研究成果

[雑誌論文] Lysophosphatidic acid stimulates epidermal growth factor-family ectodomain shedding and paracrine signaling from human lung fibroblasts.

Shiomi T, Boudreault F, Padem N, Higashiyama S, Drazen JM, Tschumperlin DJ. 2011

[学会発表] 増殖因子による増殖の正と負のシグナル制御機構と癌微小環境制御

東山繁樹 2010

[学会発表] Development of Ientivirus vector system for conditional gene knockdown

Natsuki Mtasushita, Sachi Matsushita, Satoshi Hirakawa, Shigeki Higashiyama 2010

[雑誌論文] Activation of epidermal growth factor receptor gene is involved in transforming growth factor-beta-mediated fibronectin expression in a chondrocyte progenitor cell line

Takeda H, Inoue H, Kutsuna T, Matsushita N, Takahashi T, Watanabe S, Higashiyama S, Yamamoto H. 2010

[学会発表] Identification of novel molecules that regulate ectodomain shedding of EGF ligands

福田信治、中山寛尚、東山繁樹 2010

[学会発表] Ectodomain shedding of LYVE-1 : VEGF-A promotes the initial step of pathological lymphoangiogenesis

Satoshi Hirakawa, Shigeki Higashiyama 2010

[雑誌論文] Corneal epithelial wound healing impaired in keratinocyte-specific HB-EGF-deficient mice in vivo and in vitro.

Yoshioka R, Shiraishi A, Kobayashi T, Morita S, Hayashi Y, Higashiyama S, Ohashi Y. 2010

[雑誌論文] Induction of striatal neurogenesis and generation of region-specific functional mature neurons after ischemia by growth factors

Yoshikawa G, Momiyama T, Oya S, Takai K, Tanaka JI, Higashiyama S, Saito N, Kirino T, Kawahara N. 2010

[雑誌論文] TGFβ induces proHB-EGF shedding and EGFR transactivation through ADAM activation in gastric cancer cells.

Ebi M, Kataoka H, Shimura T, Kubota E, Hirata Y, Mizushima T, Mizoshita T, Tanaka M, Mabuchi M, Tsukamoto H, Tanida S, Kamiya T, Higashiyama S, Joh T. 2010

[学会発表] C-terminal fragment signaling of proHB-EGF for protection of cardiac cell death

東山繁樹、井上博文 2010

[雑誌論文] Insulin-Induced Ectodomain Shedding of Heparin-Binding Epidermal Growth Factor-Like Growth Factor in Adipocytes In Vitro

Yamamoto T, Suganami T, Kiso-Narita M, Scherle PA, Kamei Y, Isobe M, Higashiyama S, Ogawa Y. 2010

[雑誌論文] Induction of striatal neurogenesis and generation of region-specific functional mature neurons after ischemia by growth factors.Laboratory investigation.

Yoshikawa G, Momiyama T, Oya S, Takai K, Tanaka J, Higashiyama S, Saito N, Kirino T, Kawahara N. 2010

[学会発表] 増殖因子による増殖の正と負のシグナル制御機構と癌微小環境制御

東山繁樹 2010

[学会発表] Identification of novel molecules that regulate ectodomain shedding of EGF ligands

福田信治、中山寛尚、東山繁樹 2010

[学会発表] Inner nuclear membrane targeting of membrane-anchored growth factors and transcriptional regulation (Invited)

Shigeki Higashiyama 2009

[学会発表] Nuclear signaling of membrane-anchored growth factors and cell growth regulation

東山繁樹 2009

[雑誌論文] Ectodomain shedding of E-cadherin and c-Met is induced by Helicobacter pylori infection

Schimmeister W, Gnad T, Wex T, Higashiyama S, Wolke C, Naumann M, Lendeckel U. 2009

[雑誌論文] Thromboxane A2 receptor-mediated epidermal growth factor receptor transactivation : involvement of PKC-delta and PKC-epsilon in the in the shedding of epidermal growth factor receptor ligands

Uchiyama K, Saito M, Sasaki M, Obara Y, Higashiyama S, Nakahata N 2009

[学会発表] Nuclear signaling of membrane-anchored growth factors and cell growth regulation (Invited)

Shigeki Higashiyama 2009

[学会発表] Inner nuclear membrane translocation and nuclear signaling of membrane-anchored growth factors

東山繁樹 2009

[雑誌論文] BCL6 degradation caused by the interaction with the C-terminus of pro-HB-EGF induces cyclin D2 expression in gastric cansers

Hirata Y, Ogasawara N, Sasaki M, Mizushima T, Shimura T, Mizoshita T, Mori Y, Kubota E, Wada T, Tanida S, Kataoka H, Kamiya T, Higashiyama S, Joh T 2009

[雑誌論文] Mitochondrial reactive oxygen species mediate GPCR-induced TACE/ADAM17-dependent transforming growth factor-alpha shedding.

Myers TJ, Higashiyama S 2009

[学会発表] Plasma membrane-anchored growth factors HB-EGF and amphiregulin targeted to the inner nuclear membrane and regulated gene expression.

Mayumi Isokane, Miki Hieda, Shigeki Higashiyama 2009

[雑誌論文] Attenuation of Notch signaling promotes the differentiation of neural progenitors into neurons in the hippocampal CAl region after ischemic injury

Oya S, Yoshikawa G, Takai K, Tanaka JI, Higashiyama S, Saito N, Kirino T, Kawahara N. 2009

[学会発表] Inner nuclear membrane targeting of membrane-anchored growth factors and transcriptional regulation

東山繁樹 2009

[雑誌論文] Carbon-ion beam irradiation effectively suppresses migration and invasion of human non-small-cell lung cancer cells

Akino Y, Teshima T, Kihara A, Kodera-Suzumoto Y, Inaoka M, Higashiyama S, Furusawa Y, Matsuura N 2009

[学会発表] Innernuclear membrane targeting of membrane-anchored growth factors and transcriptional regulation

東山繁樹 2009

[学会発表] 膜型増殖因子の Ectodomain Shedding-分子機構から生理機能まで

東山繁樹 2009

[雑誌論文] Insufficiency of pro-heparin-binding epidermal growth factor shedding enhances hypoxic cell death in H9c2 cardiomyoblasts via activation of caspase-3 and c-Jun N-terminal kinase

Uetani T, Nakayama H, Okayama H, Okura T, Higaki J, Inoue H, Higashiyama S. 2009

[雑誌論文] Promyelocytic leukemia zinc finger protein regulates interferon-mediated innate immunity

Xu D, Holko M, Sadler AJ, Scott B, Higashiyama S, Berkofsky-fessler W, McConnell MJ, Pandolfi PP, Licht JD, Williams BR 2009

[雑誌論文] Generation and characterization of conditional heparin-binding EGF-like growth factor knockout mice

Oyagi A, Oida Y, Kakefuda K, Shimarawa M, Shioda N, Moriguchi S, Kitaichi K, Nanba D, Yamaguchi K, Furuta Y, Fukunaga K, Higashiyama S, Hara H 2009

[学会発表] A novel amphiregulin-binding protein, ARP35, regulates the amphiregulin-ADAM17 interaction and the ectodomain shedding

中山寛尚, 福田信治, 井上博文, 東山繁樹 2009

[雑誌論文] Serine protease inhibitor Kazaltype 1 promotes proliferation of pancreatic cancer cells through the epidermal growth factor receptor

Ozaki N, Ohmuraya M, Hirota M, Ida S, Wang J, Takamori H, Higashiyama S, Baba H, Yamamura K. 2009

[雑誌論文] Localisation of endothelin B receptor variants to plasma membrane microdomains and its effects on downstream signalling

Grossmann S, Higashiyama S, Oksche A, Schaefer M, Tannert A 2009

[学会発表] A zinc finger transcription factor regulates vascular sprouting through the downregulation of Notch signaling in vascular endothelial cells.

Hidetaka Ohnuki, Shigeki Higashiyama, et al. 2009

[雑誌論文] Mitochondrial reactive oxygen Species mediate GPCR-induced TACE/ADAM17-dependent transforming growth-alpha shedding

Myers TJ, Brennaman LH, Stevenson M, Higashiyama S, Russell WE, Lee DC, Sunnarborg SW 2009

[雑誌論文] Promyelocytic leukemia zinc finger protein regulates interferon-mediated innate immunity.

Xu D, Higashiyama S 2009

[学会発表] ADAMによる膜型増殖因子sheddingとcell cycle制御

福田信治 2009

[学会発表] Inner nuclear membrane translocation and nuclear signaling of membrane-anchored growth factors

東山繁樹 2009

[学会発表] Plasma membrane anchored growth factors HB-EGF and amphiregulin targeted to the inner nuclear membrane and regulate gene expressioa.

Mayumi Isokane, Shigeki Higashiyama, et al. 2008

[学会発表] Inner nuclear membrane targeting of pro-amphiregulin regulates Oral Squamous Cell Carcinoma cell viability

Mayumi Isokane, Shigeki Higashiyama, et al. 2008

[学会発表] Plaama membrane anchored growth factors proHB-EGF and proamphiregulin targeted to the nuclear inner membrane and regulate gene expression (Symposium)

Shigeki Higashiyama, et al. 2008

[学会発表] The ectodomian shedding of amphiregulin (AREG) is regulated by a 35kDa protein, a novel proAREG associated protein

Hironao Nakayama, Shigeki Higashiyama, et al. 2008

[学会発表] Ectodomian shedding of EGF family members -the molecular mechanism and the physiological roles- (Symposium)

Hirofumi Inoue, Shigeki Higashiyama, et al. 2008

[学会発表] Inner nuclear membrane translocation and transcriptional regulation of proHB-EGF and pro-amphiregulin (International Session)

Shigeki Higashiyama 2008

[雑誌論文] Plasma-membrane-anchored growth factor pro-amphiregulin binds A-type lamin and regulates global transcription.

Isokane M, Hieda M, Higashiyama S. 2008

[学会発表] 膜型増殖因子EGFファミリー分子は細胞膜から核膜へ局在変化する

檜枝美紀, 東山繁樹, (他1名) 2008

[学会発表] 膜型増殖因子amphiregulinの細胞内輸送経路およびその解析

礒兼真由美, 東山繁樹, (他2名) 2008

新規ユビキチンリガーゼ及びその利用法

血管新生制御剤、及びそのスクリーニンク方法、並びにスクリーニンク用キット