免疫ドミナンス制御機構の分子メカニズムと生物学的意義の解明

トップ›研究者を探す›免疫ドミナンス制御機構の分子メカニズムと生物学的意義の解明

代表研究者	岡崎一美
研究課題番号	KAKENHI-PROJECT-19H03423
研究種目	基盤研究(B)
研究分野
研究機関	東京大学
研究期間開始年月日	2019/4/1
研究期間終了年度	2021
研究ステータス	完了 (2021/4/1)
配分額（合計）	17,420,000 (直接経費 :13,400,000、間接経費 :4,020,000)
配分額（履歴）	2021年度：5,460,000 (直接経費 :4,200,000、間接経費 :1,260,000) 2020年度：5,460,000 (直接経費 :4,200,000、間接経費 :1,260,000) 2019年度：6,500,000 (直接経費 :5,000,000、間接経費 :1,500,000)
キーワード	免疫ドミナンス LAG-3 免疫偏向性

研究成果

[学会発表] PD-1 elicitation by the dissociation of cis-PD-L1/CD80 duplex inhibits T cell activation and alleviates autoimmunity.

Daisuke Sugiura, Il-mi Okazaki, Takumi Maruhashi, Kenji Shimizu, Reiko Arakaki, Naozumi Ishimaru, Taku Okazaki 2021

[学会発表] PD-1 preferentially inhibits the activation of low affinity T cells.

Kenji Shimizu, Daisuke Sugiura, Il-mi Okazaki, Takumi Maruhashi, Taku Okazaki 2021

[学会発表] Regulatory mechanisms of T cell activation by immuno-inhibitory co-receptors.

Taku Okazaki, Kenji Shimizu, Takumi Maruhashi, Daisuke Sugiura, Il-mi Okazaki 2021

[学会発表] Regulatory mechanisms of T cell activation by immuno-inhibitory co-receptors

Taku Okazaki, Daisuke Sugiura, Takumi Maruhashi, Kenji Shimizu, Il-mi Okazaki 2021

[学会発表] LAG-3 engagement with stable pMHCII is essential for the exertion of its inhibitory function.

Takumi Maruhashi, Daisuke Sugiura, Il-mi Okazaki, Kenji Shimizu, Taku Okazaki 2021

[雑誌論文] PD-1 Imposes Qualitative Control of Cellular Transcriptomes in Response to T Cell Activation

Shimizu Kenji、Sugiura Daisuke、Okazaki Il-mi、Maruhashi Takumi、Takegami Yujiro、Cheng Chaoyang、Ozaki Soichi、Okazaki Taku 2020

[学会発表] シスPD-L1/CD80結合がT細胞活性化段階におけるPD-1の抑制機能を制限する

杉浦大祐, 丸橋拓海, 岡崎一美, 清水謙次, 岡崎　拓 2020

[学会発表] Regulatory mechanisms of T cell activation by immuno-inhibitory co-receptors.

Taku Okazaki, Kenji Shimizu, Daisuke Sugiura, Takumi Maruhashi, Il-mi Okazaki 2020

[学会発表] Restriction of PD-1 function by cis-PD-L1/CD80 interactions is required for optimal T cell responses

Okazaki T, Sugiura D, Maruhashi T, Shimizu K, Okazaki IM 2019

[学会発表] LAG-3 inhibits the activation of CD4+ T cells that recognize stable pMHCII through its conformation-dependent recognition of pMHCII

Maruhashi T, Okazaki IM, Sugiura D, Takahashi S, Maeda TK, Shimizu K, Okazaki T 2019

[学会発表] PD-1 imposes qualitative control of cellular transcriptomes in response to T cell activation

Shimizu K, Sugiura D, Okazaki IM, Maruhashi T, Takegami Y, Cheng C, Ozaki S, Okazaki T 2019

[学会発表] T細胞の抗原刺激による遺伝子発現変動にPD-1が与える影響の網羅的解析

清水謙次, 杉浦大祐, 岡崎一美, 丸橋拓海, 岡崎　拓 2019

[学会発表] Restriction of PD-1 function for optimal T cell activation

Okazaki T, Sugiura D, Maruhashi T, Shimizu K, Okazaki IM 2019

[学会発表] Restriction of PD-1 function for optimal T cell responses

Okazaki T, Sugiura D, Maruhashi T, Shimizu K, Okazaki IM 2019

[学会発表] Restriction of PD-1 function by cis-PD-L1/CD80 interactions is required for optimal T cell responses

Sugiura D, Maruhashi T, Okazaki IM, Shimizu K, Maeda TK, Takemoto T, Okazaki T 2019

[学会発表] シスPD-L1/CD80結合がT細胞活性化段階におけるPD-1の抑制機能を制限する

杉浦大祐,　丸橋拓海, 岡崎一美, 清水謙次, 竹本龍也, 岡崎　拓 2019

[雑誌論文] Glucocorticoids potentiate the inhibitory capacity of programmed cell death 1 by up-regulating its expression on T cells

Maeda Natsumi、Maruhashi Takumi、Sugiura Daisuke、Shimizu Kenji、Okazaki Il-mi、Okazaki Taku 2019

[雑誌論文] PD-1 aborts the activation trajectory of autoreactive CD8+ T cells to prohibit their acquisition of effector functions

Okamura Hikari、Okazaki Il-mi、Shimizu Kenji、Maruhashi Takumi、Sugiura Daisuke、Mizuno Reina、Okazaki Taku 2019

[雑誌論文] Stimulatory and Inhibitory Co-signals in Autoimmunity

Okazaki Taku、Okazaki Il-mi 2019

[学会発表] Binding properties between LAG-3 and two potential ligands, stable pMHCII and FGL1

Maruhashi T, Ikubo J, Sugiura D, Okazaki IM, Okazaki T 2019

[学会発表] Restriction of PD-1 function by cis-PD-L1/CD80 interactions is required for optimal T cell responses

Sugiura D, Maruhashi T, Okazaki IM, Shimizu K, Maeda TK, Takemoto T, Okazaki T 2019

[学会発表] 抑制性免疫補助受容体によるがん免疫と自己免疫の制御

岡崎拓, 丸橋拓海, 杉浦大祐, 清水謙次, 岡崎一美 2019

[学会発表] Restriction of PD-1 function by cis-PD-L1/CD80 interactions is required for optimal T cell responses

Sugiura D, Maruhashi T, Shimizu K, Okazaki IM, Okazaki T 2019

[学会発表] シンギュラリティ生物学による自己免疫疾患制御機構の解明

岡崎　拓, 岡村陽香里, 清水謙次, 丸橋拓海, 杉浦大祐, 岡崎一美 2019

[学会発表] 抑制性免疫補助受容体PD-1の機能制御機構

岡崎拓, 杉浦大祐, 丸橋拓海, 清水謙次, 岡崎一美 2019