Tリンパ球依存性胸腺微少環境構築機構

トップ›研究者を探す›Tリンパ球依存性胸腺微少環境構築機構

代表研究者	高濱洋介
研究課題番号	KAKENHI-PROJECT-20390144
研究種目	基盤研究(B)
研究分野	生物系医歯薬学基礎医学免疫学
研究機関	徳島大学
研究分担者	新田剛
研究分担者	上野智雄
研究期間開始年月日	2008/4/1
研究期間終了年度	2010
研究ステータス	完了 (2010/4/1)
配分額（合計）	19,630,000 (直接経費 :15,100,000、間接経費 :4,530,000)
配分額（履歴）	2010年度：6,240,000 (直接経費 :4,800,000、間接経費 :1,440,000) 2009年度：6,370,000 (直接経費 :4,900,000、間接経費 :1,470,000) 2008年度：7,020,000 (直接経費 :5,400,000、間接経費 :1,620,000)
キーワード	免疫学獲得免疫胸腺分化胸腺微小環境胸腺上皮細胞胸腺髄質上皮細胞胸腺皮質上皮細胞ケモカイン胸腺プロテアソーム・5t RANKL Aire CCR7 XCL1 CD40L

研究成果

[学会発表] Thymic microenvironments that shape T lymphocyte repertoire

Yousuke Takahama 2011

[雑誌論文] Cytokine crosstalk for thymic medulla formation.

Nitta T, Ohigashi I, Nakagawa Y, Takahama Y. 2011

[雑誌論文] Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development.

Lei Y, Mat Ripen A, Ishimaru N, Ohigashi I, Nagasawa T, Jeker L, Bosl M, Hollander GA, Hayashi Y, de Waal Malefyt R, Nitta T, Takahama Y. 2011

[学会発表] Mechanisms to establish self-tolerance in the thymic medulla

Yousuke Takahama 2011

[学会発表] 自己免疫疾患と胸腺

高浜洋介 2010

[学会発表] XCL1 regulates medullary accumulation of thymic dendritic cells and thymic development of regulatory T cells

Yousuke Takahama 2010

[学会発表] XCL1 regulates medullary accumulation of thymic dendritic cells and thymic development of regulatory T cells.

Takahama Y. 2010

[学会発表] Thymus-specific self-peptide repertoire shaped immunocompetent repertoire of T cells

Yousuke Takahama 2010

[学会発表] T-cell repertoire formation in the thymus.

Takahama Y. 2010

[学会発表] Positive selection by thymoproteasome-expressing thymic epithelial cells shapes immunocompetent repertoire of CD8 T cells

Yousuke Takahama 2010

[雑誌論文] Role of thymic cortex-specific self-peptides in positive selection of T cells.

Takahama Y, Nitta T, Mat Ripen A, Nitta S, Murata S, Tanaka K. 2010

[雑誌論文] Another zinc finger in the pie of CD4-CD8 lineage choice

Takada K, Takahama Y. 2010

[学会発表] Thymic microenvironments that shape T cell repertoire

Yousuke Takahama 2010

[雑誌論文] Top three reasons to come to Kobe for the 14th International Congress of Immunology

Takahama Y, Miyasaka M. 2010

[学会発表] Aire regulates XCL1-mediated medullary accumulation of thymic dendritic cells and thymic development of regulatory T cells.

Takahama Y. 2010

[雑誌論文] Role of thymic cortex-specific self-peptides in positive selection of T cells

Takahama Y, et al. 2010

[学会発表] T-cell repertoire formation in the thymus

Yousuke Takahama 2010

[学会発表] 胸腺の構築

高浜洋介 2010

[学会発表] Thymic microenvironments that shape T cell repertoire.

Takahama Y. 2010

[雑誌論文] Thymoproteasome shapes immunocompetent repertoire of CD8+ T cells.

Nitta T, Murata S, Sasaki K, Fujii H, Mat Ripen A, Ishimaru N, Koyasu S, Tanaka K, Takahama Y. 2010

[学会発表] Aire regulates XCL1-mediated medullary accumulation of thymic dendritic cells and thymic development of regulatory T cells

Yousuke Takahama 2010

[雑誌論文] Top three reasons to come to Kobe for the 14th International Congress of Immunology

Takahama Y, et al. 2010

[学会発表] 胸腺におけるT細胞選択と自己免疫疾患

高浜洋介 2010

[図書] Systems Biology : The Challenge of Complexity. (Toward understanding how the immune system establishes a diverse yet self-tolerant T-cell repertoire: stepwise roles of thymic microenvironments.) (eds. Nakanishi S, Kageyama R, Watanabe D).

Nitta T, Takahama Y. 2009

[雑誌論文] CCR7-mediated medulla migration of developing thymocytes is essential for negative selection to tissue-restricted antigens.

Nitta T, Nitta S, Lei Y, Lipp M, Takahama Y. 2009

[図書] 免疫学最新イラストレイテッド改訂第2版

高浜洋介 2009

[雑誌論文] The global thymus network : past, present, and future

Takahama Y, et al. 2009

[学会発表] 胸腺と自己免疫疾患

高浜洋介 2009

[学会発表] Positive selection by thymoproteasome-expressing thymic epithelial cells shapes immunocompetent repertoire of CD8 T cells

Yousuke Takahama 2009

[学会発表] Thymus-specific self-peptide repertoire shapes immunocompetent repertoire of T cells

Yousuke Takahama 2009

[学会発表] Positive selection by thymo proteasome-expressing thymic epithelial cells shapes immunocompetent repertoire of CD8 T cells.

Takahama Y. 2009

[雑誌論文] Gene expression profile of third pharyngeal pouch reveals role of mesenchymal MafB in embryonic thymus development.

Sultana DA, Tomita S, Hamada M, Iwanaga Y, Kitahama Y, Khang NV, Hirai S, Ohigashi I, Nitta S, Amagai T, Takahashi S, Takahama Y. 2009

[学会発表] 中枢性自己寛容と自己免疫疾患

高浜洋介 2008

[雑誌論文] One small step for immunologists.

Takahama Y, et al. 2008

[雑誌論文] Modest cortex and promiscuous medulla for thymic repertoire formation.

Takahama Y, et al. 2008

[学会発表] Thymoproteasome governs positive selection of CD8 T cells.

Takahama Y. 2008

[学会発表] Thymoproteasome governs positive selection of CD8 T cells

Yousuke Takahama 2008

[学会発表] RANK ligand produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator

Yousuke Takahama 2008

[学会発表] Development of thymus and T lymphocytes in medaka

高浜洋介 2008

[雑誌論文] Thymic microenvironments for T-cell repertoire formation.

Nitta T, Murata S, Ueno T, Tanaka K, Takahama Y. 2008

[雑誌論文] The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator.

Hikosaka Y, Nitta T, Ohigashi I, Yano K, Ishimaru N, Hayashi Y, Matsumoto M, Matsuo K, Penninger JM, Takayanagi H, Yokota Y, Yamada H, Yoshikai Y, Inoue J, Akiyama T, Takahama Y. 2008