トップ研究者を探す細胞内コリン産生系の薬理学的修飾による血管新生の可能性とその機序の解析

細胞内コリン産生系の薬理学的修飾による血管新生の可能性とその機序の解析

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-19590251
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
基礎医学
薬理学一般
研究機関 高知大学
代表研究者 柿沼 由彦
代表研究者 柿沼 由彦
研究分担者 佐藤 隆幸
研究分担者 KATARE RAJESH
研究分担者 有川 幹彦
連携研究者 佐藤 隆幸
連携研究者 有川 幹彦
研究期間 開始年月日 2007/4/1
研究期間 終了年度 2008
研究ステータス 完了 (2008/4/1)
配分額(合計) 4,420,000 (直接経費 :3,400,000、間接経費 :1,020,000)
配分額(履歴) 2008年度:1,950,000 (直接経費 :1,500,000、間接経費 :450,000)
2007年度:2,470,000 (直接経費 :1,900,000、間接経費 :570,000)
キーワード 循環
血管新生
アセチルコリン
下肢虚血モデル
VEGF

研究成果

[学会発表] Donepezil, an Acetylcholinesterase Inhibitor Against Alzheimers Dementia, Prevents Remodeling in Volume-Overload Heart Failure Mice : Local and Central effect of Donepezil

Handa T, Sato T, Kakinuma Y, Arikawa M, Sasaguri S 2009

[雑誌論文] Vagal nerve stimulation prevents reperfusion injury through inhibition of opening of mitochondrial permeability transition pore independent of the bradycardiac effect

Katare GR, Ando M, Kakinuma Y, Arikawa M, Handa T, Yamasaki F, Sato T 2009

[雑誌論文] Donepezilを使用した容量負荷心不全マウスにおける心機能改善効果、生存率改善効果の検討

半田武巳、Katare GR、柿沼由彦, 有川幹彦、安藤元規、山崎文靖、佐藤隆幸、篠栗志朗 2009

[雑誌論文] Chronic intermittent fasting improves the survival following large myocardial ischemia by activation of BDNF/VEGF/PI3K signaling pathway

Katare GR, Kakinuma Y, Arikawa M, Yamasaki F, Sato T. 2009

[学会発表] Donepezil, Anti-Alzheimer's Disease Drug, Prevented the Progression of Ventricular Dysfunction after Myocardial Infarction

Arikawa M, Katare R, Kakinuma Y, Handa T, Andoh M,Yamasaki F, Sato T 2008

[学会発表] Donepezil, anti-Alzheimer's disease drug, prevented the progression of ventricular dysfunction after myocardial infarction

Arikawa, M 2008

[学会発表] Cardiomyocytes Produces Acetylcholine in Circulation Response to Muscarinic Receptor Stimulation : a Possible Mechanism for Amplification of Cardioprotective Effects of Cardiac Vagal Nerve Circulation 116 : II-159(819)

Kakinuma Y, Akiyama T, Arikawa M, Handa T, Sato T. 2008

[雑誌論文] A HIF-1alpha-related gene involved in cell protection from hypoxia by suppression of mitochondrial function

Kakinuma Y, Katare RG, Arikawa M, Muramoto K, Yamasaki F, Sato T 2008

[学会発表] Donepezil, an Acetylcholinesterase Inhibitor Against Alzheimers Dementia, Prevents Remodeling and Improves Survival in Volume-Overload Heart Failure Mice

Handa T, Sato T, Kakinuma Y, Arikawa M. 2008

[雑誌論文] Acute Inactivation of the VHL gene Contributes to Protective Effects of Ischemic Preconditioning in the Mouse Kidney

Iguchi M, Kakinuma Y, Kurabayashi A, Sato T, Shuin T, Hong S-B, Schmidt LS, Furihata M 2008

[学会発表] A HIF-1α-related gene involved in cell protection from hypoxia by suppression of mitochondrial function

Kakinuma Y, Sato T. 2008

[学会発表] Myocardial Infarction is Prevented by Anti-Alzheimer's Disease Drug, Donepezil Circulation 116 : II-291(1416)

7.Arikawa M, Katare GR, Kakinuma Y, Handa T, Ando M, Yamasaki F, Sato T. 2007

[学会発表] Donepezil Promotes Angiogenesis in an Ischemic Limb Model of Nicotinic α7 Receptor KO Mice

Kakinuma Y, Katare GR, Arikawa M, Handa T, Yamsaki F, Sato T. 2007

[学会発表] Tumor Necrosis Factor Receptor-2 Plays a Critical Role for Induction of Post Ischemic Neovascularization in Mouse Model of Hind Limb Ischemia. Circulation 116 : II-274(1339)

Katare GR., Kakinuma Y, Arikawa M, Handa T, Yamasaki F, Sato T. 2007

[学会発表] Vagal Nerve Stimulation Salvage the Myocardium Agaisnt Reperfusion Injury Through Inhibition of Opening of Mitochondrial Permeability Transition Pore

Katare R, Kakinuma Y, Andoh M, Arikawa M, Handa T, Sasaguri S, Yamasaki F, Sato T. 2007

[学会発表] Acetylcholiesterase Inhibitor Against Alzheimer's Dementia, Promotes Angiogenesis in an Ischemic Limb Model of Nicotinic α7 KO Mice Circulation 116 : II-159(819)

Kakinuma Y, Katare GR, Arikawa M, Handa T, Yamasaki F, Li M, Zheng C, Sugimachi M, Sato T. 2007

[学会発表] Cardiomyocytes Produce Acetylcholine in Response to Muscarinic Receptor Agonists : a Possible Mechanism for Cardioprotective Effects of Vagal Stimulation on Cardiomyocytes

Kakinuma Y, Katare R, Arikawa M, Handa T, Akiyama T, Andoh M, Yamasaki F, Sato T 2007

[学会発表] Donepezil Promotes Angiogenesis through the Mechanisms Independent of Cholinesterase Inhibition and Nicotinic α7 Receptor

Kakinuma Y, Katare R, Arikawa M, Handa T, Andoh M, Li M, Zheng C, Yamasaki F, Sato T. 2007

[学会発表] Vagal Nerve Stimulation Protects Heart Against Ischemic Insult through Differential Regulation of Myocardial TNF Receptor Subtypes

Katare R, Andoh M, Kakinuma Y, Arikawa M, Handa T, Yamasaki F, Sato T 2007

[学会発表] Electrophysiological Approaches to the Mechanism of Arrhythmogenesis in Artificially-Arranged Cardiomyocytes

Arikawa M, Katare R, Kakinuma Y, Andoh M, Handa T, Yamasaki F, Sato T. 2007

[学会発表] Myocardial infarction is prevented by anti-Alzheimer's disease drug, donepezil

Arikawa, M 2007

[学会発表] Cholinesterase Inhibitor Donepezil Improves Ventricular Function of Mice with Non-Ischemic Chronic Heart Failure

Handa T, Katare R, Kakinuma Y, Arikawa M, Ando M, Sasaguri S, Sato T. 2007

[学会発表] Nitric Oxide Has Beneficial Effects on Cardiomyocytes by Activation of the Vascular Endothelial Growth Factor

Kuwabara M, Kakinuma Y, Andoh M, Katare R, Yamasaki F, Doi Y, Sato T. 2007