末梢血白血球遺伝子発現からの機能性精神障害の解明

トップ›研究者を探す›末梢血白血球遺伝子発現からの機能性精神障害の解明

代表研究者	上野修一
研究課題番号	KAKENHI-PROJECT-19591357
研究種目	基盤研究(C)
研究分野	生物系医歯薬学内科系臨床医学精神神経科学
研究機関	愛媛大学徳島大学
研究分担者	大森哲郎
研究分担者	沼田周助
研究期間開始年月日	2007/4/1
研究期間終了年度	2008
研究ステータス	完了 (2008/4/1)
配分額（合計）	4,550,000 (直接経費 :3,500,000、間接経費 :1,050,000)
配分額（履歴）	2008年度：2,080,000 (直接経費 :1,600,000、間接経費 :480,000) 2007年度：2,470,000 (直接経費 :1,900,000、間接経費 :570,000)
キーワード	神経化学脳・神経ストレスゲノムマイクロアレイ統合失調症うつ病末梢血白血球 mRNA発現解析疾患対照関連解析 PDE4B遺伝子 PCNT2遺伝子性周期遺伝子発現解析遺伝子関連解析 HDAC5 CREB VEGF TGFBR2

研究成果

[雑誌論文] Positive Association of The PDE4B (Phosphodiesterase 4B) gene with Schizophrenia in the Japanese Population.

S. Numata, S. Ueno, J. Iga, S. Hongwei, M. Nakataki, S. Tayoshi, S. Sumitani, M. Tomotake, M. Itakura, A. Sano, T. Ohmori 2009

[雑誌論文] Positive Association of The PDB4B(Phosphodie sterase4B)gene with Schizophrenia in the Japanese Population

S. Numata, S. Ueno, J. Iga, 他 2009

[雑誌論文] Positive Association of the PCNT2 gene with Major Depressive Disorder in tie Japanese Population

S. Numata, J. Ige, M Nakataki, 他 2009

[雑誌論文] Gene expression and association analyses of the PDE4B (Phosphodiesterase 4B)gene in major depressive disorder in the Japanese Population

S. Numata, J. Iga, M. Nakataki, 他 2009

[雑誌論文] Molecular assessment of depression from mRNAs in the peripheral leukocytes

J. Iga, S. Ueno, T. Ohmori 2008

[雑誌論文] Noassociation between the NDEl gene and schizophrenia in the Japanese Population.

S. Numata, S. Ueno, J. Iga, 他 2008

[雑誌論文] FKBP5, SERT and COMTmRNA expressions in the peripheral leukocytes during menstruation cycle in healthy reproductive females.

S. Kinouchi, J. lga, S. Ueno, K. Yamauchi, 他 2008

[雑誌論文] No association between the NDE1 gene and schizophrenia in the Japanese Population.

S. Numata, S. Ueno, J. Iga, M. Nakataki, T. Tanahashi, M. Itakura, A. Sano, K. Ohi, R. Hashimoto, M. Takeda, T. Ohmori 2008

[雑誌論文] FKBP5, SERT and COMT mRNA expressions in the peripheral leukocytes during menstruation cycle in healthy reproductive females

S. Kinouchi, J. Iga, S. Ueno, K. Yamauchi, S. Numata, H. Song, S. Sumitani, S. Shibuya-Tayoshi, M. Haku, T. Yasui, M. Irahara, K. Morita, K. Rokutan, T. Ohmori. 2008

[学会発表] うつ病の心因、内因、器質因 : うつ病を遺伝子から考える

上野修一、伊賀淳一、沼田周助、宋鴻偉、田吉伸哉、中滝理仁、山内健、大森哲郎 2007

[雑誌論文] Gene expression and association analysis of vascular endothelial growth factor in major depressive disorder.

J. Iga, S. Ueno, K. Yamauchi, S. Numata, S. Tayoshi, S. Kinouchi, M. Nakataki, H. Song, K. Hokoishi, H. Tanabe, T. Ohmori 2007

[雑誌論文] The Val66Met polymorphism of the brain-derived neurotrophic factor gene is associated with psychotic feature and suicidal behavior in Japanese major depressive patients

J. Iga J, S. Ueno, K. Yamauchi, S. Numata, S. Tayoshi-Shibuya, S. Kinouchi, M. Nakataki, H. Song, K. Hokoishi, H. Tanabe, A. Sano, T. Ohmori. 2007

[学会発表] Positive association of the PDE4B (Phosphodiesterase 4B) gene with schizophrenia and major depressive disorder in Japanese population.

S. Numata, S. Ueno, J. Iga, S. Hongwei, M. Nakataki, M. itakura, A. Sano, T. Ohmori. 2007

[雑誌論文] Gene expression in the peripheral leukocytes and association analysis of PDLIM5 gene in schizophrenia.

S. Numata, S. Ueno, J. Iga, K. Yamauchi, S. Hongwei, S. Kinouchi, Hashimoto R, Takeda M, Kunugi H, Itakura M, T. Ohmori 2007

[学会発表] Gene expression and association analysis of vascular endothelial growth factor in major depressive disorder

M. Nakataki, J. Iga, S. Ueno, K. Yamauchi, S. Numata, S. Tayoshi-Shibuya, S. Kinouchi, H. Song, K. Hokoishi, H. Tanabe, A. Sano, T. Ohmori. 2007

[雑誌論文] Association between PNPO and schizophrenia in the Japanese population

H. Song, S. Ueno, S. Numata, J. Iga, S. Shibuya-Tayoshi, M. Nakataki, S. Tayoshi, K. Yamauchi, S. Sumitani, T. Tomotake, T. Tada, T. Tanahashi, M. Itakura, T. Ohmori 2007

[雑誌論文] TGFBR2 gene expression and genetic association with schizophrenia

S. Numata S, S. Ueno, J. Iga, K. Yamauchi, H. Song, R. Hashimoto, M. Takeda, H. Kunugi, M. Itakura, T. Ohmori. 2007

[雑誌論文] Altered HDAC5 and CREB mRNA expressions in the peripheral leukocytes of major depression.

J. Iga, S. Ueno, K. Yamauchi, S. Numata, S. Kinouchi, S. Tayoshi, H. Song, T. Ohmori 2007

[学会発表] TGFBR2 gene expression and genetic association with schizophrenia

S. Numata, et, al. 2007

[雑誌論文] Gene expression in the peripheral leukocytes and association analysis of PDLIM5 gene in schizophrenia

S. Numata, et. al. 2007

[雑誌論文] Gene expression and association analyses of the PDE4B (Phosphodiesterase 4B) gene in major depressive disorder in the Japanese Population

S. Numata, J. Iga, M. Nakataki, S. Tayoshi, K. Taniguchi, S. Sumitani, M. Tomotake, T. Tanahashi, M. Itakura, Y. Kamegaya, M. Tatsumi, A. Sano, T. Asada, H. Kunugi, S. Ueno, T. Ohmori

[雑誌論文] Positive Association of the PCNT2 gene with Major Depressive Disorder in the Japanese Population

S. Numata, J. Iga, M. Nakataki, S. Tayoshi, T. Tanahashi, M. Itakura, S. Ueno, T. Ohmori