トップ研究者を探す表皮のリモデリングによる発癌抑制メカニズム

表皮のリモデリングによる発癌抑制メカニズム

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-19790790
研究種目 若手研究(B)
研究分野 生物系
医歯薬学
内科系臨床医学
皮膚科学
研究機関 久留米大学
代表研究者 大日 輝記
研究期間 開始年月日 2007/4/1
研究期間 終了年度 2008
研究ステータス 完了 (2008/4/1)
配分額(合計) 3,290,000 (直接経費 :2,900,000、間接経費 :390,000)
配分額(履歴) 2008年度:1,690,000 (直接経費 :1,300,000、間接経費 :390,000)
2007年度:1,600,000 (直接経費 :1,600,000)
キーワード ケミカルピーリング
紫外線
角化細胞
皮膚腫瘍学

研究成果

[雑誌論文] Lesinnal Th17 cells in nemnhigus vulgaris and nemnhigus foliaceus

Arakawa M, Dainichi T, et.al. 2009

[雑誌論文] Bullous pemphigoid followed by pustular psoriasis showing immunological dynamics among Th1, Th2, Treg and Th17.

Yasukawa S, Dainichi T, Kokuba H, Moroi Y, Urabe K, Hashimoto T, Furue M. 2009

[雑誌論文] Lesional Th17 cells in pemphigus vulgaris and pemphigus foliaceus.

Arakawa M, Dainichi T, Yasumoto S, Hashimoto T. 2009

[雑誌論文] Bullous pemphigoid followed by pustular psoriasis showing Thl, Th2, Trea and Th17 immunological changes

Yasukawa S, Dainichi T, et.al. 2009

[図書] マウスからのメッセージ.ケミカルピーリング これが私のコツと技.(2009年2版.古川福実、船坂陽子、上田説子編.)

大日輝記 2009

[雑誌論文] Anti-laminin gamma-1 pemphigoid

Dainichi T, et.al. 2009

[雑誌論文] Anti-laminin gamma-1 pemphigoid.

Dainichi T, Kurono S, Ohyama B, Ishii N, Sanzen N, Hayashi M, Shimono C, Taniguchi Y, Koga H, Karashima T, Yasumoto S, Zillikens D, Sekiguchi K, Hashimoto T. 2009

[学会発表] Laminin-gamma1 is a major autoantigen in anti-p200 pemphigoid.

Dainichi T. Kurono S, Ohyama B, Ishii N, Hayashi M, Shimono C, Taniguchi Y, Sanzen N, Karashima T, Yasutomo S, Sekiguchi K, Zillikens D, Hashimoto T. 2008

[雑誌論文] Overexpression of phosphorylated-ATF2 and STAT3 in cutaneous angiosarcoma and pyogenic granuloma

Chen SY, Takeuchi S, Urabe K, Hayashida S, Kido M, Tomoeda H, Uchi H, Dainichi T. Takahara M, Shibata S. Tu YT, Furue M, Moroi Y 2008

[学会発表] Autoantigen in anti-p200 pemphigoid.

Dainichi T, Kurono S, Ohyama B, Ishii N, Hayashi M, Shimono C, Taniguchi Y, Sanzen N, Karashima T, Yasutomo S, Sekiguchi K, Zillikens D, Hashimoto T. 2008

[雑誌論文] By the grace of peeling : the brace function of the stratum corneum in the protection from photo-induced keratinocyte carcinogenesis.

Dainichi T, Ueda S, Furue M, Hashimoto T. 2008

[雑誌論文] Expression of minichromosome maintenance 5 protein in proliferative and malignant skin diseases.

Liu H, Takeuchi S, Moroi Y, Lin N, Urabe K, Kokuba H, lmafuku S, Dainichi T, Uchi H, Furue M, Tu Y. 2008

[学会発表] アトピー性皮膚炎に対するケミカルピーリングの効果

大日輝記、上田説子、古江増隆、橋本隆. 2008

[雑誌論文] Paraneoplastic acanthosis nigricans accompanied by silent meningioma producing transforming growth factor-alpha.

Dainichi T, Moroi Y, Duan H, Urabe K, Koga T, Miyazono M, Sasaki T, Hashimoto T, Furue M. 2008

[図書] 美容治療は皮膚癌の発生を予防できるか?(Monthly Book Derma増刊号・メスを使わない美容治療実践マニュアル.山本有紀編.)

大日輝記 2008

[雑誌論文] Successful treatment of nail bed hypoplasia after nail loss by acrylic nail

Dainichi T, et.al. 2008

[学会発表] フラクショナルレーザーによるフェイスリフト効果

大日輝記、上田説子、田尻力也、文森健明、桐生美麿、橋本隆. 2008

[学会発表] 薬疹と遺伝

大日輝記 2008

[雑誌論文] Successful treatment of nail bed hypoplasia following nail loss by acrylic nail.

Dainichi T, Omori M, Hamada M, Hosokawa C, Moroi Y, Hashomoto T, Furue M. 2008

[図書] 美容治療は皮膚癌の発生を予防できるか?Monthly Book Derma増刊号・メスを使わない美容治療実践マニュアル.山本有紀編

大日輝記 2008

[雑誌論文] By the grace of peeling : the brace function of the stratum corneum in the protection from photo-induced keratinocyte carcinogenesis

Dainichi, T, et.al. 2008

[雑誌論文] Paraneoplastic acanthosis nigricans and silent meningioma producing transforming growth factor-alpha

Dainichi T, et.al. 2008

[雑誌論文] Clavus detected incidentally by positron emission tomography with computed tomography.

Dainichi T, Honma Y, Hashimoto T, Furue M. 2008

[雑誌論文] Vitiligo onset removes congenital nevocellular nevus cells.

Dainichi T, Moroi Y, Urabe K, Hashimoto T, Furue M. 2008

[雑誌論文] Overexpression of phosphorylated-ATF2 and STAT3 in cutaneous angiosarcoma and pyogenic granuloma.

Chen SY, Takeuchi S, Urabe K, Hayashida S, Kido M, Tomoeda H, Uchi H, Dainichi T, Takahara M, Shibata S, Tu YT, Furue M, Moroi Y. 2008

[雑誌論文] By the grace of peeling: the brace function of the stratum comeum in theprotection from photo-induced keratinocyte carcinogenesis

Dainichi T, Ueda S, Furue M, Hashimoto T 2008

[雑誌論文] Vitiligo onset removes congenital nevocellular nevus cells

Dainichi T, et.al. 2008

[雑誌論文] Excellent clinical results with a new preparation for chemical peeling in acne : 30% salicylic acid in polyethylene glycol vehicle.

Dainichi T, Ueda S, Imayama S, Furue M. 2008

[雑誌論文] Overexpression of phosphorylated ATF2 and STAT3 in eccrine porocarcinomaand eccrine poroma.

Chen SY, Takeuchi S, Urabe K, Kido M, Hayashida S, Tomoeda H, Uchi H, Dainichi T, Takahara M, Shibata S, Furue M, Moroi Y, TuYT 2008

[雑誌論文] Overexpression of phosphorylated ATF2 and STAT3 in eccrine porocarcinoma and eccrine poroma.

Chen SY, Takeuchi S, Urabe K, Kido M, Hayashida S, Tomoeda H, Uchi H, Dainichi T, Takahara M, Shibata S, Furue M, Moroi Y, Tu YT. 2008

[雑誌論文] Excellent clinical Tesults with a new preparation for chemical peeling inacne : 30% salicylic acid in polyethylene glycol vehicle

Dainichi T, et.al. 2008

[学会発表] フラクショナルレーザーによるフェイスリフト効果

大日輝記、他 2008

[学会発表] Laminin-2ammal is a major autoantigen in and-p200 pemphigoid

Dainichi T, et.al. 2008

[学会発表] Autoantigen in and-p200 pemphigoid

Dainichi T, et.al. 2008

[雑誌論文] Clavus detected incidentally by positron emission tomography with computed tomography

Dainichi T, et.al. 2008

[学会発表] Birt-Hogg-Dube症候群と考えた症例.

大日輝記、今田憲二郎、角田俊之、澤村大輔、占部和敬、古注増隆. 2007

[雑誌論文] Expression of the p38 MAPK, NF-kappaB and cyclin D1 in extramammary Paget's disease.

Lin N, Uchi H, Moroi Y, Fukiwake N, Dainichi T, Takeuchi S, Takahara M, Tu Y, Furue M, UrabeK. 2007

[学会発表] 天疱瘡におけるTh17の免疫組織化学的評価.

荒川正崇、大日輝記、橋本隆. 2007

[雑誌論文] Expression of minichromosome maintenance 5 protein in proliferative and malignant skin diseases.

Liu H, Takeuchi S, Moroi Y, Lin N, Urabe K, Kokuba H, Imafuku S, Dainichi T, Uchi H, Furue M, Tu Y. 2007

[雑誌論文] Significance of the express ion of phosphorylated signal transducer and activatorof traiiscription-3, -Akt, arid -cyclin D1 in angiosarcoma.

Lin N, Uchi H, Moroi Y, Fukiwake N, Dainichi T, Takeuchi S, Takahara M, Tu Y, Fmnie M, Urabe K. 2007

[図書] ケミカルピーリングによる角化の正常化.(What's New in皮膚科学2008-2009)

大日輝記 2007

[学会発表] Birt-Hogg-Dube症候群と考えた症例

大日輝記、今田憲二郎、角田俊之、澤村大輔、占部和敬、古江増隆. 2007

[学会発表] アトピー性皮膚炎へのサリチル酸マクロゴールピーリング 角層正常化による側面より.

大日輝記 2007

[学会発表] Chemical peeling normalizes keratinization and suppresses pre-maligant change in photo-damaged skin

Dainichi T, Amano S, Matsunaga Y, Iriyama S, Hirao T, Hariya T, Hibino T, Katagiri C, Takahashi M, Ueda S, Hashimoto T, Fiirue M. 2007

[学会発表] アトピー性皮膚炎へのサリチル酸マクロゴールヒーリング 角層正常化による側面より.

大日輝記 2007

[学会発表] VII型コラーゲンに反応し、コルヒチンが著効したBrunsting-Perry型類天疱瘡様後天性表皮水痘症

田中倫子、大山文悟、大日輝記、安元慎一郎、橋本隆、大野貴司、岩月啓氏. 2007

[雑誌論文] Significance of the expression of phosphorylated-STAT3, -Akt, and -ERK1/2 in several tumors of the epidermis.

Lin N, Moroi Y, Uchi H, Fukiwake N, Dainichi T, Takeuchi S, Takahara M, Tu Y, Furue M, Urabe K. 2007

[雑誌論文] Interdigital amelanotic spindle-cell melanomamimicking an inflammatory process due to dermatophytosis.

Dainichi T, Kobayashi C, Fujita S, Shiramizu K, Ishiko T, Kiryu H, Urabe K, Tsuneyoshi M, Furue M. 2007

[雑誌論文] Expression and prognostic significance of Stat5a and E-cadherin in extramammary Paget's disease.

Liu H, Urabe K, Uchi H, Takeuchi S, Nakahara T, Dainichi T, TuY Furue M, Moroi Y. 2007

[雑誌論文] Stevens-Johnson syndrome, drug-induced hypersensitivity syndrome and toxic epidermal necrolysis caused by allopurinol in patients with a common HLA allele: what causes the diversity?

Dainichi T, Uchi H, Moroi Y Furue M. 2007

[雑誌論文] 神経線維腫瘤V型に続発した悪性神経鞘腫.

藤田尚平、土井和子、大日輝記、増田禎一、師井洋一、占部和敬、古注増隆、今福信一. 2007

[図書] ケミカルピーリングによる角化の正常化(WHAT'S NEW in 皮膚科学.宮地良樹編.)

大日輝記 2007

[雑誌論文] Interdigital amelanotic spindle-cell melanoma mimicking an inflammatory process due to dermatophytosis.

Dainichi T, Kobayashi C, Fujita S, Shiramizu K, Ishiko T, Kiryu H, Urabe K, Tsuneyoshi M, Fume M. 2007

[雑誌論文] Cutaneous reactions induced by pegylated-interferon plus ribavirin combination therapy in a patient with chronic hepatitis C.

Enjoji M, Dainichi T, Gondo H, Urabe K. 2007

[学会発表] Chemical peeling normalizes keratinization and suppresses pre-malignant change in photo-damaged skin.

Dainichi T, Amano S, Matsunaga Y, Iriyama S, Hirao T, Hariya T, Hibino T, Katagiri C, Takahashi M, Ueda S, Hashimoto T, Furue M. 2007

[学会発表] 皮膚バリア機能および免疫応答におけるカテプシンEの役割.

大日輝記、城戸真希子、筑波隆幸、山本健二、古江増隆. 2007

[雑誌論文] Significance of the expression of phosphorylated signal transducer and activator of transcription-3, -Akt, and -cyclin D1 in angiosarcoma.

Lin N, Uchi H, Moroi Y, Fukiwake N, Dainichi T, Takeuchi S, Takahara M, Tu Y, Furue M, Urabe K. 2007

[学会発表] VII型コラーゲンに反応し、コルヒチンが著効したBrunsting-Perry型類天疱瘡様後天性表皮水疱症.

田中倫子、大山文悟、大日輝記、安元慎一郎、橋本隆、大野貴司、岩月啓氏. 2007

[学会発表] 全身性エリテマトーデスに菌状息肉症を併発し、光線療法が奏功した1例.

中村暁子、友枝裕人、大日輝記、上ノ土武、師井洋一、古江増隆. 2007

[雑誌論文] Significance of the expression of phosphorylated-STAT3, -Akt, and -ERK1/2 in several tumors of the epidermis.

Lin N, Moroi Y, Uchi H, Fukiwake N, Dainichi T, Takeuchi S, Takahara M, Tu Y, Fume M, Urabe K. 2007

[雑誌論文] C型慢性肝炎に対するペグインターフェロン+リハビリン併用療法における副作用としての皮膚症状

遠城寺宗近、大日輝記、権藤寿喜、占部和敬 2007

[雑誌論文] サリチル酸マクロゴールピーリングによるざ瘡の治療効果

大日輝記、上田説子 2007

[雑誌論文] A case of epidermolysis bullosa acquisita with clinical features of Brunsting-Perry pemphigoid showing an excellent response to colchicine.

Tanaka N, Dainichi T, Ohyama B, Yashumoto S, Oono T, Iwatsuki K, Elfert S, Fritsch A, Bruckner-Tuderman L, Hashimoto T.

[雑誌論文] Phototherapy for mycosis fungoides in a patient with coincident systemic lupus erythematosus.

Nakamura A, Dainichi T, Tomoeda H, Moroi Y, Urabe K, Furue M, Uenotsuchi T.

[雑誌論文] Birt-Hogg-Dube syndrome with clear-cell and oncocytic renal tumour and trichoblastoma associated with a novel FLCN mutation.

Imada K, Dainichi T, Yokomizo A, Tsunoda T, Song YH, Nagasaki A, Sawamura D, Nishie W, Shimizu H, Fukagawa S, Urabe K, Furue M, Hashimoto T, Naito S.

[雑誌論文] Refractory oral ulcers with multiple IgG/IgA autoantibodies without skin lesions.

Dainichi T, Ohyama B, Ishii N, Yamaguchi Z, Yasumoto S, Hashimoto T

[雑誌論文] Skin tightening effect by a fractional laser treatment II: a pilot animal study on skin remodeling.

Dainichi T, Ueda S, Fumimori T, Kiryu H, Hashimoto T.

[雑誌論文] Skin tightening effect by a fractional laser treatment I : A randomized half-side pilot study on faces of acne patients.

Dainichi T, Kawaguchi A, Ueda S, Tajiri R, Fumimori T, Kakuta T, Hashimoto T.