トップ研究者を探す心血管系組織における活性酸素依存性細胞内情報伝達に関わる一酸化窒素の役割

心血管系組織における活性酸素依存性細胞内情報伝達に関わる一酸化窒素の役割

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-19590250
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
基礎医学
薬理学一般
研究機関 香川大学
代表研究者 木村 正司
研究分担者 永井 由紀子
研究分担者 西山 成
研究分担者 大森 浩二
研究分担者 張 國興
研究分担者 宮武 明
連携研究者 西山 成
連携研究者 大森 浩二
研究期間 開始年月日 2007/4/1
研究期間 終了年度 2008
研究ステータス 完了 (2008/4/1)
配分額(合計) 4,680,000 (直接経費 :3,600,000、間接経費 :1,080,000)
配分額(履歴) 2008年度:1,950,000 (直接経費 :1,500,000、間接経費 :450,000)
2007年度:2,730,000 (直接経費 :2,100,000、間接経費 :630,000)
キーワード 高血圧
酸化ストレス
一酸化窒素合成酵素
アンジオテンシン
活性酸素
MAPキナーゼ
ミトコンドリア
血管平滑筋

研究成果

[雑誌論文] The opposite roles of nNOS in cardiac ischemia-reperfusion-induced injury and in ischemia preconditioning-induced cardioprotection in mice.

Lu XM, Zhang GX, Yu YQ, Kimura S, Nishiyama A, Matsuyoshi H, Shimizu J, Takaki M. 2009

[雑誌論文] Role of neuronal NO synthase in regulating vascular superoxide levels and mitogen-activated protein kinase phos

Zhang GX, Kimura S, Murao K, Shimizu J, Matsuyoshi H, Takaki M. 2009

[雑誌論文] Role of neuronal NO synthase in regulating vascular superoxide levels and mitogen-activated protein kinase phosphorylatlon.

Zhang, et al. 2009

[図書] D-allose suppresses development of hypertension in salt-loaded spontaneously hypertensive rats(RARE SUGARS II, Edited by Asada Y, Kawanami Y, Tajima S)

Zhang GX, Nagai Y, Fujisawa Y, Nishiyama A, Kimura S. 2008

[雑誌論文] Aldosterone induces myofibroblastic transdifferentiation and collagen gene expression through the Rho-kinase dependent signaling pathway in rat mesangial cells

Diah S, Zhang GX, Nagai Y, Zhang W, Gang L, Kimura S, Hamid MRWA, Tamiya T, Nishiyama A, Hitomi H. 2008

[雑誌論文] Possible involvement of Rho-kinase in aldosterone-induced vascular remodeling

Miyata K, Sun GP, Guo P, Hitomi H, Kimura S, Kiyomoto H, Hosomi N, Kohno M and Nishiyama A. 2008

[図書] D-psicose, a rare sugar, prevents Di-(2-ethylhexyl)phthalate (DEHP)-induced testicular injury by suppressing the generation of reactive oxygen species in rat testis(RARE SUGARS II, Edited by Asada Y, Kawanami Y, Tajima S)

Suna S, Jistunari F, Tokuda M, Yamaguchi F, Kimura S 2008

[雑誌論文] Modulating effect of the PI3-kinase inhibitor LY294002 on cisplatin in human pancreatic cancer cells

Fujiwara M, Izuishi K, Sano T, HossainMA, Kimura S, Masaki T, Suzuki Y. 2008

[雑誌論文] Effects of adrenomedullin 2 on regional hemodynamics in conscious rats

Fujisawa Y, Nagai Y, Miyatake A, Miura K, Nishiyama A, Kimura S, Abe Y. 2007

[雑誌論文] Role of mitochondria in angiotensn II-induced reactive oxygen species and mitogen-activated protein kinase activation

Zhang GX, Lu XM, Kimura S, Nishiyama A. 2007

[雑誌論文] Role of AT1 receptor in isoproterenol-induced cardiac hypertrophy and oxidative stress in mi

Zhang GX, Ohmori K, Nagai Y, Fujisawa Y, Nishiyama A, Abe Y, Kimura S 2007

[雑誌論文] Involvement of endogenous nitric oxide in angiotensin II-induced activation of vascular mitogen-activated protein kinases

Zhang GX, Nagai Y, Nakagawa T, Miyanaka H, Fujisawa Y, Nishiyama A, Izuishi K, Ohmori K, Kimura S. 2007

[雑誌論文] Preventive effect of D-psicose, one of rare ketohexoses, on di-(2-ethylhexyl) phthalate (DEHP)-induced testicular injury in rat

Suna S, Yamaguchi F, Kimura S, Tokuda M, Jitsunari F. 2007

[学会発表] Involvement of endogenous nitric oxide in angiotensin II-induced activation of vascular mitogen-activated protein kinases

Zhang, et. al. 2007

[学会発表] Involvement of endogenous nitric oxide in Angiotensin II-induced activation of vascular mitogenactivated protein kinases

Zhang, et. al. 2007

[学会発表] Involvement of endogenous nitric oxide in Angiotensin II-induced activation of vascular mitogen-activated protein kinases

Zhang GX et.al. 2007

[学会発表] Effects of 10-N-nonyl acridine orange(NAO)on ischemic/reperfusion injury in rat heart

張 国興, 他 2007

[雑誌論文] Role of AT1 receptor in isoproterenol-induced cardiac hypertrophy and oxidative stress in mice

Zhang, et. al. 2007

[学会発表] Involvement of endogenous nitric oxide in angiotensin II-induced activation of vascular mitogen-activated protein kinases

Zhang GX et.al. 2007

[雑誌論文] Involvement of endogenous nitric oxide in Angiotensin II-induced activation of vascular mitogen-activated protein kinases

Zhang, et. al. 2007

[雑誌論文] Role of mitochondria angiotensn II-induced reactive oxygen species and mitogen-activated protein kinase activation

Zhang, et. al. 2007