トップ›研究者を探す›脂肪酸β酸化能を規定する遺伝子多型の特定とその結晶蛋白構造解析

脂肪酸β酸化能を規定する遺伝子多型の特定とその結晶蛋白構造解析

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-19590772
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
内科系臨床医学
消化器内科学
研究機関 高知大学
代表研究者 西原 利治
研究分担者 戸田 勝巳
研究分担者 高橋 昌也
研究期間 開始年月日 2007/4/1
研究期間 終了年度 2008
研究ステータス 完了 (2008/4/1)
配分額（合計） 4,550,000 (直接経費 :3,500,000、間接経費 :1,050,000)
配分額（履歴） 2008年度：1,560,000 (直接経費 :1,200,000、間接経費 :360,000)
2007年度：2,990,000 (直接経費 :2,300,000、間接経費 :690,000)
キーワード 脂肪酸β酸化
遺伝子多型
リパーゼ
結晶解析
Fatty acid
Beta-oxidation
PPAR
Crystalography

研究成果

[図書] 2009今日の治療指針

西原利治 2009

[図書] 消化器疾患最新の治療

西原利治 2009

[図書] C型肝炎のベスト治療

西原利治 2009

[図書] Annual Review消化器2009

西原利治 2009

[雑誌論文] Expression of fascin-1, an actin-bundling protein, in migrating hepatoblasts during rat liver development.

Hayashi Y. Toda K, Saibara T, Okamoto S, et al. 2008

[学会発表] Angiotensin II type 1 receptor blocker attenuates the progression of nonalcoholic steatohepatitis (NASH).

Hirose A, Ono M, Saibara T, Nozaki Y, et al. 2008

[雑誌論文] Mutations in the small heterodimer partner gene increase morbidity risk in Japanese type 2 diabetes patients

Enya M, Horikawa Y, Kuroda E, Yonemaru K, Tonooka N, Tomura H, Oda N, Yokoi N, Yamagata K, Shihara N, Iizuka K, Saibara T, Seino S, Takeda J 2008

[学会発表] Methionine-choline metabolism is involved in the pathogenesis of nonalcoholic steatohepatitis

Tokumitsu K, Ogasawara K, Maki M, Hirose A, Nozaki Y, Takahashi M, Ono M, Iwasaki S, Saibara T, Onishi S. 2008

[図書] 第94回日本消化器病学会総会ポストグラジュエイトコース

西原利治 2008

[雑誌論文] Preserved tissue-structure of efferent ductules in aromatase deficient mice

Toda K, Okada T, Hayashi Y, Saibara T. 2008

[学会発表] Secondary extrahepatic portal obstruction resulted from thrombus in splenic vein aneurysma

Kuratani Y, Ichikawa H, Hirose A, Nozaki Y, Takahashi M, Iwasaki S, Saibara T, Onishi S. 2008

[図書] 酸化ストレスと肝疾患

杜井峰、小笠原光成、植瑞希、廣瀬享、野崎靖子、小野正文、岩崎信二、西原利治、大西三朗 2008

[図書] キーワードでわかるメタボリックシンドローム

西原利治、小野正文 2008

[雑誌論文] Preserved tissue-structure of efferent ductules in aromatase deficient mice.

Toda K, Okada T, Hayashi Y, Saibara T. 2008

[学会発表] Super-paramagnetic iron oxide-MRI : A novel technique in experimental liver studies shows defective Kupffer cell phagocytic function in human non alcoholic fatty liver disease

Ono M, Kubota K, Hirose A, Nozaki Y, Takahashi M, Iwasaki S, Saibara T, Ogawa Y, Onishi S, Oben JA. 2008

[学会発表] Angiotensin II type 1 receptor blocker attenuates the progression of nonalcoholic steatohepatitis (NASH)

Hirose A, Ono M , Saibara T, Nozaki Y, Takahashi M, Iwasaki S, Oben JA, Onishi S. 2008

[雑誌論文] Expression of fascin-1, an actin-bundling protein, in migrating hepatoblasts during rat liver development

Hayashi Y, Toda K, Saibara T, Okamoto S, Osanai M, Enzan H, Lee GH 2008

[図書] NASH診療best approach

西原利治 2008

[図書] 病気と薬パーフェクトBOOK

西原利治、小野正文 2008

[図書] 肝疾患レジデントマニュアル

西原利治 2008

[学会発表] Metabolic syndrome as the pathogenic background for the development of NASH

T.Saibara, M.Ono, A.Hirose, et. al. 2007

[雑誌論文] Decreased lipoprotein lipase in obstructive sleep apnea syndrome

lesato K, Tatsumi K, Saibara T, et. al. 2007

[雑誌論文] Fibrate for treatment of primary biliary cirrhosis

Iwasaki S, Akisawa N, Saibara T, Onishi S. 2007

[図書] 肝臓病の最新治療

西原利治、小野正文、大西三朗 2007

[図書] 肝硬変のマネジメント

西原利治、小野正文、大西三朗 2007

[学会発表] The Cog2 gene A2217G single nucleotide polymorphism confers susceptibility to hepatocyte ballooning in NASH patients

Saibara T, Yoshioka A, Hirose A, Nozaki Y, Takahashi M, Ono M, Iwasaki S, Onishi S 2007

[学会発表] Metabolic syndrome as the pathogenic background for the development of NASH

Saibara T, Ono M, Hirose A, Onishi S 2007

[雑誌論文] Angiotensin II type 1 receptor blocker inhibits fibrosis in rat nonalcoholic steatohepatitis

Hirose A, Ono M, Saibara T, Nozaki Y, Masuda K, Yoshioka A, Takahashi M, Akisawa N, Iwasaki S, Oben JA, Onishi S. 2007

[雑誌論文] Spur cells and acanthocytes in liver diseases

T.Saibara 2007

[図書] 薬剤師のための臨床講座

西原利治 2007

[学会発表] Angiotensin II type 1 receptor blocker inhibits fibrosis in rats steatohepatitis

Ono M, Hirose A, Saibara T, Nozaki Y, Masuda K, Yoshioka A, Takahashi M, Akisawa N, Iwasaki S, Onishi S 2007

[雑誌論文] What are the risk factors and settings for non-alcoholic fatty liver disease in Asia-Pacific?

Fan JG, Saibara T, Chitturi S, et. al. 2007

[雑誌論文] Obstructive sleep apnea syndrome is associated with some components of metabolic syndrome

Kono M, Tatsumi K, Saibara T, et. al. 2007

[図書] NASH診療ハンドブック

西原利治 2007

[学会発表] The Cog2 gene A2217G single nucleotide polymorphism confers susceptibility to hepatocyte ballooning in NASH patients

T.Saibara, A.Yoshioka, A.Hirose, et. al. 2007

[学会発表] Possible involvement of impaired choline-methionine metabolism in the pathogenesis of nonalcoholic fatty liver disease.

T.Saibara, M.Ono, S.Onishi 2007

[学会発表] Angiotensin II type 1 receptor blocker inhibits fibrosis in rats steatohepatitis

M.Ono, A.Hirose, T.Saibara, et. al. 2007

[雑誌論文] Angiotensin II type 1 receptor blocker inhibits fibrosis in rat nonal coholic steatohepatitis

Hirose A, Ono M, Saibara T, et. al. 2007

[雑誌論文] The phosphatidyl ethanolamine N-methyltransferase gene V175M single nucleotide polymorphism confers the susceptibility to NASH in Japanese population

Dong H, Wang J, Li C, Hirose A, Nozaki Y, Takahashi M, Ono M, Akisawa N, Iwasaki S, Saibara T, Onishi S. 2007

[雑誌論文] Obstructive sleep apnea syndrome is associated with some components of metabolic syndrome

Kono M, Tatsumi K, Saibara T, Nakamura A, Tanabe N, Takiguchi Y, Kuriyama T. 2007

[図書] アルコールと医学生物学

李春媚、小笠原光成、植瑞希、廣瀬享、野崎靖子、高橋昌也、小野正文、岩崎信二、西原利治、大西三朗 2007

[学会発表] Nonalcoholic fatty liver disease is a hepatic manifestation of metabolic syndrome

T.Saibara 2007

[雑誌論文] Decreased lipoprotein lipase in obstructive sleep apnea syndrome

Iesato K, Tatsumi K, Saibara T, Nakamura A, Terada J, Tada Y, Sakao S, Tanabe N, Takiguchi Y, Kuriyama T 2007

[図書] Dataで読み解く内科疾患

西原利治 2007

[図書] Annual Review 消化器 2007

西原利治 2007

[図書] わかりやすい内科学

西原利治、大西三朗 2007

[雑誌論文] Fibrate for treatment of primary biliary cirrhosis

Iwasaki S, Akisawa N, Saibara T, et. al. 2007

[雑誌論文] Phosphatidylcholine could have a key role in the pathogenesis of steatohepatitis-Reply

Saibara T, Ono M. 2007

[学会発表] The phosphatidylethanolamine N-methyltransferase gene V175M single nucleotide polymorphism confers the susceptibility to NASH in Japanese population

Saibara T, Yoshioka A, Hirose A, Nozaki Y, Takahashi M, Ono M, Iwasaki S, Onishi S 2007

[学会発表] The phosphatidylethanolamine N-methyltransferase gene V175M single nucleotide polymorphism confers the susceptibility to NASH in Japanese population

T.Saibara, A.Yoshioka, A.Hirose, et. al. 2007