運動器機能の統合的制御に関する基礎的研究

トップ›研究者を探す›運動器機能の統合的制御に関する基礎的研究

代表研究者	田中栄
研究課題番号	KAKENHI-PROJECT-20249064
研究種目	基盤研究(A)
研究分野	生物系医歯薬学外科系臨床医学整形外科学
研究機関	東京大学
研究分担者	二川健
研究分担者	緒方徹
研究分担者	芳賀信彦
研究期間開始年月日	2008/4/1
研究期間終了年度	2011
研究ステータス	完了 (2011/4/1)
配分額（合計）	46,540,000 (直接経費 :35,800,000、間接経費 :10,740,000)
配分額（履歴）	2011年度：9,620,000 (直接経費 :7,400,000、間接経費 :2,220,000) 2010年度：9,620,000 (直接経費 :7,400,000、間接経費 :2,220,000) 2009年度：11,570,000 (直接経費 :8,900,000、間接経費 :2,670,000) 2008年度：15,730,000 (直接経費 :12,100,000、間接経費 :3,630,000)
キーワード	骨軟骨筋神経 Bcl-2ファミリー Bcl-xL 破骨細胞 TGF-beta Cbl-b RANTES VICOM Oligodendrocyte 運動器筋細胞アポトーシス c-Src Bc1-2 RFN10 apoptosis

研究成果

[雑誌論文] Unloading stress disturbs muscle regeneration through perturbed recruitment and function of macrophages

Kohno S, Nikawa T, et al. 2012

[雑誌論文] Identification of a redox-modulatory interaction between uncoupling protein 3 and thioredoxin 2 in the mitochondrial intermembrane space

Hirasaka K, Lago CU, Kenaston MA, Fathe K, Nowinski SM, Nikawa T, Mills EM. 2011

[雑誌論文] Hes1 functions downstream of growth factors to maintain oligodendeocyte lineage cells in the early progenitor stage

Ogata T, Ueno T, Hoshikawa S, Ito J, Okazaki R, Hayakawa K, Morioka K, Yamamoto S, Nakamura K, Tanaka S, Akai M. 2011

[雑誌論文] Rantes secreted from macrophages disturbs skeletal muscle regeneration after cardiotoxin inj ection in Cbl-b-deficient mice.

Kohono S, Nikawa T, et al. 2011

[雑誌論文] Hyperphosphorylated neurofilament NF-H as a biomarker of the efficacy of minocycline therapy for spinal cord injury

Ueno T, Ohori Y, Ito J, Hoshikawa S, Yamamoto S, Nakamura K, Tanaka S, Akai M, Tobimatsu Y, Ogata T. 2011

[雑誌論文] Rantes secreted from macrophages disturbs skeletal muscle regeneration after cardiotoxin injection in Cbl-b-deficient mice

Kohno S, Ueji T, Abe T, Nakao R, Hirasaka K, Oarada M, Harada-Sukeno A, Ohno A, Higashibata A, Mukai R, Terao J, Okumura Y, Nikawa T. 2011

[雑誌論文] Ubiquitin ligase Cbl-b is a negative regulator for insulin-like growth factor 1 signaling during muscle atrophy caused by unloading.

Nakao R, Nikawa T, et al. 2009

[雑誌論文] Ubiquitin ligase Cbl-b is a negative regulator for insulin-like growth factor 1 signaling during muscle atrophy caused by unloading

Nakao R, Hirasaka K, Goto J, Ishidoh K, Yamada C, Ohno A, Okumura Y, Nonaka I, Yasutomo K, Baldwin KM, Kominami E, Higashibata A, Nagano K, Tanaka K, Yasui N, Mills EM, Takeda S, Nikawa T. 2009

[雑誌論文] Ubiquitin ligase Cbl-b is a negative regulator for insulin-like growth factor 1 signaling during muscle atrophy caused by unloading.

Nakao, R., Hirasaka, K., Goto, J., Ishidoh, K., Yamada, C., Ohno, A., Okumura, Y., Nonaka, I., Yasutomo, K., Baldwin, K.M., Nikawa, T., et al. 2009

[雑誌論文] A novel function of RING finger protein 10 in transcriptional regulation of the myelin-associated glycoprotein gene and myelin formation in Schwann cells.

Hoshikawa S, Ogata T, Fujiwara S, Nakamura K, Tanaka S. 2008

[雑誌論文] A novel function of RING finger protein 10 in transcriptional protein 10 in transcriptional regulation of the myelin-associated glycoprotein gene and myelin formation in Schwann cells.

Hoshikawa, S., Ogata, T., Fujiwara, S., Nakamura, K., Tanaka, S. 2008