研究成果

[雑誌論文] Lack of promoting effects from physical pulmonary collapse in a female A/J mouse lung tumor initiated with 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone (NNK) with remarkable mesothelial cell reactions in the thoracic cavity by the polymer.

Yokohira M, Hashimoto N, Yamakawa K, Saoo K, Kuno T, Imaida K. 2011

[学会発表] ラット気管内投与によるnicotineの毒性作用

今井田克己 2011

[雑誌論文] Molecular analysis of carcinogen induced rodent lung tumors-Invovement of microRNA expression and Kras or EGFR mutation.

Yamakawa K, Kuno T, Hashimoto N, Yokohira M, Suzuki S, Nakano Y, Saoo K, Imaida, K. 2010

[雑誌論文] Risk analysis of environmental chemicals on lung carcinogenesis.

Imaida K, Yokohira M, Hashimoto N, Kuno T. 2010

[雑誌論文] Potassium octatitanate fibers (TISMO) induce pleural mesothelial cell reactions with iron accumulation in female A/J mice

Yokohira M, Hashimoto N, Imaida K, et al. 2010

[雑誌論文] Tumorigenesis of 2-Amino-3,8-dimethylimidazo[4,5-f]qu inoxaline (MeIQx), but not enhancing effects of concomitant high fat diet, on lung carcinogenesis in female A/J mice.

Takeuchi H, Saoo K, Yamakawa K, Matsuda Y, Yokohira M, Zeng Y, Kuno T, Totsuka Y, Takahashi M, Wakabayashi K, Imaida K. 2010

[雑誌論文] Different threshold levels for 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MelQx) initiation of lung and colon carcinogenesis and the effects of an additional initiation by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in A/J mice.

Suzuki S, Yokohira M, Hashimoto N, Saoo K, Matsuda Y, Yamakawa K, Nakano Y, Kuno T, Imaida K. 2010

[雑誌論文] Lack of promoting effects from physical pulmonary collapse in a female A/J mouse lung tumor initiated with 4-(methylnitro-samino)-1-(3-pyridyl)-1-butanone (NNK) with remarkable mesothelial cell reactions in the thoracic cavity by the polymer

Yokohira M, Hashimoto N, Imaida K, et al. 2010

[雑誌論文] Potassium octatitanate fibers (TISMO) induce pleural mesothelial cell reactions with iron accumulation in female A/J mice.

Yokohira M, Hashimoto N, Yamakawa K, Suzuki S, Saoo K, Kuno T, Imaida K. 2010

[雑誌論文] Potassium octatitanate fibers (TISMO) induce pleural mesothelial cell reactions with iron accumulation in female A/J mice.

Yokohira M 2010

[雑誌論文] Immunohistochemically detected expression of p27kip1 and skp2 predicts survival in patients with intrahepatic cholangiocarcinomas.

Hashimoto N, Yachida S, Okano K, Wakabayashi H, Imaida K, Kurokohchi K, Masaki T, Kinoshita H, Tominaga M, Ajiki T, Ku Y, Okabayashi T, Hanazaki K, Hiroi M, Izumi S, Mano S, Okada S, Karasawa V, Maeba V, Suzuki Y. 2009

[雑誌論文] A lung carcinogenic bioassay of CuO and TiO2 nanoparticles with intratracheal instillation using F344 male rats

Yokohira M, Hashimoto N, Imaida K, et al. 2009

[学会発表] Comparison of nano- and micro-sized particles by three different route administrations using a medium-term liver carcinogenesis bioassay in F344 rats

Hashimoto N, Yokohira M, Imaida K, et al. 2009

[雑誌論文] Enhancing effects of a high fat diet on 2-amino-3,8-dimethylimidazo[4,5-f]qui noxaline (MeIQx) induced lung tumorigenesis in female A/J mice.

Matsuda Y, Takeuchi H, Yokohira M, Saoo K, Hosokawa K, Yamakawa K, Zeng Y, Totsuka Y, Wakabayashi K, Imaida K. 2009

[学会発表] Comparison of nano- and micro-sized particles by three different route administrations using a medium-term liver carcinogenesis bioassay in F344 rats.

橋本希, 横平正直, 今井田克己, et al. 2009

[学会発表] 気管内投与によるCuOナノサイズ粒子の急性変化の検討-マイクロサイズ粒子との比較による-

橋本希、横平正直、今井田克己, 他 2009

[雑誌論文] An intratracheal instillation bioassay system for detection of lung toxicity due to fine particles in F344 rats.

Yokohira M, Kuno T, Yamakawa K, Hashimoto N, Ninomiya F, Suzuki S, Saoo K, Imaida K. 2009

[図書] 第2部社会問題となった疾患と病理学〈環境〉(4.内分泌撹乱化学物質(環境ホルモン)病理と臨床 臨時増刊号)(深山正久, 樋野興夫, 坂元亨宇, 中山淳, 羽場礼次(編集)

今井田克己 2009

[雑誌論文] Lack of modifying effects of intra-tracheal instillation of quartz or dextran sulfate sodium (DSS) in drinking water on lung tumor development initiated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-buta none (NNK) in female A/J mice

Yokohira M, Hashimoto N, Imaida K, et al. 2009

[雑誌論文] Lack of modifying effects of intratracheal instillation of quartz or dextran sulfate sodium (DSS) in drinking water on lung tumor development initiated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in female A/J mice.

Yokohira M, Hashimoto N, Yamakawa K, Suzuki S, Saoo K, Kuno T, Imaida K. 2009

[雑誌論文] carcinogenic bioassay of CuO and TiO2 nanoparticles with intratracheal instillation using F344 male rats.

Yokohira M, Hashimoto N, Yamakawa K, Suzuki S, Saoo K, Kuno T, Imaida K. A lung 2009

[雑誌論文] An intratracheal instillation bioassay system for detection of lung toxicity due to fine particles in F344 rats

Yokohira M, Kuno T, Imaida K, et al. 2009

[学会発表] 気管内投与によるCuOナノサイズ粒子の急性変化の検討-マイクロサイズ粒子との比較による-

橋本希, 横平正直, 今井田克己, 他 2009

[学会発表] Comparison of nano-and micro-sized particles by three different route administration using a medium-term liver carcinogenesis bioassay in F344 rats

橋本希 2009

[学会発表] Comparison of nano-and micro-sized particles by three different route administrations using a medium-term liver carcinogenesis bioassay in F344 rats.

橋本 希 2009

[雑誌論文] Lack of modifying effects of intratracheal instillation of quartz or dextran sulfate sodium (DSS) in drinking water on lung tumor development initiated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in female A/J mice

Yokohira M. 2009

[雑誌論文] A lung carcinogenic bioassay of CuO and TiO2 nanoparticles with intratracheal instillation using F344 male rats

Yokohira M. 2009

[学会発表] Intratracheal instillation of CuO nanoparticles promotes liver carcinogenesis in F344 rats.

橋本希, 横平正直, 今井田克己, et al. 2008

[学会発表] Intratracheal instillation of CuO nanoparticles promotes liver carcinogenesis in F344 rats

Hashimoto N, Yokohira M, Imaida K, et al. 2008

[雑誌論文] Lung toxicity of 16 fine particles on intratracheal instillation in a bioassay model using F344 male rats.

Yokohira M, Kuno T, Yamakawa K, Hosokawa K, Matsuda Y, Hashimoto N, Suzuki S, Saoo K, Imaida K. 2008

[雑誌論文] Establishment of a bioassay model for lung cancer chemoprevention initiated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in female A/J mice.

Yokohira M, Takeuchi H, Saoo K, Matsuda Y, Yamakawa K, Hosokawa K, Kuno T, Imaida K. 2008

[雑誌論文] Lack of modifying potential of 8-methoxypsoralen in the promotion or progression stages of lung carcinogenesis in A/J emale ice.

Kuno T, Yokohira M, Matsuda Y, Suzuki S, Hashimoto N, Yamakawa K, Saoo K, Imaida K. 2008

[学会発表] Potential of inhibitory effects by D-allose, a rare sugar, on liver carcinogenesis in a rat medium-term bioassay

Yamakawa K, Yokohira M, Kuno T, Matsuda Y, Hashimoto N, Hosokawa K, Saoo K, Imaida K. 2007

[学会発表] A study on the threshold for MeIQx carcinogenesis in lung using A/J mice

Suzuki S, Yokohira M, Kuno T, Yamakawa K, Hosokawa K, Matsuda Y, Shiooka T, Imaida, K. 2007

[雑誌論文] Bioassay by intratracheal instillation for detection of lupg toxicity due to fine particles in F344 male rats

Yokohira M, Takeuchi H, Yamakawa K, Saoo K, Matsuda Y, Zeng Y, Hosokawa K, Imaida K 2007

[雑誌論文] CYP2A6 overexpression in human lung cancers corelates with a high malignant status

Matsuda Y, Yamakawa K, Saoo K, Hosokawa K, Yokohira M, Kuno T, Iwai J, Shirai T, Obika K, Kamataki T, Imaida K 2007

[雑誌論文] Overexpression of CYP2A6 in Human Colorectal Tumors

Matsuda Y, Saoo K, Yamakawa K, Yokohira M, Suzuki S, Kuno T, Kamataki T, Imaida K. 2007

[雑誌論文] 毒性病理学の最近の話題:経気道曝露による肺毒性-喫煙と大気汚染-

今井田 克己、横平 政直 2007

[学会発表] Detection of epidermal growth factor receptor(EGFR)gene mutation in rat lung tumors induced by X-ray irradiation

Kitahashi T, Takahashi M, Tutsumi M, Kusuoka O, Yokohira M Imaida K, Takasuka N, Sugimura T, Wakabayashi K 2007

[学会発表] Modulation effect of NNK-induced lung tumor by CYP2A inhibitor,8-MOP administered during promotion or progression phase

Kuno T, Saoo K, Yokohira M, Yamakawa K, Hashimoto N, Hosokawa K. Matsuda Y. Imaida K 2007

[学会発表] Short-term effect of various chemicals on NNK-induced tumorigenesis in A/J female mouse

Matsuda Y, Yamakawa K, Saoo K, Yokohira M, Hosokawa K, Kuno T, Naito Z, Imaida, K. 2007

[雑誌論文] Post-initiation chemopreventive effects of dietary bovine lactoferrin on4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesisin female A/J mice

Matsuda Y, Saoo K, Hosokawa K, Yamakawa K, Yokohira M, Zeng Y, Takeuchi H, Imaida, K 2007

[学会発表] Enzymatically modified isogercitrin and isoquercitorin, in a rat medium-term liver carcinogenesis bioassay

Hosokawa K, Yokohira M, Yamakawa K, Saoo K, Matsuda Y, Suzuki S, Kuno T, Imaida K. 2007

[雑誌論文] Bioassay by intratracheal instillation for detection of lung toxicity due to fine particles in F344 male rats.

Yokohira M, Takeuchi H, Yamakawa K, Saoo K, Matsuda Y, Zeng Y, Hosokawa K, Imaida K. 2007

[雑誌論文] Detection of Carcinogenic and Modifying Potentials by Test Compounds Using a Mouse Lung Carcinogenesis Bioassay

Imaida K, Yokohira Y, Kuno T 2007

[学会発表] Establishment of a bioassay for lung carcinogenesis due to fine particlesinstilled intratracheally in F344 rats

Yokohira M, Kuno T, Saoo K, Yamakawa K, Suzuki S, Hosokawa K, Matsuda Y, Kinouchi S, Imaida K 2007

[学会発表] Expression of p27 and Skp2 predicts postoperative survival for patients with intrahepatic

Hashimoto N, Yachida S, Okano K, Wakabayashi H, Imaida K, Suzuki Y 2007

[雑誌論文] Detection of carcinogenic and modifying potentials by test compounds using amouse lung carcinogenesis bioassay.

Imaida K, Yokohira Y, Kuno T. 2007