トップ›研究者を探す›自己免疫性膵炎および硬化性胆管炎における発症機序と進展に関する免疫学的研究

自己免疫性膵炎および硬化性胆管炎における発症機序と進展に関する免疫学的研究

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-20590810
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
内科系臨床医学
消化器内科学
研究機関 関西医科大学
代表研究者 岡崎 和一
研究分担者 松崎 恒一
研究分担者 内田 一茂
研究期間 開始年月日 2008/4/1
研究期間 終了年度 2010
研究ステータス 完了 (2010/4/1)
配分額（合計） 4,550,000 (直接経費 :3,500,000、間接経費 :1,050,000)
配分額（履歴） 2010年度：910,000 (直接経費 :700,000、間接経費 :210,000)
2009年度：1,690,000 (直接経費 :1,300,000、間接経費 :390,000)
2008年度：1,950,000 (直接経費 :1,500,000、間接経費 :450,000)
キーワード 自己免疫性膵炎
IgG4
硬化性胆管炎
動物モデル
制御性T細胞
IL-10
Th17
原発性硬化性胆管炎

研究成果

[雑誌論文] Endoscopic retrograde pancreatography criteria to diagnose autoimmune pancreatitis : an international multicentre study.

Sugumar A, Levy MJ, Kamisawa T, J M Webster G, Kim MH, Enders F, Amin Z, Baron TH, Chapman MH, Church NI, Clain JE, Egawa N, Johnson GJ, Okazaki K, Pearson RK, Pereira SP, Petersen BT, Read S, Sah RP, Sandanayake NS, Takahashi N, Topazian MD, Uchida K, Vege SS, Chari ST 2011

[雑誌論文] Comparison of steroid pulse therapy and conventional oral steroid therapy as initial treatment for autoimmune pancreatitis.

Tomiyama T, Uchida K, Matsushita M, Ikeura T, Fukui T, Takaoka M, Nishio A, Okazaki K. 2011

[雑誌論文] Recent advances in the concept and diagnosis of autoimmune pancreatitis and IgG4-related disease.

Okazaki K, Uchida K, Koyabu M, Miyoshi H, Takaoka M 2011

[雑誌論文] The Role of Innate Immunity in the Pathogenesis of Experimental Autoimmune Pancreatitis in Mice.

Nishio A, Asada M, Uchida K, Fukui T, Chiba T, Okazaki K 2011

[学会発表] Analysis of ICOS and IL-10 positive regulatory T cells in patients with autoimmune pancreatitis.

K Uchida, T Kusuda, K Okazaki, et al. 2010

[学会発表] Involvement of ICOS and IL-10 positive regulatory T cells in the development of autoimmune pancreatitis.

Kazushige Uchida, Takeo Kusuda, Masanori Koyabu, Kazuichi Okazaki, et al 2010

[雑誌論文] Analysis of humoral immune response in experimental autoimmune pancreatitis in mice.

Asada M, Nishio A, Akamatsu T, Tanaka J, Saga K, Kido M, Watanabe N, Uchida K, Fukui T, Okazaki K, Chiba T 2010

[学会発表] Analysis of ICOS and IL-10 positive regulatory T cells in patients with autoimmune pancreatitis.

K Uchida, T Kusuda, K Okazaki, et al 2010

[学会発表] Possible role of regulatory T cells in producing IgG4 in the involved organs with autoimmune pancreatitis.

Koyabu M, Uchida K, Okazaki K, et al 2010

[雑誌論文] Analysis of regulatory T cells and IgG4-positive plasma cells among patients of IgG4-related sclerosing cholangitis and autoimmune liver diseases.

Koyabu M, Uchida K, Miyoshi H, Sakaguchi Y, Fukui T, Ikeda H, Takaoka M, Hirohara J, Nishio A, Uemura Y, Uemoto S, Okazaki K 2010

[学会発表] Involvement of ICOS and IL-10 positive regulatory T cells in the development of autoimmune pancreatitis.

Uchida K, Kusuda T, Koyabu M, Okazaki K, et al. 2010

[学会発表] 自験例よりみた自己免疫性膵炎の治療法とその予後

内田一茂、岡崎和一 2010

[学会発表] Relationship between T cells and IgG4-positive plasma cells in the involved.

K.Uchida, M.Koyabu, T.Kusuda, H.K.Okazaki, et al. 2010

[学会発表] Possible role of regulatory T cells in producing IgG4 in the involved organs with autoimmune pancreatitis.

Koyabu M, Uchida K, Okazaki, K, et al. 2010

[学会発表] 自己免疫性膵炎をめぐる新たな展開自己免疫性膵炎(AIP-LPSP)と好中球病変(IDCP)の免疫学的相違に関する検討

楠田武生, 内田一茂, 岡崎和一 2010

[雑誌論文] Autoimmune pancreatitis- a new evolving pancreatic disease?

Okazaki K, Uchida K, Fukui T, Takaoka M, Nishio A 2010

[雑誌論文] Idiopathic Duct-Centric Pancreatitis (IDCP) with Immunological Studies.

Kusuda T, Uchida K, Okazaki K, et al. 2010

[雑誌論文] Recent Concepts of Autoimmune Pancreatitis and IgG4-Related Disease.

Okazaki K, Uchida K, Miyoshi H, Ikeura T, Takaoka M, Nishio A 2010

[学会発表] 自己免疫性膵炎をめぐる新たな展開自己免疫性膵炎(AIP-LPSP)と好中球病変(IDCP)の免疫学的相違に関する検討

楠田武生,内田一茂,岡崎和一 2010

[雑誌論文] Primary sclerosing cholangitis with elevated serum IgG4 levels and/or infiltration of abundant IgG4-positive plasma cells.

Koyabu M, Uchida K, Fukata N, Kusuda T, Ikeura T, Sakaguchi Y, Yoshida K, Shimatani M, Fukui T, Matsushita M, Uemura Y, Kaibori M, Takaoka M, Nishio A, Okazaki K 2010

[雑誌論文] Idiopathic duct-centric pancreatitis (IDCP) with immunological studies.

Kusuda T, Uchida K, Satoi S, Koyabu M, Fukata N, Miyoshi H, Ikeura T, Sakaguchi Y, Yoshida K, Fukui T, Shimatani M, Matsushita M, Takaoka M, Nishio A, Uemura Y, Kwon AH, Okazaki K 2010

[雑誌論文] Primary sclerosing cholangitis with elevated serum IgG4 levels and/or infiltration of abundant IgG4-positive plasma cells.

Koyabu M, Uchida K, Okazaki K, et al. 2010

[学会発表] 自験例よりみた自己免疫性膵炎の治療法とその予後

内田一茂、岡崎和一 2010

[学会発表] Relationship between T cells and IgG4-positive plasma cells in the involved.

K.Uchida, M.Koyabu, T.Kusuda, H.K.Okazaki, et al. 2010

[図書] 見て診て学ぶ膵腫瘍の画像診断

岡崎和一、内田一茂、福井寿朗 2009

[雑誌論文] Atypical retroperitoneal fibrosis associated with biliary stricture : IgG4-related sclerosing disease?

Matsushita M, Fukui T, Uchida K, Nishio A, Okazaki K 2009

[学会発表] Regulatory T cells in patients with autoimmune pancreatitis.

Uchida K, Miyoshi H, Okazaki K, et al 2009

[学会発表] 自己免疫性膵炎における制御性T細胞に関する検討

内田一茂,楠田武生、岡崎和一 2009

[学会発表] 自己免疫性膵炎における制御性T細胞とIgG4に関する検討

内田一茂、小薮雅紀、楠田武夫、三好秀明、坂口雄沢、西尾彰功、岡崎和一 2009

[雑誌論文] Long-term outcome of autoimmune pancreatitis

Uchida K, et al.(12人中12番目) 2009

[学会発表] Analysis of CD4+CD25high regulatory T cells in patients with autoimmune pancreatitis.

Uchida K, Miyoshi H, Okazaki K, et al 2009

[雑誌論文] Long-term outcome of autoimmune pancreatitis.

Uchida K, Yazumi S, Nishio A, Kusuda T, Koyabu M, Fukata M, Miyoshi H, Sakaguchi Y, Fukui T, Matsushita M, Takaoka M, Okazaki K 2009

[雑誌論文] The Wistar Bonn Kobori rat, a unique animal model for autoimmune pancreatitis with extrapancreatic exocrinopathy.

Sakaguchi Y, Inaba M, Tsuda M, Quan GK, Omae M, Ando Y, Uchida K, Okazaki K, Ikehara S. 2008

[雑誌論文] Recent advances in autoimmune pancreatitis : concept, diagnosis, and pathogenesis.

Okazaki K, Uchida K, Fukui T. 2008

[雑誌論文] Circulating naive and CD4+CD25high regulatory T cells in patients with autoimmune pancreatitis.

Miyoshi H, Uchida K, Taniguchi T, Yazumi S, Matsushita M, Takaoka M, Okazaki K. 2008

[学会発表] Analysis of regulatory T cells in patients with autoimmune pancreatitis.

Miyoshi H, K uchida, M Matsushita, M Takaoka, K Okazaki. 2008

[雑誌論文] Pancreatic cancer associated with autoimmune pancreatitis in remission.

Fukui T, Mitsuyama T, Takaoka M, Uchida K, Matsushita M, Okazaki K. 2008