研究成果

[雑誌論文] Bosentan improves systemic sclerosis-related peripheral circulation insufficiency.

Yagi S, Akaike M, Aihara KI, Iwase T, Sumitomo-Ueda Y, Yoshida S, Matsumoto T, Sata M 2011

[雑誌論文] Activation of Peroxisome Proliferator-activated Receptor alpha in Megakaryocytes Reduces Platelet-derived Growth Factor-BB in Platelets

Hashizume S, Akaike M, Azuma H, Ishikawa K, Yoshida S, Sumitomo-Ueda Y, Yagi S, Ikeda Y, Iwase T, Aihara KI, Abe M, Sata M, Matsumoto T 2011

[雑誌論文] Plasma heparin cofactor II activity is inversely associated with left atrial volume and diastolic dysfunction in humans with cardiovascular risk factors.

Ise T, Aihara K, Sumitomo-Ueda Y, Yoshida S, Ikeda Y, Yagi S, Iwase T, Yamada H, Akaike M, Sata M, Matsumoto T 2011

[雑誌論文] High plasma aldosterone concentration is a novel risk factor of cognitive impairment in patients with hypertension.

Yagi S, Akaike M, Aihara K, Iwase T, Yoshida S, Sumitomo-Ueda Y, Ikeda Y, Ishikawa K, Matsumoto T, Sata M 2011

[雑誌論文] Delayed treatment with vitamin C and N-acetyl-L:-cysteine protects Schwann cells without compromising the anti-myeloma activity of bortezomib.

Nakano A, Abe M, Oda A, Amou H, Hiasa M, Nakamura S, Miki H, Harada T, Fujii S, Kagawa K, Takeuchi K, Watanabe T, Ozaki S, Matsumoto T 2011

[雑誌論文] TGF-β-related mechanisms of bone destruction in multiplemyeloma.

Matsumoto T, Abe M 2011

[雑誌論文] Transient inflammatory reaction during Ienalidomide plus reduced-dose dexamethasone therapy in two patients with relapsed multiple myeloma.

Ozaki S, Harada T, Fujii S, Nakamura S, Miki H, Nakano A, Kagawa K, Takeuchi K, Abe M, Matsumoto T 2011

[雑誌論文] The serine/threonine kinase Pim-2 is a novel anti-apoptotic mediator in myeloma cells

Asano J, Nakano A, Oda A, Amou H, Hiasa M, Takeuchi K, Miki H, Nakamura S, Harada T, Fujii S, Kagawa K, Endo I, Yata K-I, Sakai A, Ozaki S, Matsumoto T, Abe M 2011

[雑誌論文] Vitamin D Insufficiency Defined by Serum 25-Hydroxyvitamin D and Parathyroid Hormone Before and After Oral Vitamin D3 Load in Japanese Subjects.

Okazaki R, Sugimoto T, Kaji H, Fujii Y, Shiraki M, Inoue D, Endo I, Okano T, Hirota T, Matsumoto T 2011

[雑誌論文] Chapter 11. Mechanosensing and Signaling Crosstalks.

Matsumoto T, Kuriwaka-Kido R, Kido S 2011

[雑誌論文] Heparin cofactor II protects against angiotensin II-induced cardiac remodeling via attenuation of oxidative stress in mice.

Sumitomo-Ueda Y, Aihara K, Ise T, Yoshida S, Ikeda Y, Uemoto R, Yagi S, Iwase T, Ishikawa K, Hirata Y, Akaike M, Sata M, Kato S, Matsumoto T 2010

[雑誌論文] Androgen receptor counteracts Doxorubicin-induced cardiotoxicity in male mice.

Ikeda Y, Aihara K, Akaike M, Sato T, Ishikawa K, Ise T, Yagi S, Iwase T, Ueda Y, Yoshida S, Azuma H, Walsh K, Tamaki T, Kato S, Matsumoto T 2010

[雑誌論文] Dehydroepiandrosterone sulfate is inversely associated with sex-dependent diverse carotid atherosclerosis regardless of endothelial function.

Yoshida S, Aihara K, Azuma H, Uemoto R, Sumitomo-Ueda Y, Yagi S, Ikeda Y, Iwase T, Nishio S, Kawano H, Miki J, Yamada H, Hirata Y, Akaike M, Sata M, Matsumoto T 2010

[雑誌論文] Ezetimibe ameliorates metabolic disorders and microalbuminuria in patients with hypercholesterolemia.

Yagi S, Akaike M, Aihara K, Iwase T, Ishikawa K, Yoshida S, Sumitomo-Ueda Y, Kusunose K, Niki T, Yamaguchi K, Koshiba K, Hirata Y, Dagvasumberel M, Taketani Y, Tomita N, Yamada H, Soeki T, Wakatsuki T, Matsumoto T, Sata M 2010

[雑誌論文] Inhibition of thrombin action ameliorates insulin resistance in type 2 diabetic db/db mice.

Mihara M, Aihara K, Ikeda Y, Yoshida S, Kinouchi M, Kurahashi K, Fujinaka Y, Akaike M, Matsumoto T 2010

[学会発表] ロスバスタチンによる心筋リモデリング抑制効果の検討

粟飯原賢一 2010

[学会発表] Heparin cofactor II is a novel anticardiac remodeling factor against angiotensin II excess

粟飯原賢一 2010

[学会発表] フェノフィブラートはアンジオテンシンII負荷による高血圧と心筋リモデリングを制御する

粟飯原賢一 2010

[雑誌論文] Endothelial nitric oxide synthase-independent protective action of statin against angiotensin II-induced atrial remodeling via reduced oxidant injury.

Yagi S, Akaike M, Aihara K, Ishikawa K, Iwase T, Ikeda Y, Soeki T, Yoshida S, Sumitomo-Ueda Y, Matsumoto T, Sata M 2010

[雑誌論文] Induction of endosomal/lysosomal pathways in differentiating osteoblasts as revealed by combined proteomic and transcriptomic analyses.

Taniguchi T, Kido S, Yamauchi E, Abe M, Matsumoto T, Taniguchi H 2010

[雑誌論文] Tgf-Beta inhibition restores terminal osteoblast differentiation to suppress myeloma growth.

Takeuchi K, Abe M, Hiasa M, Oda A, Amou H, Kido S, Harada T, Tanaka O, Miki H, Nakamura S, Nakano A, Kagawa K, Yata K, Ozaki S, Matsumoto T 2010

[雑誌論文] Size-controlled synthesis, surface functionalization, and biological applications of thiol-organosilica particles.

Nakamura M, Ozaki S, Abe M, Doi H, Matsumoto T, Ishimura K 2010

[学会発表] TIMP-3 up-regulation facilitates osteoclastogenesis and suppresses DC differentiation from monocytes in the bone marrow microenvironment in myeloma

安倍正博 2010

[学会発表] TIMP-3 up-regulation facilitates osteoclastogenesis and suppresses DC differentiation from monocytes in the bone marrow microenvironment in myeloma

Masahiro Abe 2010

[雑誌論文] A defucosylated anti-CD317 antibody exhibited enhanced antibody-dependent cellular cytotoxicity against primary myeloma cells in the presence of effectors from patients.

Ishiguro T, Kawai S, Habu K, Sugimoto M, Shiraiwa H, Iijima S, Ozaki S, Matsumoto T, Yamada-Okabe H 2010

[雑誌論文] Validation of the Japanese Osteoporosis Quality of Life Questionnaire.

Kumamoto K, Nakamura T, Suzuki T, Gorai I, Fujinawa O, Ohta H, Shiraki M, Yoh K, Fujiwara S, Endo N, Matsumoto T 2010

[学会発表] Serum ICTP can be a surrogate marker of coronary unstable plaques

遠藤逸朗 2010

[雑誌論文] Mechanical Stress Activates Smad Pathway through PKC δ to Enhance Interleukin-11 Gene Transcription in Osteoblasts.

Kido S, Kuriwaka-Kido R, Umino-Miyatani Y, Endo I, Inoue D, Taniguchi H, Inoue Y, Imamura T, Matsumoto T 2010

[雑誌論文] Comparison of the effects of eldecalcitol and alfacalcidol on bone and calcium metabolism.

Matsumoto T 2010

[雑誌論文] Comparison of the effects of eldecalcitol and alfacalcidol on bone and calcium metabolism.

Matsumoto T, Takano T, Yamakido S, Takahashi F, Tsuji N 2010

[雑誌論文] Effects of teriparatide on bone mineral density and bone turnover markers in Japanese subjects with osteoporosis at high risk of fracture in a 24-month clinical study : 12-month, randomized, placebo-controlled, double-blind and 12-month open-label phases.

Miyauchi A, Matsumoto T, Sugimoto T, Tsujimoto M, Warner MR, Nakamura T 2010

[雑誌論文] Chapter 11. Mechanosensing and Signaling Crosstalks.

Matsumoto T 2010

[学会発表] 新しいビタミンDによる骨折予防

松本俊夫 2010

[学会発表] 新しいビタミンDによる骨折予防

松本俊夫 2010

[学会発表] 宇宙医学の成果とその社会への還元

松本俊夫 2010

[雑誌論文] TGF-β-related mechanisms of bone destruction in multiple myeloma.

Matsumoto T 2010

[学会発表] ロスバスタチンによる心筋リモデリング抑制効果の検討

粟飯原賢一 2010

[雑誌論文] Heparin cofactor II as a novel vascular protective factor against atherosclerosis.

Aihara, K 2009

[雑誌論文] Decrease in plasma brain natriuretic peptide level in the early phase after the start of carvediolo therapy is a novel predictor of long-term outcome in patients with chronic heart failure.

Fujimura M, Akaike M, Iwase T, Yoshida S, Sumitomo Y, Yagi S, Ikeda Y, Hashizume S, Aihara K, Nishiuchi T, Yasumura Y, Matsumoto T 2009

[雑誌論文] Androgen-androgen receptor system protects against angiotensin II-inducedvascular remodeling.

Ikeda Y, Aihara K, Yoshida S, Sato T, Yagi S, Iwase T, Sumitomo Y, Ise T, Ishikawa K, Azuma H, Akaike M, Kato S, Matsumoto T 2009

[学会発表] 尿中アルブミンは内臓脂肪蓄積の強力な増悪因子である

粟飯原賢一 2009

[雑誌論文] Heparin Cofactor II Is an Independent Protective Factor Against Peripheral Arterial Disease in Elderly Subjects With Cardiovascular Risk Factors.

Aihara, K-I 2009

[学会発表] Influence of lipid profile on endothelial function in subjects with cardiovascular risk factors

粟飯原賢一 2009

[雑誌論文] Heparin cofactor II is an independent protective factor against peripheral arterial disease in elderly subjects with cardiovascular risk factors.

Aihara K, Azuma H, Akaike M, Kurobe H, Takamori N, Ikeda Y, Sumitomo Y, Yoshida S, Yagi S, Iwase T, Ishikawa K, Sata M, Kitagawa T, Matsumoto T 2009

[雑誌論文] Heparin cofactor II is an independent protective factor against peripheral arterial disease in elderly subjects with cardiovascular risk factors.

Aihara, K 2009

[雑誌論文] Heparin cofactor II as a novel vascular protective factor against atherosclerosis.

Aihara K, Akaike M, Sata M, Matsumoto T 2009

[学会発表] 内臓脂肪蓄積制御に関わる因子の臨床的検討

粟飯原賢一 2009

[学会発表] Facilitation of osteoblast differentiation by ATF-4accumulation through proteasome inhibition

安倍正博 2009

[雑誌論文] Valproic acid exerts anti-tumor as well as anti-angiogenic effects on myeloma.

Kitazoe K, Abe M, Hiasa M, Oda A, Amou H, Harada T, Nakano A, Takeuchi K, Hashimoto T, Ozaki S, Matsumoto T 2009

[雑誌論文] Vicious cycle between myeloma cell binding to bone marrow stromal cells via VLA-4-VCAM-1 adhesion and macrophage inflammatory protein(MIP)-1α and MIP-1β production

Abe M 2009

[雑誌論文] GM-CSF and IL-4 induce dendritic cell differentiation and disrupt osteoclastogenesis through M-CSF receptor shedding by up-regulation of TNF-alpha converting enzyme (TACE).

Hiasa M, Abe M, Nakano A, Oda A, Amou H, Kido S, Takeuchi K, Kagawa K, Yata K, Hashimoto T, Ozaki S, Asaoka K, Tanaka E, Moriyama K, Matsumoto T 2009

[雑誌論文] Chimeric and humanized anti-HM1.24 antibodies mediate antibody-dependent cellular cytotoxicity against lung cancercells.

Wang W, Nishioka Y, Ozaki S, Jalili A, Verma V, Hanibuchi M, Abe S, Minakuchi K, Matsumoto T, Sone S 2009

[雑誌論文] Vicious cycle between myeloma cell binding to bone marrow stromal cells via VLA-4-VCAM-1 adhesion and macrophage inflammatory protein-lalpha and MIP-1beta production.

Abe, M 2009

[学会発表] Bone marrow microenvironment up-regulates Pim-2 expression in myeloma cells to enhance myeloma cell survival

安倍正博 2009

[雑誌論文] HM1.24 (CD317) is a novel target against lung cancer for immunotherapy using anti-HM1.24 antibody.

Wang W, Nishioka Y, Ozaki S, Jalili A, Abe S, Kakiuchi S, Kishuku M, Minakuchi K, Matsumoto T, Sone S 2009

[雑誌論文] Marked improvement of platelet transfusion refractoriness after bortezomib therapy in multiple myeloma.

Miki H, Ozaki S, Tanaka O, Lee E, Takimoto T, Watanabe H, Fujii S, Nakamura S, Kagawa K, Takeuchi K, Yata K, Abe M, Kagami S, Matsumoto T 2009

[雑誌論文] Vicious cycle between myeloma cell binding to bone marrow stromal cells via VLA-4-VCAM-1 adhesion and macrophage inflammatory protein-lalpha and MIP-lbeta production.

Abe M, Hiura K, Ozaki S, Kido S, Matsumoto T 2009

[学会発表] Bone marrow microenvironment up-regulates Pim-2 expression in myeloma cells to enhance myelorna cell survival

安倍正博 2009

[雑誌論文] Pinl down-regulates transforming growth factor-beta (TGF-beta) signaling by inducing degradation of Smad proteins.

Nakano A, Koinuma D, Miyazawa K, Uchida T, Saitoh M, Kawabata M, Hanai J, Akiyama H, Abe M, Miyazono K, Matsumoto T, Imamura T 2009

[学会発表] Facilitation of osteoblast differentiation by ATF-4accumulation through proteasome inhibition

安倍正博 2009

[学会発表] A new calcilytic compound, JTT-305, inhibits enhanced signaling by activating mutations of calcium-sensing receptor in autosomal dominant hypocalcemia (ADH)

遠藤逸朗 2009

[学会発表] A new calcilytic compound, JTT-305, inhibits enhanced signaling by activating mutations of calcium-sensing receptor in autosomal dominant hypocalcemia(ADH)

遠藤逸朗 2009

[学会発表] A new calcilytic compound, JTT-305, inhibits enhanced signaling by activating mutations of calcium-sensing receptor in autosomal dominant hypocalce mia (ADH)

遠藤逸朗 2009

[学会発表] 冠動脈不安定プラーク予測因子としてのICTP

遠藤逸朗 2009

[学会発表] 脳波への徐消化を伴う重症低血糖昏睡を来した神経性食思不振症の一例

遠藤逸朗 2009

[学会発表] 常染色体優性低Ca血症(ADH)に対するcalcilyticsの治療応用への可能性

遠藤逸朗 2009

[学会発表] 微少重力や長期臥床による骨粗鬆症への挑戦

松本俊夫 2009

[雑誌論文] Mechanical stress induces Interleukin-11 expression to stimulate osteoblast differentiation.

Kido S, Kuriwaka-Kido R, Imamura T, Ito Y, Inoue D, Matsumoto T 2009

[雑誌論文] A double-blinded head-to-head trial of minodronate and alendronate in women with postmenopausal osteoporosis.

Hagino H, Nishizawa Y, Sone T, Morii H, Taketani Y, Nakamura T, Itabashi A, Mizunuma H, Ohashi Y, Shiraki M, Minamide T, Matsumoto T 2009

[雑誌論文] Targeting Bone Remodeling for the Treatment of Osteoporosis : Summary of the Proceedings of an ASBMR Workshop.

Bilezikian JP, Matsumoto T, Bellido T, Khosla S, Martin J, Recker RR, Heaney R, Seeman E, Papapoulos S, Goldring SR 2009

[雑誌論文] Effect of daily oral minodronate on vertebral fractures in Japanese postmenopausal women with established osteoporosis : a randomized placebo-controlled double-blind study.

Matsumoto T, Hagino H, Shiraki M, Fukunaga M, Nakano T, Takaoka K, Morii H, Ohashi Y, Nakamura T 2009

[雑誌論文] Effect of daily oral minodronate on vertebral fractures in Japanese postmenopausal women with established osteoporosis : a randomized placebo-controlled double-blin study.

Matsumoto, T 2009

[雑誌論文] Effect of daily oral minodronate on vertebral fractures in Japanese postmen opausal women with established osteoporosis : a randomized placebo-controlled double-blind study.

Matsumoto, T 2009

[学会発表] 常染色体優性低Ca血症(ADH)に対するcalcilyticsの治療応用への可能性

遠藤逸朗 2009

[学会発表] 脂質代謝異常による左室拡張障害の臨床的検討

粟飯原賢一 2008

[雑誌論文] Pitavastatin, an HMG-GoA Reductase Inhibitor, Exerts eNOS-independent Protective Actions against Angiotensin II-Induced Cardiovascular Remodeling and Renal Insufficiency.

Yagi S, Aihara K, Ikeda Y, Sumitomo Y, Iwase T, Ishikawa K, Azuma H, Akaike M, Matsumoto T 2008

[学会発表] The active form of vitamin D, 1, 25 (OH) 2D3, prevents vascular remodeling and glucose intolerance in elderly individuals

粟飯原賢一 2008

[学会発表] Bone marrow stromal cells up-regulate M-CSF receptor in monocytes to disrupt dendritic cell differentiation while facilitating osteoclastogenesis in myeloma

安倍正博 2008

[学会発表] TACE up-regulation in monocytes by GM-CSF and IL-4 disrupts myeloma cell-induced osteoclastogenesis while inducing dendritic cell differentiation

安倍正博 2008

[学会発表] 骨髄腫骨病変に対する新規薬物療法の開発(シンポジウム)

安倍正博 2008

[学会発表] 多発性骨髄腫骨病変の形成機序の解明と治療法の開発

安倍正博 2008

[雑誌論文] Clinical usefulness of measurement of fibroblast growth factor 23 (FGF23) in hypophosphatemic patients Proposal of diagnostic criteriausing FGF23 measurement.

Endo, I 2008

[雑誌論文] Causes and differential diagnosis of hypocalcemia -Recommendation proposed by expert panel supported by Ministry of Health, Labour and Welfare, Japan-.

Fukumoto, Namba N, Ozono K, Yamauchi M, Sugimoto T, Michigami T, Tanaka H, Inoue D, Minagawa M, Endo I, Matsumoto T 2008

[学会発表] Clinical usefulness of measurement of fibroblast growth factor 23 (FGF23) in hypophosphatemic patients-Proposal of diagnostic criteria using FGF23 measurement

遠藤逸朗 2008

[雑誌論文] Clinical usefulness of measurement of fibroblast growth factor 23 (FGF23) in hypophosphatemic patients Proposal of diagnostic criteria using FGF23 measurement.

Endo I, Fukumoto S, Ozono K, Namba N, Tanaka H, Inoue D, Minagawa M, Sugimoto T, Yamauchi M, Michigami T, Matsumoto T 2008

[学会発表] 骨粗鬆症診療の進歩

松本俊夫 2008

[学会発表] 骨カルシウム内分泌学の他領域との融合に向けた研究

松本俊夫 2008

[雑誌論文] Effect of Teriparatide on Bone Mineral Density and Biochemical Markers in Japanese Women with Postmenopausal Osteoporosis : a 6-month Dose-response Study.

Miyauchi A, Matsumoto T, Shigeta H, Tsujimoto M, Thiebaud D, Nakamura T 2008

[学会発表] 悪性腫瘍と骨病変

松本俊夫 2008