トップ›研究者を探す›脂肪肝グラフト部分肝移植における機能不全の解明と統合的治療法の開発

脂肪肝グラフト部分肝移植における機能不全の解明と統合的治療法の開発

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-20390359
研究種目 基盤研究(B)
研究分野 生物系
医歯薬学
外科系臨床医学
消化器外科学
研究機関 徳島大学
代表研究者 島田 光生
研究分担者 安友 康二
研究分担者 田中 真二
研究分担者 中村 隆範
研究分担者 居村 暁
研究分担者 森根 裕二
研究分担者 武田 英二
研究分担者 宇都宮 徹
研究分担者 池本 哲也
研究期間 開始年月日 2008/4/1
研究期間 終了年度 2010
研究ステータス 完了 (2010/4/1)
配分額（合計） 19,760,000 (直接経費 :15,200,000、間接経費 :4,560,000)
配分額（履歴） 2010年度：3,640,000 (直接経費 :2,800,000、間接経費 :840,000)
2009年度：4,160,000 (直接経費 :3,200,000、間接経費 :960,000)
2008年度：11,960,000 (直接経費 :9,200,000、間接経費 :2,760,000)
キーワード 肝不全
肝移植
脂肪肝
肝虚血再灌流傷害
虚血再潅流傷害
大量肝切除術

研究成果

[雑誌論文] Human adipose-derived stem cells : potential clinical applications in surgery.

Utsunomiya T, Shimada M 2011

[雑誌論文] Impact of a New Refrigerator for the Preservation of Whole Blood.

Kanamoto M, Shimada M 2011

[雑誌論文] The Impact of Pegylated-Interferon alpha-2b on Partial and Massive Hepatectomy Model in Rats.

Mori H, Shimada M 2011

[雑誌論文] Role of dihydropyrimidine dehydrogenase and thymidylate synthase expression in immunohistochemistry of intrahepatic cholangiocarcinoma.

Nishi M, Shimada M 2011

[雑誌論文] Beneficial Effects of Follistatin in Hepatic Ischemia-Reperfusion Injuries in Rats.

Kanamoto M, Shimada M 2011

[雑誌論文] Effects of Pegylated Interferon α2b on Metastasis of Hepatocellular Carcinoma.

Arakawa Y, Shimada M 2011

[雑誌論文] New stepwise cooling system for short-term porcine islet preservation.

Ikemoto T, Shimada M 2010

[雑誌論文] Impact of splenectomy in patients with liver cirrhosis : Results from 18 patients in a single center experience.

Imura S, et al. 2010

[雑誌論文] Impact of splenectomy in patients with liver cirrhosis : Results from 18 patients in a single center experience.

Imura S, Shimada M 2010

[雑誌論文] Notch2 signaling is required for potent antitumor immunity in vivo.

Sugimoto K, Shimada M 2010

[雑誌論文] Effect of long-term late-evening snack on health-related quality of life in cirrhotic patients.

Yamanaka-Okumura H, Shimada M 2010

[雑誌論文] High expression of Toll-like receptor 4/myeloid differentiation factor 88 signals correlates with poor prognosis in colorectal cancer.

Wang EL, Shimada M 2010

[学会発表] Advances in the Liver Cancer Surgery.

Shimada M. 2010

[雑誌論文] Molecular signatures of noncancerous liver tissue can predict the risk for late recurrence of hepatocellular carcinoma.

Utsunomiya T, Shimada M 2010

[学会発表] Small for size syndrome in liver transplantation.

Shimada M. 2010

[雑誌論文] CD133 expression is a potential prognostic indicator in intrahepatic cholangio-carcinoma.

島田光生 2010

[学会発表] ABO-incompatible living donor liver transplantation for HCV-positive recipients.

Shimada M. 2010

[学会発表] ABO-incompatible living donor liver transplantation for HCV-positive recipients.

Shimada M 2010

[雑誌論文] 性差による肝胆膵疾患の臨床、病態、治療効果のDiscrepancy I.性差と各種肝疾患7)肝移植と性差

島田光生, et al. 2010

[雑誌論文] 肝疾患に対する脾摘・PSEの功罪肝切除と脾臓過小グラフト(Small-for-size-graft)に対する治療戦略門脈循環制御における脾摘の有用性

島田光生, et al. 2010

[雑誌論文] Living donor liver transplantation using a left hepatic graft from a donor with a history of gastric cancer operation.

Uchiyama H, Shimada M 2010

[雑誌論文] 肝移植の画診断-生体ドナーの安全とレシピエントの予後向上をめざして-肝移植後の血栓、血管狭窄の診断と治療

島田光生, et al. 2010

[雑誌論文] Gene-expression phenotypes for vascular invasiveness of hepatocellular carcinomas.

Tanaka S, Shimada M 2010

[雑誌論文] Notch signaling drives IL-22 secretion in CD4+ T cells by stimulating the aryl hydrocarbon receptor.

Alam MS, Shimada M 2010

[学会発表] Small for size syndrome in liver transplantation.

Shimada M 2010

[学会発表] Timing of salvage transplantation after primary hepatectomy for hepatocellular carcinoma : a special reference to recurrence pattern and Up-to-7 criteria.

Utsunomiya T, Shimada M, et al. 2010

[学会発表] Impact of left lobe graft on adult-to-adult living donor liver transplantation.

Imura S, Shimada M, et al. 2009

[雑誌論文] Real-Time Elastography for noninvasive diagnosis of hepatic fibrosis.

Kanamoto M, Shimada M, Ikegami T, Imura S, Morine Y, Kanemura H, Arakawa Y, Nii A. 2009

[学会発表] Impact of left lobe graft on adult-to-adult living donor liver transplantation.

Imura S, Shimada M, et al. 2009

[雑誌論文] Geranylgeranylacetone prevents acute liver damage after massive hepatectomy in rats through suppression of a CXC chemokine GR01 and induction of heat shock proteins.

Kanemura H, Shimada M 2009

[雑誌論文] Real time elastography for noninvasive diagnosis of liver fibrosis.

Kanamoto M, Shimada M 2009

[雑誌論文] 高度進行肝癌に対する外科的アプローチミラノ基準外症例に対する肝移植

島田光生, et al. 2009

[学会発表] The usefulness of a new refrigerator for preservation of whole blood.

Kanamoto M, Shimada M, et al. 2009

[学会発表] Congestion of remnant liver after procurement of an extended left lobe graft in live donor.

Shimada M. 2009

[雑誌論文] Dual hepatic artery reconstruction in living donor liver transplantation using a left hepatic graft with 2 hepatic arterial stumps.

Uchiyama H, Shimada M 2009

[雑誌論文] Significance of dihydropyrimidine dehydrogenase and thymidylate synthase mRNA expressions in hepatocellular carcinoma.

Nii A, Shimada M 2009

[雑誌論文] Beneficial effects of splenectomy on massive hepatectomy model in rats.

Arakawa Y, Shimada M 2009

[学会発表] Congestion of remnant liver after procurement of an extended left lobe graft in live donor.

Shimada M. 2009

[雑誌論文] The changes of the medial right lobe, transplanted with left lobe liver graft from living donors.

Ikegami T, Shimada M 2009

[学会発表] Pathogenesis-oriented strategy for small-for-size graft in living donor adult liver transplantation.

Shimada M. 2009

[雑誌論文] A simple formula to calculate the liver drainage volume of the accessory right hepatic vein using its diameter alone.

Hanaoka J, Shimada M 2009

[雑誌論文] Argon gas embolism in the application of laparoscopic microwave coagulation therapy.

Ikegami T, Shimada M 2009

[学会発表] Pathogenesis-oriented strategy for small-for-size graft in living donor adult liver transplantation.

Shimada M.(招待) 2009

[雑誌論文] Surgical contribution to recurrence-free survival in patients with macrovascular-invasion- negative hepatocellular carcinoma.

Tanaka S, Shimada M 2009

[雑誌論文] Optimal administration of tacrolimus in reduced-size liver.

Morine Y, Shimada M 2009

[学会発表] Effect of Kampo medicine 'Dai-kenchu-to' on portal blood flow in living donor liver transplant recipients.

Kawata Y, Shimada M, et al. 2009

[雑誌論文] Hypocaloric high-protein diet improves fatty liver and hypertriglyceridemia in sucrose-fed obese rats via two pathways.

Takeda E. 2009

[雑誌論文] Optimal administration of tacrolimus in reduced-size liver.

Morine Y,. 2009

[雑誌論文] Strategies for improving the outcomes of small-for-size grafts in adult-to-adult living-donor liver transplantation.

Imura S, Shimada M 2008

[雑誌論文] Spontaneous retroperitoneal massive hematoma after living-donor liver transplantation : an unpredictable but critical complication.

Imura S, Shimada M 2008

[雑誌論文] A new technique to acquire additional liver volume for left lobe graft in living donor liver transplantation.

Imura S, Shimada M 2008

[雑誌論文] Influence of Dai-kenchu-to (DKT) on human portal blood flow.

Ogasawara T, Shimada M 2008

[雑誌論文] Biliary reconstruction in right lobe living donor liver transplantation.

Ikegami T, Shimada M 2008

[学会発表] Our strategies for breaking the barrier of blood type incompatibility in living donor liver transplantation.

Uchiyama H, Shimada M, et al. 2008

[雑誌論文] Current concept of small-for-size grafts in living donor liver transplantation.

Ikegami T, Shimada M 2008

[雑誌論文] Beneficial use of the round ligament as a patch graft for vena cava reconstruction.

Ikegami T, Shimada M 2008

[雑誌論文] Recent role of splenectomy in chronic hepatic disorders.

Ikegami T, Shimada M 2008

[学会発表] Serial change of nutritional and metabolic status in Living donor liver transplant recipients.

Shimada M. 2008

[雑誌論文] Beneficial effects of fluvastatin on liver microcirculation and regeneration after massive hepatectomy in rats.

Tokunaga T, Shimada M 2008

[雑誌論文] Beneficial effects of Kampo medicine Inchin-ko-to on liver function and regeneration after hepatectomy in rats.

Ogasawara T, Shimada M 2008

[雑誌論文] The timing of liver transplantation after primary hepatectomy for hepatocellular carcinoma : a special reference to recurrence pattern and Milan criteria.

Ikegami T, Shimada M 2008

[学会発表] Effect of mhn-02 on ischemia-reperfusion injury in rat liver.

Hanaoka J, Shimada M, et al. 2008