トップ›研究者を探す›同一病因遺伝子変異を持つ肥大型心筋症患者における病態修飾因子の検討

同一病因遺伝子変異を持つ肥大型心筋症患者における病態修飾因子の検討

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-20790533
研究種目 若手研究(B)
研究分野 生物系
医歯薬学
内科系臨床医学
循環器内科学
研究機関 高知大学
代表研究者 久保 亨
研究期間 開始年月日 2008/4/1
研究期間 終了年度 2010
研究ステータス 完了 (2010/4/1)
配分額（合計） 2,470,000 (直接経費 :1,900,000、間接経費 :570,000)
配分額（履歴） 2010年度：780,000 (直接経費 :600,000、間接経費 :180,000)
2009年度：780,000 (直接経費 :600,000、間接経費 :180,000)
2008年度：910,000 (直接経費 :700,000、間接経費 :210,000)
キーワード 臨床心血管病態学
肥大型心筋症
遺伝子
臨床

研究成果

[雑誌論文] Combined measurements of cardiac troponin I and brain natriuretic peptide are useful for predicting adverse outcome in hypertrophic cardiomyopathy.

Kubo T, Kitaoka H, Matsumura Y, 他9名 2011

[学会発表] Combined measurements of cardiac troponin I and brain natriuretic peptide are useful for predicting adverse outcomes in hypertrophic cardiomyopathy

Kubo T 2010

[学会発表] Combined measurements of cardiac troponin I and brain natriuretic peptide are useful for predicting adverse outcomes in hypertrophic cardiomyopathy

Kubo T 2010

[雑誌論文] A novel cardiac myosin-binding prote in C S297X mutation in hypertrophic cardiomyopathy.

Hirota T, Kubo T, Kitaoka H, 他8名 2010

[学会発表] Combined measurements of cardiac troponin I and brain natriuretic peptide are useful for predicting adverse outcomes in hypertrophic cardiomyopathy

Kubo T 2010

[図書] 循環器病学基礎と臨床

久保亨、大川真理、北岡裕章、土居義典, 他 2010

[図書] 循環病学基礎と臨床

久保亨、大川真理、北岡裕章、土居義典 2010

[雑誌論文] Hemolytic anemia in a patient with hypertrophic obstructive cardiomyopathy.

Kubo T, Kitaoka H, Terauchi Y, et al. 2010

[雑誌論文] Hypertrophic cardiomyopathy in the elderly.

Kubo T, Kitaoka H, Okawa M, Nishinaga M, Doi YL 2010

[雑誌論文] A frameshift deletion mutation in the cardiac myosin-binding protein C gene associated with dilated phase of hypertrophic cardiomyopathy and dilated cardiomyopathy.

Hitomi N, Kubo T, Kitaoka H, 他7名 2010

[雑誌論文] Hypertrophic cardiomyopathy in the elderly.

Kubo T, Kitaoka H, Okawa M, et al. 2010

[雑誌論文] Clinical features of dilated phase of hypertrophic cardiomyopathy in Comparison with those of dilated cardiomyopathy.

Hamada T, Kubo T, Kitaoka H, et al. 2010

[雑誌論文] Serum cardiac troponin I is related to increased left ventricular wall thickness, left ventricular dysfunction, and male gender in hypertrophy cardiomyopathy.

Kubo T, Kitaoka H, Okawa M, et al. 2010

[雑誌論文] Combined measurements of cardiac troponin I and brain natriuretic peptide are useful for predicting adverse outcome in hypertrophic cardiomyopathy

Kubo T, Kitaoka H, Okawa M, et al. 2010

[雑誌論文] A novel cardiac myosin-binding protein C S294X mutation in hypertrophic cardiomyopathy.

Hirota T, Kubo T, Kitaoka H, el al. 2010

[雑誌論文] Gender-specific differences in the clinical features of hypertrophic cardiomyopathy in a community-based Japanese population : results from Kochi RYOMA study.

Kubo T, Kitaoka H, Okawa M, et al. 2010

[雑誌論文] Clinical features of the dilated phase of hypertrophic cardiomyopathy in comparison with those of dilated cardiomyopathy.

Hamada T, Kubo T, Kitaoka H, 他10名 2010

[雑誌論文] Gender-specific differences in the clinical features of hypertrophic cardiomyopathy in a community-based Japanese population: results from Kochi RYOMA study.

Kubo T, Kitaoka H, Okawa M, 他6名 2010

[雑誌論文] Plasma adiponectin levels and left ventricular remodeling in hypertrophic cardiomyopathy.

Kitaoka H, Kubo T, Okawa M, et al. 2010

[図書] 循環器疾患最新の治療2010-2011

久保亨、土居義典, 他 2010

[雑誌論文] A novel cardiac myosin-binding protein C S294X mutation in hypertrophic cardiomyopathy.

Hirota T, Kubo T, Kitaoka H, et al. 2010

[雑誌論文] Plasma adiponectin levels and left ventricular remodeling in hypertrophic cardiomyopathy

Kitaoka H, Kubo T, Okawa M, 他4名 2010

[雑誌論文] Hemolytic anemia in a patient with hypertrophic obstructive cardiomyopathy.

Kubo T, Kitaoka H, Terauchi Y, 他5名 2010

[図書] 循環器疾患最新の治療2010-2011

久保亨、土居義典 2010

[雑誌論文] Serum cardiac troponin I is related to increased left ventricular wall thickness, left ventricular dysfunction, and male gender in hypertrophy cardiomyopathy

Kubo T, Kitaoka H, Okawa M, 他9名 2010

[雑誌論文] Clinical features of dilated phase of hypertrophic cardiomyopathy in Comparison with those of dilated cardiomyopathy.

Hamada T, Kubo T, Kitaoka H, et al. 2010

[雑誌論文] A frameshift deletion mutation in the cardiac myosin-binding protein C gene associated with dilated phase of hypertrophic cardiomyopathy and dilated cardiomyopathy.

Hitomi N, Kubo T, Kitaoka H, et al. 2010

[雑誌論文] Impact of metalloproteinases on left ventricular remodeling and heart failure events in patients with hypertrophic cardiomyopathy.

Kitaoka H, Kubo T, Okawa M, et al. 2010

[学会発表] Combined measurements of cardiac troponin I and brain natriuretic peptide are useful for predicting adverse outcomes in hypertrophic cardiomyopathy.

Kubo T 2010

[雑誌論文] Clinical profiles of hypertrophic cardiomyopathy with apical phenotype .comparison of pure-apical form and distal-dominant form.

Kubo T, Kitaoka H, Okawa M, 他9名 2009

[学会発表] Gender differences in the clinical features of hypertrophic cardiomyopathy in an unselected regional Japanese population: Results from Kochi RYOMA study

久保亨 2009

[雑誌論文] Cardiac ankyrin repeat protein gene (ANKRD1) mutations in hypertrophy cardiomyopathy.

Arimura T, Bos JM, Sato A, Kubo T, 他9名 2009

[学会発表] 地域在住高齢心筋症患者の病態に関する検討

久保亨 2009

[雑誌論文] Clinical impact of atrial fibrillation in patients with hypertrophic cardiomyopathy. Results fro Kochi RYOMA Study.

Kubo T, Kitaoka H, Okawa M, et al. 2009

[雑誌論文] Cardiac ankyrin repeat protein gene(ANKRD1)mutations in hypertrophic cardiomyopathy.

Arimura T, Bos JM, Sato A, Kubo T, et al. 2009

[学会発表] Cardiac troponin I is related to increased left ventricular wall thickness, left ventricular dysfunction and male gender in hypertrophic Cardiomyopathy.

Kubo T 2009

[雑誌論文] Clinical profiles of hypertrophic cardiomyopathy with apical phenotype : Comparison of pure-apical form and distal-dominant form.

Kubo T, Kitaoka H, Okawa M, et al. 2009

[雑誌論文] Utility of tissue Doppler imaging to predict exercise capacity in hypertrophic cardiomyopathy: comparison with B-type natriuretic peptide.

Kitaoka H, Kubo T, Okawa M, 他5名 2009

[学会発表] Gender differences in the clinical features of hypertrophic cardiomyopathy in an unselected regional Japanese population : Results from Kochi RYOMA study.

久保亨 2009

[雑誌論文] Clinical features of dilated phase of hypertrophic cardiomyopathy in comparison with those of dilated cardiomyopathy

Hamada T, KuboT, Kitaoka H, et.al. 2009

[学会発表] Cardiac troponin I is related to increased left ventricular wall thickness, left ventricular dysfunction and male gender in hypertrophic Cardiomyopathy

Kubo T 2009

[雑誌論文] Utility of tissue Doppler imaging to predict exercise capacity in hypertrophic cardioniyopathy : Comparison with B-type natriuretic peptide

Kitaoka H, Kubo T, Okawa M, et.al. 2009

[学会発表] Clinical profiles of hypertrophic cardiomyopathy with apical phenotype: comparison of pure-apical from and distal-dominant form

久保亨 2009

[雑誌論文] A case report : hemolytic anemia in a patient with hypertrophic obstructive cardiomyopathy

KuboT, Kitaoka H, Terauchi Y, et.al. 2009

[雑誌論文] Clinical impact of atrial fibrillation in patients with hypertrophic cardiomyopathy : results from Kochi RYOMA Study

Kubo T, Kitaoka H, Okawa M, et.al. 2009

[学会発表] 肥大型心筋症患者の病因遺伝子スクリーニング:重複遺伝子変異とその臨床的意義

久保亨 2009

[学会発表] Clinical profiles of hypertrophic cardiomyopathy with apical phenotype : comnarison of nure-anical from and distal-dominant form

久保亨 2009

[雑誌論文] Clinical impact of atrial fibrillation in patients with hypertrophic cardiomyopathy.Results from Kochi RYOMA Study

Kubo T, Kitaoka H, Okawa M, 他7名 2009

[雑誌論文] Utility of tissue Doppler imaging to predict exercise capacity in hypertrophic cardiomyopathy : comparison with B-type natriuretic peptide.

Kitaoka H, Kubo T, Okawa M, et al. 2009

[学会発表] 肥大型心筋症患者の病因遺伝子スクリーニング:重複遺伝子変異とその臨床的意義

久保亨 2009

[学会発表] Impact of atrial fibrillation in elderly patients with hypertrophic cardiomyopathy

Kubo T 2009

[学会発表] Genetic screening and compound mutations in patients with hypertrophic cardiomyopathy

久保亨 2009

[学会発表] Impact of atrial fibrillation in elderly patients with hypertrophic cardiomyopathy.

Kubo T 2009

[学会発表] Genetic screening and compound mutations in patients with hypertrophic cardiomyopathy

久保亨 2009

[学会発表] 地域在住高齢心筋症患者の病態に関する検討

久保亨 2009

[図書] 新しい診断と治療のABC心筋症

久保亨、北岡裕章、土居義典 2008

[雑誌論文] Hypertrophic cardiomyopathy with mild left ventricular remodeling : echocardiographic assessment using left ventricular wall motion score.

Hayato K, Okawa M, Matsumura Y, Kitaoka H, Kubo T, et.al. 2008

[図書] 新しい診断と治療のABC心筋症

久保亨、北岡裕章、土居義典, 他 2008

[雑誌論文] Hypertrophic cardiomyopathy with mild left ventricular remodeling: echocardiographic assessment using left ventricular wall motion score.

Hayato K, Okawa M, Matsumura Y, Kitaoka H, Kubo T, 他7名 2008

[図書] 循環器科循環器疾患の発症・増悪関連遺伝子最近の話題

久保亨、土居義典, 他 2008

[図書] 循環器科循環器疾患の発症・増悪関連遺伝子最近の話題

久保亨、土居義典 2008

[雑誌論文] Impact of metalloproteinases on left ventricular remodeling and heart failure events in patients with hypertrophic cardiomyopathy.

Kitaoka H, Kubo T, Okawa M, 他4名