研究成果

[雑誌論文] Acute down-regulation of sodium-dependent phosphate transporter NPT2a involves predominantly the cAMP/PKA pathway as revealed by signaling-selective parathyroid hormone analogs.

Nagai S, Okazaki M, Segawa H, Bergwitz C, Dean T, Potts JT Jr, Mahon MJ, Gardella TJ, Juppner H. 2011

[雑誌論文] Sodium-dependent phosphate cotransporters : Lessons from gene knockout and mutation studies.

Miyamoto KI, Haito-Sugino S, Kuwahara S, Ohi A, Nomura K, Ito M, Kuwahata M, Kido S, Tatsumi S, Kaneko I, Segawa H. 2011

[雑誌論文] Transgenic overexpression of the extra-large Gsα variant XL αs enhances Gsα-mediated responses in the mouse renal proximal tubule in vivo.

Liu Z, Segawa H, Aydin C, Reyes M, Erben RG, Weinstein LS, Chen M, Marshansky V, Frohlich LF, Bastepe M. 2011

[雑誌論文] Hypophosphatemia in vitamin D receptor null mice : effect of rescue diet on the developmental changes in renal Na+ -dependent phosphate cotransporters.

Kaneko I, Segawa H, Furutani J, Kuwahara S, Aranami F, Hanabusa E, Tominaga R, Giral H, Caldas Y, Levi M, Kato S, Miyamoto K. 2011

[雑誌論文] Source matters : from phosphorus load to bioavailability.

Fukagawa M, Komaba H, Miyamoto K. 2011

[学会発表] 高リン血症治療の標的分子探索:腸管リントランスポーターノックアウトマウスの解析

瀬川博子 2010

[学会発表] PTH-Dependent Regulation of Npt2a and Npt2c Expression Appears To Involve Predominantly cAMP/PKA-Dependent Mechanisms.

Segawa H, Maeda A, Thomas J, Gardella, Miyamoto K, Harald J. 2010

[雑誌論文] Fibroblast growth factor 23 mediates the phosphaturic actions of cadmium.

Aranami F, Segawa H, Furutani J, Kuwahara S, Tominaga R, Hanabusa E, Tatsumi S, Kido S, Ito M, Miyamoto KI. 2010

[雑誌論文] Immunohistochemical analyses of parathyroid hormone-dependent downregulation of renal type II Na-Pi cotransporters by cryobiopsy.

Matsumoto N, Hemmi A, Yamato H, Ohnishi R, Segawa H, Ohno S, Miyamoto K. 2010

[学会発表] Phosphate Homeostasis in Osteocyte-Ablated Mice.

Tatsumi S, Yamaguchi S,Kamatani T, Shiozaki Y, Nomura K, Saito Y, Kido S, Segawa H, Miyamoto K. 2010

[雑誌論文] Thyroid hormones regulate phosphate homoeostasis through transcriptional control of the renal type IIa sodium-dependent phosphate co-transporter (Npt2a) gene.

Ishiguro M, Yamamoto H, Masuda M, Kozai M, Takei Y, Tanaka S, Sato T, Segawa H, Taketani Y, Arai H, Miyamoto K, Takeda E. 2010

[雑誌論文] Phosphaturic action of fibroblast growth factor 23 in Npt2 null mice.

Tomoe Y, Segawa H, Shiozawa K, Kaneko I, Tominaga R, Hanabusa E, Aranami F, Furutani J, Kuwahara S, Tatsumi S, Matsumoto M, Ito M, Miyamoto KI. 2010

[学会発表] Harald Jueppner(2010)PTH-Dependent Regulation of Npt2a and Npt2c Expression Appears To Involve Predominantly cAMP/PKA-Dependent Mechanisms.

Hiroko Segawa 2010

[雑誌論文] Regulation of renal sodium-dependent phosphate cotransporter genes (Npt2a and Npt2c) by all-trans-retinoic acid and its receptors.

Masuda M, Yamamoto H, Kozai M, Tanaka S, Ishiguro M, Takei Y, Nakahashi O, Ikeda S, Uebanso T, Taketani Y, Segawa H, Miyamoto KI, Takeda E. 2010

[雑誌論文] An apical expression signal of the renal type IIc Na+-dependent phosphate cotransporter in renal epithelial cells.

Ito M, Sakurai A, Hayashi K, Ohi A, Kangawa N, Nishiyama T, Sugino S, Uehata Y, Kamahara A, Sakata M, Tatsumi S, Kuwahata M, Taketani Y, Segawa H, Miyamoto KI. 2010

[図書] 骨粗鬆症治療

宮本賢一, 他 2010

[図書] 機能性タンパク質・ペプチドと生体利用

宮本賢一, 他 2010

[図書] トランスポートソームの世界-膜輸送研究の源流から未来へ

宮本賢一, 他 2010

[図書] 改訂第3版認定病態栄養専門師のための病態栄養ガイドブック

宮本賢一, 他 2010

[雑誌論文] フォスファトニンとリン

宮本賢一, 他 2010

[雑誌論文] 摂取過剰で老化が進む? 解明進むリン代謝系

宮本賢一 2010

[学会発表] 腸管とリン代謝

宮本賢一 2010

[学会発表] 慢性腎臓病時におけるリン管理の重要性 Management of hyperp hosphatemia in patients with chronic kidney disease

宮本賢一 2010

[学会発表] 無機リン酸代謝調節に関する分子栄養学的研究

宮本賢一 2010

[雑誌論文] 骨と腸管の臓器相関

宮本賢一 2010

[学会発表] リンの話題

宮本賢一 2010

[雑誌論文] Type 11c sodium- dependent phosphate transporter regulates calcium metabolism.

Segawa H, Onitsuka A, Kuwahata M, Hanabusa E, Furutani J, Kaneko I, Tomoe Y, Aranami H, Matsumoto M, Li M, Amizuka N, Miyamoto K. 2009

[雑誌論文] The roles of Na/Pi II transporters in phosphate metabolism

Segawa H. 2009

[雑誌論文] Type llc Sodium-Dependent Phosphate Transporter Regulates Calcium Metabolism

Segawa H. 2009

[雑誌論文] Npt2a and Npt2c in mice play distinct and synergistic roles in inorganic phosphate metabolism and skeletal development

Segawa H. 2009

[雑誌論文] Management of phosphate in chronic kidney disease-Regulation of posphate homeostasis

Segawa H. 2009

[学会発表] Inorganic Phosphate Homeostasis in the Type 1 Na/Pi-transporter(NPT1)Null Mice.

Segawa H, Sawai Y, Tominaga R, Hanabusa E,Kuwahara S, Aranami F, Furutani J, Kaneko I, Kuroiwa Y, Kisuhara H,Sugiyama Y, Miyamoto K. 2009

[学会発表] FGF23/klothoとカルシウム・リンバランス調節機構

瀬川博子 2009

[学会発表] Inorganic Phosphate Homeostasis in the Type 1 Na/Pi-transporter(NPT1)Null Mice

Segawa H. 2009

[学会発表] Deficiency of Vitamin D Receptor Prevents the Development of Renal Pi Reabsorption.

Kaneko I, Segawa H, Hanabusa E, Miyamoto K. 2009

[雑誌論文] Klothoとリン代謝

瀬川 博子 2009

[雑誌論文] Mutant FGF23 Prevents the Progression Chronic Kidney Disease but Aggravates Renal Osteodystrophy in Uremic Rats.

Kusano K, Saito H, Segawa H, Fukushima N, Miyamoto K. 2009

[学会発表] klotho Modulates the Activity of Type 11c Na+-Dependent Phosphate Cotransporter (NaPi-11c) in Renal Epithelial Cells.

Nishiyama T, Ito M, Ohi A,Sugino S, Kaneko I,Sakata M,Kamahara A, Kido S, Tatsumi S, Segawa H, Miyamoto K. 2009

[雑誌論文] Npt2a and Npt2c in mice play distinct and synergistic roles in inorganic phosphate metabolism and skeletal development.

Segawa H, Onitsuka A, Furutani J, Kaneko I, Aranami F, Matsumoto N, Tomoe Y, Kuwahata M, Ito M, Matsumoto M, Li M, Amizuka N, Miyamoto K. 2009

[雑誌論文] The roles of Na/Pi-II transporters in phosphate metabolism.

Segawa H, Aranami H, Kaneko I, Tomoe Y, Miyamoto K. 2009

[雑誌論文] Differential regulation of the renal sodium-phosphate cotransporters NaPi-IIa, NaPi-IIc, and PiT-2 in dietary potassium deficiency.

Breusegem SY, Takahashi H, Giral-Arnal H, Wang X, Jiang T, Verlander JW, Wilson P, Miyazaki-Anzai S, Sutherland E, Caldas Y, Blaine JT, Segawa H, Miyamoto K, Barry NP, Levi M. 2009

[学会発表] Characterization of Phosphate Metabolism in the NaPi-11b Hetero Knockout Mice.

Hanabusa E, Ueda O, Segawa H, Kaneko I, Kuwahara S, Tatsumi S, Ohtomo S, Horiba N, Tachibe T, Wada N, Kawase Y, Jishage K, Fukushima N, Miyamoto K 2009

[雑誌論文] Kkithoとカルシウム/リン代謝の最前線

宮本 賢一 2009

[雑誌論文] Progress in the identification of intestinal Pi transport inhibitors

Miyamoto K. 2009

[雑誌論文] リン低下薬の今後の行方

宮本賢一 2009

[学会発表] リン代謝調節解明の進歩

宮本賢一 2009

[雑誌論文] カルシウム/リン代謝調節機序の最近の進歩

宮本賢一 2009

[雑誌論文] リン低下薬の今後の行方

宮本賢一 2009

[学会発表] リン代謝研究の新しい展開

宮本賢一 2009

[学会発表] リン酸代謝研究の新しい展開

宮本賢一 2009

[雑誌論文] Role of low protein and low phosphorus diet in the progression of chronic kidney disease in uremic rats.

Kusano K, Segawa H, Ohnishi R, Fukushima N, Miyamoto K 2008

[学会発表] 1.25 (OH) 2Vitamin D3 Modulates The Expression of the Humman Type IIcSodium-Dependent Phosphate Cotranspoter (NaPi-IIc) Gene in Renal Osteoblast Cells.

Tatsumi S, Fukushima Y, Shimamura S, Ito M, Segawa H, Miyamoto K. 2008

[学会発表] The Synergistic Role of Npt2a and Npt2c in Inorganic Phoshate Metabolism of Mice.

Segawa H, Tomoe Y, Furutani J, Kaneko I, Aranami F, Kuwahara S, Ito M, Miyamoto K. 2008

[学会発表] Effect of Fibroblast Growth Factor (FGF) 23 on Npt2a, Npt2c Double-Knockout (WKO) Mice.

Tomoe Y, Segawa H,Kaneko I, Furutani J, Aranami F, Kuwahara S, Tominaga R, Hanabusa E, Ito M, Miyamoto K. 2008

[学会発表] 高Ca尿を伴う遺伝子低リン血症性くる病発症機構の解明

瀬川 博子 2008

[雑誌論文] Polypyrimidine tract-binding protein is involved in regulation of albumin synthesis in response to food intake.

Kuwahata M, Kuramoto Y, Sawai Y, Amano S, Tomoe Y, Segawa H, Tatsumi S, Ito M, Kobayashi Y, Kido Y, Oka T, Miyamoto K. 2008

[学会発表] The Synergistic Role Npt2a and Npt2c in Inorganic PhoshateMetabolism of Mice.

Segawa H. 2008

[雑誌論文] 生体内バランス調節機構

瀬川 博子 2008

[学会発表] Mutation of Type IIc Na+- Dependent Phosphate Cotransporter (NaPi-IIc) and Hereditary Hypophosphatemic Rickets with Hypercalciuria (HHRH) The American Society of Nephrology.

Ito M, Sakurai A, Ohi A, Hayashi K, Nishiyama T, Kangawa N, Sugino S, Tatsumi S, Segawa H, Miyamoto K. 2008

[図書] 最新トランスポーター研究〜リントランスポーターと疾患〜

宮本 賢一 2008

[雑誌論文] 生体におけるリン代謝とその異常

宮本 賢一 2008

[学会発表] リン再吸収障害とクル病/骨軟化症の病態生理 : カドミウム代謝との関係

宮本 賢一 2008

[雑誌論文] 新しいリン調節薬

宮本 賢一 2008

[雑誌論文] 栄養管理の重要性

宮本 賢一 2008

[雑誌論文] リントランスポーター疾患

宮本 賢一 2008

[学会発表] The American Society of Nephrology.

Miyamoto K, Klotho, Minerals, Aging. 2008

[図書] トランスポーター化学最前線

宮本 賢一 2008