歯薬学
外科系臨床医学
眼科学
研究機関 京都大学
代表研究者 吉村 長久
研究分担者 大谷 篤史
研究分担者 山城 健児
研究分担者 山田 亮
研究期間 開始年月日 2009/4/1
研究期間 終了年度 2011
研究ステータス 完了 (2011/4/1)
配分額(合計) 44,980,000 (直接経費 :34,600,000、間接経費 :10,380,000)
配分額(履歴) 2011年度:8,970,000 (直接経費 :6,900,000、間接経費 :2,070,000)
2010年度:15,340,000 (直接経費 :11,800,000、間接経費 :3,540,000)
2009年度:20,670,000 (直接経費 :15,900,000、間接経費 :4,770,000)
キーワード 眼細胞生物学
加齢黄斑変性
個別化医療
遺伝子多型
テーラーメード医療

研究成果

[雑誌論文] Relationship between retinal morphological findings and visual function in age-related macular degeneration

Akagi-Kurashige Y, Tsujikawa A, Oishi A, Ooto S, Yamashiro K, Tamura H, Nakata I, Ueda-Arakawa N, Yoshimura N. 2012

[雑誌論文] Relationship between retinal morphological findings and visual function in age-related macular degeneration

Akagi-Kurashige Y, Tsujikawa A, Oishi A, Ooto S, Yamashiro K, Tamura H, Nakata I, Ueda-Arakawa N, Yoshimura N 2012

[雑誌論文] Factors Associated With the Response of Age-Related Macular Degeneration to Intravitreal Ranibizumab Treatment

Yamashiro K, Tomita K, Tsujikawa A, Nakata I, Akagi-Kurashige Y, Miyake M, Ooto S, Tamura H, Yoshimura N 2012

[雑誌論文] Significance of C2/CFB variants in age-related macular degeneration and polypoidal choroidal vasculopathy in a Japanese population

Nakata I, Yamashiro K, Yamada R, Gotoh N, Nakanishi H, Hayashi H, Akagi-Kurashige Y, Tsujikawa A, Otani A, Saito M, Iida T, Oishi A, Matsuo K, Tajima K, Matsuda F, Yoshimura N 2012

[雑誌論文] Vascular endothelial growth factor gene polymorphisms and choroidal neovascularization in highly myopic eyes

Akagi-Kurashige Y, Kumagai K, Yamashiro K, Nakanishi H, Nakata I, Miyake M, Tsujikawa A, Moriyama M, Ohno-Matsui K, Mochizuki M, Yamada R, Matsuda F, Yoshimura N 2012

[雑誌論文] Significance ofC2/CFB variants in age-related macular degeneration and polypoidal choroidalvasculopathy in a Japanese population

Nakata I, Yamashiro K, Yamada R, Gotoh N, Nakanishi H, Hayashi H, Akagi-Kurashige Y, Tsujikawa A, Otani A, Saito M, Iida T, Oishi A, Matsuo K, TajimaK, Matsuda F, Yoshimura N. 2012

[雑誌論文] Vascular endothelial growth factor gene polymorphisms and choroidalneovascularization in highly myopic eyes

Akagi-Kurashige Y, Kumagai K, Yamashiro K, Nakanishi H, Nakata I, MiyakeM, Tsujikawa A, Moriyama M, Ohno-Matsui K, Mochizuki M, Yamada R, Matsuda F, Yoshimura N 2012

[雑誌論文] Macular Choroidal Thickness and Volume in Eyes With Angioid Streaks Measured by Swept Source Optical Coherence Tomography

Ellabban AA, Tsujikawa A, Matsumoto A, Ogino K, Hangai M, Ooto S, Yamashiro K, Akiba M, Yoshimura N. 2012

[雑誌論文] Macular Choroidal Thickness and Volume in Eyes With Angioid Streaks Measured by Swept Source Optical Coherence Tomography

Ellabban AA, Tsujikawa A, Matsumoto A, Ogino K, Hangai M, Ooto S, Yamashiro K, Akiba M, Yoshimura N 2012

[雑誌論文] Retinal microstructural abnormalities in central serous chorioretinopathy and polypoidal choroidal vasculopathy.

Ooto S, Tsujikawa A, Mori S, Tamura H, Yamashiro K, Otani A, Yoshimura N. 2011

[雑誌論文] VEGFgene polymorphism and response tointravitreal bevacizumab and triple therapy in age-related macular degeneration

Nakata I, Yamashiro K, NakanishiH, Tsujikawa A, Otani A, Yoshimura N. 2011

[雑誌論文] Association of 15q14 and 15q25 with High Myopia in Japanese.

Hayashi H, Yamashiro K, Nakanishi H, Nakata I, Kurashige Y, Tsujikawa A, Moriyama M, Ohno-Matsui K, Mochizuki M, Ozaki M, Yamada R, Matsuda F, Yoshimura N. 2011

[雑誌論文] VEGF gene polymorphism and response to intravitreal bevacizumab and triple therapy in age-related macular degeneration

Nakata I, Yamashiro K, Nakanishi H, Tsujikawa A, Otani A, Yoshimura N 2011

[雑誌論文] Macular choroidal thickness and volume in normal subjects measured by swept-source optical coherence tomography

Hirata M, Tsujikawa A, Matsumoto A, Hangai M, Ooto S, Yamashiro K, Akiba M, Yoshimura N 2011

[雑誌論文] Association of elastin gene polymorphism to age-related macular degeneration and polypoidal choroidal vasculopathy

Yamashiro K, Mori K, Nakata I, Tsuchihashi T, Horie-Inoue K, Nakanishi H, Tsujikawa A, Saito M, Iida T, Yamada R, Matsuda F, Inoue S, Awata T, Yoneya S, Yoshimura N 2011

[雑誌論文] Association between the SERPING1 gene and age-related macular degeneration and polypoidal choroidal vasculopathy in Japanese

Nakata I, Yamashiro K, Yamada R, Gotoh N, Nakanishi H, Hayashi H, Tsujikawa A, Otani A, Saito M, Iida T, Oishi A, Matsuo K, Tajima K, Matsuda F, Yoshimura N 2011

[雑誌論文] Association of lesion size and visual prognosis to polypoidal choroidalvasculopathy

Tsujikawa A, Ojima Y, Yamashiro K, Nakata I, Ooto S, Tamura H, Nakanishi H, Hayashi H, Otani A, Yoshimura N 2011

[雑誌論文] Association between the SERPING1 gene andage-related macular degeneration andpolypoidal choroidal vasculopathy in Japanese

Nakata I, Yamashiro K, Yamada R, Gotoh N, Nakanishi H, Hayashi H, TsujikawaA, Otani A, Saito M, Iida T, Oishi A, MatsuoK, Tajima K, Matsuda F, Yoshimura N 2011

[雑誌論文] Treatment of polypoidal choroidal vasculopathy with photodynamic therapy combined with intravitreal injections of ranibizumab

Tomita K, Tsujikawa A, Yamashiro K, Ooto S, Tamura H, Otani A, Nakayama Y, Yoshimura N 2011

[雑誌論文] Association of Lesion Size and Visual Prognosis to Polypoidal Choroidal Vasculopathy.

Tsujikawa A, Ojima Y, Yamashiro K, Nakata I, Ooto S, Tamura H, Nakanishi H, Hayashi H, Otani A, Yoshimura N. 2011

[雑誌論文] Genetic variants in pigment epithelium-derived factor influence response of polypoidal choroidal vasculopathy to photodynamic therapy

Nakata I, Yamashiro K, Yamada R, Gotoh N, Nakanishi H, Hayashi H, Tsujikawa A, Otani A, Ooto S, Tamura H, Saito M, Saito K, Iida T, Oishi A, Kurimoto Y, Matsuda F, Yoshimura N 2011

[雑誌論文] Prognostic factors for visual outcomes 2-years afterintravitreal bevacizumab for myopicchoroidal neovascularization

Nakanishi H, Tsujikawa A, Yodoi Y, Ojima Y, Otani A, Tamura H, Yamashiro K, Ooto S, Yoshimura N. 2011

[雑誌論文] Association of elastin gene polymorphism to age-related macular degeneration and polypoidal choroidalvasculopathy

Yamashiro K, Mori K, Nakata I, Tsuchihashi T, Horie-Inoue K, Nakanishi H, Tsujikawa A, Saito M, Iida T, Yamada R, Matsuda F, Inoue S, Awata T, Yoneya S, Yoshimura N 2011

[雑誌論文] Development of polypoidal lesions inage-related macular degeneration

Tsujikawa A, Ojima Y, Yamashiro K, Ooto S, Tamura H, Nakata I, Yoshimura N 2011

[雑誌論文] Association of 15q14 and 15q25 with high myopia in Japanese

Hayashi H, Yamashiro K, Nakanishi H, Nakata I, Kurashige Y, Tsujikawa A, Moriyama M, Ohno-Matsui K, Mochizuki M, Ozaki M, Yamada R, Matsuda F, Yoshimura N 2011

[雑誌論文] Macular choroidal thickness and volume in normal subjects measured by swept-source optical coherence tomography

Hirata M, Tsujikawa A, MatsumotoA, Hangai M, Ooto S, Yamashiro K, Akiba M, Yoshimura N. 2011

[雑誌論文] Retinal micro structural abnormalities in central serous chorioretinopathy andpolypoidal choroidal vasculopathy

Ooto S, Tsujikawa A, Mori S, Tamura H, Yamashiro K, Otani A, Yoshimura N 2011

[雑誌論文] Association of 15q14 and 15q25 with high myopia in Japanese

Hayashi H, Yamashiro K, NakanishiH, Nakata I, Kurashige Y, Tsujikawa A, Moriyama M, Ohno-Matsui K, Mochizuki M, Ozaki M, Yamada R, Matsuda F, Yoshimura N. 2011

[雑誌論文] Association of lesion size and visual prognosis to polypoidal choroidal vasculopathy

Tsujikawa A, Ojima Y, Yamashiro K, Nakata I, Ooto S, Tamura H, Nakanishi H, Hayashi H, Otani A, Yoshimura N 2011

[雑誌論文] Genetic variants in pigment epithelium-derived factor influence response of polypoidal choroidalvasculopathy to photodynamic therapy

Nakata I, Yamashiro K, Yamada R, Gotoh N, Nakanishi H, Hayashi H, TsujikawaA, Otani A, Ooto S, Tamura H, Saito M, SaitoK, Iida T, Oishi A, Kurimoto Y, Matsuda F, Yoshimura N. 2011

[雑誌論文] Treatment of polypoidal choroidal vasculopathy by intravitreal injection of bevacizumab.

Tsujikawa A, Ooto S, Yamashiro K, Tamura H, Otani A, Yoshimura N. 2010

[雑誌論文] Single-nucleotide polymorphisms in the promoter region of matrixmetalloproteinase-1,-2, and-3 in Japanese with high myopia

Nakanishi H, Hayashi H, Yamada R, Yamashiro K, Nakata I, Shimada N, Ohno-Matsui K, Mochizuki M, Ozaki M, Yoshitake S, Kuriyama S, Saito M, Iida T, Matsuo K, Matsuda F, Yoshimura N 2010

[雑誌論文] Thickness of photoreceptor layers inpolypoidal choroidal vasculopathy and central serous chorioretinopathy

Ooto S, Tsujikawa A, Mori S, Tamura H, Yamashiro K, Yoshimura N. 2010

[雑誌論文] Genetic Variants in Pigment Epithelium-Derived Factor Influence Response of Polypoidal Choroidal Vasculopathy to Photodynamic Therapy.

Nakata I, Yamashiro K, Yamada R, Gotoh N, Nakanishi H, Hayashi H, Tsujikawa A, Otani A, Ooto S, Tamura H, Saito M, Saito K, Iida T, Oishi A, Kurimoto Y, Matsuda F, Yoshimura N. 2010

[雑誌論文] Restoration of outer segments of foveal photoreceptors after resolution of central serouschorioretinopathy

Ojima Y, Tsujikawa A, Yamashiro K, Ooto S, Tamura H, Yoshimura N 2010

[雑誌論文] CFH and ARMS2 variations in age-related macular degeneration, polypoidal choroidal vasculopathy, and retinal angiomatous proliferation.

Hayashi H, Yamashiro K, Gotoh N, Nakanishi H, Nakata I, Tsujikawa A, Otani A, Saito M, Iida T, Matsuo K, Tajima K, Yamada R, Yoshimura N. 2010

[雑誌論文] Relationship between retinal sensitivity and morphologic changes in eyes with confluent soft drusen

Iwama D, Tsujikawa A, Ojima Y, Nakanishi H, Yamashiro K, Tamura H, OotoS, Yoshimura N 2010

[雑誌論文] Sterile endophthalmitis afterintravitreal injection of bevacizumabobtained from a single batch

Yamashiro K, Tsujikawa A, Miyamoto K, Oh H, Otani A, Tamuara H, Ooto S, Sasahara M, Iwama D, Yoshimura N. 2010

[雑誌論文] Single-nucleotide polymorphisms in the promoter region of matrix metal loproteinase-1, -2, and -3 in Japanese with high myopia.

Nakanishi H, Hayashi H, Yamada R, Yamashiro K, Nakata I, Shimada N, Ohno-Matsui K, Mochizuki M, Ozaki M, Yoshitake S, Kuriyama S, Saito M, Iida T, Matsuo K, Matsuda F, Yoshimura N. 2010

[雑誌論文] Joint effect of cigarette smoking and CFH and LOC387715/HTRA1 polymorphisms onpolypoidal choroidal vasculopathy

Nakanishi H, Yamashiro K, Yamada R, Gotoh N, Hayashi H, Nakata I, Saito M, Iida T, Oishi A, Kurimoto Y, Matsuo K, Tajima K, Matsuda F, Yoshimura N 2010

[雑誌論文] Macular hole formation following photodynamic therapy combined with intravitreal injection ofbevacizumab and triamcinolone acetonide

Iwama D, Ooto S, Tsujikawa A, Yamashiro K, Yoshimura N. 2010

[雑誌論文] Haplotype analysis of the ARMS2/HTRA1 region in Japanese patients with typical neovascular age-related macular degeneration or polypoidal choroidal vasculopathy.

Gotoh N, Yamashiro K, Nakanishi H, Saito M, Iida T, Yoshimura N. 2010

[雑誌論文] Joint effect of cigarette smoking and CFH and LOC387715/HTRA1 polymorphisms on polypoidal choroidal vasculopathy.

Nakanishi H, Yamashiro K, Yamada R, Gotoh N, Hayashi H, Nakata I, Saito M, Iida T, Oishi A, Kurimoto Y, Matsuo K, Tajima K, Matsuda F, Yoshimura N. 2010

[雑誌論文] Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration.

Chen W, Stambolian D, Edwards AO, Branham KE, Othman M, Jakobsdottir J, Tosakulwong N, Pericak-Vance MA, Campochiaro PA, Klein ML, Tan PL, Conley YP, Kanda A, Kopplin L, Li Y, Augustaitis KJ, Karoukis AJ, Scott WK, Agarwal A, Kovach JL, Schwartz SG, Postel EA, Brooks M, Baratz KH, Brown WL, Complications of Age-Related Macular Degeneration Prevention Trial Research Group, Brucker AJ, Orlin A, Brown G, Ho A, Regillo C, Donoso L, Tian L, Kaderli B, Hadley D, Hagstrom SA, Peachey NS, Klein R, Klein BE, Gotoh N, Yamashiro K, Ferris Iii F, Fagerness JA, Reynolds R, Farrer LA, Kim IK, Miller JW, Corton M, Carracedo A, Sanchez-Salorio M, Pugh EW, Doheny KF, Brion M, Deangelis MM, Weeks DE, Zack DJ, Chew EY, Heckenlively JR,, Yoshimura N, Iyengar SK, Francis PJ, Katsanis N, Seddon JM, Haines JL, Gorin MB, Abecasis GR, Swaroop A. 2010

[雑誌論文] High-resolution imaging of resolved central serous chorioretinopathy using adaptive optics scanning laser ophthalmoscopy.

Ooto S, Hangai M, Sakamoto A, Tsujikawa A, Yamashiro K, Ojima Y, Yamada Y, Mukai H, Oshima S, Inoue T, Yoshimura N. 2010

[雑誌論文] Intravitreal bevacizumab for type 1 idiopathic macular telangiectasia

Takayama K, Ooto S, Tamura H, Yamashiro K, Otani A, Tsujikawa A, Yoshimura N. 2010

[雑誌論文] Haplotypeanalysis of the ARMS2/HTRA1 region in Japanese patients with typicalneovascular age-related macular degeneration or polypoidal choroidal vasculopathy

Gotoh N, Yamashiro K, Nakanishi H, Saito M, Iida T, Yoshimura N 2010

[雑誌論文] Relationship between retinal sensitivity and morphologic changes in eyes with confluent soft drusen.

Iwama D, Tsujikawa A, Ojima Y, Nakanishi H, Yamashiro K, Tamura H, Ooto S, Yoshimura N. 2010

[雑誌論文] Thickness of photoreceptor layers in polypoidal choroidal vasculopathy and central serous chorioretinopathy.

Ooto S, Tsujikawa A, Mori S, Tamura H, Yamashiro K, Yoshimura N. 2010

[雑誌論文] Punctate hyperfluorescent spots associated with central serous chorioretinopathy as seen on indocyanine green angiography.

Tsujikawa A, Ojima Y, Yamashiro K, Ooto S, Tamura H, Nakagawa S, Yoshimura N. 2010

[雑誌論文] ARMS2/HTRA1 and CFH polymorphisms are not associated withchoroidal neovascularization in highly myopic eyes of the elderly Japanese population

Nakanishi H, Gotoh N, Yamada R, Yamashiro K, Otani A, Hayashi H, TsujikawaA, Shimada N, Ohno-Matsui K, Mochizuki M, Saito M, Saito K, Iida T, Matsuda F, Yoshimura N. 2010

[雑誌論文] Treatment of polypoidal choroidal vasculopathy byintravitreal injection of bevacizumab

Tsujikawa A, Ooto S, Yamashiro K, Tamura H, Otani A, Yoshimura N. 2010

[雑誌論文] High-resolution imaging of resolved central serous chorioretinopathy using adaptive optics scanning laserophthalmoscopy

Ooto S, Hangai M, Sakamoto A, Tsujikawa A, Yamashiro K, Ojima Y, Yamada Y, Mukai H, Oshima S, Inoue T, Yoshimura N 2010

[雑誌論文] Punctate hyper fluorescent spots associated with central serouschorioretinopathy as seen on indocyaninegreen angiography

Tsujikawa A, Ojima Y, Yamashiro K, Ooto S, Tamura H, Nakagawa S, Yoshimura N. 2010

[雑誌論文] Prognostic factors of vitreous hemorrhage secondary to exudative age-related macular degeneration

Hasegawa T, Otani A, Sasahara M, Gotoh N, Ooto S, Tamura H, Yamashiro K, Tsujikawa A, Yoshimura N. 2010

[雑誌論文] CFH and ARMS2variations in age-related macular degeneration, polypoidal choroidalvasculopathy, and retinal angiomatous proliferation

Hayashi H, Yamashiro K, Gotoh N, Nakanishi H, Nakata I, Tsujikawa A, OtaniA, Saito M, Iida T, Matsuo K, Tajima K, Yamada R, Yoshimura N. 2010

[雑誌論文] Macular hole formation following photodynamic therapy combined with intravitreal injection of bevacizumab and triamcinolone acetonide.

Iwama D, Ooto S, Tsujikawa A, Yamashiro K, Yoshimura N. 2010

[学会発表] 加齢黄斑変性に対するbevacizumab硝有子体内投与の治療効果とARMS2 A69S

仲田勇夫、山城健児、中西秀雄, 等 2009

[学会発表] ARMS2遺伝子A69S多型の迅速検出キットの開発および加齢黄斑変性診療における臨床応用

山城健児、後藤謙元、中西秀雄, 等 2009

[学会発表] ポリープ状脈絡膜血管症への光線力学療法の治療効果とARMS2 A69S多きちまはとの相関

林寿子、山城健児、中西秀雄, 等 2009