トップ›研究者を探す›慢性腎不全にともなうミネラル骨代謝異常における新規活性および阻害分子の作用機序

慢性腎不全にともなうミネラル骨代謝異常における新規活性および阻害分子の作用機序

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-19590950
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
内科系臨床医学
腎臓内科学
研究機関 神戸大学
代表研究者 深川 雅史
研究分担者 濱田 康弘
研究期間 開始年月日 2007/4/1
研究期間 終了年度 2008
研究ステータス 完了 (2008/4/1)
配分額（合計） 4,550,000 (直接経費 :3,500,000、間接経費 :1,050,000)
配分額（履歴） 2008年度：1,430,000 (直接経費 :1,100,000、間接経費 :330,000)
2007年度：3,120,000 (直接経費 :2,400,000、間接経費 :720,000)
キーワード 人工透析学
骨代謝
腎不全
副甲状腺ホルモン
糖尿病
酸化ストレス
インドキシル硫酸
骨芽細胞
AGE
RAGE
賢不全

研究成果

[雑誌論文] Thioredoxin-1 overexpression in transgenic mice attenuates streptozotocin-induced diabetic oeteoporosis: A novel role of oxidative stress and therapeutic implications. Bone

Hamada Y, Fujii H, Kitazawa R, Yodoi J, Kitazawa S, Fukagawa M 2009

[学会発表] Putative roles of receptors for AGEs (RAGE) in bone metabolism under non-diabetic and diabetic condition

Hamada Y, et al 2008

[雑誌論文] Alteration of duodenal iron absorption in adenine-induced renal failurerats : a possible mechanism of iron deficiency in chronic kidney disease patients with erythropoietin treatment.

Hamada Y, et al 2008

[雑誌論文] Bone formation in the newly established non-obese type 2 diabetic model rats; Spontaneously Diabetic Torii (SDT) rats. Bone

Fujii H, Hamada Y, Fukagawa M 2008

[雑誌論文] Serum hepcidin as an indicator of iron status in dialysis patients. Ther Aphr Dial

Tsuchihashi D, Abe T, Komaba H, Fujii H, Hamada Y, Nii-Kono T, Tanaka M, Fukagawa M 2008

[雑誌論文] The whole-PTH/intact-PTH ratio is a useful predictor of severity of secondary hyperparathyroidism. NDT Plus (Supple)

Tanaka M, Komaba H, Itoh K, Matsushita K, Matsushita K, Hamada Y, Fujii H, Fukagawa M 2008

[学会発表] Putative roles of receptors for AGEs (RAGE) in bone metabolism under non-diabetic and diabetic

Hamada Y, Goto S, Komaba H, Fujii H, Fukagawa M 2008

[学会発表] Different roles of oxidative stress and asymmetric dimethylarginine for the progression of diabetic nephropathy in the newly established non-obese type 2 diabetic model rata: Spontaneously Diabetic Torii (SDT) rats

Fujii H, Hamada Y, Komaba H, Kitazawa R, Kitazawa S, Fukagawa M 2008

[雑誌論文] Alteration of duodenal iron absorption in adenine-induced renal failure rats: a possible mechanism of iron deficiency in chronic kidney disease patients with erythropoietin treatment. Nephrol Dial Transplant

Hamada Y, Nii-Kono T, Moriguchi Y, Higuchi M, Fukagawa M 2008

[雑誌論文] Overexpression of thioredoxin I in transgenic mice suppresses development of diabetic nephropathy

Hamada Y, et. al 2007

[雑誌論文] A Possible role of thioredoxine interacting protein in the pathogenesis of streptozotocin-induced diabetic nephropathy. Kobe J Med Sci

Hamada Y, Fukagawa M 2007

[学会発表] 1-84PTH/intact PTH ratio is a useful predictor of the severity of secondary hyperparathyroidism

Tanaka M, Itoh K, Matsushita K, Matsushita K, Hamada Y, Fujii H, Fukagawa M 2007

[学会発表] Overexpression of Thioredoxin-1, a Major Intracellular Antioxidant, Attenuates Streptozotocin-Induced Diabetic Osteopenia

Hamada Y, et. al. 2007

[雑誌論文] Overexpression of thioredoxin 1 in transgenic mice suppresses development of diabetic nephropathy. Nephrol Dial Transplant

Hamada Y, Miyata S, Nii-Kono T, Kitazawa R, Kitazawa S, Higo S, Fukunaga M, Ueyama S, Nakamura H, Yodoi J, Fukagawa M, Kasuga M 2007

[雑誌論文] Histomorphometric analysis of diabetic osteopenia in streptozotocin-induced diabetic mice: a possible role of oxidative stress. Bone

Hamada Y, Kitazawa S, Kitazawa R, Fujii H, Kasuga M, Fukagawa M 2007

[雑誌論文] Histomorphometric analysis of diabetic osteopenia in streptozotocin-induced diabet ic mice: a possible role of oxidative stress

Hamada Y, et. al. 2007