自然免疫の包括的研究

代表研究者	審良静男
研究課題番号	KAKENHI-PROJECT-20002008
研究種目	特別推進研究
研究分野
研究機関	大阪大学
研究分担者	竹内理
研究分担者	河合太郎
研究分担者	齋藤逹哉
研究分担者	佐藤荘
研究期間開始年月日	2008/4/1
研究期間終了年度	2012
研究ステータス	完了 (2012/4/1)
配分額（合計）	873,080,000 (直接経費 :671,600,000、間接経費 :201,480,000)
配分額（履歴）	2012年度：206,960,000 (直接経費 :159,200,000、間接経費 :47,760,000) 2011年度：206,960,000 (直接経費 :159,200,000、間接経費 :47,760,000) 2010年度：157,690,000 (直接経費 :121,300,000、間接経費 :36,390,000) 2009年度：141,830,000 (直接経費 :109,100,000、間接経費 :32,730,000) 2008年度：159,640,000 (直接経費 :122,800,000、間接経費 :36,840,000)
キーワード	自然免疫炎症性疾患感染症サイトカインインターフェロン生活習慣病炎症マクロファージ好中球パターン認識受容体シグナル伝達蛋白質分解遺伝子発現 Toll-like receptor エピジェネティクス H3K27メチル化ユビキチン化病原体センサーオートファジー自己免疫疾患

研究成果

[雑誌論文] Neutrophil extracellular traps mediate a host defense response to human immunodeficiency virus-1.

Saitoh T, Komano J, Saitoh Y, Misawa T, Takahama M, Kozaki T, Uehata T, Iawasaki H. Omori H, Yamaoka S, Yamamoto N, Akira S. 2012

[雑誌論文] Antiviral protein Viperin promotes TOll-like receptor 7- and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells

Saitoh T, et al 2011

[雑誌論文] Antiviral protein Viperin promotes Toll-like receptor 7- and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells.

Saitoh T, Satoh T, Yamamoto N, Uematsu S, Takeuchi O, Kawai T, Akira S. 2011

[雑誌論文] The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR-IL-1R by controlling degradation of regnase-1.

Iwasaki H, Takeuchi O, Teraguchi S, Matsushita K, Uehata T, Kuniyoshi K, Satoh T, Saitoh T, Matsushita M, Standley DM, Akira S. 2011

[雑誌論文] The Jmjd3-Irf4 axis regulates M2 macropharge polarization and host responses against helminth infection.

Satoh T, Takeuchi O, Vandenbon A, Yasuda K, Kumagai Y, Miyake T, Matsuyama T, Yui K, Okazaki T, Saitoh T, Honma K, Nakai,K Akira S. 2010

[雑誌論文] The Ubiquitin Ligase TRIM56 Regulates Innate Immune Responses to Intracellular Double-Stranded DNA.

Tsuchida T, Zou J, Saitoh T, Kumar H, Abe T, Matsuura Y, Kawai T, Akira S. 2010

[雑誌論文] The Ubiquitin Ligase TRIM56 Regulates Innate Immune Responses to Intracellular Double-Stranded DNA.

Tsuchida, T., Zou, J., Saitoh, T., Kumar, H., Abe, T., Matsuura, Y., Kawai, T., Akira, S. 2010

[雑誌論文] The Ubiquitin Ligase TRIM56 Regulates Innate Immune Responses to Intracellular Double-Stranded DNA.

Tsuchida, T., Zou, J., Saitoh, T., Kumar, H., Abe, T., Matsuura, Y., Kawai, T., Akira, S. 2010

[雑誌論文] The Jmjd3-lrf4 axis regulates M2 macropharge polarization and host responses against helminth infection.

Satoh, T., Takeuchi, O., Vandenbon, A., Yasuda, K., Kumagai, Y., Miyake, T., Matsuyama, T., Yui, K., Okazaki, T., Saitoh, T., Honma, K., Nakai, K.and Akira, S. 2010

[雑誌論文] Regulation of innate immune responses by autophagy-related proteins.

Saitoh, T., Akira, S. 2010

[雑誌論文] Regulation of dsDNA-induced innate immune responses by membrane trafficking.

Saitoh, T., Fujita, N., Yoshimori, T., Akira, S. 2010

[雑誌論文] The Jmjd3-Irf4 axis regulates M2 macropharge polarization and host responses against helminth infection.

Satoh, T., Takeuchi, O., Vandenbon, A., Yasuda, K., Kumagai, Y., Miyake, T., Matsuyama, T., Yui, K., Okazaki, T., Saitoh, T., Honma, K., Nakai, K., Akira, S. 2010

[雑誌論文] Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response.

Saitoh T, Fujita N, Hayashi T, Takahara K, Satoh T, Lee H, Matsunaga K, Kageyama S, Omori H, Noda T, Yamamoto N, Kawai T, Ishii K, Takeuchi O, Yoshimori T, Akira S. 2009

[雑誌論文] Involvement of the NLRP3 inflammasome in innate and humoral adaptive immune responses to fungal beta-glucan.

Kumar, H., Kumagai, Y., Tsuchida, T., Koening, P.A., Satoh, T., Guo, Z., Jang, M.H., Saitoh, T., Akira, S., Kawai, T. 2009

[雑誌論文] Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2.

Kawagoe T, Sato S, Matsushita K, Kato H, Matsui K, Kumagai Y, Saitoh T, Kawai T, Takeuchi O, Akira S. 2008

[雑誌論文] Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1 beta production

Saitoh T, Fujita N, Jang M.H, Uematsu S, Yang B.G, Satoh T, Omori H, Noda T, Yamamoto N, Komatsu M, Tanaka K, Tsujimura T, Takeuchi O, Yoshimori T, Akira S 2008

[雑誌論文] Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production.

Saitoh, T., Fujita, N., Jang, M.H., Uematsu, S., Yang, B.G., Satoh, T., Omori, H., Noda, T., Yamamoto, N., Komatsu, M., Tanaka, K., Tsujimura, T., Takeuchi, O., Yoshimori, T., Akira S. 2008

[雑誌論文] Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production.

Saitoh T, Fujita N, Jang M.H, Uematsu S, Yang B.G, Satoh T, Omori H, Noda T, Yamamoto N, Komatsu M, Tanaka K, Tsujimura T, Takeuchi O, Yoshimori T, Akira S. 2008