トップ研究者を探す抗加齢ドック受診者を対象とした循環器疾患の発症に関する 長期縦断疫学研究

抗加齢ドック受診者を対象とした循環器疾患の発症に関する 長期縦断疫学研究

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-20390185
研究種目 基盤研究(B)
研究分野 生物系
医歯薬学
社会医学
公衆衛生学・健康科学
研究機関 京都大学
愛媛大学
代表研究者 田原 康玄
研究分担者 三木 哲郎
研究分担者 小原 克彦
研究分担者 大澤 春彦
研究期間 開始年月日 2008/4/1
研究期間 終了年度 2012
研究ステータス 完了 (2012/4/1)
配分額(合計) 17,550,000 (直接経費 :13,500,000、間接経費 :4,050,000)
配分額(履歴) 2012年度:3,120,000 (直接経費 :2,400,000、間接経費 :720,000)
2011年度:2,990,000 (直接経費 :2,300,000、間接経費 :690,000)
2010年度:2,990,000 (直接経費 :2,300,000、間接経費 :690,000)
2009年度:3,640,000 (直接経費 :2,800,000、間接経費 :840,000)
2008年度:4,810,000 (直接経費 :3,700,000、間接経費 :1,110,000)
キーワード 動脈硬化
長期縦断疫学研究
ゲノム
動脈硬化性疾患
長期縦断研究

研究成果

[雑誌論文] Association of hematological parameters with insulin resistance, insulin sensitivity, and asymptomatic cerebrovascular damage: The J-SHIP Toon Health Study

Tabara Y, Igase M, Saito I, Nishida W, Kohara K, Sakurai S, Kawamura R, Okada Y, Hitsumoto S, Onuma H, Nagai T, Takata Y, Uetani E, Takita R, Kido T, Ochi N, Osawa H, Tanigawa T, Miki T 2013

[雑誌論文] Association of Chr17q25 with cerebral white matter hyperintensities and cognitive impairment: the J-SHIPP study

Tabara Y, Igase M, Okada Y, Nagai T, Uetani E, Kido T, Ochi N, Takita R, Yamamoto M, Kohara K, Miki T 2013

[雑誌論文] Positive natural selection of TRIB2, a novel gene that influences visceral fat accumulation, in East Asia.

Nakayama K, Ogawa A, Miyashita H, Tabara Y, Igase M, Kohara K, Miki T, Kagawa Y, Yanagisawa Y, Katashima M, Onda T, Okada K, Fukushima S, Iwamoto S 2013

[学会発表] ヘマトクリットとインスリン抵抗性,インスリン感受性ならびに無症候性脳血管障害との関連

田原康玄・大澤春彦・伊賀瀬道也・斉藤 功・西田 亙・小原克彦・櫻井 進 川本龍一・上谷英里・櫃本真一・大沼 裕・多喜田理絵・高田康徳・永井勅久 岡田陽子・城戸知子・越智南美子・谷川武・三木哲郎 2012

[学会発表] 見た目年齢と加齢性血圧変化

小原克彦・城戸美和子・宮脇さおり・田原康玄・伊賀瀬道也・三木哲郎 2012

[雑誌論文] Perceived age of facial features is a significant diagnosis criterion for age-related carotid atherosclerosis in Japanese subjects: J-SHIPP study

Kido M, Kohara K, Miyawaki S, Tabara Y, Igase M, Miki T 2012

[雑誌論文] Potential utility of soluble p3-alcadeinα plasma levels as a biomarker for sporadic Alzheimer's disease

Kamogawa K, Kohara K, Tabara Y, Takita R, Miki T, Konno T, Hata S, Suzuki T 2012

[雑誌論文] Postprandial hypertension, an overlooked risk marker for arteriosclerosis

Uetani E, Tabara Y, Igase M, Guo H, Kido T, Ochi N, Takita R, Kohara K, Miki T 2012

[雑誌論文] Arterial stiffness in sarcopenic visceral obesity in the elderly: J-SHIPP study

Kohara K, Ochi M, Tabara Y, Nagai T, Igase M, Miki T 2012

[雑誌論文] Liver Enzyme and Adipocytokine Profiles are Synergistically Associated with Insulin Resistance: the J-SHIPP Study

Uetani E, Tabara Y, Igase M, Kido T, Ochi N, Takita R, Kohara K, Miki T. 2012

[学会発表] 下肢筋力量推定における腸腰筋インデックスの有用性についての検討

越智雅之・小原克彦・篠原奈子・岡田陽子・永井勅久・多喜田理絵・伊賀瀬道也・三木哲郎・田原康玄 2012

[学会発表] 加齢と日中の眠気

永井勅久・小原克彦・田原康玄・岡田陽子・越智雅之・城戸知子・ 上谷英里・城戸美和子・伊賀瀬道也・三木哲郎 2012

[学会発表] 血管老化指標としての見た目年齢

小原克彦・田原康玄・永井勅久・越智雅之・岡田陽子・篠原奈子・多喜田理絵・伊賀瀬道也・三木哲郎 2012

[雑誌論文] Atherosclerotic indices for the prediction of cognitive impairment in a middle-aged to elderly general population: shimanami health promoting program study

Kohara K, Igase M, Tabara Y, Miki T 2012

[雑誌論文] Association of hematological parameters with insulin resistance, insulin sensitivity, and asymptomatic cerebrovascular damage: The J-SHIP Toon Health Study

Tabara Y, Igase M, Saito I, Nishida W, Kohara K, Sakurai S, Kawamura R, Okada Y, Hitsumoto S, Onuma H, Nagai T, Takata Y, Uetani E, Takita R, Kido T, Ochi N, Osawa H, Tanigawa T, Miki T 2012

[雑誌論文] Relatively lower central aortic pressure in patients with impaired insulin sensitivity and resistance: the Toon Health Study

Tabara Y, Saito I, Nishida W, Kohara K, Sakurai S, Kawamura R, Onuma H, Takata Y, Osawa H, Miki T, Tanigawa T 2011

[学会発表] 一般地域住民においてレジスチンは一塩基多型(SNP)-420及びSNP-358は代謝関連の量的形質とは関連しない

大澤春彦, 他 2011

[学会発表] Relatively lower central aortic pressure in subjects with impaired insulin sensitivity and resistance: The Toon Health Study

Tabara Y, Saito I, Nishida W, Kohara K, Sakurai S, Kawamura R, Onuma H, Takata Y, Osawa H, Miki T, Tanigawa T 2011

[雑誌論文] Genotype risk score of common susceptible variants for prediction of type 2 diabetes mellitus in Japanese: the Shimanami Health Promoting Program (J-SHIPP study). Development of type 2 diabetes mellitus and genotype risk score

Tabara Y, Osawa H, Kawamoto R, Onuma H, Shimizu I, Makino H, Kohara K, Miki T 2011

[雑誌論文] Leptin in sarcopenic visceral obesity: possible link between adipocytes and myocytes

Kohara K, Ochi M, Tabara Y, Nagai T, Igase M, Miki T 2011

[雑誌論文] Leptin in sarcopenic visceral obesity : possible link between adipocytes and myocytes

Kohara K, et al 2011

[学会発表] Reduced lower extremity muscle mass is an independent risk factor for incidence of falls

Tabara Y, Igase M, Uetani E, Kido T, Ochi N, Kohara K, Miki T 2011

[学会発表] 一般住民における認知機能障害と関連する動脈硬化指数

小原克彦, 他 2011

[学会発表] Arterial Stiffness in Sarcopenic Obesity, the Common Form of Obesity in the Elderly : J-SHIPP Study

Kohara K, et al 2011

[学会発表] Postprandial hypertension; an overlooked risk factor for arterial stiffness

Uetani E, Tabara Y, Igase M, Ochi N, Kido T, Miki T, Kohara K 2011

[雑誌論文] A at single nucleotide polymorphism-358 is required for G at -420 to confer the highest plasma resistin in the general Japanese population

Onuma H, Tabara Y, Kawamura R, Tanaka T, Ohashi J, Nishida W, Takata Y, Ochi M, Yamada K, Kawamoto R, Kohara K, Miki T, Makino H, Osawa H 2010

[雑誌論文] The GCKR rs780094 polymorphism is associated with susceptibility of type 2 diabetes, reduced fasting plasma glucose levels, increased triglycerides levels and lower HOMA-IR in Japanese population

Onuma H, Tabara Y, Kawamoto R, Shimizu I, Kawamura R, Takata Y, Nishida W, Ohashi J, Miki T, Kohara K, Makino H, Osawa H 2010

[雑誌論文] Is rs34861192 or rs1862513 a more promising variant for determining plasma resistin in an aged Japanese population?

Osawa H, et al. 2010

[雑誌論文] Is rs34861192 or rs1862513 a more promising variant for determining plasma resistin in an aged Japanese population?

Osawa H, Tabara Y, Ohashi J, Kawamura R, Onuma H, Makino H 2010

[学会発表] 血中レジスチンは全ゲノム関連解析(GWAS)で同定された2型糖尿病感受性一塩基多型(SNP)THADAと関連する

大澤春彦, 他 2010

[雑誌論文] Quadriceps sarcopenia and visceral obesity are risk factors for postural instability in the middle-aged to elderly population

Ochi M, Tabara Y, Kido T, Uetani E, Ochi N, Igase M, Miki T, Kohara K 2010

[学会発表] Class effects of BP-lowering drugs on central blood pressure measurement

Uetani E, Tabara Y, Igase M, Ochi N, Kido T, Kohara K, Miki T 2010

[雑誌論文] Abnormal nocturnal blood pressure profile is associated with mild cognitive impairment in the elderly : the J-SHIPP study.

Guo H, Tabara Y, Igase M, Yamamoto M, Ochi N, Kido T, Uetani E, Taguchi K, Miki T, Kohara K. 2010

[学会発表] Class effects of BP-lowering drugs on central blood pressure measurement.

Uetani E, Tabara Y, Igase M, Kido T, Ochi N, Kohara K, Miki T. 2010

[雑誌論文] Common variants in the ATP2B1 gene are associated with susceptibility to hypertension: the Japanese Millennium Genome Project.

Tabara Y, Kohara K, Kita Y, Hirawa N, Katsuya T, Ohkubo T, Hiura Y, Tajima A, Morisaki T, Miyata T, Nakayama T, Takashima N, Nakura J, Kawamoto R, Takahashi N, Hata A, Soma M, Imai Y, Kokubo Y, Okamura T, Tomoike H, Iwai N, Ogihara T, Inoue I, Tokunaga K 2010

[雑誌論文] Postural instability is associated with brain atrophy and cognitive impairment in the elderly: the J-SHIPP study

Kido T, Tabara Y, Igase M, Ochi N, Uetani E, Nagai T, Yamamoto M, Taguchi K, Miki T, Kohara K 2010

[雑誌論文] Abnormal nocturnal blood pressure profile is associated with mild cognitive impairment in the elderly: the J-SHIPP study

Guo H, Tabara Y, Igase M, Yamamoto M, Ochi N, Kido T, Uetani E, Taguchi K, Miki T, Kohara K 2010

[雑誌論文] Associations between short one-leg standing time and speed of sound of calcaneal bone in a general population: the Shimanami Health Promoting Program (J-SHIPP) study

Kido T, Tabara Y, Igase M, Uetani E, Ochi N, Miki T, Kohara K 2010

[雑誌論文] Association of four genetic loci with uric acid levels and reduced renal function: the J-SHIPP Suita study

Tabara Y, Kohara K, Kawamoto R, Hiura Y, Nishimura K, Morisaki T, Kokubo Y, Okamura T, Tomoike H, Iwai N, Miki T 2010

[学会発表] Postprandial hypotension as a risk factor for cognitive decline in community-dwelling elderly persons.

Uetani E, Tabara Y, Igase M, Kido T, Ochi N, Yamamoto M, Kohara K, Miki T. 2010

[雑誌論文] Postural instability is associated with brain atrophy and cognitive impairment in the elderly : the J-SHIPP study.

Kido T, Tabara Y, Igase M, Ochi N, Uetani E, Nagai T, Yamamoto M, Taguchi K, Miki T, Kohara K. 2010

[雑誌論文] Association of central systolic blood pressure with intracerebral small vessel disease in Japanese

Ochi N, Kohara K, Tabara Y, Nagai T, Kido T, Uetani E, Ochi M, Igase M, Miki T 2010

[雑誌論文] Association of four genetic loci with uric acid levels and reduced renal function : the J-SHIPP Suita study.

Tabara Y, Kohara K, Kawamoto R, Hiura Y, Nishimura K, Morisaki T, Kokubo Y, Okamura T, Tomoike H, Iwai N, Miki T. 2010

[雑誌論文] Cross-sectional characterization of all classes of antihypertensives in terms of central blood pressure in Japanese hypertensive patients

Miyashita H, Aizawa A, Hashimoto J, Hirooka Y, Imai Y, Kawano Y, Kohara K, Sunagawa K, Suzuki H, Tabara Y, Takazawa K, Takenaka T, Yasuda H, Shimada K 2010

[雑誌論文] Arterial stiffness is associated with low thigh muscle mass in middle-aged to elderly men

Ochi M, Kohara K, Tabara Y, Kido T, Uetani E, Ochi N, Igase M, Miki T. 2010

[学会発表] Postprandial hypotension as a risk factor for cognitive decline in community-dwelling elderly persons

Uetani E, Tabara Y, Igase M, Kido T, Ochi N, Yamamoto M, Kohara K, Miki T 2010

[雑誌論文] Abdominal fat, adipose-derived hormones and mild cognitive impairment: the J-SHIPP study

Kamogawa K, Kohara K, Tabara Y, Uetani E, Nagai T, Yamamoto M, Igase M, Miki T 2010

[雑誌論文] Replication study of candidate genes associated with type 2 diabetes based on genome-wide screening.

Tabara Y, Osawa H, Kawamoto R, Onuma H, Shimizu I, Miki T, Kohara K, Makino H. 2009

[学会発表] Postural instability is-associated with brain atrophy and cognitive impairment in elderly : the J-SHIPP study.

Kido T, Tabara Y, Igase M, Ochi N, Uetani E, Nagai T, Yamamoto M, Taguchi K, Kohara K, Miki T. 2009

[学会発表] Postprandial hypotension is associated with asymptomatic cerebrovascular damage in community-dwelling elderly

Tabara Y, Igase M, Nagai T, Kido T, Ochi N, Uetani E, Miki T, Kohara K 2009

[雑誌論文] Silent cerebral microbleeds associated with arterial stiffness in an apparently healthy subject

Ochi N, Tabara Y, Igase M, Nagai T, Kido T, Miki T, Kohara K 2009

[学会発表] Postprandial hypotension is associated with asymptomatic cerebrovascular damage in community-dwelling elderly.

Tabara Y, Igase M, Nagai T, Kido T, Ochi N, Uetani E, Miki T, Kohara K. 2009

[学会発表] Postural instability is-associated with brain atrophy and cognitive impairment in elderly: the J-SHIPP study

Kido T, Tabara Y, Igase M, Ochi N, Uetani E, Nagai T, Yamamoto M, Taguchi K, Miki T, Kohara K 2009

[雑誌論文] Clinical usefulness of the second peak of radial systolic blood pressure for estimation of aortic systolic blood pressure

Kohara K, et al. 2009

[雑誌論文] Composition of lower extremity in relation to a high ankle-brachial index.

Tabara Y, Igase M, Kido T, Ochi N, Miki T, Kohara K. 2009

[雑誌論文] Asymptomatic cerebral microbleeds seen in healthy subjects have a strong association with asymptomatic lacunar infarction

Igase M, Tabara Y, Igase K, Nagai T, Ochi N, Kido T, Nakura J, Sadamoto K, Kohara K, Miki T 2009

[雑誌論文] Reduced high-molecular-weight adiponectin and elevated high-sensitivity C-reactive protein are synergistic risk factors for metabolic syndrome in a large-scale middle-aged to elderly population: the Shimanami Health Promoting Program Study

Tabara Y, Osawa H, Kawamoto R, Tachibana-Iimori R, Yamamoto M, Nakura J, Miki T, Makino H, Kohara K 2008

[学会発表] Reduced high-molecular weight adiponectin and elevated hsCRP are synergistic risk factors for metabolic syndrome in a large scale middle-aged to elderly population : The J-SHIPP study

Tabara Y, Osawa H, Kawamoto R, Tachibana R, Yamamoto M, Nakura J, Miki T, Makino H, Kohara K 2008

[学会発表] メタボリックシンドロームに対する高分子量アディポネクチンと高感度CRPとの相乗的相関

田原康玄, 大澤春彦, 川本龍一, 名倉 潤, 三木哲郎, 牧野英一, 小原克彦 2008

[雑誌論文] No association of INSIG2 gene rs7566605 polymorphism with being overweight in Japanese population

Tabara Y, Kawamoto R, Osawa H, Nakura J, Makino H, Miki T, Kohara K 2008

[雑誌論文] Reduced high-molecular-weight adiponectin and elevated high-sensitivity C-reactive protein are synergistic risk factors for metabolic syndrome in a large-scale middle-aged to elderly population

Tabara Y, Osawa H, Kawamoto R, Tachibana R, Yamamoto M, Nakura J, Miki T, Makino H, Kohara K. 2008

[雑誌論文] No association between INSIG2 Gene rs7566605 polymorphism and being overweight in Japanese population

Tabara Y, Kawamoto R, Osawa H, Nakura J, Makino H, Miki T, Kohara K 2008

[雑誌論文] Resistin, glomerular filtration rate, and insulin resistance.

Tabara Y, Igase M, Osawa H, Makino H, Miki T, Kohara K. 2008

[学会発表] Resistin, GFR and insulin resistance

Tabara Y, Igase M, Osawa H, Makino H, Miki T, Kohara K 2008

[雑誌論文] Resistin, glomerular filtration rate, and insulin resistance

Tabara Y, Igase M, Osawa H, Makino H, Miki T, Kohara K 2008

[学会発表] 下肢筋量と起立性血圧調節障害、ならびに動脈スティッフネスとの相関

越智雅之, 田原康玄, 伊賀瀬道也, 越智南美子, 三木哲郎, 小原克彦 2008

[学会発表] 高脂血症感受性遺伝子多型の日本人一般地域住民における再現性の検討

田原康玄, 川本龍一, 山本美由紀, 名倉 潤, 三木哲郎, 小原克彦 2008

[学会発表] Urate anion exchanger gene, SLC22A12, polymorphism is associated with plasma uric acid levels but not inflammation and insulin resistance

Tabara Y, Kawamoto R, Tachibana-Iimori R, Yamamoto M, Miki T, Kohara K 2008

[学会発表] Plasma leptin levels and orthostatic hypertension in the elderly

Tabara Y, Igase M, Tomoko K, Namiko O, Tetsuro M, Kohara K 2008

[学会発表] Composition of the lower extremity in relation to a high ankle-brachial index : The J-SHIPP study

Tabara Y, Igase M, Kido T, Ochi N, Miki T, Kohara K 2008

[学会発表] Urate anion exchanger gene, SLC22A12, polymorphism is associated with plasmauric acid levels but not inflammation and insulin resistance

Tabara Y, Kawamoto R, Tachibana-Iimori R, Yamamoto M, Miki T, Kohara K 2008

[学会発表] 起立によるAugmentation indexの変化と無症候性脳梗塞との相関

田原康玄, 伊賀瀬道也, 永井勅久, 城戸知子, 越智南美子, 三木哲郎, 小原克彦 2008

[学会発表] Association between silent cerebral microbleeds and carotid arterial parameters in comparison with lacunar infarction and leukoaraiosis

Ochi N, Tabara Y, Igase M, Nagai T, Kido T, Miki T, Kohara K. 2008

[学会発表] Association between metabolic syndrome and silent cerebral infarction

Kido T, Tabara Y, Igase M, Nagai T, Ochi N, Miki T, Kohara K 2008

[雑誌論文] An association between decreased estimated glomerular filtration rate and arterial stiffness

Kawamoto R, Kohara K, Tabara Y, Miki T, Ohtsuka N, Kusunoki T, Yorimitsu N. 2008

[学会発表] 体重に対する大腿筋量の相対的な低下と重心動揺

田原康玄, 伊賀瀬道也, 城戸知子, 越智南美子, 三木哲郎, 小原克彦 2008

[学会発表] CRP遺伝子多型と血中高感度CRP濃度ならびにメタボリックシンドロームとの相関

田原康玄, 川本龍一, 山本美由紀, 森田昭彦, 中山智祥, 吉田安彦, 根本靖久, 三木哲郎, 小原克彦 2008

[雑誌論文] Blood pressure is the main determinant of the reflection wave in patients with type 2 diabetes

Tomita H, Kawamoto R, Tabara Y, Miki T, Kohara K 2008

[学会発表] Orthostatic decline in augmentation index and late systolic blood pressure is a risk factor for silent lacunar infarction

Tabara Y, Igase M, Nagai T, Kido T, Ochi N, Tetsuro M, Kohara K 2008

[学会発表] 無症候性微小脳出血と動脈硬化性因子との関連

越智南美子, 田原康玄, 伊賀瀬道也, 永井勅久, 三木哲郎, 小原克彦 2008

[学会発表] アディポネクチンとHDLコレステロールとの相関に対するCETP遺伝子多型の交互作用

田原康玄, Haiyan Guo, 川本龍一, 山本美由紀, 小原克彦, 三木哲郎 2008

[図書] 抗加齢ドックの実際-動脈硬化と闘うために-

三木哲郎, 伊賀瀬道也, 小原克彦, 田原康玄 2008

[学会発表] 簡便な認知症診断システムの構築

田口敬子, 田原康玄, 川尻真和, 伊賀瀬道也, 小原克彦, 三木哲郎 2008

[雑誌論文] Blood pressure is the main reterminant of the reflection wave in patients with type 2 diabetes

Tomita H, Kawamoto R, Tabara Y, Miki T, Kohara K 2008

[学会発表] Composition of the lower extremity in relation to a high ankle-brachial index: The J-SHIPP study

Tabara Y, Igase M, Kido T, Ochi N, Miki T, Kohara K 2008

[雑誌論文] An association between metabolic syndrome and the estimated glomerular filtration rate.

Kawamoto R, Kohara K, Tabara Y, Miki T. 2008

[学会発表] 一般地域住民における軽度認知機能障害と血圧日内変動との相関

田原康玄, 伊賀瀬道也, 山本美由紀, 名倉 潤, 越智南美子, 城戸知子, 三木哲郎, 小原克彦 2008

[学会発表] 血圧日内変動と軽度認知機能障害

田原康玄, 郭海燕, 伊賀瀬道也, 山本美由紀, 越智南美子, 城戸知子, 上谷英里, 田口敬子, 三木哲郎, 小原克彦 2008

[雑誌論文] Association between serum gamma-glutamyl transferase level and prehypertension among community-dwelling men.

Kawamoto R, Kohara K, Tabara Y, Kusunoki T, Otsuka N, Miki T. 2008

[学会発表] Nocturnal blood pressure and mild cognitive impairment in elderly

Tabara Y, Igase M, Yamamoto M, Nakura J, Ochi N, Kido T, Miki T, Kohara K 2008

[学会発表] Nocturnal blood pressure and mild cognitive impairment in elderly

Tabara Y, Igase M, Yamamoto M, Nakura J, Ochi N, Kido T, Miki T, Kohara K 2008

[学会発表] Orthostatic decline in augmentation index and late systolic blood pressure is a risk factor for silent lacunar infarction

Tabara Y, Igase M, Nagai T, Kido T, Ochi N, Tetsuro M, Kohara K 2008

[学会発表] Plasma leptin levels and orthostatic hypertension in the elderly

Tabara Y, Igase M, Tomoko K, Namiko O, Tetsuro M, Kohara K 2008