トップ研究者を探す新たな動物モデルを用いた難治性感染症とがんに対する革新的免疫遺伝子治療

新たな動物モデルを用いた難治性感染症とがんに対する革新的免疫遺伝子治療

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-19659254
研究種目 萌芽研究
研究分野 生物系
医歯薬学
内科系臨床医学
膠原病・アレルギー・感染症内科学
研究機関 愛媛大学
代表研究者 安川 正貴
研究期間 開始年月日 2007/4/1
研究期間 終了年度 2008
研究ステータス 完了 (2008/4/1)
配分額(合計) 3,300,000 (直接経費 :3,300,000)
配分額(履歴) 2008年度:1,600,000 (直接経費 :1,600,000)
2007年度:1,700,000 (直接経費 :1,700,000)
キーワード がん
ウイルス感染症
T細胞レセプター
遺伝子治療
細胞傷害性T細胞
ワクチン
白血病
ウイルス

研究成果

[雑誌論文] HBZ is an immunogenic protein but not a target antigen for HTLV-1-specific cytotoxic T lymphocytes

Suemori, K., Yasukawa, M., et al. 2009

[雑誌論文] Identification of a novel epitope derived from CML66 which is recognized by anti-leukaemia cytotoxic T lymphocytes

Suemori, K., Yasukawa, M., et al. 2009

[雑誌論文] Clinical efficacy of WT1 peptide vaccination in patients with acute myelogenous leukamia and myelodysplastic syndrome

Yasukawa, M., et al. 2009

[雑誌論文] Clinical significance of co-expression of CD21 and LFA-1 in non-Hodgkin's B-cell lymphoma

Tanimoto, K., Yasukawa, M., et al. 2009

[雑誌論文] The role of zinc finger protein 521/early hematopoietic zinc finger protein in erythroid cell differentiation

Matsubara, E., Yasukawa, M., et al. 2009

[雑誌論文] Therapeutic effect of accumulation of CXCR3-expressing regulatory T cells on liver and intestinal damages in a murine acute GVHD model

Hasegawa, H., Yasukawa, M., et al. 2009

[雑誌論文] Aurora-A kinase : A novel target of cellular immunotherapy for leukemia

Ochi, T., Yasukawa, M., et al. 2009

[雑誌論文] Identification ofan epitope derived from CML66,a novel tumor-associated antigen broadly expressed in human leukemia,recognized by HLA-A*2402-restricted cytotoxic Tlymphocytes

Suemori K, Yasukawa M, et. al. 2008

[雑誌論文] Allogeneic stem cell transplantation for refractory adult T-cell leukemia using a non-T-cell-depleted HLA-incompatible family donor graft, with reference to the grown-up child donor to parent recipient setting : report of a pilot study

Fujiwara, H., Yasukawa, M., et al. 2008

[学会発表] Aurora-A kinase : A novel target of cellular immunotherapy for human leukemia

Ochi, T., Yasukawa, M., et al. 2008

[学会発表] Development of anti-leukemic immunotherapy targeting Aurora-A kinase

Ochi, T., Yasukawa, M., et al. 2008

[雑誌論文] Cooperative role of the membrane-proximal and distal residues of the integrin beta 3 cytoplasmic domain in regulation of talin-mediated alpha II bbeta 3 activation

Hato T, Yasukawa M, et. al. 2008

[雑誌論文] Cooperative role of the membrane-proximal and distal residues of the integrin beta 3 cytoplasmic domain in regulation of talin-mediated alpha IIbbeta 3 activation

Hato, T., Yasukawa, M., et al. 2008

[学会発表] 腫瘍関連抗原CML66の臨床的有用性

末盛浩一郎, 安川正貴, 他 2008

[学会発表] Aurora-A kinaseを標的とした抗白血病免疫療法の開発

越智俊元, 安川正貴, 他 2008

[学会発表] Clinical significance of CD21 Co-Expression with LFA-1 in Non-Hodgkin's B-cell limphoma

Tanimoto, K., Yasukawa, M., et al. 2008

[図書] Oncogene proteins : Structures, Functions and Analyses

Fujiwara, H., Yasukawa, M. 2008

[学会発表] Establishment and characterization of a novel CD8+T cell line with cytotoxicity via perforin / granzyme B

Suemori, K., Yasukawa, M., et al. 2008

[学会発表] Integrin β3 membrane-proximal and - distal residues cooperatively regulate talin-mediated α IIb β3 activation

Yamanouchi, J., Yasukawa, M., et al. 2008

[雑誌論文] Therapeutic effect of accumulation of CXCR3-expressing regulatory T cells on liver and intestinal damages in a murine acute GVHD model

Hasegawa H, Yasukawa M, et. al. 2008

[学会発表] Zinc finger protein 521/early heraatopoietic zinc finger protein の赤血球分化における役割

松原悦子, 安川正貴, 他 2008

[雑誌論文] Identification of an epitope derived from CML66, a novel tumor-associated antigen broadly expressed in human leukemia, recognized by HLA-A*2402-restricted cytotoxic T lymphocytes

Suemori, K., Yasukawa, M., et al. 2008

[学会発表] Zinc finger protein 521 の赤血球分化における制御機構の解析

松原悦子, 安川正貴, 他 2008

[学会発表] ヒト細胞傷害性T細胞が認識するAurora-A由来エピトープの同定

越智 俊元、安川 正貴, 他 2007

[学会発表] Induction and functional analysis of CML66-specific cytotoxic T lymphocytes

Suemori K, Yasukawa M, et. al. 2007

[図書] 造血器腫瘍「細胞免疫療法総論」

安川 正貴 2007

[学会発表] Aurora-A kinase: A novel target for the immunotherapy against humanleukemias

Ochi T, Yasukawa M, et. al. 2007

[雑誌論文] Therapy for pneumonitis and sialadenitis by accumulation of CCR2-expressing CD4+CD25+regulatory T cells in MRL/lpr mice

Hasegawa H, Yasukawa M, et. al. 2007

[雑誌論文] Identification and characterization of a WT1(Wilms'tumor gene)protein-derived HLA-DRB1*0405-restricted 16-mer helper peptide that promotes the induction and activation of WT1-speific cytotoxic T lymphocytes

Fujiki F, Yasukawa M, et. al. 2007

[雑誌論文] Wilms tumor gene WT1 peptide-based immunotherapy induced a minimal response in a patient with advanced therapy-resistant multiple myeloma

Tsuboi A, Yasukawa M, et. al. 2007

[雑誌論文] The role of Wilms'tumor gene peptide-specific cytotoxic T lymphocytes in immunologic selection of a paroxysmal nocturnal hemoglobinuria clone

Ikeda K, Yasukawa M, et. al. 2007

[図書] 造血器腫瘍「細胞免疫療法各論」

安川 正貴 2007

[学会発表] 腫瘍関連抗原CML66特異的細胞傷害性T細胞の誘導と機能解析

末盛 浩一郎、安川 正貴, 他 2007

[学会発表] Cytotoxic T-lymphocytes harnessing CML66 can kill human myeloid leukemia cells in vitro

Suemori K, Yasukawa M, et. al. 2007

[雑誌論文] A mitotic kinase TOPK enhances cdk1/cyclin B1-dependent phosphorylation of PRC1 and promotes cytokinesis

Abe Y, Yasukawa M, et. al. 2007

[学会発表] Therapeutic effect of CXCR3-expressing regulatory T cells on liver and intestinal dameges in a murine acute GVHD model

Yamanouchi J, YasukawaM, et. al. 2007

[学会発表] Identification of an epitope derived from Aurora-A kinase which induces leukemia-specific CTL

Ochi T, Yasukawa M, et. al. 2007