トップ›研究者を探す›"生物学的等価性"に重点をおいた新規4'-セレノRNAの合成と性質・機能解析

"生物学的等価性"に重点をおいた新規4'-セレノRNAの合成と性質・機能解析

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-20611001
研究種目 基盤研究(C)
研究分野 ケミカルバイオロジー
研究機関 徳島大学
代表研究者 南川 典昭
研究期間 開始年月日 2008/4/1
研究期間 終了年度 2010
研究ステータス 完了 (2010/4/1)
配分額（合計） 4,420,000 (直接経費 :3,400,000、間接経費 :1,020,000)
配分額（履歴） 2010年度：1,300,000 (直接経費 :1,000,000、間接経費 :300,000)
2009年度：1,690,000 (直接経費 :1,300,000、間接経費 :390,000)
2008年度：1,430,000 (直接経費 :1,100,000、間接経費 :330,000)
キーワード ヌクレオシド
RNA
4'-セレノRNA
生物学的等価性
セレン

研究成果

[雑誌論文] Synthesis and properties of a novel nucleoside derivative possessing a 2,3,5,6-tetraazabenzo[cd]azulene skelton.

Y.Hirama, H.Abe, N.Minakawa, A.Matsuda 2010

[学会発表] Synthesis of 4'-selenoribonucleosides using hypervalent iodine

H.Taniike, Y.Inagaki, A.Matsuda, N.Minakawa 2010

[学会発表] Evaluation of potency and duration of gene silencing activity by siRNAs containing hybrid type of chemically modified nucleotides

M.Takahashi, C.Nagai, H.Hatakeyama, N.Minakawa, H.Harashima, A.Matsuda 2010

[学会発表] Convenient RNA synthesis using a phosphoramidite possessing a photocleavable group

N.Minakawa 2010

[雑誌論文] A convenient RNA synthesis using a phosphoramidite possessing a biotinylated photocleavable group.

K.Tomaya, M.Takahashi, N.Minakawa, A.Matsuda 2010

[学会発表] Unnatural imidazopyridopyrimidine : naphthyridine base pairs : selective incorporation and extension reaction by DNA polymerase.

N.Minakawa, S.Ogata, M.Takahashi, A.Matsuda 2009

[学会発表] Unnatural imidazopyridopyrimidine : naphthyridine base pairs : selective incorporation and extension reaction by DNA polymerase

N.Minakawa, et al. 2009

[雑誌論文] Synthesis and characterization of 2'-modified-4'-thioRNA : a comprehensive comparison of nuclease stability.

M.Takahashi, N.Minakawa, A.Matsuda 2009

[学会発表] Development od Chemical Probes to Investigate the Molecular Mechanism of RNAi

S.Ide, N.Minakawa, A.Matsuda 2009

[雑誌論文] Unnatural imidazopyridopyrimidine : naphthyridine base pairs : selective incorporation and extension reaction by DNA polymerase

N.Minakawa, et al. 2009

[雑誌論文] Selective recognition of unnatural imidazopyridopyrimidine : naphthyridine base pairs consisting of four hydrogen bonds by the Klenow fragment

N.Minakawa, et al. 2009

[雑誌論文] Selective recognition of unnatural imidazopyridopyrimidine : naphthyridine base pairs consisting of four hydrogen bonds by the Klenow fragment.

N.Minakawa, S.Ogata, M.Takahashi, A.Matsuda 2009

[学会発表] Synthesis and properties of 2'-modified-4'-thioRNA.

M.Takahashi, N.Minakawa, A.Matsuda 2008

[雑誌論文] Oligodeoxynucleotides containing 3-bromo-3-deazaadenine and 7-bromo-7-deazaadenine nucleosides as chemical probes to investigate DNA-protein interaction.

N.Minakawa, Y.Kawano, S.Murata, N.Inoue, A.Matsuda 2008

[学会発表] Synthesis and properties of oligonucleotides containing 4'-selenoribonucleosides.

Y.Inagaki, N.Minakawa, A.Matsuda 2008

[雑誌論文] Unxepected A-form formation of 4'-thioDNA in solution, revealed by NMR, and the implications as to the mechanism of nuclease-resistance.

A.Matsugami, T.Ohyama, M.Inada, N.Inoue, N.Minakawa, A.Matsuda, M.Katahira 2008