Vanishing bile ductモデルマウスの開発

トップ›研究者を探す›Vanishing bile ductモデルマウスの開発

代表研究者	大西三朗
研究課題番号	KAKENHI-PROJECT-19590773
研究種目	基盤研究(C)
研究分野	生物系医歯薬学内科系臨床医学消化器内科学
研究機関	高知大学
研究分担者	西原利治
研究分担者	高橋昌也
研究期間開始年月日	2007/4/1
研究期間終了年度	2008
研究ステータス	完了 (2008/4/1)
配分額（合計）	4,550,000 (直接経費 :3,500,000、間接経費 :1,050,000)
配分額（履歴）	2008年度：1,690,000 (直接経費 :1,300,000、間接経費 :390,000) 2007年度：2,860,000 (直接経費 :2,200,000、間接経費 :660,000)
キーワード	胆管炎 TRAIL 自己免疫胆汁性肝硬変胆管障害 TRAILレセプター death domain 遺伝子多型 bile duct death receptor apoptosis autoimmune mouse

研究成果

[図書] 消化器疾患最新の治療

西原利治 2009

[図書] 2009今日の治療指針

西原利治 2009

[図書] C型肝炎のベスト治療

西原利治 2009

[図書] Annual Review 消化器 2009

西原利治 2009

[図書] 第94回日本消化器病学会総会ポストグラジュエイトコース

西原利治 2008

[雑誌論文] Preserved tissue-strueture of efferent duetules in aromatase deficient mice.

Toda K, Okada T, Hayashi Y, Saibara T. 2008

[学会発表] Methionine-choline metabolism is involved in the pathogenesis of nonalcoholic steatohepatitis

Tokumitsu K, Ogasawara K, Maki M, Hirose A, Nozaki Y, Takahashi M, Ono M, Iwasaki S, Saibara T, Onishi S. 2008

[雑誌論文] Preserved tissue-structure of efferent ductules in aromatase deficient mice

Toda K, Okada T, Hayashi Y, Saibara T. 2008

[学会発表] Angiotensin II type 1 receptor blocker attenuates the progression of nonalcoholic steatohepatitis (NASH).

Hirose A, Ono M, Saibara T, Nozaki Y, et al. 2008

[学会発表] Super-paramagnetic iron oxide-MRI : A novel technique in experimental liver studies shows defective Kupffer cell phagocytic function in human non alcoholic fatty liver disease

Ono M, Kubota K, Hirose A, Nozaki Y, Takahashi M, Iwasaki S, Saibara T, Ogawa Y, Onishi S, Oben JA 2008

[雑誌論文] Expression of fascin-1, an actin-bundling protein, in migrating hepatoblasts during rat liver development.

Hayashi Y, Toda K, Saibara T, Okamoto S, et al. 2008

[図書] 肝疾患レジデントマニュアル

西原利治 2008

[図書] 酸化ストレスと肝疾患

杜井峰、小笠原光成、植瑞希、廣瀬享、野崎靖子、小野正文、岩崎信二、西原利治、大西三朗 2008

[学会発表] Angiotensin II type 1 receptor blocker attenuates the progression of nonalcoholic steatohepatitis (NASH)

Hirose A, Ono M, Saibara T, Nozaki Y, Takahashi M, Iwasaki S, Oben JA, Onishi S. 2008

[学会発表] Secondary extrahepatic portal obstruction resulted from thrombus in splenic vein aneurysma

Kuratani Y, Ichikawa H, Hirose A, Nozaki Y, Takahashi M, Iwasaki S, Saibara T, Onishi S. 2008

[図書] キーワードでわかるメタボリックシンドローム

西原利治、小野正文 2008

[図書] 病気と薬パーフェクトBOOK

西原利治、小野正文 2008

[雑誌論文] Mutations in the small heterodimer partner gene increase morbidity risk in Japanese type 2 diabetes patients

Enya M, Horikawa Y, Kuroda E, Yonemaru K, Tonooka N, Tomura H, Oda N, Yokoi N, Yamagata K, Shihara N, Iizuka K, Saibara T, Seino S, Takeda J 2008

[図書] NASH診療best approach

西原利治 2008

[雑誌論文] Expression of fascin-1, an actin-bundling protein, in migrating hepatoblasts during rat liver development.

Hayashi Y, Toda K, Saibara T, Okamoto S, Osanai M, Enzan H, Lee GH. 2008

[学会発表] Nonalcoholic fatty liver disease is a hepatic manifestation of metabolic syndrome

T.Saibara 2007

[学会発表] The Cog2 gene A2217G single nucleotide polymorphism confers susceptibility to hepatocyte ballooning in NASH patients

Saibara T, Yoshioka A, Hirose A, Nozaki Y, Takahashi M, Ono M, Iwasaki S, Onishi S 2007

[学会発表] The Cog2 gene A2217G single nucleotide polymorphism confers susceptibility to hepatocyte ballooning in NASH patients

T.Saibara, A.Yoshioka, A.Hirose, et. al. 2007

[学会発表] Angiotensin II type 1 receptor blocker inhibits fibrosis in rats steatohepatitis

Ono M, Hirose A, Saibara T, Nozaki Y, Masuda K, Yoshioka A, Takahashi M, Akisawa N, Iwasaki S, Onishi S 2007

[図書] 薬剤師のための臨床講座

西原利治 2007

[学会発表] Metabolic syndrome as the pathogenic background for the development of NASH

Saibara T, Ono M, Hirose A, Onishi S 2007

[図書] アルコールと医学生物学

李春媚、小笠原光成、植瑞希、廣瀬享、野崎靖子、高橋昌也、小野正文、岩崎信二、西原利治、大西三朗 2007

[図書] Dataで読み解く内科疾患

西原利治 2007

[雑誌論文] Angiotensin II type 1 receptor blocker inhibits fibrosis in rat nonalcoholic steatohepatitis

Hirose A, Ono M, Saibara T, et. al. 2007

[図書] 肝硬変のマネジメント

西原利治、小野正文、大西三朗 2007

[雑誌論文] Obstructive sleep apnea syndrome is associated with some components of metabolic syndrome

Kono M, Tatsumi K, Saibara T, Nakamura A, Tanabe N, Takiguchi Y, Kuriyama T. 2007

[図書] わかりやすい内科学

西原利治、大西三朗 2007

[雑誌論文] The phosphatidyl ethanolamine N-methyltransferase gene V175M single nucleotide polymorphism confers the susceptibility to NASH in Japanese population

Dong H, Wang J, Li C, Hirose A, Nozaki Y, Takahashi M, Ono M, Akisawa N, Iwasaki S, Saibara T, Onishi S. 2007

[学会発表] Angiotensin II type 1 receptor blocker inhibits fibrosis in rats steatohepatitis

M.Ono, A.Hirose, T.Saibara, et. al. 2007

[図書] Annual Review消化器2007

西原利治 2007

[図書] 肝臓病の最新治療

西原利治、小野正文、大西三朗 2007

[雑誌論文] Fibrate for treatment of primary biliary cirrhosis

Iwasaki S, Akisawa N, Saibara T, et. al. 2007

[学会発表] Possibie involvement of impaired choline-methionine metabolism in the pathogenesis of nonalcoholic fatty liver disease

T.Saibara, M.Ono, S.Onishi 2007

[雑誌論文] Fibrate for treatment of primary biliary cirrhosis

Iwasaki S, Akisawa N, Saibara T, Onishi S. 2007

[雑誌論文] Angiotensin II type 1 receptor blocker inhibits fibrosis in rat nonalcoholic steatohepatitis

Hirose A, Ono M, Saibara T, Nozaki Y, Masuda K, Yoshioka A, Takahashi M, Akisawa N, Iwasaki S, Oben JA, Onishi S. 2007

[雑誌論文] Decreased lipoprotein lipase in obstructive sleep apnea syndrome

Iesato K, Tatsumi K, Saibara T, Nakamura A, Terada J, Tada Y, Sakao S, Tanabe N, Takiguchi Y, Kuriyama T. 2007

[図書] NASH診療ハンドブック

西原利治 2007

[学会発表] Metabolic syndrome as the pathogenic background for the development of NASH

T.Saibara, M.Ono, A.Hirose, et. al. 2007

[学会発表] The phosphatidylethanolamine N-methyltransferase gene V175M single nucleotide polymorphism confers the susceptibility to NASH in Japanese population

Saibara T, Yoshioka A, Hirose A, Nozaki Y, Takahashi M, Ono M, Iwasaki S, Onishi S 2007

[学会発表] The phosphatidylethanolamine N-methyltransferase gene V175M single nucleotide polymorphism confers the susceptibility to NASH in Japanese population

T.Saibara, A.Yoshioka, A.Hirose, et. al. 2007