トップ研究者を探すレニン・アンジオテンシン系に関わる受容体依存性リガンド非依存性肥大心の解析

レニン・アンジオテンシン系に関わる受容体依存性リガンド非依存性肥大心の解析

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-19790190
研究種目 若手研究(B)
研究分野 生物系
医歯薬学
基礎医学
薬理学一般
研究機関 奈良県立医科大学
香川大学
代表研究者 張 国興
研究協力者 木村 正司
研究協力者 野間 貴久
研究協力者 宮武 明
研究協力者 永井 由起子
研究協力者 藤澤 良秀
研究期間 開始年月日 2007/4/1
研究期間 終了年度 2008
研究ステータス 完了 (2008/4/1)
配分額(合計) 3,780,000 (直接経費 :3,300,000、間接経費 :480,000)
配分額(履歴) 2008年度:2,080,000 (直接経費 :1,600,000、間接経費 :480,000)
2007年度:1,700,000 (直接経費 :1,700,000)
キーワード ARB
AT1R
MAPK
Cardiac Hypertrophy
alpha-, beta adrenergic receptor
ATIR
cardiac hypertrophy
alDha-, beta adrenergic receptor
アンジオテンシン
アドレナリン作用薬
心肥大
酸化ストレス
mitogen-activated protein kinase
Rap-1

研究成果

[学会発表] Role of nNOS in basal and angiotensin II-induced vascular O2 generation and MAPK phosphorylation

Guo-Xing Zhang 2009

[雑誌論文] Role of euronal NO synthase in regulating vascular superoxide levels and mitogen-activated protein kinase phosphorylation

Zhang GX, Kimura S, Murao K, Shimizu J, Matsuyoshi H, Takaki M 2009

[雑誌論文] Role of neuronal NO synthase in regulating vascular superoxide levels and mitogen-activated protein kinase phosphorylation

Guo-Xing Zhang 2009

[学会発表] Role of nNOS in basal and angiotensin II-induced vascular O_2 generation and MAPK nhosohorvlation

Guo-Xing Zhang 2009

[雑誌論文] Possible involvement of Rho-kinase in aldosterone-induced vascular smooth muscle cell remodeling

Miyata K, Hitomi H, Guo P, Zhang GX, Kimura S, Kiyomoto H, Hosomi N, Kagami S, Kohno M, Nishiyama A 2008

[学会発表] Opposite roles of nNOS in cardiac ischemia reperfusion-induced injury and in ischemia preconditioning -induced cardioprotection in mice

Guo-Xing Zhang 2008

[学会発表] Opposite roles of nNOS in cardiac ischemia reperfusion-induced injury and in ischemia preconditioning-induced cardioprotection in mice

Guo-Xing Zhang 2008

[雑誌論文] Aldosterone induces myofibroblastic transdifferentiation and collagen gene expression through the Rho-kinase dependent signaling pathway in rat mesangial cells

Diah S, Zhang GX, Nagai Y, Zhang W, Gang L, Kimura S, Hamid MR, Tamiya T, Nishiyama A, Hitomi H 2008

[雑誌論文] Role of mitochondria in angiotensin II-induced reactive oxygen species and mitogen-activated protein kinase activation

Zhang GX, Lu XM, Kimura S, Nishiyama A 2007

[雑誌論文] R ole of AT1 receptor in isoproterenol-induced cardiac hypertrophy and oxidative stress in mice

6.Zhang GX, Ohmori K, Nagai Y, Fujisawa Y, Nishiyama A, Abe Y, Kimura S 2007

[学会発表] NAO(10-N-nonyl acridineorang)は心筋虚血再還流時のミトクロムC漏出を抑制する

張国興 2007

[雑誌論文] Role of mitochondria in angiotensn Il-induced reactive oxygen species andmitoaen-activated protein kinase activation.

Zhang, et. al. 2007

[学会発表] Effects of 1 0-N-nonyl acridine orange (NAO)on ischemic/reperfiision injury in rat heart

張 国興, 他 2007

[雑誌論文] Role of ATI receptor in isoproterenol-induced cardiac hypertrophy andoxidative stress in mice.

Zhang, et. al. 2007

[雑誌論文] Involvement of endogenous nitric oxide in angiotensin II-induced activation of vascular mitogen-activated protein kinases

5.Zhang GX, Nagai Y, Nakagawa T, Miyanaka H, Fujisawa Y, Nishiyama A, Izuishi K, Ohmori K, Kimura S 2007

[雑誌論文] Involvement of endogenous nitric oxide in Angiotensin Il-induced activation of vascular mitoeen-activated protein kinases.

Zhang, et. al. 2007

[学会発表] Involvement of endogenous nitric oxide in nangiotensin II-induced activation of vascular mitogen- activated protein kinases

Guo-Xing Zhang 2007

[学会発表] Involvement of endogenous nitric oxide in angiotensin Il-induced activation of vascular mitogen-activated protein kinases.

Zhang, et. al. 2007

[学会発表] Involvement of endogenous nitric oxide in Angiotensin Il-induced activation of vascular mitogen-activated protein kinases.

Zhang, et. al. 2007