トップ研究者を探す心筋症の病因と病態進展機構の究明に関する縦断的研究

心筋症の病因と病態進展機構の究明に関する縦断的研究

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-20590827
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
内科系臨床医学
循環器内科学
研究機関 高知大学
代表研究者 土居 義典
研究分担者 北岡 裕章
研究分担者 松村 敬久
研究分担者 久保 亨
研究分担者 大川 真理
研究期間 開始年月日 2008/4/1
研究期間 終了年度 2011
研究ステータス 完了 (2011/4/1)
配分額(合計) 3,770,000 (直接経費 :2,900,000、間接経費 :870,000)
配分額(履歴) 2011年度:910,000 (直接経費 :700,000、間接経費 :210,000)
2010年度:910,000 (直接経費 :700,000、間接経費 :210,000)
2009年度:910,000 (直接経費 :700,000、間接経費 :210,000)
2008年度:1,040,000 (直接経費 :800,000、間接経費 :240,000)
キーワード 心筋症
遺伝子
臨床
予後
臨床心血管病態学

研究成果

[雑誌論文] Serum tenascin-C levels as a prognostic biomarker of heart failure events in patients with hypertrophic cardiomyopathy

Kitaoka H, Kubo T, Baba Y, Yamasak N, Matsumura Y, Furuno T, Doi YL 2012

[学会発表] Prognostic significance of high-sensitivity cardiac troponin T in hypertrophic cardiomyopathy

Kubo T 2012

[雑誌論文] Plasma metalloproteinase levels and left ventricular remodeling in hypertrophic cardiomyopathy in patients with an identical mutation

Kitaoka H, Kubo T, Okawa M, Takenaka N, Baba Y, et al 2011

[学会発表] Plasma tenescin-C level as a prognostic biomarker of heart failure events in patients with hypertrophic cardiomyopathy

Kitaoka H 2011

[学会発表] Plasma tenescin-C level as a prognostic biomarker of heart failure events in patients with hypertrophic cardiomyopathy

Kitaoka H 2011

[雑誌論文] Genetic screening and doublemutation in Japanese patients with hypertrophic cardiomyopathy

Kubo T, Kitaoka H, Okawa M, Baba Y, Hirota T, Hayato K, Yamasaki N, Matsumura Y, Otsuka H, Ariura A, Doi YL 2011

[雑誌論文] Combined measurements of cardiac troponin I and brain natriuretic peptide are useful for predicting adverse outcomes in hypertrophic cardiomyopathy

Kubo T, Kitaoka H, Okawa M, Yamanaka S, Hirota T, Baba Y, Hayato K, Yamasaki N, Matsumura Y, Yasuda N, Sugiura T, Doi YL 2011

[雑誌論文] Genetic screening and double mutation in Japanese patients with hypertrophic cardiomyopathy

Kubo T, Kitaoka H, Okawa M, Baba Y, Hirota T, et al 2011

[雑誌論文] Tissue Doppler imaging and plasma BNP levels to assess the prognosis in patients with hypertrophic cardiomyopathy

Kitaoka H, Kubo T, Okawa M, Takenaka N, Sakamoto C, Baba Y, Hayashi K, Yamasaki N, Matsumura Y, Doi YL 2011

[雑誌論文] Effect of left ventricular reverse remodeling on long-term prognosis after therapy with angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers and beta blockersin patients with idiopathic dilatedcardiomyopathy

Hoshikawa E, Matsumura Y, Kubo T, Okawa M, Yamasaki N, Kitaoka H, Furuno T, Takata J, Doi YL 2011

[学会発表] 血清心筋トロポニンI値はサルコメア遺伝子変異を有する肥大型心筋症患者の左室リモデリングと関連する

久保亨 2011

[学会発表] Elevation of serum cardiac troponin I is associated with left ventricular remodeling in hypertrophic cardiomyopathy caused by sarcomere gene mutations

Kubo T 2011

[雑誌論文] Effect of left ventricular reverse remodeling on long-term prognosis after therapy with angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers and beta blockers in patients with idiopathic dilated cardiomyopathy

Hoshikawa E, Matsumura Y, Kubo T, Okawa M, Yamasaki N, Kitaoka H, Furuno T, Takata J, Doi YL 2011

[雑誌論文] Plasma adiponectin levels and left ventricular remodeling in hypertrophic cardiomyopathy

Kitaoka H, Kubo T, Okawa M, Yamasaki N, Matsumura Y, Nishinaga M, Doi YL 2010

[雑誌論文] Clinical features of dilated phase of hypertrophic cardiomyopathy in Comparison with those of dilated cardiomyopathy

Hamada T, Kubo T, Kitaoka H, et al. 2010

[雑誌論文] Hemolytic anemia in a patient with hypertrophic obstructive cardiomyopathy

Kubo T, Kitaoka H, Terauchi Y, et al. 2010

[雑誌論文] Clinical features of dilated phase of hypertrophic cardiomyopathy in Comparison with those of dilated cardiomyopathy.

Hamada T, Kubo T, Kitaoka H, et al. 2010

[雑誌論文] A frameshift deletion mutation in the cardiac myosin-binding protein C gene associated with dilated phase of hypertrophic cardiomyopathy and dilated cardiomyopathy.

Hitomi N, Kubo T, Kitaoka H, et al. 2010

[雑誌論文] Combined measurements of cardiac troponin I and brain natriuretic peptide are useful for predicting adverse outcome in hypertrophic cardiomyopathy.

Kubo T, Kitaoka H, Okawa M, et al. 2010

[雑誌論文] Gender-specific differences in the clinical features of hypertrophic cardiomyopathy in a community-based Japanese population : results from Kochi RYOMA study.

Kubo T, Kitaoka H, Okawa, M, et al. 2010

[雑誌論文] Hypertrophic cardiomyopathy in the elderly. Geriatrics and Gerontology

Kubo T, Kitaoka H, Okawa M, Nishinaga M, Doi YL 2010

[図書] 循環器病学 基礎と臨床

久保亨・大川真理・北岡裕章・土居義典 2010

[雑誌論文] Serum cardiac troponin I is related to increased left ventricular wall thickness, left ventricular dysfunction, and male gender in hypertrophy cardiomyopathy

Kubo T, Kitaoka H, Okawa M, et al. 2010

[雑誌論文] Impact of metalloproteinases on left ventricular remodeling and heart failure events in patients with hypertrophic cardiomyopathy.

Kitaoka H, Kubo T, Okawa M, et al. 2010

[雑誌論文] Impact of metalloproteinases on left ventricular remodeling and heart failure events in patients with hypertrophic cardiomyopathy

Kitaoka H, Kubo T, Okawa M, Hayato K, Yamasaki N, Matsumura Y, Doi YL 2010

[図書] 循環病学 基礎と臨床

久保亨、大川真理、北岡裕章、土居義典 2010

[雑誌論文] Plasma adiponectin levels and left ventricular remodeling in hypertro phic cardiomyopathy

Kitaoka H, Kubo T, Matsumura Y, Doi Y L 2010

[雑誌論文] Clinical features of dilated phase of hypertrophic cardiomyopathy in comparison with those of dilated cardiomyopathy

Hamada T, Kubo T, Kitaoka H, Hirota T, Hoshikawa E, Hayato K, Shimizu Y, Okawa M, Yamasaki N, Matsumura Y, Yabe T, Takata J, Doi YL 2010

[雑誌論文] A novel cardiac myosin-binding protein C S294X mutation in hypertrophic cardiomyopathy.

Hirota T, Kubo T, Kitaoka H, et al. 2010

[雑誌論文] A novel cardiac myosin-binding protein C S294X mutation in hypertrophic cardiomyopathy

Hirota T, Kubo T, Kitaoka H, et al. 2010

[学会発表] Tissue Doppler imaging combined with plasma BNP levels to assess the prognosis of hypertrophic cardiomyopathy

Kitaoka H 2010

[学会発表] Multi-biomarkers and left ventricular remodeling in hypertrophic Cardiomyopathy

Kitaoka H 2010

[雑誌論文] Hypertrophic cardiomyopathy in the elderly

Kubo T, Kitaoka H, Okawa M, et al. 2010

[雑誌論文] Serum cardiac troponin I is related to increased left ventricular wall thickness, left ventricular dysfuncti on, and male gender in hypertrophy card iomyopathy

Kubo T, Kitaoka H, Matsumura Y, Doi Y L 2010

[雑誌論文] Plasma adiponectin levels and left ventricular remodeling in hypertrophic cardiomyopathy

Kitaoka H, Kubo T, Okawa M, et al. 2010

[雑誌論文] Combined measurements of cardiac troponin I and brain natriuretic peptide are useful for predicting adverse outcome in hypertrophic cardiomyopathy

Kubo T, Kitaoka H, Matsumura Y, Doi Y L 2010

[図書] 循環病学基礎と臨床

久保亨, 大川真理, 北岡裕章, 土居義典 2010

[学会発表] Tissue Doppler imaging combined with plasma BNP levels to assess the prognosis of hypertrophic cardiomyopathy

Kitaoka H 2010

[雑誌論文] Impact of metalloproteinases on left ventricular remodeling and heart failure events in patients with hypert rophic cardiomyopathy

Kitaoka H, Kubo T, Matsumura Y, Doi Y L 2010

[学会発表] Tissue Doppler imaging combined with plasma BNP levels to assess the prognosis of hypertrophic cardiomyopathy.

Kitaoka H 2010

[雑誌論文] Gender-specific differences in the clinical features of hypertrophic cardiomyopathy in a community-basedJapanese population : results from Kochi RYOMA study

Kubo T, Kitaoka H, Okawa M, Hirota T, Hayato K, Yamasaki N, Matsumura Y, Yabe T, Doi YL 2010

[雑誌論文] Serum cardiac troponin I is related to increased left ventricular wall thickness

Kubo T, Kitaoka H, Okawa M, Yamanaka S, Hirota T, Hoshikawa E, Hayato K, Yamasaki N, Matsumura Y, Yasuda N, Sugiura T, Doi YL 2010

[図書] 循環器疾患 最新の治療2010-2011

久保亨、土居義典 2010

[学会発表] Combined measurements of cardiac troponin I and brain natriuretic peptide are useful for predicting adverse outcomes in hypertrophic cardiomyopathy.

Kubo T 2010

[学会発表] Combined measurements of cardiac troponin I and brain natriuretic peptide are useful for predicting adverse outcomes in hypertrophic cardiomyopathy

Kubo T 2010

[学会発表] Combined measurements of cardiac troponin I and brain natriuretic peptide are useful for predicting adverse outcomes in hypertrophic cardiomyopathy

久保亨 2010

[図書] 循環器疾患 最新の治療22010-2011

久保亨・土居義典 2010

[図書] 循環器疾患最新の治療

久保亨, 土居義典 2010

[学会発表] Metalloproteinases and left ventricular remodeling in hypertrophic cardiomyopathy caused by an identical mutation in the cardiac myosin-binding protein C gene.

Kitaoka H 2010

[学会発表] Metalloproteinases and left ventricular remodeling in hypertrophic cardiomyopathy caused by an identical mutation in the cardiac myosin-binding protein C gene

Kitaoka H 2010

[学会発表] Multi-biomarkers and left ventricular remodeling in hypertrophic cardiomyopathy

Kitaoka H 2009

[雑誌論文] Clinical impact of atrial fibrillation in patients with hypertrophic cardiomyopathy

Kubo T, Kitaoka H, Okawa M, Hirota T, Hayato K, Yamasaki N, Matsumura Y, Yabe T, Takata J, Doi YL 2009

[雑誌論文] Utility of tissue Doppler imaging to predict exercise capacity in hypertrophic cardiomyopathy : Comparison with B-type natriuretic peptide

Kitaoka H, Kubo T, Okawa M, et al. 2009

[学会発表] 肥大型心筋症の左室リモデリングにおけるマトリックスメタロプロテアーゼの重要性

北岡裕章 2009

[雑誌論文] Clinical impact of atrial fibrillation in patients with hypertrophic cardiomyopathy : results from Kochi RYOMA Study

Kubo T, Kitaoka H, Okawa M, et al. 2009

[雑誌論文] Clinical profiles of hypertrophic cardiomyopathy with apical phenotype : Comparison of pure-apical form and distal-dominant form

Kubo T, Kitaoka H, Okawa M, Hirota T, Hoshikawa E, Hayato K, Yamasaki N, Matsumura Y, Yabe T, Nishinaga M, Takata J, Doi YL 2009

[学会発表] Impact of metalloproteinases on LV remodeling and prognosis in hypertrophic cardiomyopathy

Kitaoka H 2009

[雑誌論文] Clinical impact of atrial fibril lation in patients with hypertrophic cardiomyopathy. Results fro Kochi RYOMA Study

Kubo T, Kitaoka H, Matsumura Y, Doi YL 2009

[雑誌論文] Clinical features of dilated phase of hypertrophic cardiomyopathy in comparison with those of dilated cardiomyopathy

Hamada T, KuboT, Kitaoka H, et al. 2009

[学会発表] Impact of metalloproteinases on LV remodeling and prognosis in hypertrophic cardiomyopathy

北岡裕章 2009

[雑誌論文] Utility of tissue Doppler imaging to predict exercise capacity in hypertrophic cardiomyopathy : comparison with B-type natriuretic peptide

Kitaoka H, Kubo T, Okawa M, et al. 2009

[雑誌論文] Clinical impact of atrial fibrillation in patients with hypertrophic cardiomyopathy. Results fro Kochi RYOMA Study

Kubo T, Kitaoka H, Okawa M, et al. 2009

[雑誌論文] Clinical profiles of hypertrophic cardiomyopathy with apical phenotype : Comparison of pure-apical form and distal-dominant form

Kubo T, Kitaoka H, Okawa M, et al. 2009

[雑誌論文] A case report : hemolytic anemia in a patient with hypertrophic obstructive cardiomyopathy

KuboT, Kitaoka H, Terauchi Y, et al. 2009

[学会発表] 地域在住高齢心筋症患者の病態に関する検討

久保亨 2009

[学会発表] Gender differences in the clinical features of hypertrophic cardiomyopathy in an unselected regional Japanese population : Results from Kochi RYOMA study

久保亨 2009

[学会発表] Clinical profiles of hypertrophic cardiomyopathy with apical phenotype : comparison of pure-apical from and distal-dominant form

久保亨 2009

[学会発表] 肥大型心筋症患者の病因遺伝子スクリーニング:重複遺伝子変異とその臨床的意義

久保亨 2009

[学会発表] Cardiac troponin I is related to increased left ventricular wall thickness, left ventricular dysfunction and male gender in hypertrophic Cardiomyopathy

Kubo T 2009

[学会発表] Impact of atrial fibrillation in elderly patients with hypertrophic cardiomyopathy

Kubo T 2009

[学会発表] Genetic screening and compound mutations in patients with hypertrophic cardiomyopathy

久保亨 2009

[学会発表] 肥大型心筋症患者の病因遺伝子スクリーニング:重複遺伝子変異とその臨床的意義

久保亨 2009

[学会発表] 地域在住高齢心筋症患者の病態に関する検討

久保亨 2009

[雑誌論文] Hypertrophic cardiomyopathy with mild left ventricular remodeling : echocardiographic assessment usingleft ventricular wall motion score

Hayato K, Okawa M, Matsumura Y, Kitaoka H, Kubo T, Hitomi N, Yamasaki N, Yabe T, Furuno T, Takata J, Nishinaga M, Doi YL 2008

[図書] 新しい診断と治療のABC 心筋症

久保亨, 北岡裕章, 土居義典 2008

[雑誌論文] Hypertrophic cardiomyopathy with mild left ventricular remodeling : echocardiographic assessment using left ventricular wall motion score.

Hayato K, Okawa M, Matsumura Y, Kitaoka H, Kubo T, et al. 2008

[雑誌論文] Improvement in prognosis of dilated cardiomyopathy in the elderly over the past 20 years

Kubo T, Matsumura Y, Kitaoka H, Okawa M, Hirota T, Hamada T, Hitomi N, Hoshikawa E, Hayato K, Shimizu Y, Yamasaki N, Yabe T, Nishinaga M, Takata J, Doi Y 2008

[雑誌論文] Improvement in prognosis of dilated cardiomyopathy in the elderly over the past 20 years.

Kubo T, Matsumura Y, Kitaoka H, et al. 2008

[図書] 循環器科 循環器疾患の発症・増悪関連遺伝子 最近の話題

久保亨, 土居義典 2008

[図書] 心エコー 心筋症を診る 拡張型心筋症 収縮予備能を診る

松村敬久, 土居義典 2008