トップ›研究者を探す›ナノキャリアの生体反応性とバイオ応用に関する研究

ナノキャリアの生体反応性とバイオ応用に関する研究

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-20390013
研究種目 基盤研究(B)
研究分野 生物系
医歯薬学
薬学
物理系薬学
研究機関 徳島大学
代表研究者 際田 弘志
研究分担者 石田 竜弘
研究期間 開始年月日 2008/4/1
研究期間 終了年度 2010
研究ステータス 完了 (2010/4/1)
配分額（合計） 17,680,000 (直接経費 :13,600,000、間接経費 :4,080,000)
配分額（履歴） 2010年度：3,380,000 (直接経費 :2,600,000、間接経費 :780,000)
2009年度：4,290,000 (直接経費 :3,300,000、間接経費 :990,000)
2008年度：10,010,000 (直接経費 :7,700,000、間接経費 :2,310,000)
キーワード ナノキャリア
免疫系
抗PEG-IgM
B細胞
ナノトキシコロジー
DDS
リポソーム
ポリエチレングリコール
免疫反応

研究成果

[学会発表] PEG on nanocarriers induces anti PEG IgM production as a result of activation of immune system., Nano in Cancer : Linking Chemistry

Hashiguchi Y., Shimizu T., Ichihara M., Ishida T., Kiwada H. 2011

[雑誌論文] Anti-PEG IgM response against PEGylated liposomes in mice and rats.

Ichihara M., Shimizu T., Imoto A., Hashiguchi Y., Uehara Y., Ishida T, Kiwada H. 2011

[雑誌論文] Anti-PEG IgM production by siRNA encapsulated in a PEGylated lipid nanocarrier is dependent on the sequence of the siRNA.

Tagami T., Uehara Y., Moriyoshi N., Ishida T., Kiwada H. 2011

[学会発表] PEG修飾ナノキャリア生体内投与後に生ずる免疫活性化(ABC現象)機構解明に関する検討

市原理子、石田竜弘、際田弘志 2010

[雑誌論文] Evasion of the accelerated blood clearance phenomenon by coating of nanoparticles with various hydrophilic polymers.

Ishihara T., Maeda T., Sakamoto H., Takasaki N., Shigyo M., Ishida T., Kiwada H., Mizushima Y., Mizushima T. 2010

[学会発表] Sequential treatment, pre-dose with empty PEGylated liposome (SL) and second dose antigen-encapsulating SL, promotes activation in a primary immune response.

Hashiguchi, Y., Shimizu, T., Ishida T., Kiwada H. 2010

[雑誌論文] CpG motifs in pDNA-sequences increase anti-PEG IgM production induced by PEG-coated pDNA-lipoplexes.

Tagami, T., Nakamura, K., Shimizu, T., Yamazaki, N., Ishida, T., Kiwada, H. 2010

[学会発表] Immunostimulatory properties of liposomes containing PEG.

Ishida, T., Kiwada, H. 2010

[雑誌論文] Optimized PEGylated adenovirus vector reduces the anti-vector humoral immune response against adenovirus and induces a therapeutic effect against metastatic lung cancer.

Eto Y., Yoshioka Y., Ishida T., Yao X., Morishige T., Narimatsu S., Mizuguchi H., Mukai Y., Okada N., Kiwada H., Nakagawa S. 2010

[学会発表] 核酸デリバリーにおけるABC現象

石田竜弘 2010

[雑誌論文] T cell-independent B cell response is responsible for ABC phenomenon induced by repeated injection of PEGylated liposomes.

Koide H., Asai, T., Hatanaka, K., Akai, S., Ishii, T., Kenjo, E., Ishida, T., Kiwada, H., Tsukada, H., Oku, N. 2010

[学会発表] Immunostimulatory properties of liposomes containing PEG

Ishida, T. 2010

[学会発表] Spleen cells secret anti-PEG IgM following intravenous injection of PEGylated liposome.

Ichihara, M., Imoto, A., Hashiguchi, Y., Uehara, Y., Ishida T., Kiwada H. 2010

[学会発表] 核酸デリバリーにおけるABC現象、遺伝子・デリバリー研究会

石田竜弘、際田弘志 2010

[学会発表] Elucidation of ABC phenomenon caused by repeat injection of PEGylated nanocarrier.

Koide, H., Asai, T., Yokoyama, M., Ishida T., Kiwada H., Oku, N. 2009

[雑誌論文] Accelerated blood clearance phenomenon upon repeated injection of PEG-modified PLA-nanoparticles.

Ishihara, T., Takeda, M., Sakamoto, H., Kimoto, A., Kobayashi, C., Takasaki, N., Yuki, K., Tanaka, K., Takenaga, M., Igarashi, R., Maeda, T., Yamakawa, N., Okamoto, Y., Otsuka, M., Ishida, T., Kiwada, H. 2009

[図書] Unexpected reactions by in vivo application of PEGylated liposomes. "(Safety of Nanoparticles : From Manufacturing to Clinical Applications (A volume in the Nanostructure Science and Technology series))(T.J.Webster (Ed.)), Chapter 6, p111-130

Ishida, T., Kiwada, H. 2009

[学会発表] 核酸デリバリーにおけるaccelerated blood clearance (ABC)現象

石田竜弘、際田弘志 2009

[学会発表] 核酸デリバリーにおける accelerated blood clearance (ABC)現象

石田竜弘 2009

[雑誌論文] Effect of siRNA in PEG-coated siRNA-lipoplex on anti-PEG IgM production.

Tagami, T., Nakamura, K., Shimizu, T., Ishida, T., Kiwada, H. 2009

[学会発表] Interaction of PEGylated liposomes with splenic marginal zone B cells may trigger production of anti-PEG IgM in the ABC phenomenon.

Shimizu, T., Ishida T., Kiwada H. 2008

[学会発表] Effect of siRNA on anti-PEG IgM production in the accelerated blood clearance (ABC) phenomenon when formulated with PEGylated cationic liposome.

Tagami, T., Nakamura, K., Shimizu, T., Ishida T., Kiwada H. 2008

[雑誌論文] The contribution of phagocytic activity of liver macrophages to the accelerated blood clearance (ABC) phenomenon of PEGylated liposomes in rats.

Ishida, T., et al. 2008

[雑誌論文] Accelerated blood clearance (ABC) phenomenon upon repeated injection of PEGylated liposomes.

Ishida, T., Kiwada, H. 2008

[雑誌論文] The contribution of phagocytic activity of liver macrophages to the accelerated blood clearance (ABC) phenomenon of PEGylated liposomes in rats.

Ishida, T., Kashima, S., Kiwada, H. 2008

[学会発表] PEG修飾微粒子キャリアー投与時の免疫反応

石田竜弘 2008

[学会発表] Unexpected immunological response against sterically stabilized, PEGylated, liposome after intravenous injection.

石田竜弘, 際田弘志 2008

[雑誌論文] Particle size-dependent triggering of accelerated blood clearance phenomenon.

Koide H., Asai, T., Hatanaka, K., Urakami, T., Ishii, T., Kenjo, E., Nishihara, M., Yokoyama, M., Ishida, T., Kiwada, H., Oku, N. 2008

[学会発表] Unexpected immunological response against sterically stabilized, PEGylated, liposome after intravenous injection.

Ishida, T. 2008

[学会発表] Accelerated blood clearance (ABC) phenomenon on PEGylated nanocarrier : Unexpected immune-reaction against PEGylated liposome.

Shimizu, T., Ishida T., Kiwada H. 2008