複製ストレス制御因子SLFN11のがん抑制遺伝子としての発展研究

トップ›研究者を探す›複製ストレス制御因子SLFN11のがん抑制遺伝子としての発展研究

代表研究者	村井純子
研究課題番号	KAKENHI-PROJECT-19H03505
研究種目	基盤研究(B)
研究分野
研究機関	慶應義塾大学
研究期間開始年月日	2019/4/1
研究期間終了年度	2021
研究ステータス	完了 (2021/4/1)
配分額（合計）	17,550,000 (直接経費 :13,500,000、間接経費 :4,050,000)
配分額（履歴）	2021年度：4,160,000 (直接経費 :3,200,000、間接経費 :960,000) 2020年度：4,160,000 (直接経費 :3,200,000、間接経費 :960,000) 2019年度：9,230,000 (直接経費 :7,100,000、間接経費 :2,130,000)
キーワード	がん抑制遺伝子複製 DNA修復 DNAダメージ複製ストレス SLFN11 バイオマーカーがん遺伝子抗がん剤トランスジェニックマウスがんがん抑制因子 DNA損傷 PARP阻害剤白金製剤細胞周期薬剤耐性 MYC クロマチンプラチナ感受性抗がん剤耐性

研究成果

[雑誌論文] Schlafen 11 predicts response to platinum-based chemotherapy in gastric cancers

Takashima Tsuyoshi、Taniyama Daiki、Sakamoto Naoya、Yasumoto Maika、Asai Ryuichi、Hattori Takuya、Honma Ririno、Thang Pham Quoc、Ukai Shoichi、Maruyama Ryota、Harada Kenji、Kuraoka Kazuya、Tanabe Kazuaki、Sasaki Atsuo T.、Ohdan Hideki、Morii Eiichi、Murai Junko、Yasui Wataru 2021

[雑誌論文] SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors

Jo Ukhyun、Murai Yasuhisa、Chakka Sirisha、Chen Lu、Cheng Ken、Murai Junko、Saha Liton Kumar、Miller Jenkins Lisa M.、Pommier Yves 2021

[雑誌論文] Schlafen 11 expression in human acute leukemia cells with gain-of-function mutations in the interferon-JAK signaling pathway

Murai Yasuhisa、Jo Ukhyun、Murai Junko、Fukuda Shinsaku、Takebe Naoko、Pommier Yves 2021

[雑誌論文] SLFN11 Inactivation Induces Proteotoxic Stress and Sensitizes Cancer Cells to Ubiquitin Activating Enzyme Inhibitor TAK-243

Murai Yasuhisa、Jo Ukhyun、Murai Junko、Jenkins Lisa M.、Huang Shar-Yin N.、Chakka Sirisha、Chen Lu、Cheng Ken、Fukuda Shinsaku、Takebe Naoko、Pommier Yves 2021

[学会発表] SLFN11 enhances chromatin accessibility in response to DNA-targeting anti-cance agents

村井純子 2021

[学会発表] あなたの知らないSLFN11の世界（シンポジウム）

村井純子 2021

[学会発表] PARP阻害剤の作用機序

村井純子 2021

[雑誌論文] Schlafen 11 predicts response to platinum-based chemotherapy in gastric cancers

[雑誌論文] SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors

Jo Ukhyun、Murai Yasuhisa、Chakka Sirisha、Chen Lu、Cheng Ken、Murai Junko、Saha Liton Kumar、Miller Jenkins Lisa M.、Pommier Yves 2021

[学会発表] がん治療に直結する最新複製制御機構(シンポジウム）

村井純子 2021

[学会発表] あなたの知らないSLFN11の世界

村井純子 2020

[学会発表] PARP Inhibitors Beyond Homologous Recombination and Platinum Sensitivity in Breast and Ovarian Cancers

村井純子 2020

[雑誌論文] Resistance to the CHK1 inhibitor prexasertib involves functionally distinct CHK1 activities in BRCA wild-type ovarian cancer

Nair Jayakumar、Huang Tzu-Ting、Murai Junko、Haynes Brittany、Steeg Patricia S.、Pommier Yves、Lee Jung-Min 2020

[雑誌論文] The first evidence for SLFN11 expression as an independent prognostic factor for patients with esophageal cancer after chemoradiotherapy

Kagami Takuma、Yamade Mihoko、Suzuki Takahiro、Uotani Takahiro、Tani Shinya、Hamaya Yasushi、Iwaizumi Moriya、Osawa Satoshi、Sugimoto Ken、Miyajima Hiroaki、Baba Satoshi、Sugimura Haruhiko、Murai Junko、Pommier Yves、Furuta Takahisa 2020

[雑誌論文] Sensitivity of Mesothelioma Cells to PARP Inhibitors Is Not Dependent on BAP1 but Is Enhanced by Temozolomide in Cells With High-Schlafen 11 and Low-O6-methylguanine-DNA Methyltransferase Expression

Rathkey Daniel、Khanal Manakamana、Murai Junko、Zhang Jingli、Sengupta Manjistha、Jiang Qun、Morrow Betsy、Evans Christine N.、Chari Raj、Fetsch Patricia、Chung Hye-Jung、Xi Liqiang、Roth Mark、Filie Armando、Raffeld Mark、Thomas Anish、Pommier Yves、Hassan Raffit 2020

[雑誌論文] Chromatin Remodeling and Immediate Early Gene Activation by SLFN11 in Response to Replication Stress

Murai Junko、Zhang Hongliang、Pongor Lorinc、Tang Sai-Wen、Jo Ukhyun、Moribe Fumiya、Ma Yixiao、Tomita Masaru、Pommier Yves 2020

[雑誌論文] Immunohistochemical analysis of SLFN11 expression uncovers potential non-responders to DNA-damaging agents overlooked by tissue RNA-seq

Takashima Tsuyoshi、Sakamoto Naoya、Murai Junko、Taniyama Daiki、Honma Ririno、Ukai Shoichi、Maruyama Ryota、Kuraoka Kazuya、Rajapakse Vinodh N.、Pommier Yves、Yasui Wataru 2020

[学会発表] SLFN11が増強するDNA障害型抗がん剤の殺細胞効果

村井純子 2019

[学会発表] Multiple functions of SLFN11, a restriction factor for replication stress induced by DNA-targeting anti-cancer agents

村井純子 2019

[雑誌論文] PARP Trapping Beyond Homologous Recombination and Platinum Sensitivity in Cancers

Murai Junko、Pommier Yves 2019

[学会発表] Schlafen 11 (SLFN11): an emerging focus for DNA-targeted anti-cancer therapies

村井純子 2019

[雑誌論文] Schlafen 11 (SLFN11), a restriction factor for replicative stress induced by DNA-targeting anti-cancer therapies

Murai Junko、Thomas Anish、Miettinen Markku、Pommier Yves 2019

[雑誌論文] Phosphatase 1 Nuclear Targeting Subunit, a Novel DNA Repair Partner of PARP1

Murai Junko、Pommier Yves 2019

[雑誌論文] PARP Inhibitor Sensitivity Does Not Depend on BAP1 but Is Enhanced by Temozolomide in MGMT Deficient Human Mesothelioma Cells

Rathkey D.、Khanal M.、Murai J.、Zhang J.、Jiang Q.、Morrow B.、Evans C.、Chari R.、Sengupta M.、Thomas A.、Pommier Y.、Hassan R. 2019