トップ研究者を探す健康長寿の基盤となる新たな栄養シグナルの発見と疾病予防における役割

健康長寿の基盤となる新たな栄養シグナルの発見と疾病予防における役割

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-19680030
研究種目 若手研究(A)
研究分野 総合・新領域系
総合領域
健康・スポーツ科学
応用健康科学
研究機関 徳島大学
代表研究者 竹谷 豊
研究協力者 首藤 恵泉
研究協力者 田中 理恵子
研究協力者 渡里 恵梨子
研究協力者 北村 知世
研究協力者 塩田 あすか
研究協力者 TAN Vu van
研究協力者 上番増 喬
研究協力者 阿望 幾久子
研究協力者 谷村 綾子
研究期間 開始年月日 2007/4/1
研究期間 終了年度 2009
研究ステータス 完了 (2009/4/1)
配分額(合計) 16,120,000 (直接経費 :12,400,000、間接経費 :3,720,000)
配分額(履歴) 2009年度:4,160,000 (直接経費 :3,200,000、間接経費 :960,000)
2008年度:4,160,000 (直接経費 :3,200,000、間接経費 :960,000)
2007年度:7,800,000 (直接経費 :6,000,000、間接経費 :1,800,000)
キーワード シグナル伝達
リン
血管内皮細胞
高リン血症
心血管疾患
慢性腎臓病
予防栄養学
血管内皮機能
血管内皮

研究成果

[学会発表] Sodium-dependent phosphate transporter and cardiovascular disease

Yutaka Taketani 2010

[学会発表] Sodium-dependent phosphate transporter and cardiovascular disease

Yutaka Taketani 2010

[学会発表] Fluctuation of Serum Phosphorus Levels Impairs Endothelial Function in Rats.

Eriko Watari, Tormoyo Kitamura, Yutaka Taketani, Ayako Tanimura, Asuka Shiota, Enai Shuto, Tan Vu Van, Hironori Yamamoto, Eiji Takeda 2009

[学会発表] Hyperphosphatemia Mediates Oxidative Stress in Bovine Aortic Endothelial Cells

Shuto E, Taketani Y. Tanaka R, Tanimura A, Isshiki M, Harada N, Yamamoto H, Takeda E. 2009

[学会発表] Acute effect of elevation of serum phosphorus on endothelial function with reference to oxidative stress and NO production.

Taketani Y, Shuto E, Shiota A, Watari E, Kitamura T, HaradaN, Nakaya Y, Miyamoto K, Takeda E. 2009

[雑誌論文] Dose-dependent effects of barley cooked with white rice on postprandial glucose and desacyl ghrelin levels.

Sakuma M, Yamanaka-Okumura H, Naniwa Y, Matsumoto D, Tsunernatsu M, Yamamoto H, Taketani Y, Takeda E. 2009

[学会発表] Sodium-dependent phosphate transporter in the cardiovascular dysfunction.

Taketani Y, Shuto E, Tanaka R, Isshiki M, Miyamoto K, Takeda E. 2009

[雑誌論文] Hypocaloric high protein diet improves fatty liver and hypertriglyceridemia in sucrose-fed obese rats via two pathways.

Uebanso T, Taketani Y, Fukaya M, Sato K, Takei Y, Sato T, Sawada N, Arno K, Harada N, Arai H, Yamamoto H, Takeda E. 2009

[雑誌論文] Dietary phosphorus acutely impairs endothelial function.

Shuto E, Taketani Y, Tanaka R, Harada N, Isshiki M, Sato M, Nashiki K, Arno K, Yamamoto H, Higashi Y, Nakaya Y, Takeda E. 2009

[雑誌論文] Identification of cis-acting promoter sequences required for expression of the glycerol-3-phosphate acyltransferase 1 gene in mice.

Yoshida M, Harada N, Yamamoto H, Taketani Y, Nakagawa T Yin Y, Hattori A, Zenitani T, Hara S, Yonemoto H, Nakamura A, Nakano M, Mawatari K, Teshigawara K, Arai H, Hosaka T, Takahashi A, Yoshimoto K, Nakaya Y. 2009

[学会発表] Excessive Dietary Phosphorus Acutely Impairs Endothelial Function in Healthy Men.

Emi Shuto, Yutaka Taketani, Wakana Kusunose, Terumi Tanaka, Daisuke Eerie, Kikuko Amo, Hironori Yamamoto, Tohru Sakai, Eiji Takeda 2009

[学会発表] Over-Intake of Dietary Phosphorus Accelerates Progression of Atherosclerotic Lesions in Apolipoprotein E Deficient

Asuka Shiota, Yutaka Taketani, Ayako Tanimura, Hironori Yamamoto, Eiji Takeda 2009

[学会発表] Dual Role of Type III Sodium-Dependent Phosphate Transporter in the Pathogenesis of Arteriosclerosis Caused by Hyperphosphatemia.

Yutaka Taketani 2009

[雑誌論文] Stanniocalcin 2 is positively and negatively controlled by 1, 25(OH)(2)D(3) and PTH in renal proximal tubular cells.

Takei Y, Yamamoto H, Masuda M, Sato T, Taketani Y, Takeda E. 2009

[学会発表] Sodium-dependent phosphate transporter in the cardiovascular dysfunction

Taketani Y, et.al. 2008

[学会発表] Postprandial Hyperphosphatemia is a Novel Risk Factor for Cardiovascular Disease by Involving Endothelial Dysfunction.

Shuto E, Taketani Y, Tanaka R, Tanimura A, Uebanso T, Isshiki M, Harada N, Yamamoto H, Nakaya Y, Takeda E. 2008

[図書] 「栄養素トランスポーターの分子制御とホルモン代謝:リン酸トランスポーターをめぐる話題」トランスポーター科学最前線(総編集:辻彰)

宮本賢一、竹谷豊、桑波田雅士、伊藤美紀子、瀬川博子、辰巳佐和子 2008

[雑誌論文] Naito and viscous vegetables in a Japanese style meal suppress postprandial glucose and insulin responses.

Taniguchi A, Yamanaka-Okumura H, Nishida Y, Yamamoto H, Taketani Y, Takeda E. 2008

[雑誌論文] Palatinose and oleic acid act together to prevent pancreatic islet disruption in nondiabetic obese Zucker rats.

Sato K, Arai H, Miyazawa Y, Fukaya M, Uebanso T, Koganei M, Sasaki H, Sato T, Yamamoto H, Taketani Y, Takeda E. 2008

[学会発表] Mutation of Type IIc Na+-Dependent Phosphate Cotransporter (NaPPi-IIc) and Hereditary Hypophosphatemic Rickets with Hypercalciuria (HHRH)

Mikiko Ito, Aya Sakurai, Akiko Ohi, Keiji Hayashi, Takashi Nishiyama, Natsumi Kangawa, Sakiko Sugino, Sawako Tatsumi, Hiroko Segawa, Yutaka Taketani, Ken-ichi Miyamoto 2008

[学会発表] Effects of Postprandial Hyperphosphatemia on Endothelial Function.

Yutaka Taketani, Emi Shuto, Rieko Tanaka, Masashi Isshiki, Kikuko Amo, Hironori Yamamoto, Ken-ichi Miyamoto, Eiji Takeda 2008

[雑誌論文] Effects of a palatinose-based liquid diet (Inslow) on glycemic control and the second-meal effect in healthy men.

Arai H, Mizuno A, Sakuma M, Fukaya M, Ivlatsuo K, Muto K, Sasaki H, Matsuura M, Okumura H, Yamamoto H, Taketani Y, Doi T, Takeda E. 2007

[雑誌論文] Dietary Palatinose and Oleic Acid Ameliorates Disorders of Glucose and Lipid Metabolism in Zucker Fatty Rats.

Sato K, Arai H, Mizuno A, Fukaya M, Sato T, Koganei M, Sasaki H, Yamamoto H, Taketani Y, Doi T, Takeda E. 2007

[雑誌論文] Caveolin-1 in extracellular matrix vesicles secreted from osteoblasts.

Sawada N, Taketani Y, Amizuka N, Ichikawa M, Ogawa C, Nomoto K, Nashiki K, Sato K, Arai H, Isshiki M, Segawa H, Yamamoto H, Miyamoto K, Takeda E. 2007

[雑誌論文] Effects of Prolonged High Phosphorus Diet on Phosphonis and Calcium Balance in Rats.

Tani Y, Sato T, Yamanaka-Okumura H, Yamamoto H, Arai H, Sawada N, Genjida K, Taketani Y, Takeda E. 2007

[雑誌論文] Mechanism of rapid-phase insulin response to elevation of portal glucose concentration.

Fukaya M, Mizuno A, AraiH, Muto K, Uebanso T, Matsuo K, Yamamoto H, Taketani Y, Doi T, Takeda E. 2007

[雑誌論文] Parathyroid hormone dependent endocytosis of renal type Be Na/Pi cotransporter.

Segawa H, Yamanaka S, Onitsuka A, Tomoe Y, Kuwahata M, Ito M, Taketani Y, Miyamoto KT. 2007

[雑誌論文] Advantage of low glycemie index and low phosphate diet on diabetic nephropathy and aging-related diseases.

Taketani Y, Shuto E, Nishida Y, Tanaka R. 2007

[雑誌論文] Involvement of cell-surface ATP synthase in flow-induced ATP release by vascular endothelial cells.

Yamamoto K, Shimizu N, Obi S, Kumagaya S, Taketani Y, Kamiya A, Ando J. 2007